Multiploid inheritance of HIV-1 during cell-to-cell infection

Journal of Virology

Volumn 85, Issue 14, 2011, Pages 7169-7176

  Del Portillo, Armando ^a   Tripodi, Joseph ^a   Najfeld, Vesna ^a   Wodarz, Dominik ^b   Levy, David N ^c   Chen, Benjamin K ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c NEW YORK UNIVERSITY COLLEGE OF DENTISTRY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

VIRUS DNA;

ARTICLE; CELL FREE SYSTEM; CONTROLLED STUDY; ENDOREDUPLICATION; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; INFECTION RATE; INHERITANCE; NONHUMAN; PRIORITY JOURNAL; PROVIRUS; T LYMPHOCYTE; VIRUS EXPRESSION; VIRUS TITRATION; VIRUS TRANSMISSION;

CELL LINE; FLOW CYTOMETRY; HIV-1; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; POLYPLOIDY; T-LYMPHOCYTES;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 79960409830     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.00231-11     Document Type: Article

References (29)

1. Barbosa, P., P. Charneau, N. Dumey, and F. Clavel. 1994. Kinetic analysis of HIV-1 early replicative steps in a coculture system. AIDS Res. Hum. Retroviruses 10, 53-59.
2. Besnier, C., Y. Takeuchi, and G. Towers. 2002. Restriction of lentivirus in monkeys. Proc. Natl. Acad. Sci. U. S. A. 99, 11920-11925.
3. Chen, B. K., R. T. Gandhi, and D. Baltimore. 1996. CD4 down-modulation during infection of human T cells with human immunodeficiency virus type 1 involves independent activities of vpu, env, and nef. J. Virol. 70, 6044-6053.
4. Chen, J., et al. 2005. Mechanisms of nonrandom human immunodeficiency virus type 1 infection and double infection, preference in virus entry is important but is not the sole factor. J. Virol. 79, 4140-4149.
5. Chen, J., et al. 2009. High efficiency of HIV-1 genomic RNA packaging and heterozygote formation revealed by single virion analysis. Proc. Natl. Acad. Sci. U. S. A. 106, 13535-13540.
6. Chen, P., W. Hübner, M. A. Spinelli, and B. K. Chen. 2007. Predominant mode of human immunodeficiency virus transfer between T cells is mediated by sustained Env-dependent neutralization-resistant virological synapses. J. Virol. 81, 12582-12595.
7. Coffin, J. M. 1995. HIV population dynamics in vivo, implications for genetic variation, pathogenesis, and therapy. Science 267, 483-489.
8. Dang, Q., et al. 2004. Nonrandom HIV-1 infection and double infection via direct and cell-mediated pathways. Proc. Natl. Acad. Sci. U. S. A. 101, 632-637.
9. Dimitrov, D. S., et al. 1993. Quantitation of human immunodeficiency virus type 1 infection kinetics. J. Virol. 67, 2182-2190.
10. Dixit, N. M., and A. S. Perelson. 2004. Multiplicity of human immunodeficiency virus infections in lymphoid tissue. J. Virol. 78, 8942-8945.
11. Gelderblom, H. C., et al. 2008. Viral complementation allows HIV-1 replication without integration. Retrovirology 5, 60.
12. Haase, A. T. 1999. Population biology of HIV-1 infection, viral and CD4+ T cell demographics and dynamics in lymphatic tissues. Annu. Rev. Immunol. 17, 625-656.
13. Hu, W. S., and H. M. Temin. 1990. Genetic consequences of packaging two RNA genomes in one retroviral particle, pseudodiploidy and high rate of genetic recombination. Proc. Natl. Acad. Sci. U. S. A. 87, 1556-1560.
14. Hübner, W., et al. 2007. Sequence of human immunodeficiency virus type 1 (HIV-1) Gag localization and oligomerization monitored with live confocal imaging of a replication-competent, fluorescently tagged HIV-1. J. Virol. 81, 12596-12607.
15. Hübner, W., et al. 2009. Quantitative 3D video microscopy of HIV transfer across T cell virological synapses. Science 323, 1743-1747.
16. Jolly, C., K. Kashefi, M. Hollinshead, and Q. J. Sattentau. 2004. HIV-1 cell to cell transfer across an Env-induced, actin-dependent synapse. J. Exp. Med. 199, 283-293.
17. Jung, A., et al. 2002. Recombination, multiply infected spleen cells in HIV patients. Nature 418, 144.
18. Kutsch, O., E. N. Benveniste, G. M. Shaw, and D. N. Levy. 2002. Direct and quantitative single-cell analysis of human immunodeficiency virus type 1 reactivation from latency. J. Virol. 76, 8776-8786.
19. Lauring, A. S., and R. Andino. 2010. Quasispecies theory and the behavior of RNA viruses. PLoS Pathog. 6, e1001005.
20. Levy, D. N., G. M. Aldrovandi, O. Kutsch, and G. M. Shaw. 2004. Dynamics of HIV-1 recombination in its natural target cells. Proc. Natl. Acad. Sci. U. S. A. 101, 4204-4209.
21. Martin, N., et al. 2010. Virological synapse-mediated spread of human immunodeficiency virus type 1 between T cells is sensitive to entry inhibition. J. Virol. 84, 3516-3527.
22. Overbaugh, J., and C. R. Bangham. 2001. Selection forces and constraints on retroviral sequence variation. Science 292, 1106-1109.
23. Perelson, A. S., A. U. Neumann, M. Markowitz, J. M. Leonard, and D. D. Ho. 1996. HIV-1 dynamics in vivo, virion clearance rate, infected cell life-span, and viral generation time. Science 271, 1582-1586.
24. Richardson, M. W., et al. 2008. Mode of transmission affects the sensitivity of human immunodeficiency virus type 1 to restriction by rhesus TRIM5alpha. J. Virol. 82, 11117-11128.
25. Rowland-Jones, S. L. 1999. HIV: The deadly passenger in dendritic cells. Curr. Biol. 9, R248-R250.
26. Sato, H., J. Orenstein, D. Dimitrov, and M. Martin. 1992. Cell-to-cell spread of HIV-1 occurs within minutes and may not involve the participation of virus particles. Virology 186, 712-724.
27. Sourisseau, M., N. Sol-Foulon, F. Porrot, F. Blanchet, and O. Schwartz. 2007. Inefficient human immunodeficiency virus replication in mobile lymphocytes. J. Virol. 81, 1000-1012.
28. Vandegraaff, N., R. Kumar, C. J. Burrell, and P. Li. 2001. Kinetics of human immunodeficiency virus type 1 (HIV) DNA integration in acutely infected cells as determined using a novel assay for detection of integrated HIV DNA. J. Virol. 75, 11253-11260.
29. Wodarz, D., and D. N. Levy. 2011. Effect of different modes of viral spread on the dynamics of multiply infected cells in human immunodeficiency virus infection. J. R. Soc. Interface 8, 289-300.