메뉴 건너뛰기




Volumn 3, Issue 9, 2011, Pages 228-249

Terpenoids as potential chemopreventive and therapeutic agents in liver cancer

Author keywords

Apoptosis; Cell cycle; Chemoprevention; Hepatocarcinogenesis; Hepatocellular carcinoma; Liver cancer cells; Terpenoids; Treatment

Indexed keywords


EID: 84861024238     PISSN: None     EISSN: 19485182     Source Type: Journal    
DOI: 10.4254/wjh.v3.i9.228     Document Type: Review
Times cited : (273)

References (194)
  • 1
    • 0020696332 scopus 로고
    • Pathology of hepatocellular carcinoma in Japan. 232 Consecutive cases autopsied in ten years
    • Nakashima T, Okuda K, Kojiro M, Jimi A, Yamaguchi R, Sakamoto K, Ikari T. Pathology of hepatocellular carcinoma in Japan. 232 Consecutive cases autopsied in ten years. Cancer 1983; 51: 863-877
    • (1983) Cancer , vol.51 , pp. 863-877
    • Nakashima, T.1    Okuda, K.2    Kojiro, M.3    Jimi, A.4    Yamaguchi, R.5    Sakamoto, K.6    Ikari, T.7
  • 3
    • 24644439190 scopus 로고    scopus 로고
    • Trends in the leading causes of death in the United States, 1970-2002
    • Jemal A, Ward E, Hao Y, Thun M. Trends in the leading causes of death in the United States, 1970-2002. JAMA 2005; 294: 1255-1259
    • (2005) JAMA , vol.294 , pp. 1255-1259
    • Jemal, A.1    Ward, E.2    Hao, Y.3    Thun, M.4
  • 4
    • 20344392430 scopus 로고    scopus 로고
    • Hepatocellular carcinoma: epidemiology, risk factors, and screening
    • Sherman M. Hepatocellular carcinoma: epidemiology, risk factors, and screening. Semin Liver Dis 2005; 25: 143-154
    • (2005) Semin Liver Dis , vol.25 , pp. 143-154
    • Sherman, M.1
  • 5
    • 7044231396 scopus 로고    scopus 로고
    • Hepatocellular carcinoma: recent trends in the United States
    • El-Serag HB. Hepatocellular carcinoma: recent trends in the United States. Gastroenterology 2004; 127: S27-S34
    • (2004) Gastroenterology , vol.127
    • El-Serag, H.B.1
  • 7
    • 38549137014 scopus 로고    scopus 로고
    • Natural history of hepatocellular carcinoma and current treatment options
    • Raoul JL. Natural history of hepatocellular carcinoma and current treatment options. Semin Nucl Med 2008; 38: S13-S18
    • (2008) Semin Nucl Med , vol.38
    • Raoul, J.L.1
  • 8
    • 67650938576 scopus 로고    scopus 로고
    • Hepatocellular carcinoma--epidemiological trends and risk factors
    • Schütte K, Bornschein J, Malfertheiner P. Hepatocellular carcinoma--epidemiological trends and risk factors. Dig Dis 2009; 27: 80-92
    • (2009) Dig Dis , vol.27 , pp. 80-92
    • Schütte, K.1    Bornschein, J.2    Malfertheiner, P.3
  • 10
    • 0036189111 scopus 로고    scopus 로고
    • Prognostic prediction and treatment strategy in hepatocellular carcinoma
    • Bruix J, Llovet JM. Prognostic prediction and treatment strategy in hepatocellular carcinoma. Hepatology 2002; 35: 519-524
    • (2002) Hepatology , vol.35 , pp. 519-524
    • Bruix, J.1    Llovet, J.M.2
  • 11
    • 0033646209 scopus 로고    scopus 로고
    • Results of surgical and nonsurgical treatment for small-sized hepatocellular carcinomas: a retrospective and nationwide survey in Japan. The Liver Cancer Study Group of Japan
    • Arii S, Yamaoka Y, Futagawa S, Inoue K, Kobayashi K, Kojiro M, Makuuchi M, Nakamura Y, Okita K, Yamada R. Results of surgical and nonsurgical treatment for small-sized hepatocellular carcinomas: a retrospective and nationwide survey in Japan. The Liver Cancer Study Group of Japan. Hepatology 2000; 32: 1224-1229
    • (2000) Hepatology , vol.32 , pp. 1224-1229
    • Arii, S.1    Yamaoka, Y.2    Futagawa, S.3    Inoue, K.4    Kobayashi, K.5    Kojiro, M.6    Makuuchi, M.7    Nakamura, Y.8    Okita, K.9    Yamada, R.10
  • 12
    • 17944382914 scopus 로고    scopus 로고
    • Power Doppler signals after percutaneous ethanol injection therapy for hepatocellular carcinoma predict local recurrence of tumors: a prospective study using 199 consecutive patients
    • Sato S, Shiratori Y, Imamura M, Teratani T, Obi S, Koike Y, Imai Y, Yoshida H, Shiina S, Omata M. Power Doppler signals after percutaneous ethanol injection therapy for hepatocellular carcinoma predict local recurrence of tumors: a prospective study using 199 consecutive patients. J Hepatol 2001; 35: 225-234
    • (2001) J Hepatol , vol.35 , pp. 225-234
    • Sato, S.1    Shiratori, Y.2    Imamura, M.3    Teratani, T.4    Obi, S.5    Koike, Y.6    Imai, Y.7    Yoshida, H.8    Shiina, S.9    Omata, M.10
  • 15
    • 0035028451 scopus 로고    scopus 로고
    • Vascular invasion and histopathologic grading determine outcome after liver transplantation for hepatocellular carcinoma in cirrhosis
    • Jonas S, Bechstein WO, Steinmüller T, Herrmann M, Radke C, Berg T, Settmacher U, Neuhaus P. Vascular invasion and histopathologic grading determine outcome after liver transplantation for hepatocellular carcinoma in cirrhosis. Hepatology 2001; 33: 1080-1086
    • (2001) Hepatology , vol.33 , pp. 1080-1086
    • Jonas, S.1    Bechstein, W.O.2    Steinmüller, T.3    Herrmann, M.4    Radke, C.5    Berg, T.6    Settmacher, U.7    Neuhaus, P.8
  • 16
    • 0034991518 scopus 로고    scopus 로고
    • Liver transplantation for hepatocellular carcinoma: expansion of the tumor size limits does not adversely impact survival
    • Yao FY, Ferrell L, Bass NM, Watson JJ, Bacchetti P, Venook A, Ascher NL, Roberts JP. Liver transplantation for hepatocellular carcinoma: expansion of the tumor size limits does not adversely impact survival. Hepatology 2001; 33: 1394-1403
    • (2001) Hepatology , vol.33 , pp. 1394-1403
    • Yao, F.Y.1    Ferrell, L.2    Bass, N.M.3    Watson, J.J.4    Bacchetti, P.5    Venook, A.6    Ascher, N.L.7    Roberts, J.P.8
  • 17
    • 18144411666 scopus 로고    scopus 로고
    • Updated treatment approach to hepatocellular carcinoma
    • Llovet JM. Updated treatment approach to hepatocellular carcinoma. J Gastroenterol 2005; 40: 225-235
    • (2005) J Gastroenterol , vol.40 , pp. 225-235
    • Llovet, J.M.1
  • 19
    • 0037180344 scopus 로고    scopus 로고
    • A comparison of the molecular clock of hepatitis C virus in the United States and Japan predicts that hepatocellular carcinoma incidence in the United States will increase over the next two decades
    • Tanaka Y, Hanada K, Mizokami M, Yeo AE, Shih JW, Gojobori T, Alter HJ. A comparison of the molecular clock of hepatitis C virus in the United States and Japan predicts that hepatocellular carcinoma incidence in the United States will increase over the next two decades. Proc Natl Acad Sci USA 2002; 99: 15584-15589
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 15584-15589
    • Tanaka, Y.1    Hanada, K.2    Mizokami, M.3    Yeo, A.E.4    Shih, J.W.5    Gojobori, T.6    Alter, H.J.7
  • 22
    • 77950612887 scopus 로고    scopus 로고
    • Where are we in the chemoprevention of hepatocellular carcinoma?
    • Lu SC. Where are we in the chemoprevention of hepatocellular carcinoma? Hepatology 2010; 51: 734-736
    • (2010) Hepatology , vol.51 , pp. 734-736
    • Lu, S.C.1
  • 23
    • 70349393610 scopus 로고    scopus 로고
    • Risk of bleeding with vascular endothelial growth factor receptor tyrosine-kinase inhibitors sunitinib and sorafenib: a systematic review and metaanalysis of clinical trials
    • Je Y, Schutz FA, Choueiri TK. Risk of bleeding with vascular endothelial growth factor receptor tyrosine-kinase inhibitors sunitinib and sorafenib: a systematic review and metaanalysis of clinical trials. Lancet Oncol 2009; 10: 967-974
    • (2009) Lancet Oncol , vol.10 , pp. 967-974
    • Je, Y.1    Schutz, F.A.2    Choueiri, T.K.3
  • 24
    • 0034011263 scopus 로고    scopus 로고
    • Chemoprevention of cancer
    • Sporn MB, Suh N. Chemoprevention of cancer. Carcinogenesis 2000; 21: 525-530
    • (2000) Carcinogenesis , vol.21 , pp. 525-530
    • Sporn, M.B.1    Suh, N.2
  • 25
    • 33845904405 scopus 로고    scopus 로고
    • Chemoprevention of breast cancer with selective oestrogen-receptor modulators
    • Jordan VC. Chemoprevention of breast cancer with selective oestrogen-receptor modulators. Nat Rev Cancer 2007; 7: 46-53
    • (2007) Nat Rev Cancer , vol.7 , pp. 46-53
    • Jordan, V.C.1
  • 27
    • 33646028804 scopus 로고    scopus 로고
    • Molecular targets of dietary agents for prevention and therapy of cancer
    • Aggarwal BB, Shishodia S. Molecular targets of dietary agents for prevention and therapy of cancer. Biochem Pharmacol 2006; 71: 1397-1421
    • (2006) Biochem Pharmacol , vol.71 , pp. 1397-1421
    • Aggarwal, B.B.1    Shishodia, S.2
  • 28
    • 34447283477 scopus 로고    scopus 로고
    • Ins and outs of dietary phytochemicals in cancer chemoprevention
    • Russo GL. Ins and outs of dietary phytochemicals in cancer chemoprevention. Biochem Pharmacol 2007; 74: 533-544
    • (2007) Biochem Pharmacol , vol.74 , pp. 533-544
    • Russo, G.L.1
  • 29
    • 47549102103 scopus 로고    scopus 로고
    • Comprehensive review of cancer chemopreventive agents evaluated in experimental carcinogenesis models and clinical trials
    • Naithani R, Huma LC, Moriarty RM, McCormick DL, Mehta RG. Comprehensive review of cancer chemopreventive agents evaluated in experimental carcinogenesis models and clinical trials. Curr Med Chem 2008; 15: 1044-1071
    • (2008) Curr Med Chem , vol.15 , pp. 1044-1071
    • Naithani, R.1    Huma, L.C.2    Moriarty, R.M.3    McCormick, D.L.4    Mehta, R.G.5
  • 30
    • 43749107872 scopus 로고    scopus 로고
    • The role of herbs and spices in cancer prevention
    • Kaefer CM, Milner JA. The role of herbs and spices in cancer prevention. J Nutr Biochem 2008; 19: 347-361
    • (2008) J Nutr Biochem , vol.19 , pp. 347-361
    • Kaefer, C.M.1    Milner, J.A.2
  • 31
    • 69249186365 scopus 로고    scopus 로고
    • Dietary chemopreventive phytochemicals: too little or too much?
    • Moiseeva EP, Manson MM. Dietary chemopreventive phytochemicals: too little or too much?. Cancer Prev Res (Phila) 2009; 2: 611-616
    • (2009) Cancer Prev Res (Phila) , vol.2 , pp. 611-616
    • Moiseeva, E.P.1    Manson, M.M.2
  • 32
    • 74249085615 scopus 로고    scopus 로고
    • Natural phenolic compounds from medicinal herbs and dietary plants: potential use for cancer prevention
    • Huang WY, Cai YZ, Zhang Y. Natural phenolic compounds from medicinal herbs and dietary plants: potential use for cancer prevention. Nutr Cancer 2010 ; 62: 1-20
    • (2010) Nutr Cancer , vol.62 , pp. 1-20
    • Huang, W.Y.1    Cai, Y.Z.2    Zhang, Y.3
  • 33
    • 77951775608 scopus 로고    scopus 로고
    • Oxidative stress in cancer and neurodegenrative diseases: prevention and treatment by dietary antioxidants. In: Kozyrev D, Slutsky V
    • editors. Free radicals: formation, types and effects. Hauppauge, NY: Nova Science Publishers
    • Bishayee A, Darvesh AS. Oxidative stress in cancer and neurodegenrative diseases: prevention and treatment by dietary antioxidants. In: Kozyrev D, Slutsky V, editors. Free radicals: formation, types and effects. Hauppauge, NY: Nova Science Publishers, 2010: 1-55
    • (2010) , pp. 1-55
    • Bishayee, A.1    Darvesh, A.S.2
  • 35
    • 0042284013 scopus 로고    scopus 로고
    • Epidemiologic evidence of the protective effect of fruit and vegetables on cancer risk
    • Riboli E, Norat T. Epidemiologic evidence of the protective effect of fruit and vegetables on cancer risk. Am J Clin Nutr 2003; 78: 559S-569S
    • (2003) Am J Clin Nutr , vol.78
    • Riboli, E.1    Norat, T.2
  • 37
    • 77952515616 scopus 로고    scopus 로고
    • Phytochemicals in hepatocellular cancer prevention
    • Nishino H. Phytochemicals in hepatocellular cancer prevention. Nutr Cancer 2009; 61: 789-791
    • (2009) Nutr Cancer , vol.61 , pp. 789-791
    • Nishino, H.1
  • 38
  • 40
    • 74649083195 scopus 로고    scopus 로고
    • Resveratrol in the chemoprevention and treatment of hepatocellular carcinoma
    • Bishayee A, Politis T, Darvesh AS. Resveratrol in the chemoprevention and treatment of hepatocellular carcinoma. Cancer Treat Rev 2010; 36: 43-53
    • (2010) Cancer Treat Rev , vol.36 , pp. 43-53
    • Bishayee, A.1    Politis, T.2    Darvesh, A.S.3
  • 42
    • 0030846307 scopus 로고    scopus 로고
    • Creating isoprenoid diversity
    • Sacchettini JC, Poulter CD. Creating isoprenoid diversity. Science 1997; 277: 1788-1789
    • (1997) Science , vol.277 , pp. 1788-1789
    • Sacchettini, J.C.1    Poulter, C.D.2
  • 43
    • 16344371211 scopus 로고    scopus 로고
    • Isoprenoids: an evolutionary pool for photoprotection
    • Peñuelas J, Munné-Bosch S. Isoprenoids: an evolutionary pool for photoprotection. Trends Plant Sci 2005; 10: 166-169
    • (2005) Trends Plant Sci , vol.10 , pp. 166-169
    • Peñuelas, J.1    Munné-Bosch, S.2
  • 44
    • 33845736982 scopus 로고    scopus 로고
    • Biosynthesis and engineering of isoprenoid small molecules
    • Withers ST, Keasling JD. Biosynthesis and engineering of isoprenoid small molecules. Appl Microbiol Biotechnol 2007; 73: 980-990
    • (2007) Appl Microbiol Biotechnol , vol.73 , pp. 980-990
    • Withers, S.T.1    Keasling, J.D.2
  • 45
    • 67349264062 scopus 로고    scopus 로고
    • Terpenoids and breast cancer chemoprevention
    • Rabi T, Bishayee A. Terpenoids and breast cancer chemoprevention. Breast Cancer Res Treat 2009; 115: 223-239
    • (2009) Breast Cancer Res Treat , vol.115 , pp. 223-239
    • Rabi, T.1    Bishayee, A.2
  • 47
    • 56449128037 scopus 로고    scopus 로고
    • Oleanolic acid and related derivatives as medicinally important compounds
    • Sultana N, Ata A. Oleanolic acid and related derivatives as medicinally important compounds. J Enzyme Inhib Med Chem 2008; 23: 739-756
    • (2008) J Enzyme Inhib Med Chem , vol.23 , pp. 739-756
    • Sultana, N.1    Ata, A.2
  • 48
    • 58149083527 scopus 로고    scopus 로고
    • Boswellic acids: a group of medicinally important compounds
    • Shah BA, Qazi GN, Taneja SC. Boswellic acids: a group of medicinally important compounds. Nat Prod Rep 2009; 26: 72-89
    • (2009) Nat Prod Rep , vol.26 , pp. 72-89
    • Shah, B.A.1    Qazi, G.N.2    Taneja, S.C.3
  • 49
    • 0037930097 scopus 로고    scopus 로고
    • The evolution of function in plant secondary metabolites
    • Theis N, Lerdau M. The evolution of function in plant secondary metabolites. Int J Plant Sci 2003; 164: S93-S103
    • (2003) Int J Plant Sci , vol.164
    • Theis, N.1    Lerdau, M.2
  • 50
    • 0030867207 scopus 로고    scopus 로고
    • Cancer chemoprevention and therapy by monoterpenes
    • Gould MN. Cancer chemoprevention and therapy by monoterpenes. Environ Health Perspect 1997; 105 Suppl 4: 977-979
    • (1997) Environ Health Perspect , vol.105 , Issue.SUPPL. 4 , pp. 977-979
    • Gould, M.N.1
  • 53
    • 0032980875 scopus 로고    scopus 로고
    • Prevention and therapy of cancer by dietary monoterpenes
    • Crowell PL. Prevention and therapy of cancer by dietary monoterpenes. J Nutr 1999; 129: 775S-778S
    • (1999) J Nutr , vol.129
    • Crowell, P.L.1
  • 55
    • 25844457658 scopus 로고    scopus 로고
    • Carvone: Why and how should one bother to produce this terpene
    • de Carvalho CCCR, da Fonseca MMR. Carvone: Why and how should one bother to produce this terpene. Food Chem 2006; 95: 413-422
    • (2006) Food Chem , vol.95 , pp. 413-422
    • de Carvalho, C.C.C.R.1    da Fonseca, M.M.R.2
  • 56
    • 34247526984 scopus 로고    scopus 로고
    • Triterpenoids and rexinoids as multifunctional agents for the prevention and treatment of cancer
    • Liby KT, Yore MM, Sporn MB. Triterpenoids and rexinoids as multifunctional agents for the prevention and treatment of cancer. Nat Rev Cancer 2007; 7: 357-369
    • (2007) Nat Rev Cancer , vol.7 , pp. 357-369
    • Liby, K.T.1    Yore, M.M.2    Sporn, M.B.3
  • 57
    • 0642368436 scopus 로고    scopus 로고
    • Plant-derived triterpenoids as potential antineoplastic agents
    • Setzer WN, Setzer MC. Plant-derived triterpenoids as potential antineoplastic agents. Mini Rev Med Chem 2003; 3: 540-556
    • (2003) Mini Rev Med Chem , vol.3 , pp. 540-556
    • Setzer, W.N.1    Setzer, M.C.2
  • 58
    • 74049157757 scopus 로고    scopus 로고
    • Pentacyclic triterpenes of the lupane, oleanane and ursane group as tools in cancer therapy
    • Laszczyk MN. Pentacyclic triterpenes of the lupane, oleanane and ursane group as tools in cancer therapy. Planta Med 2009; 75: 1549-1560
    • (2009) Planta Med , vol.75 , pp. 1549-1560
    • Laszczyk, M.N.1
  • 59
  • 60
    • 41049118292 scopus 로고    scopus 로고
    • Lupeol: connotations for chemoprevention
    • Chaturvedi PK, Bhui K, Shukla Y. Lupeol: connotations for chemoprevention. Cancer Lett 2008; 263: 1-13
    • (2008) Cancer Lett , vol.263 , pp. 1-13
    • Chaturvedi, P.K.1    Bhui, K.2    Shukla, Y.3
  • 61
    • 42949176994 scopus 로고    scopus 로고
    • Dietary terpenoids and prostate cancer chemoprevention
    • Rabi T, Gupta S. Dietary terpenoids and prostate cancer chemoprevention. Front Biosci 2008; 13: 3457-3469
    • (2008) Front Biosci , vol.13 , pp. 3457-3469
    • Rabi, T.1    Gupta, S.2
  • 62
    • 76649106073 scopus 로고    scopus 로고
    • Betulinic acid, a natural compound with potent anticancer effects
    • Mullauer FB, Kessler JH, Medema JP. Betulinic acid, a natural compound with potent anticancer effects. Anticancer Drugs 2010; 21: 215-227
    • (2010) Anticancer Drugs , vol.21 , pp. 215-227
    • Mullauer, F.B.1    Kessler, J.H.2    Medema, J.P.3
  • 63
    • 79955034094 scopus 로고    scopus 로고
    • Triterpenoids as potential agents for the chemoprevention and therapy of breast cancer
    • Bishayee A, Ahmed S, Brankov N, Perloff M. Triterpenoids as potential agents for the chemoprevention and therapy of breast cancer. Front Biosci 2011; 16: 980-996
    • (2011) Front Biosci , vol.16 , pp. 980-996
    • Bishayee, A.1    Ahmed, S.2    Brankov, N.3    Perloff, M.4
  • 64
    • 84890661118 scopus 로고    scopus 로고
    • Triterpenoids for Cancer Prevention and Treatment: Current Status and Future Prospects
    • Epub ahead of print
    • Patlolla JM, Rao CV. Triterpenoids for Cancer Prevention and Treatment: Current Status and Future Prospects. Curr Pharm Biotechnol 2011; Epub ahead of print
    • (2011) Curr Pharm Biotechnol
    • Patlolla, J.M.1    Rao, C.V.2
  • 65
    • 23044440041 scopus 로고    scopus 로고
    • Oleanolic acid and ursolic acid: research perspectives
    • Liu J. Oleanolic acid and ursolic acid: research perspectives. J Ethnopharmacol 2005; 100: 92-94
    • (2005) J Ethnopharmacol , vol.100 , pp. 92-94
    • Liu, J.1
  • 67
    • 58149357667 scopus 로고    scopus 로고
    • Betulinic acid: a natural product with anticancer activity
    • Fulda S. Betulinic acid: a natural product with anticancer activity. Mol Nutr Food Res 2009; 53: 140-146
    • (2009) Mol Nutr Food Res , vol.53 , pp. 140-146
    • Fulda, S.1
  • 68
    • 33645415249 scopus 로고    scopus 로고
    • Effect of geraniol on fatty-acid and mevalonate metabolism in the human hepatoma cell line Hep G2
    • Polo MP, de Bravo MG. Effect of geraniol on fatty-acid and mevalonate metabolism in the human hepatoma cell line Hep G2. Biochem Cell Biol 2006; 84: 102-111
    • (2006) Biochem Cell Biol , vol.84 , pp. 102-111
    • Polo, M.P.1    de Bravo, M.G.2
  • 69
    • 36049035359 scopus 로고    scopus 로고
    • Andrographolide inhibits human hepatoma-derived Hep3B cell growth through theactivation of c-Jun N-terminal kinase
    • Ji L, Liu T, Liu J, Chen Y, Wang Z. Andrographolide inhibits human hepatoma-derived Hep3B cell growth through theactivation of c-Jun N-terminal kinase. Planta Med 2007; 73: 1397-1401
    • (2007) Planta Med , vol.73 , pp. 1397-1401
    • Ji, L.1    Liu, T.2    Liu, J.3    Chen, Y.4    Wang, Z.5
  • 70
    • 66449116607 scopus 로고    scopus 로고
    • ExcisaninA, a diterpenoid compound purified from Isodon MacrocalyxinD, induces tumor cells apoptosis and suppresses tumor growth through inhibition of PKB/AKT kinase activity and blockade of its signal pathway
    • Deng R, Tang J, Xia LP, Li DD, Zhou WJ, Wang LL, Feng GK, Zeng YX, Gao YH, Zhu XF. ExcisaninA, a diterpenoid compound purified from Isodon MacrocalyxinD, induces tumor cells apoptosis and suppresses tumor growth through inhibition of PKB/AKT kinase activity and blockade of its signal pathway. Mol Cancer Ther 2009; 8: 873-882
    • (2009) Mol Cancer Ther , vol.8 , pp. 873-882
    • Deng, R.1    Tang, J.2    Xia, L.P.3    Li, D.D.4    Zhou, W.J.5    Wang, L.L.6    Feng, G.K.7    Zeng, Y.X.8    Gao, Y.H.9    Zhu, X.F.10
  • 71
    • 64949084842 scopus 로고    scopus 로고
    • G2-phase arrest through p21( WAF1 / Cip1) induction and cdc2 repression by gnidimacrin in human hepatoma HLE cells
    • Yoshida M, Matsui Y, Iizuka A, Ikarashi Y. G2-phase arrest through p21( WAF1 / Cip1) induction and cdc2 repression by gnidimacrin in human hepatoma HLE cells. Anticancer Res 2009; 29: 1349-1354
    • (2009) Anticancer Res , vol.29 , pp. 1349-1354
    • Yoshida, M.1    Matsui, Y.2    Iizuka, A.3    Ikarashi, Y.4
  • 72
    • 50149087699 scopus 로고    scopus 로고
    • Reactive oxygen species mediate oridonin-induced HepG2 apoptosis through p53, MAPK, and mitochondrial signaling pathways
    • Huang J, Wu L, Tashiro S, Onodera S, Ikejima T. Reactive oxygen species mediate oridonin-induced HepG2 apoptosis through p53, MAPK, and mitochondrial signaling pathways. J Pharmacol Sci 2008; 107: 370-379
    • (2008) J Pharmacol Sci , vol.107 , pp. 370-379
    • Huang, J.1    Wu, L.2    Tashiro, S.3    Onodera, S.4    Ikejima, T.5
  • 76
    • 56149120962 scopus 로고    scopus 로고
    • Proapoptotic and microtubule-disassembly effects of ardisiacrispin (A+B), triterpenoid saponins from Ardisia crenata on human hepatoma Bel- 7402 cells
    • Li M, Wei SY, Xu B, Guo W, Liu DL, Cui JR, Yao XS. Proapoptotic and microtubule-disassembly effects of ardisiacrispin (A+B), triterpenoid saponins from Ardisia crenata on human hepatoma Bel- 7402 cells. J Asian Nat Prod Res 2008; 10: 739-746
    • (2008) J Asian Nat Prod Res , vol.10 , pp. 739-746
    • Li, M.1    Wei, S.Y.2    Xu, B.3    Guo, W.4    Liu, D.L.5    Cui, J.R.6    Yao, X.S.7
  • 77
    • 22844444927 scopus 로고    scopus 로고
    • [Investigation on the molecular mechanisms of anti-hepatocarcinoma herbs of traditional Chinese medicine by cell cycle microarray]
    • Wang GL, Chen CB, Gao JM, Ni H, Wang TS, Chen L. [Investigation on the molecular mechanisms of anti-hepatocarcinoma herbs of traditional Chinese medicine by cell cycle microarray]. Zhongguo Zhongyao Zazhi 2005; 30: 50-54
    • (2005) Zhongguo Zhongyao Zazhi , vol.30 , pp. 50-54
    • Wang, G.L.1    Chen, C.B.2    Gao, J.M.3    Ni, H.4    Wang, T.S.5    Chen, L.6
  • 78
    • 77149121747 scopus 로고    scopus 로고
    • Proteomic characterization of the cellular response to chemopreventive triterpenoid astragaloside IV in human hepatocellular carcinoma cell line HepG2
    • Qi H, Wei L, Han Y, Zhang Q, Lau AS, Rong J. Proteomic characterization of the cellular response to chemopreventive triterpenoid astragaloside IV in human hepatocellular carcinoma cell line HepG2. Int J Oncol 2010; 36: 725-735
    • (2010) Int J Oncol , vol.36 , pp. 725-735
    • Qi, H.1    Wei, L.2    Han, Y.3    Zhang, Q.4    Lau, A.S.5    Rong, J.6
  • 79
    • 0036883604 scopus 로고    scopus 로고
    • Asiatic acid, a triterpene, induces apoptosis through intracellular Ca2+ release and enhanced expression of p53 in HepG2 human hepatoma cells
    • Lee YS, Jin DQ, Kwon EJ, Park SH, Lee ES, Jeong TC, Nam DH, Huh K, Kim JA. Asiatic acid, a triterpene, induces apoptosis through intracellular Ca2+ release and enhanced expression of p53 in HepG2 human hepatoma cells. Cancer Lett 2002; 186: 83-91
    • (2002) Cancer Lett , vol.186 , pp. 83-91
    • Lee, Y.S.1    Jin, D.Q.2    Kwon, E.J.3    Park, S.H.4    Lee, E.S.5    Jeong, T.C.6    Nam, D.H.7    Huh, K.8    Kim, J.A.9
  • 80
    • 70449457428 scopus 로고    scopus 로고
    • Betulinic acid treatment promotes apoptosis in hepatoblastoma cells
    • Eichenmüller M, von Schweinitz D, Kappler R. Betulinic acid treatment promotes apoptosis in hepatoblastoma cells. Int J Oncol 2009; 35: 873-879
    • (2009) Int J Oncol , vol.35 , pp. 873-879
    • Eichenmüller, M.1    von Schweinitz, D.2    Kappler, R.3
  • 81
    • 0036559186 scopus 로고    scopus 로고
    • Gli and hedgehog in cancer: tumours, embryos and stem cells
    • Ruizi Altaba A, Sánchez P, Dahmane N. Gli and hedgehog in cancer: tumours, embryos and stem cells. Nat Rev Cancer 2002; 2: 361-372
    • (2002) Nat Rev Cancer , vol.2 , pp. 361-372
    • Ruizi Altaba, A.1    Sánchez, P.2    Dahmane, N.3
  • 83
    • 58849166215 scopus 로고    scopus 로고
    • Targeted constitutive activation of signal transducer and activator of transcription 3 in human hepatocellular carcinoma cells by cucurbitacin B
    • Zhang M, Zhang H, Sun C, Shan X, Yang X, Li-Ling J, Deng Y. Targeted constitutive activation of signal transducer and activator of transcription 3 in human hepatocellular carcinoma cells by cucurbitacin B. Cancer Chemother Pharmacol 2009; 63: 635-642
    • (2009) Cancer Chemother Pharmacol , vol.63 , pp. 635-642
    • Zhang, M.1    Zhang, H.2    Sun, C.3    Shan, X.4    Yang, X.5    Li-Ling, J.6    Deng, Y.7
  • 84
    • 77953021503 scopus 로고    scopus 로고
    • Cucurbitacin B induces apoptosis and S phase cell cycle arrest in BEL- 7402 human hepatocellular carcinoma cells and is effective via oral administration
    • Chan KT, Meng FY, Li Q, Ho CY, Lam TS, To Y, Lee WH, Li M, Chu KH, Toh M. Cucurbitacin B induces apoptosis and S phase cell cycle arrest in BEL- 7402 human hepatocellular carcinoma cells and is effective via oral administration. Cancer Lett 2010; 294: 118-124
    • (2010) Cancer Lett , vol.294 , pp. 118-124
    • Chan, K.T.1    Meng, F.Y.2    Li, Q.3    Ho, C.Y.4    Lam, T.S.5    To, Y.6    Lee, W.H.7    Li, M.8    Chu, K.H.9    Toh, M.10
  • 85
    • 61649114173 scopus 로고    scopus 로고
    • Cucurbitacin D isolated from Trichosanthes kirilowii induces apoptosis in human hepatocellular carcinoma cells in vitro
    • Takahashi N, Yoshida Y, Sugiura T, Matsuno K, Fujino A, Yamashita U. Cucurbitacin D isolated from Trichosanthes kirilowii induces apoptosis in human hepatocellular carcinoma cells in vitro. Int Immunopharmacol 2009; 9: 508-513
    • (2009) Int Immunopharmacol , vol.9 , pp. 508-513
    • Takahashi, N.1    Yoshida, Y.2    Sugiura, T.3    Matsuno, K.4    Fujino, A.5    Yamashita, U.6
  • 86
    • 57149119928 scopus 로고    scopus 로고
    • Cytotoxic cucurbitanetype triterpenoids from Elaeocarpus hainanensis
    • Meng D, Qiang S, Lou L, Zhao W. Cytotoxic cucurbitanetype triterpenoids from Elaeocarpus hainanensis. Planta Med 2008; 74: 1741-1744
    • (2008) Planta Med , vol.74 , pp. 1741-1744
    • Meng, D.1    Qiang, S.2    Lou, L.3    Zhao, W.4
  • 87
    • 4344601965 scopus 로고    scopus 로고
    • Molecular mechanisms of echinocystic acid-induced apoptosis in HepG2 cells
    • Tong X, Lin S, Fujii M, Hou DX. Molecular mechanisms of echinocystic acid-induced apoptosis in HepG2 cells. Biochem Biophys Res Commun 2004; 321: 539-546
    • (2004) Biochem Biophys Res Commun , vol.321 , pp. 539-546
    • Tong, X.1    Lin, S.2    Fujii, M.3    Hou, D.X.4
  • 88
    • 73949100760 scopus 로고    scopus 로고
    • Escin, a natural mixture of triterpene saponins, exhibits antitumor activity against hepatocellular carcinoma
    • Zhou XY, Fu FH, Li Z, Dong QJ, He J, Wang CH. Escin, a natural mixture of triterpene saponins, exhibits antitumor activity against hepatocellular carcinoma. Planta Med 2009; 75: 1580-1585
    • (2009) Planta Med , vol.75 , pp. 1580-1585
    • Zhou, X.Y.1    Fu, F.H.2    Li, Z.3    Dong, Q.J.4    He, J.5    Wang, C.H.6
  • 89
    • 23844505623 scopus 로고    scopus 로고
    • Ganoderic acid produced from submerged culture of Ganoderma lucidum induces cell cycle arrest and cytotoxicity in human hepatoma cell line BEL7402
    • Yang HL. Ganoderic acid produced from submerged culture of Ganoderma lucidum induces cell cycle arrest and cytotoxicity in human hepatoma cell line BEL7402. Biotechnol Lett 2005; 27: 835-838
    • (2005) Biotechnol Lett , vol.27 , pp. 835-838
    • Yang, H.L.1
  • 90
    • 33746411468 scopus 로고    scopus 로고
    • Ganoderiol F, a ganoderma triterpene, induces senescence in hepatoma HepG2 cells
    • Chang UM, Li CH, Lin LI, Huang CP, Kan LS, Lin SB. Ganoderiol F, a ganoderma triterpene, induces senescence in hepatoma HepG2 cells. Life Sci 2006; 79: 1129-1139
    • (2006) Life Sci , vol.79 , pp. 1129-1139
    • Chang, U.M.1    Li, C.H.2    Lin, L.I.3    Huang, C.P.4    Kan, L.S.5    Lin, S.B.6
  • 91
    • 0030037902 scopus 로고    scopus 로고
    • Ginsenoside-Rg1 positively regulates cyclin E-dependent kinase activity in human hepatoma SK-HEP-1 cells
    • Lee KY, Lee SK. Ginsenoside-Rg1 positively regulates cyclin E-dependent kinase activity in human hepatoma SK-HEP-1 cells. Biochem Mol Biol Int 1996; 39: 539-546
    • (1996) Biochem Mol Biol Int , vol.39 , pp. 539-546
    • Lee, K.Y.1    Lee, S.K.2
  • 92
    • 0030942927 scopus 로고    scopus 로고
    • Ginsenoside-Rg5 suppresses cyclin E-dependent protein kinase activity via up-regulating p21Cip/ WAF1 and down-regulating cyclin E in SK-HEP- 1 cells
    • Lee KY, Lee YH, Kim SI, Park JH, Lee SK. Ginsenoside-Rg5 suppresses cyclin E-dependent protein kinase activity via up-regulating p21Cip/ WAF1 and down-regulating cyclin E in SK-HEP- 1 cells. Anticancer Res 1997; 17: 1067-1072
    • (1997) Anticancer Res , vol.17 , pp. 1067-1072
    • Lee, K.Y.1    Lee, Y.H.2    Kim, S.I.3    Park, J.H.4    Lee, S.K.5
  • 93
    • 0030596179 scopus 로고    scopus 로고
    • Ginsenoside-Rh2 blocks the cell cycle of SK-HEP-1 cells at the G1/S boundary by selectively inducing the protein expression of p27kip1
    • Lee KY, Park JA, Chung E, Lee YH, Kim SI, Lee SK. Ginsenoside-Rh2 blocks the cell cycle of SK-HEP-1 cells at the G1/S boundary by selectively inducing the protein expression of p27kip1. Cancer Lett 1996; 110: 193-200
    • (1996) Cancer Lett , vol.110 , pp. 193-200
    • Lee, K.Y.1    Park, J.A.2    Chung, E.3    Lee, Y.H.4    Kim, S.I.5    Lee, S.K.6
  • 94
    • 0030777703 scopus 로고    scopus 로고
    • Activation of caspase-3 protease via a Bcl-2-insensitive pathway during the process of ginsenoside Rh2-induced apoptosis
    • Park JA, Lee KY, Oh YJ, Kim KW, Lee SK. Activation of caspase-3 protease via a Bcl-2-insensitive pathway during the process of ginsenoside Rh2-induced apoptosis. Cancer Lett 1997; 121: 73-81
    • (1997) Cancer Lett , vol.121 , pp. 73-81
    • Park, J.A.1    Lee, K.Y.2    Oh, Y.J.3    Kim, K.W.4    Lee, S.K.5
  • 95
    • 44349088197 scopus 로고    scopus 로고
    • Anti-tumor activity of the ginsenoside Rk1 in human hepatocellular carcinoma cells through inhibition of telomerase activity and induction of apoptosis
    • Kim YJ, Kwon HC, Ko H, Park JH, Kim HY, Yoo JH, Yang HO. Anti-tumor activity of the ginsenoside Rk1 in human hepatocellular carcinoma cells through inhibition of telomerase activity and induction of apoptosis. Biol Pharm Bull 2008; 31: 826-830
    • (2008) Biol Pharm Bull , vol.31 , pp. 826-830
    • Kim, Y.J.1    Kwon, H.C.2    Ko, H.3    Park, J.H.4    Kim, H.Y.5    Yoo, J.H.6    Yang, H.O.7
  • 96
    • 70350463830 scopus 로고    scopus 로고
    • Autophagy inhibition enhances apoptosis induced by ginsenoside Rk1 in hepatocellular carcinoma cells
    • Ko H, Kim YJ, Park JS, Park JH, Yang HO. Autophagy inhibition enhances apoptosis induced by ginsenoside Rk1 in hepatocellular carcinoma cells. Biosci Biotechnol Biochem 2009; 73: 2183-2189
    • (2009) Biosci Biotechnol Biochem , vol.73 , pp. 2183-2189
    • Ko, H.1    Kim, Y.J.2    Park, J.S.3    Park, J.H.4    Yang, H.O.5
  • 97
    • 0032588931 scopus 로고    scopus 로고
    • Ginsenoside-Rs3, a new diol-type ginseng saponin, selectively elevates protein levels of p53 and p21WAF1 leading to induction of apoptosis in SK-HEP- 1 cells
    • Kim SE, Lee YH, Park JH, Lee SK. Ginsenoside-Rs3, a new diol-type ginseng saponin, selectively elevates protein levels of p53 and p21WAF1 leading to induction of apoptosis in SK-HEP- 1 cells. Anticancer Res 1999; 19: 487-491
    • (1999) Anticancer Res , vol.19 , pp. 487-491
    • Kim, S.E.1    Lee, Y.H.2    Park, J.H.3    Lee, S.K.4
  • 98
    • 0037179551 scopus 로고    scopus 로고
    • Regulation of Bcl- 2 family molecules and activation of caspase cascade involved in gypenosides-induced apoptosis in human hepatoma cells
    • Wang QF, Chen JC, Hsieh SJ, Cheng CC, Hsu SL. Regulation of Bcl- 2 family molecules and activation of caspase cascade involved in gypenosides-induced apoptosis in human hepatoma cells. Cancer Lett 2002; 183: 169-178
    • (2002) Cancer Lett , vol.183 , pp. 169-178
    • Wang, Q.F.1    Chen, J.C.2    Hsieh, S.J.3    Cheng, C.C.4    Hsu, S.L.5
  • 99
    • 0842264760 scopus 로고    scopus 로고
    • A ginseng saponin metabolite-induced apoptosis in HepG2 cells involves a mitochondria-mediated pathway and its downstream caspase- 8 activation and Bid cleavage
    • Oh SH, Lee BH. A ginseng saponin metabolite-induced apoptosis in HepG2 cells involves a mitochondria-mediated pathway and its downstream caspase- 8 activation and Bid cleavage. Toxicol Appl Pharmacol 2004; 194: 221-229
    • (2004) Toxicol Appl Pharmacol , vol.194 , pp. 221-229
    • Oh, S.H.1    Lee, B.H.2
  • 100
    • 34447288092 scopus 로고    scopus 로고
    • Anti-proliferation and apoptosis induced by a novel intestinal metabolite of ginseng saponin in human hepatocellular carcinoma cells
    • Ming YL, Song G, Chen LH, Zheng ZZ, Chen ZY, Ouyang GL, Tong QX. Anti-proliferation and apoptosis induced by a novel intestinal metabolite of ginseng saponin in human hepatocellular carcinoma cells. Cell Biol Int 2007; 31: 1265-1273
    • (2007) Cell Biol Int , vol.31 , pp. 1265-1273
    • Ming, Y.L.1    Song, G.2    Chen, L.H.3    Zheng, Z.Z.4    Chen, Z.Y.5    Ouyang, G.L.6    Tong, Q.X.7
  • 102
    • 0036780654 scopus 로고    scopus 로고
    • Ketoand acetyl-keto-boswellic acids inhibit proliferation and induce apoptosis in Hep G2 cells via a caspase-8 dependent pathway
    • Liu JJ, Nilsson A, Oredsson S, Badmaev V, Duan RD. Ketoand acetyl-keto-boswellic acids inhibit proliferation and induce apoptosis in Hep G2 cells via a caspase-8 dependent pathway. Int J Mol Med 2002; 10: 501-505
    • (2002) Int J Mol Med , vol.10 , pp. 501-505
    • Liu, J.J.1    Nilsson, A.2    Oredsson, S.3    Badmaev, V.4    Duan, R.D.5
  • 103
    • 38049016812 scopus 로고    scopus 로고
    • The antiinvasive effect of lucidenic acids isolated from a new Ganoderma lucidum strain
    • Weng CJ, Chau CF, Chen KD, Chen DH, Yen GC. The antiinvasive effect of lucidenic acids isolated from a new Ganoderma lucidum strain. Mol Nutr Food Res 2007; 51: 1472-1477
    • (2007) Mol Nutr Food Res , vol.51 , pp. 1472-1477
    • Weng, C.J.1    Chau, C.F.2    Chen, K.D.3    Chen, D.H.4    Yen, G.C.5
  • 104
    • 38849178686 scopus 로고    scopus 로고
    • Lucidenic acid inhibits PMA-induced invasion of human hepatoma cells through inactivating MAPK/ERK signal transductionpathway and reducing binding activities of NF-kappaB and AP-1
    • Weng CJ, Chau CF, Hsieh YS, Yang SF, Yen GC. Lucidenic acid inhibits PMA-induced invasion of human hepatoma cells through inactivating MAPK/ERK signal transductionpathway and reducing binding activities of NF-kappaB and AP-1. Carcinogenesis 2008; 29: 147-156
    • (2008) Carcinogenesis , vol.29 , pp. 147-156
    • Weng, C.J.1    Chau, C.F.2    Hsieh, Y.S.3    Yang, S.F.4    Yen, G.C.5
  • 105
    • 60849136358 scopus 로고    scopus 로고
    • Lupeol, a dietary triterpene, inhibited growth, and induced apoptosis through down-regulation of DR3 in SMMC7721 cells
    • Zhang L, Zhang Y, Zhang L, Yang X, Lv Z. Lupeol, a dietary triterpene, inhibited growth, and induced apoptosis through down-regulation of DR3 in SMMC7721 cells. Cancer Invest 2009; 27: 163-170
    • (2009) Cancer Invest , vol.27 , pp. 163-170
    • Zhang, L.1    Zhang, Y.2    Zhang, L.3    Yang, X.4    Lv, Z.5
  • 106
    • 40449137626 scopus 로고    scopus 로고
    • Growth inhibition and G1 cell cycle arrest mediated by 25-methoxyhispidol A, a novel triterpenoid, isolated from the fruit of Poncirus trifoliata in human hepatocellular carcinoma cells
    • Hong J, Min HY, Xu GH, Lee JG, Lee SH, Kim YS, Kang SS, Lee SK. Growth inhibition and G1 cell cycle arrest mediated by 25-methoxyhispidol A, a novel triterpenoid, isolated from the fruit of Poncirus trifoliata in human hepatocellular carcinoma cells. Planta Med 2008; 74: 151-155
    • (2008) Planta Med , vol.74 , pp. 151-155
    • Hong, J.1    Min, H.Y.2    Xu, G.H.3    Lee, J.G.4    Lee, S.H.5    Kim, Y.S.6    Kang, S.S.7    Lee, S.K.8
  • 107
    • 77649184736 scopus 로고    scopus 로고
    • Oleanolic acid and ursolic acid induce apoptosis in four human liver cancer cell lines
    • Yan SL, Huang CY, Wu ST, Yin MC. Oleanolic acid and ursolic acid induce apoptosis in four human liver cancer cell lines. Toxicol In Vitro 2010; 24: 842-848
    • (2010) Toxicol In Vitro , vol.24 , pp. 842-848
    • Yan, S.L.1    Huang, C.Y.2    Wu, S.T.3    Yin, M.C.4
  • 108
    • 77952615172 scopus 로고    scopus 로고
    • Oleanolic acid and ursolic acid induce apoptosis in HuH7 human hepatocellular carcinoma cells through a mitochondrial-dependent pathway and downregulation of XIAP
    • Shyu MH, Kao TC, Yen GC. Oleanolic acid and ursolic acid induce apoptosis in HuH7 human hepatocellular carcinoma cells through a mitochondrial-dependent pathway and downregulation of XIAP. J Agric Food Chem 2010; 58: 6110-6118
    • (2010) J Agric Food Chem , vol.58 , pp. 6110-6118
    • Shyu, M.H.1    Kao, T.C.2    Yen, G.C.3
  • 109
    • 33645090927 scopus 로고    scopus 로고
    • Antihepatoma activity and mechanism of ursolic acid and its derivatives isolated from Aralia decaisneana
    • Tian Z, Lin G, Zheng RX, Huang F, Yang MS, Xiao PG. Antihepatoma activity and mechanism of ursolic acid and its derivatives isolated from Aralia decaisneana. World J Gastroenterol 2006; 12: 874-879
    • (2006) World J Gastroenterol , vol.12 , pp. 874-879
    • Tian, Z.1    Lin, G.2    Zheng, R.X.3    Huang, F.4    Yang, M.S.5    Xiao, P.G.6
  • 110
    • 63449089496 scopus 로고    scopus 로고
    • Downregulation of survivin and activation of caspase-3 through the PI3K/Akt pathway in ursolic acid-induced HepG2 cell apoptosis
    • Tang C, Lu YH, Xie JH, Wang F, Zou JN, Yang JS, Xing YY, Xi T. Downregulation of survivin and activation of caspase-3 through the PI3K/Akt pathway in ursolic acid-induced HepG2 cell apoptosis. Anticancer Drugs 2009; 20: 249-258
    • (2009) Anticancer Drugs , vol.20 , pp. 249-258
    • Tang, C.1    Lu, Y.H.2    Xie, J.H.3    Wang, F.4    Zou, J.N.5    Yang, J.S.6    Xing, Y.Y.7    Xi, T.8
  • 111
    • 71649088587 scopus 로고    scopus 로고
    • Waltonitone induces human hepatocellular carcinoma cells apoptosis in vitro and in vivo
    • Zhang Z, Wang S, Qiu H, Duan C, Ding K, Wang Z. Waltonitone induces human hepatocellular carcinoma cells apoptosis in vitro and in vivo. Cancer Lett 2009; 286: 223-231
    • (2009) Cancer Lett , vol.286 , pp. 223-231
    • Zhang, Z.1    Wang, S.2    Qiu, H.3    Duan, C.4    Ding, K.5    Wang, Z.6
  • 112
    • 50649100506 scopus 로고    scopus 로고
    • Triterpenoid saponins from Androsace umbellata and their anti-proliferative activities in human hepatoma cells
    • Wang Y, Zhang D, Ye W, Yin Z, Fung KP, Zhao S, Yao X. Triterpenoid saponins from Androsace umbellata and their anti-proliferative activities in human hepatoma cells. Planta Med 2008; 74: 1280-1284
    • (2008) Planta Med , vol.74 , pp. 1280-1284
    • Wang, Y.1    Zhang, D.2    Ye, W.3    Yin, Z.4    Fung, K.P.5    Zhao, S.6    Yao, X.7
  • 113
    • 46249091398 scopus 로고    scopus 로고
    • A new triterpenoid from Panax ginseng exhibits cytotoxicity through p53 and the caspase signaling pathway in the HepG2 cell line
    • Huang J, Tang XH, Ikejima T, Sun XJ, Wang XB, Xi RG, Wu LJ. A new triterpenoid from Panax ginseng exhibits cytotoxicity through p53 and the caspase signaling pathway in the HepG2 cell line. Arch Pharm Res 2008; 31: 323-329
    • (2008) Arch Pharm Res , vol.31 , pp. 323-329
    • Huang, J.1    Tang, X.H.2    Ikejima, T.3    Sun, X.J.4    Wang, X.B.5    Xi, R.G.6    Wu, L.J.7
  • 114
    • 0034599893 scopus 로고    scopus 로고
    • Inhibitory effects of carotenoids on the invasion of rat ascites hepatoma cells in culture
    • Kozuki Y, Miura Y, Yagasaki K. Inhibitory effects of carotenoids on the invasion of rat ascites hepatoma cells in culture. Cancer Lett 2000; 151: 111-115
    • (2000) Cancer Lett , vol.151 , pp. 111-115
    • Kozuki, Y.1    Miura, Y.2    Yagasaki, K.3
  • 115
    • 24744436403 scopus 로고    scopus 로고
    • Lycopene inhibits cell migration and invasion and upregulates Nm23- H1 in a highly invasive hepatocarcinoma, SK-Hep- 1 cells
    • Huang CS, Shih MK, Chuang CH, Hu ML. Lycopene inhibits cell migration and invasion and upregulates Nm23- H1 in a highly invasive hepatocarcinoma, SK-Hep- 1 cells. J Nutr 2005; 135: 2119-2123
    • (2005) J Nutr , vol.135 , pp. 2119-2123
    • Huang, C.S.1    Shih, M.K.2    Chuang, C.H.3    Hu, M.L.4
  • 116
    • 51449087557 scopus 로고    scopus 로고
    • Effect of carotenoids on in vitro proliferation and differentiation of oval cells during neoplastic and non-neoplastic liver injuries in rats
    • Wójcik M, Bobowiec R, Martelli F. Effect of carotenoids on in vitro proliferation and differentiation of oval cells during neoplastic and non-neoplastic liver injuries in rats. J Physiol Pharmacol 2008; 59 Suppl 2: 203-213
    • (2008) J Physiol Pharmacol , vol.59 , Issue.SUPPL. 2 , pp. 203-213
    • Wójcik, M.1    Bobowiec, R.2    Martelli, F.3
  • 117
    • 80052447899 scopus 로고    scopus 로고
    • Effects of ascorbic acid and β-carotene on HepG2 human hepatocellular carcinoma cell line
    • Yurtcu E, Iseri OD, Sahin FI. Effects of ascorbic acid and β-carotene on HepG2 human hepatocellular carcinoma cell line. Mol Biol Rep 2011; 38: 4265-4272
    • (2011) Mol Biol Rep , vol.38 , pp. 4265-4272
    • Yurtcu, E.1    Iseri, O.D.2    Sahin, F.I.3
  • 118
    • 40949104695 scopus 로고    scopus 로고
    • Growth inhibition of human hepatic carcinoma HepG2 cells by fucoxanthin is associated with down-regulation of cyclin D
    • Das SK, Hashimoto T, Kanazawa K. Growth inhibition of human hepatic carcinoma HepG2 cells by fucoxanthin is associated with down-regulation of cyclin D. Biochim Biophys Acta 2008; 1780: 743-749
    • (2008) Biochim Biophys Acta , vol.1780 , pp. 743-749
    • Das, S.K.1    Hashimoto, T.2    Kanazawa, K.3
  • 119
    • 70350134708 scopus 로고    scopus 로고
    • Inhibition of proliferation of a hepatoma cell line by fucoxanthin in relation to cell cycle arrest and enhanced gap junctional intercellular communication
    • Liu CL, Huang YS, Hosokawa M, Miyashita K, Hu ML. Inhibition of proliferation of a hepatoma cell line by fucoxanthin in relation to cell cycle arrest and enhanced gap junctional intercellular communication. Chem Biol Interact 2009; 182: 165-172
    • (2009) Chem Biol Interact , vol.182 , pp. 165-172
    • Liu, C.L.1    Huang, Y.S.2    Hosokawa, M.3    Miyashita, K.4    Hu, M.L.5
  • 120
    • 30644470449 scopus 로고    scopus 로고
    • The effect of lycopene on cell growth and oxidative DNA damage of Hep3B human hepatoma cells
    • Park YO, Hwang ES, Moon TW. The effect of lycopene on cell growth and oxidative DNA damage of Hep3B human hepatoma cells. Biofactors 2005; 23: 129-139
    • (2005) Biofactors , vol.23 , pp. 129-139
    • Park, Y.O.1    Hwang, E.S.2    Moon, T.W.3
  • 121
    • 33644671562 scopus 로고    scopus 로고
    • Inhibitory effects of lycopene on the adhesion, invasion, and migration of SK- Hep1 human hepatoma cells
    • Hwang ES, Lee HJ. Inhibitory effects of lycopene on the adhesion, invasion, and migration of SK- Hep1 human hepatoma cells. Exp Biol Med (Maywood) 2006; 231: 322-327
    • (2006) Exp Biol Med (Maywood) , vol.231 , pp. 322-327
    • Hwang, E.S.1    Lee, H.J.2
  • 122
    • 34249913180 scopus 로고    scopus 로고
    • Lycopene inhibits matrix metalloproteinase- 9 expression and down-regulates the binding activity of nuclear factor-kappa B and stimulatory protein-1
    • Huang CS, Fan YE, Lin CY, Hu ML. Lycopene inhibits matrix metalloproteinase- 9 expression and down-regulates the binding activity of nuclear factor-kappa B and stimulatory protein-1. J Nutr Biochem 2007; 18: 449-456
    • (2007) J Nutr Biochem , vol.18 , pp. 449-456
    • Huang, C.S.1    Fan, Y.E.2    Lin, C.Y.3    Hu, M.L.4
  • 123
    • 77952671540 scopus 로고    scopus 로고
    • alpha- Bisabolol induces dose- and time-dependent apoptosis in HepG2 cells via a Fas- and mitochondrial-related pathway, involves p53 and NFkappaB
    • Chen W, Hou J, Yin Y, Jang J, Zheng Z, Fan H, Zou G. alpha-Bisabolol induces dose- and time-dependent apoptosis in HepG2 cells via a Fas- and mitochondrial-related pathway, involves p53 and NFkappaB. Biochem Pharmacol 2010; 80: 247-254
    • (2010) Biochem Pharmacol , vol.80 , pp. 247-254
    • Chen, W.1    Hou, J.2    Yin, Y.3    Jang, J.4    Zheng, Z.5    Fan, H.6    Zou, G.7
  • 124
    • 65649118121 scopus 로고    scopus 로고
    • Dehydrocostuslactone, a medicinal plant-derived sesquiterpene lactone, induces apoptosis coupled to endoplasmic reticulum stress in liver cancer cells
    • Hsu YL, Wu LY, Kuo PL. Dehydrocostuslactone, a medicinal plant-derived sesquiterpene lactone, induces apoptosis coupled to endoplasmic reticulum stress in liver cancer cells. J Pharmacol Exp Ther 2009; 329: 808-819
    • (2009) J Pharmacol Exp Ther , vol.329 , pp. 808-819
    • Hsu, Y.L.1    Wu, L.Y.2    Kuo, P.L.3
  • 125
    • 42449136597 scopus 로고    scopus 로고
    • Furanodiene induces G2/ M cell cycle arrest and apoptosis through MAPK signaling and mitochondria-caspase pathway in human hepatocellular carcinoma cells
    • Xiao Y, Yang FQ, Li SP, Gao JL, Hu G, Lao SC, Conceição EL, Fung KP, Wangl YT, Lee SM. Furanodiene induces G2/ M cell cycle arrest and apoptosis through MAPK signaling and mitochondria-caspase pathway in human hepatocellular carcinoma cells. Cancer Biol Ther 2007; 6: 1044-1050
    • (2007) Cancer Biol Ther , vol.6 , pp. 1044-1050
    • Xiao, Y.1    Yang, F.Q.2    Li, S.P.3    Gao, J.L.4    Hu, G.5    Lao, S.C.6    Conceição, E.L.7    Fung, K.P.8    Wangl, Y.T.9    Lee, S.M.10
  • 126
    • 59449084540 scopus 로고    scopus 로고
    • Redifferentiation of human hepatoma cells (SMMC-7721) induced by two new highly oxygenated bisabolane-type sesquiterpenes
    • Miao R, Wei J, Zhang Q, Sajja V, Yang J, Wang Q. Redifferentiation of human hepatoma cells (SMMC-7721) induced by two new highly oxygenated bisabolane-type sesquiterpenes. J Biosci 2008; 33: 723-730
    • (2008) J Biosci , vol.33 , pp. 723-730
    • Miao, R.1    Wei, J.2    Zhang, Q.3    Sajja, V.4    Yang, J.5    Wang, Q.6
  • 127
    • 34247218059 scopus 로고    scopus 로고
    • Zerumbone induced apoptosis in liver cancer cells via modulation of Bax/ Bcl- 2 ratio
    • Sakinah SA, Handayani ST, Hawariah LP. Zerumbone induced apoptosis in liver cancer cells via modulation of Bax/ Bcl- 2 ratio. Cancer Cell Int 2007; 7: 4
    • (2007) Cancer Cell Int , vol.7 , pp. 4
    • Sakinah, S.A.1    Handayani, S.T.2    Hawariah, L.P.3
  • 129
    • 33745728931 scopus 로고    scopus 로고
    • Farnesol and geraniol chemopreventive activities during the initial phases of hepatocarcinogenesis involve similar actions on cell proliferation and DNA damage, but distinct actions on apoptosis, plasma cholesterol and HMGCoA reductase
    • Ong TP, Heidor R, de Conti A, Dagli ML, Moreno FS. Farnesol and geraniol chemopreventive activities during the initial phases of hepatocarcinogenesis involve similar actions on cell proliferation and DNA damage, but distinct actions on apoptosis, plasma cholesterol and HMGCoA reductase. Carcinogenesis 2006; 27: 1194-1203
    • (2006) Carcinogenesis , vol.27 , pp. 1194-1203
    • Ong, T.P.1    Heidor, R.2    de Conti, A.3    Dagli, M.L.4    Moreno, F.S.5
  • 130
    • 78651235126 scopus 로고    scopus 로고
    • Chemopreventive effects of β-ionone and geraniol during rat hepatocarcinogenesis promotion: distinct actions on cell proliferation, apoptosis, HMGCoA reductase, and RhoA
    • Cardozo MT, de Conti A, Ong TP, Scolastici C, Purgatto E, Horst MA, Bassoli BK, Moreno FS. Chemopreventive effects of β-ionone and geraniol during rat hepatocarcinogenesis promotion: distinct actions on cell proliferation, apoptosis, HMGCoA reductase, and RhoA. J Nutr Biochem 2011; 22: 130-135
    • (2011) J Nutr Biochem , vol.22 , pp. 130-135
    • Cardozo, M.T.1    de Conti, A.2    Ong, T.P.3    Scolastici, C.4    Purgatto, E.5    Horst, M.A.6    Bassoli, B.K.7    Moreno, F.S.8
  • 131
    • 0029616654 scopus 로고
    • Inhibitory effects of 1-O-hexyl-2,3,5-trimethylhydroquinone (HTHQ), green tea catechins and other antioxidants on 2-amino-6- methyldipyrido[1,2-a: 3',2'-d]imidazole (Glu-P-1)-induced rat hepatocarcinogenesis and dose-dependent inhibition by HTHQ of lesion induction by Glu-P- 1 or 2-amino-3,8- dimethylimidazo[4,5-f]quinoxaline (MeIQx)
    • Hirose M, Hasegawa R, Kimura J, Akagi K, Yoshida Y, Tanaka H, Miki T, Satoh T, Wakabayashi K, Ito N. Inhibitory effects of 1-O-hexyl-2,3,5-trimethylhydroquinone (HTHQ), green tea catechins and other antioxidants on 2-amino-6- methyldipyrido[1,2-a: 3',2'-d]imidazole (Glu-P-1)-induced rat hepatocarcinogenesis and dose-dependent inhibition by HTHQ of lesion induction by Glu-P- 1 or 2-amino-3,8- dimethylimidazo[4,5-f]quinoxaline (MeIQx). Carcinogenesis 1995; 16: 3049-3055
    • (1995) Carcinogenesis , vol.16 , pp. 3049-3055
    • Hirose, M.1    Hasegawa, R.2    Kimura, J.3    Akagi, K.4    Yoshida, Y.5    Tanaka, H.6    Miki, T.7    Satoh, T.8    Wakabayashi, K.9    Ito, N.10
  • 132
    • 0033194729 scopus 로고    scopus 로고
    • d-limonene chemoprevention of hepatocarcinogenesis in AKR mice: inhibition of c-jun and c-myc
    • Giri RK, Parija T, Das BR. d-limonene chemoprevention of hepatocarcinogenesis in AKR mice: inhibition of c-jun and c-myc. Oncol Rep 1999; 6: 1123-1127
    • (1999) Oncol Rep , vol.6 , pp. 1123-1127
    • Giri, R.K.1    Parija, T.2    Das, B.R.3
  • 133
    • 0037336499 scopus 로고    scopus 로고
    • Involvement of YY1 and its correlation with c-myc in NDEA induced hepatocarcinogenesis, its prevention by d-limonene
    • Parija T, Das BR. Involvement of YY1 and its correlation with c-myc in NDEA induced hepatocarcinogenesis, its prevention by d-limonene. Mol Biol Rep 2003; 30: 41-46
    • (2003) Mol Biol Rep , vol.30 , pp. 41-46
    • Parija, T.1    Das, B.R.2
  • 134
    • 0035427196 scopus 로고    scopus 로고
    • Inhibition by d-limonene of experimental hepatocarcinogenesis in Sprague-Dawley rats does not involve p21(ras) plasma membrane association
    • Kaji I, Tatsuta M, Iishi H, Baba M, Inoue A, Kasugai H. Inhibition by d-limonene of experimental hepatocarcinogenesis in Sprague-Dawley rats does not involve p21(ras) plasma membrane association. Int J Cancer 2001; 93: 441-444
    • (2001) Int J Cancer , vol.93 , pp. 441-444
    • Kaji, I.1    Tatsuta, M.2    Iishi, H.3    Baba, M.4    Inoue, A.5    Kasugai, H.6
  • 135
    • 0036197826 scopus 로고    scopus 로고
    • Chemopreventive effect of orange oil on the development of hepatic preneoplastic lesions induced by N-nitrosodiethylamine in rats: an ultrastructural study
    • Bodake HB, Panicker KN, Kailaje VV, Rao KV. Chemopreventive effect of orange oil on the development of hepatic preneoplastic lesions induced by N-nitrosodiethylamine in rats: an ultrastructural study. Indian J Exp Biol 2002; 40: 245-251
    • (2002) Indian J Exp Biol , vol.40 , pp. 245-251
    • Bodake, H.B.1    Panicker, K.N.2    Kailaje, V.V.3    Rao, K.V.4
  • 136
    • 0028928294 scopus 로고
    • Induction of apoptosis in liver tumors by the monoterpene perillyl alcohol
    • Mills JJ, Chari RS, Boyer IJ, Gould MN, Jirtle RL. Induction of apoptosis in liver tumors by the monoterpene perillyl alcohol. Cancer Res 1995; 55: 979-983
    • (1995) Cancer Res , vol.55 , pp. 979-983
    • Mills, J.J.1    Chari, R.S.2    Boyer, I.J.3    Gould, M.N.4    Jirtle, R.L.5
  • 137
    • 34548136987 scopus 로고    scopus 로고
    • Hepatoprotective effect of andrographolide against hexachlorocyclohexane-induced oxidative injury
    • Trivedi NP, Rawal UM, Patel BP. Hepatoprotective effect of andrographolide against hexachlorocyclohexane-induced oxidative injury. Integr Cancer Ther 2007; 6: 271-280
    • (2007) Integr Cancer Ther , vol.6 , pp. 271-280
    • Trivedi, N.P.1    Rawal, U.M.2    Patel, B.P.3
  • 138
    • 68949083038 scopus 로고    scopus 로고
    • Potency of andrographolide as an antitumor compound in BHC-induced liver damage
    • Trivedi NP, Rawal UM, Patel BP. Potency of andrographolide as an antitumor compound in BHC-induced liver damage. Integr Cancer Ther 2009; 8: 177-189
    • (2009) Integr Cancer Ther , vol.8 , pp. 177-189
    • Trivedi, N.P.1    Rawal, U.M.2    Patel, B.P.3
  • 139
    • 67651171647 scopus 로고    scopus 로고
    • Chemopreventive potential of Epoxy clerodane diterpene from Tinospora cordifolia against diethylnitrosamine- induced hepatocellular carcinoma
    • Dhanasekaran M, Baskar AA, Ignacimuthu S, Agastian P, Duraipandiyan V. Chemopreventive potential of Epoxy clerodane diterpene from Tinospora cordifolia against diethylnitrosamine- induced hepatocellular carcinoma. Invest New Drugs 2009; 27: 347-355
    • (2009) Invest New Drugs , vol.27 , pp. 347-355
    • Dhanasekaran, M.1    Baskar, A.A.2    Ignacimuthu, S.3    Agastian, P.4    Duraipandiyan, V.5
  • 140
    • 22344452155 scopus 로고    scopus 로고
    • Geranylgeraniol and beta-ionone inhibit hepatic preneoplastic lesions, cell proliferation, total plasma cholesterol and DNA damage during the initial phases of hepatocarcinogenesis, but only the former inhibits NF-kappaB activation
    • de Moura Espíndola R, Mazzantini RP, Ong TP, de Conti A, Heidor R, Moreno FS. Geranylgeraniol and beta-ionone inhibit hepatic preneoplastic lesions, cell proliferation, total plasma cholesterol and DNA damage during the initial phases of hepatocarcinogenesis, but only the former inhibits NF-kappaB activation. Carcinogenesis 2005; 26: 1091-1099
    • (2005) Carcinogenesis , vol.26 , pp. 1091-1099
    • de Moura Espíndola, R.1    Mazzantini, R.P.2    Ong, T.P.3    de Conti, A.4    Heidor, R.5    Moreno, F.S.6
  • 141
    • 77950462129 scopus 로고    scopus 로고
    • Chemopreventive effect of bacoside A on N-nitrosodiethylamine- induced hepatocarcinogenesis in rats
    • Janani P, Sivakumari K, Geetha A, Ravisankar B, Parthasarathy C. Chemopreventive effect of bacoside A on N-nitrosodiethylamine- induced hepatocarcinogenesis in rats. J Cancer Res Clin Oncol 2010; 136: 759-770
    • (2010) J Cancer Res Clin Oncol , vol.136 , pp. 759-770
    • Janani, P.1    Sivakumari, K.2    Geetha, A.3    Ravisankar, B.4    Parthasarathy, C.5
  • 142
    • 77249140494 scopus 로고    scopus 로고
    • Bacoside A downregulates matrix metalloproteinases 2 and 9 in DEN-induced hepatocellular carcinoma
    • Janani P, Sivakumari K, Geetha A, Yuvaraj S, Parthasarathy C. Bacoside A downregulates matrix metalloproteinases 2 and 9 in DEN-induced hepatocellular carcinoma. Cell Biochem Funct 2010; 28: 164-169
    • (2010) Cell Biochem Funct , vol.28 , pp. 164-169
    • Janani, P.1    Sivakumari, K.2    Geetha, A.3    Yuvaraj, S.4    Parthasarathy, C.5
  • 143
    • 0030936855 scopus 로고    scopus 로고
    • Tissue culture of adult human retinal ganglion cells
    • Hu DN, Ritch R. Tissue culture of adult human retinal ganglion cells. J Glaucoma 1997; 6: 37-43
    • (1997) J Glaucoma , vol.6 , pp. 37-43
    • Hu, D.N.1    Ritch, R.2
  • 147
    • 67650651929 scopus 로고    scopus 로고
    • Hepatoprotective and antihepatocarcinogenic effects of glycyrrhizin and matrine
    • Wan XY, Luo M, Li XD, He P. Hepatoprotective and antihepatocarcinogenic effects of glycyrrhizin and matrine. Chem Biol Interact 2009; 181: 15-19
    • (2009) Chem Biol Interact , vol.181 , pp. 15-19
    • Wan, X.Y.1    Luo, M.2    Li, X.D.3    He, P.4
  • 149
    • 9744231424 scopus 로고    scopus 로고
    • Squalene does not exhibit a chemopreventive activity and increases plasma cholesterol in a Wistar rat hepatocarcinogenesis model
    • Scolastici C, Ong TP, Moreno FS. Squalene does not exhibit a chemopreventive activity and increases plasma cholesterol in a Wistar rat hepatocarcinogenesis model. Nutr Cancer 2004; 50: 101-109
    • (2004) Nutr Cancer , vol.50 , pp. 101-109
    • Scolastici, C.1    Ong, T.P.2    Moreno, F.S.3
  • 150
    • 77952300961 scopus 로고    scopus 로고
    • Ursolic acid attenuates oxidative stress-mediated hepatocellular carcinoma induction by diethylnitrosamine in male Wistar rats
    • Gayathri R, Priya DK, Gunassekaran GR, Sakthisekaran D. Ursolic acid attenuates oxidative stress-mediated hepatocellular carcinoma induction by diethylnitrosamine in male Wistar rats. Asian Pac J Cancer Prev 2009; 10: 933-938
    • (2009) Asian Pac J Cancer Prev , vol.10 , pp. 933-938
    • Gayathri, R.1    Priya, D.K.2    Gunassekaran, G.R.3    Sakthisekaran, D.4
  • 151
    • 0026448684 scopus 로고
    • Potent preventive action of alpha-carotene against carcinogenesis: spontaneous liver carcinogenesis and promoting stage of lung and skin carcinogenesis in mice are suppressed more effectively by alpha-carotene than by beta-carotene
    • Murakoshi M, Nishino H, Satomi Y, Takayasu J, Hasegawa T, Tokuda H, Iwashima A, Okuzumi J, Okabe H, Kitano H. Potent preventive action of alpha-carotene against carcinogenesis: spontaneous liver carcinogenesis and promoting stage of lung and skin carcinogenesis in mice are suppressed more effectively by alpha-carotene than by beta-carotene. Cancer Res 1992; 52: 6583-6587
    • (1992) Cancer Res , vol.52 , pp. 6583-6587
    • Murakoshi, M.1    Nishino, H.2    Satomi, Y.3    Takayasu, J.4    Hasegawa, T.5    Tokuda, H.6    Iwashima, A.7    Okuzumi, J.8    Okabe, H.9    Kitano, H.10
  • 153
    • 0030066373 scopus 로고    scopus 로고
    • No evidence for an inhibitory effect of beta-carotene or of canthaxanthin on the initiation of liver preneoplastic foci by diethylnitrosamine in the rat
    • Astorg P, Gradelet S, Bergès R, Suschetet M. No evidence for an inhibitory effect of beta-carotene or of canthaxanthin on the initiation of liver preneoplastic foci by diethylnitrosamine in the rat. Nutr Cancer 1996; 25: 27-34
    • (1996) Nutr Cancer , vol.25 , pp. 27-34
    • Astorg, P.1    Gradelet, S.2    Bergès, R.3    Suschetet, M.4
  • 154
    • 0030726136 scopus 로고    scopus 로고
    • Dietary lycopene decreases the initiation of liver preneoplastic foci by diethylnitrosamine in the rat
    • Astorg P, Gradelet S, Bergès R, Suschetet M. Dietary lycopene decreases the initiation of liver preneoplastic foci by diethylnitrosamine in the rat. Nutr Cancer 1997; 29: 60-68
    • (1997) Nutr Cancer , vol.29 , pp. 60-68
    • Astorg, P.1    Gradelet, S.2    Bergès, R.3    Suschetet, M.4
  • 155
    • 54849409662 scopus 로고    scopus 로고
    • Effect of antioxidant phytochemicals on the hepatic tumor promoting activity of 3,3',4,4'-tetrachlorobiphenyl (PCB-77)
    • Tharappel JC, Lehmler HJ, Srinivasan C, Robertson LW, Spear BT, Glauert HP. Effect of antioxidant phytochemicals on the hepatic tumor promoting activity of 3,3',4,4'-tetrachlorobiphenyl (PCB-77). Food Chem Toxicol 2008; 46: 3467-3474
    • (2008) Food Chem Toxicol , vol.46 , pp. 3467-3474
    • Tharappel, J.C.1    Lehmler, H.J.2    Srinivasan, C.3    Robertson, L.W.4    Spear, B.T.5    Glauert, H.P.6
  • 156
    • 0025941669 scopus 로고
    • Inhibitory effects of beta-carotene on preneoplastic lesions induced in Wistar rats by the resistant hepatocyte model
    • Moreno FS, Rizzi MB, Dagli ML, Penteado MV. Inhibitory effects of beta-carotene on preneoplastic lesions induced in Wistar rats by the resistant hepatocyte model. Carcinogenesis 1991; 12: 1817-1822
    • (1991) Carcinogenesis , vol.12 , pp. 1817-1822
    • Moreno, F.S.1    Rizzi, M.B.2    Dagli, M.L.3    Penteado, M.V.4
  • 158
    • 0031470874 scopus 로고    scopus 로고
    • beta-carotene inhibits persistent and stimulates remodeling gamma GT-positive preneoplastic lesions during early promotion of hepatocarcinogenesis
    • Rizzi MB, Dagli ML, Jordão AA, Penteado MV, Moreno FS. beta-carotene inhibits persistent and stimulates remodeling gamma GT-positive preneoplastic lesions during early promotion of hepatocarcinogenesis. Int J Vitam Nutr Res 1997; 67: 415-422
    • (1997) Int J Vitam Nutr Res , vol.67 , pp. 415-422
    • Rizzi, M.B.1    Dagli, M.L.2    Jordão, A.A.3    Penteado, M.V.4    Moreno, F.S.5
  • 159
    • 84961012817 scopus 로고
    • Similarities in the sequence of early histological changes induced in the liver of the rat by ethionine, 2-acetylamino- fluorene, and 3'-methyl-4-dimethylaminoazobenzene
    • Farber E. Similarities in the sequence of early histological changes induced in the liver of the rat by ethionine, 2-acetylamino- fluorene, and 3'-methyl-4-dimethylaminoazobenzene. Cancer Res 1956; 16: 142-148
    • (1956) Cancer Res , vol.16 , pp. 142-148
    • Farber, E.1
  • 160
    • 0031657271 scopus 로고    scopus 로고
    • Beta-carotene reduces the ductular (oval) cell reaction in the liver of Wistar rats submitted to the resistant hepatocyte model of carcinogenesis
    • Dagli ML, Guerra JL, Sinhorini IL, Wu TS, Rizzi MB, Penteado MV, Moreno FS. Beta-carotene reduces the ductular (oval) cell reaction in the liver of Wistar rats submitted to the resistant hepatocyte model of carcinogenesis. Pathology 1998; 30: 259-266
    • (1998) Pathology , vol.30 , pp. 259-266
    • Dagli, M.L.1    Guerra, J.L.2    Sinhorini, I.L.3    Wu, T.S.4    Rizzi, M.B.5    Penteado, M.V.6    Moreno, F.S.7
  • 161
    • 0036949793 scopus 로고    scopus 로고
    • Inhibitory effects of beta-carotene and vitamin a during the progression phase of hepatocarcinogenesis involve inhibition of cell proliferation but not alterations in DNA methylation
    • Moreno FS, S-Wu T, Naves MM, Silveira ER, Oloris SC, da Costa MA, Dagli ML, Ong TP. Inhibitory effects of beta-carotene and vitamin a during the progression phase of hepatocarcinogenesis involve inhibition of cell proliferation but not alterations in DNA methylation. Nutr Cancer 2002; 44: 80-88
    • (2002) Nutr Cancer , vol.44 , pp. 80-88
    • Moreno, F.S.1    S-Wu, T.2    Naves, M.M.3    Silveira, E.R.4    Oloris, S.C.5    da Costa, M.A.6    Dagli, M.L.7    Ong, T.P.8
  • 163
    • 33846874352 scopus 로고    scopus 로고
    • Vitamin A and beta-carotene inhibitory effect during 1,2-dimethylhydrazine induced hepatocarcinogenesis potentiated by 5-azacytidine
    • Sampaio AR, Chagas CE, Ong TP, Moreno FS. Vitamin A and beta-carotene inhibitory effect during 1,2-dimethylhydrazine induced hepatocarcinogenesis potentiated by 5-azacytidine. Food Chem Toxicol 2007; 45: 563-567
    • (2007) Food Chem Toxicol , vol.45 , pp. 563-567
    • Sampaio, A.R.1    Chagas, C.E.2    Ong, T.P.3    Moreno, F.S.4
  • 164
    • 0028179826 scopus 로고
    • Inhibitory effect of beta-carotene on chronic 2-acetylaminofluorene induced hepatocarcinogenesis in rat: reflection in hepatic drug metabolism
    • Sarkar A, Mukherjee B, Chatterjee M. Inhibitory effect of beta-carotene on chronic 2-acetylaminofluorene induced hepatocarcinogenesis in rat: reflection in hepatic drug metabolism. Carcinogenesis 1994; 15: 1055-1060
    • (1994) Carcinogenesis , vol.15 , pp. 1055-1060
    • Sarkar, A.1    Mukherjee, B.2    Chatterjee, M.3
  • 165
    • 0029063030 scopus 로고
    • Inhibition of 3'-methyl- 4-dimethylaminoazobenzene-induced hepatocarcinogenesis in rat by dietary beta-carotene: changes in hepatic antioxidant defense enzyme levels
    • Sarkar A, Mukherjee B, Chatterjee M. Inhibition of 3'-methyl- 4-dimethylaminoazobenzene-induced hepatocarcinogenesis in rat by dietary beta-carotene: changes in hepatic antioxidant defense enzyme levels. Int J Cancer 1995; 61: 799-805
    • (1995) Int J Cancer , vol.61 , pp. 799-805
    • Sarkar, A.1    Mukherjee, B.2    Chatterjee, M.3
  • 166
    • 0029394873 scopus 로고
    • Beta-carotene prevents lipid peroxidation and red blood cell membrane protein damage in experimental hepatocarcinogenesis
    • Sarkar A, Bishayee A, Chatterjee M. Beta-carotene prevents lipid peroxidation and red blood cell membrane protein damage in experimental hepatocarcinogenesis. Cancer Biochem Biophys 1995; 15: 111-125
    • (1995) Cancer Biochem Biophys , vol.15 , pp. 111-125
    • Sarkar, A.1    Bishayee, A.2    Chatterjee, M.3
  • 167
    • 0030769237 scopus 로고    scopus 로고
    • Betacarotene inhibits rat liver chromosomal aberrations and DNA chain break after a single injection of diethylnitrosamine
    • Sarkar A, Basak R, Bishayee A, Basak J, Chatterjee M. Betacarotene inhibits rat liver chromosomal aberrations and DNA chain break after a single injection of diethylnitrosamine. Br J Cancer 1997; 76: 855-861
    • (1997) Br J Cancer , vol.76 , pp. 855-861
    • Sarkar, A.1    Basak, R.2    Bishayee, A.3    Basak, J.4    Chatterjee, M.5
  • 168
    • 0033839715 scopus 로고    scopus 로고
    • Further evidence for chemopreventive potential of beta-carotene against experimental carcinogenesis: diethylnitrosamine-initiated and phenobarbital-promoted hepatocarcinogenesis is prevented more effectively by beta-carotene than by retinoic acid
    • Bishayee A, Sarkar A, Chatterjee M. Further evidence for chemopreventive potential of beta-carotene against experimental carcinogenesis: diethylnitrosamine-initiated and phenobarbital-promoted hepatocarcinogenesis is prevented more effectively by beta-carotene than by retinoic acid. Nutr Cancer 2000; 37: 89-98
    • (2000) Nutr Cancer , vol.37 , pp. 89-98
    • Bishayee, A.1    Sarkar, A.2    Chatterjee, M.3
  • 169
    • 0028670227 scopus 로고
    • Chemopreventive effects of beta-carotene, alpha-tocopherol and five naturally occurring antioxidants on initiation of hepatocarcinogenesis by 2-amino-3-methylimidazo[4,5-f]quinoline in the rat
    • Tsuda H, Uehara N, Iwahori Y, Asamoto M, Iigo M, Nagao M, Matsumoto K, Ito M, Hirono I. Chemopreventive effects of beta-carotene, alpha-tocopherol and five naturally occurring antioxidants on initiation of hepatocarcinogenesis by 2-amino-3-methylimidazo[4,5-f]quinoline in the rat. Jpn J Cancer Res 1994; 85: 1214-1219
    • (1994) Jpn J Cancer Res , vol.85 , pp. 1214-1219
    • Tsuda, H.1    Uehara, N.2    Iwahori, Y.3    Asamoto, M.4    Iigo, M.5    Nagao, M.6    Matsumoto, K.7    Ito, M.8    Hirono, I.9
  • 170
    • 0028937559 scopus 로고
    • Role of reactive oxygen in synthetic estrogen induction of hepatocellularcarcinomas in rats and preventive effect of vitamins
    • Ogawa T, Higashi S, Kawarada Y, Mizumoto R. Role of reactive oxygen in synthetic estrogen induction of hepatocellularcarcinomas in rats and preventive effect of vitamins. Carcinogenesis 1995; 16: 831-836
    • (1995) Carcinogenesis , vol.16 , pp. 831-836
    • Ogawa, T.1    Higashi, S.2    Kawarada, Y.3    Mizumoto, R.4
  • 172
    • 0030965507 scopus 로고    scopus 로고
    • Modulation of aflatoxin B1 carcinogenicity, genotoxicity and metabolism in rat liver by dietary carotenoids: evidence for a protective effect of CYP1A inducers
    • Gradelet S, Astorg P, Le Bon AM, Bergès R, Suschetet M. Modulation of aflatoxin B1 carcinogenicity, genotoxicity and metabolism in rat liver by dietary carotenoids: evidence for a protective effect of CYP1A inducers. Cancer Lett 1997; 114: 221-223
    • (1997) Cancer Lett , vol.114 , pp. 221-223
    • Gradelet, S.1    Astorg, P.2    Le Bon, A.M.3    Bergès, R.4    Suschetet, M.5
  • 173
    • 0031903572 scopus 로고    scopus 로고
    • Dietary carotenoids inhibit aflatoxin B1-induced liver preneoplastic foci and DNA damage in the rat: role of the modulation of aflatoxin B1 metabolism
    • Gradelet S, Le Bon AM, Bergès R, Suschetet M, Astorg P. Dietary carotenoids inhibit aflatoxin B1-induced liver preneoplastic foci and DNA damage in the rat: role of the modulation of aflatoxin B1 metabolism. Carcinogenesis 1998; 19: 403-411
    • (1998) Carcinogenesis , vol.19 , pp. 403-411
    • Gradelet, S.1    Le Bon, A.M.2    Bergès, R.3    Suschetet, M.4    Astorg, P.5
  • 174
    • 0029947331 scopus 로고    scopus 로고
    • Initiation and post-initiation chemopreventive effects of beta-carotene in toad liver carcinogenesis
    • Sadek IA, Hayat LG. Initiation and post-initiation chemopreventive effects of beta-carotene in toad liver carcinogenesis. Histol Histopathol 1996; 11: 357-360
    • (1996) Histol Histopathol , vol.11 , pp. 357-360
    • Sadek, I.A.1    Hayat, L.G.2
  • 175
    • 3042819720 scopus 로고    scopus 로고
    • Combined supplementation of vanadium and beta-carotene suppresses placental glutathione S-transferasepositive foci and enhances antioxidant functions during the inhibition of diethylnitrosamine-induced rat liver carcinogenesis
    • Chattopadhyay MB, C B MK, Kanna PS, Ray RS, Roy S, Chatterjee M. Combined supplementation of vanadium and beta-carotene suppresses placental glutathione S-transferasepositive foci and enhances antioxidant functions during the inhibition of diethylnitrosamine-induced rat liver carcinogenesis. J Gastroenterol Hepatol 2004; 19: 683-693
    • (2004) J Gastroenterol Hepatol , vol.19 , pp. 683-693
    • Chattopadhyay, M.B.C.1    Kanna, P.S.2    Ray, R.S.3    Roy, S.4    Chatterjee, M.5
  • 176
    • 26844540048 scopus 로고    scopus 로고
    • Proton-Induced X-ray Emission (PIXE) Analysis and DNA-chain Break study in rat hepatocarcinogenesis: A possible chemopreventive role by combined supplementation of vanadium and beta-carotene
    • Chattopadhyay MB, Mukherjee S, Kulkarni I, Vijayan V, Doloi M, Kanjilal N, Chatterjee M. Proton-Induced X-ray Emission (PIXE) Analysis and DNA-chain Break study in rat hepatocarcinogenesis: A possible chemopreventive role by combined supplementation of vanadium and beta-carotene. Cancer Cell Int 2005; 5: 16
    • (2005) Cancer Cell Int , vol.5 , pp. 16
    • Chattopadhyay, M.B.1    Mukherjee, S.2    Kulkarni, I.3    Vijayan, V.4    Doloi, M.5    Kanjilal, N.6    Chatterjee, M.7
  • 177
    • 77953022969 scopus 로고    scopus 로고
    • Vanadium in the detection, prevention and treatment of cancer: the in vivo evidence
    • Bishayee A, Waghray A, Patel MA, Chatterjee M. Vanadium in the detection, prevention and treatment of cancer: the in vivo evidence. Cancer Lett 2010; 294: 1-12
    • (2010) Cancer Lett , vol.294 , pp. 1-12
    • Bishayee, A.1    Waghray, A.2    Patel, M.A.3    Chatterjee, M.4
  • 178
    • 0033979314 scopus 로고    scopus 로고
    • Diet, natural products and cancer chemoprevention
    • Singletary K. Diet, natural products and cancer chemoprevention. J Nutr 2000; 130: 465S-466S
    • (2000) J Nutr , vol.130
    • Singletary, K.1
  • 179
    • 3042736080 scopus 로고    scopus 로고
    • Studies of the isoprenoid-mediated inhibition of mevalonate synthesis applied to cancer chemotherapy and chemoprevention
    • Mo H, Elson CE. Studies of the isoprenoid-mediated inhibition of mevalonate synthesis applied to cancer chemotherapy and chemoprevention. Exp Biol Med (Maywood) 2004; 229: 567-585
    • (2004) Exp Biol Med (Maywood) , vol.229 , pp. 567-585
    • Mo, H.1    Elson, C.E.2
  • 181
    • 1342322806 scopus 로고    scopus 로고
    • Inhibitory effects of lutein and lycopene on placental glutathione S-transferase-positive preneoplastic lesions and DNA strand breakage induced in Wistar rats by the resistant hepatocyte model of hepatocarcinogenesis
    • Toledo LP, Ong TP, Pinho AL, Jordão A, Vanucchi H, Moreno FS. Inhibitory effects of lutein and lycopene on placental glutathione S-transferase-positive preneoplastic lesions and DNA strand breakage induced in Wistar rats by the resistant hepatocyte model of hepatocarcinogenesis. Nutr Cancer 2003; 47: 62-69
    • (2003) Nutr Cancer , vol.47 , pp. 62-69
    • Toledo, L.P.1    Ong, T.P.2    Pinho, A.L.3    Jordão, A.4    Vanucchi, H.5    Moreno, F.S.6
  • 182
    • 34347222521 scopus 로고    scopus 로고
    • Lutein presents suppressing but not blocking chemopreventive activity during diethylnitrosamine-induced hepatocarcinogenesis and this involves inhibition of DNA damage
    • Moreno FS, Toledo LP, de Conti A, Heidor R, Jordão A, Vannucchi H, Cardozo MT, Ong TP. Lutein presents suppressing but not blocking chemopreventive activity during diethylnitrosamine-induced hepatocarcinogenesis and this involves inhibition of DNA damage. Chem Biol Interact 2007; 168: 221-228
    • (2007) Chem Biol Interact , vol.168 , pp. 221-228
    • Moreno, F.S.1    Toledo, L.P.2    de Conti, A.3    Heidor, R.4    Jordão, A.5    Vannucchi, H.6    Cardozo, M.T.7    Ong, T.P.8
  • 183
    • 0034819804 scopus 로고    scopus 로고
    • Effects of lycopene and Sho-saiko-to on hepatocarcinogenesis in a rat model of spontaneous liver cancer
    • Watanabe S, Kitade Y, Masaki T, Nishioka M, Satoh K, Nishino H. Effects of lycopene and Sho-saiko-to on hepatocarcinogenesis in a rat model of spontaneous liver cancer. Nutr Cancer 2001; 39: 96-101
    • (2001) Nutr Cancer , vol.39 , pp. 96-101
    • Watanabe, S.1    Kitade, Y.2    Masaki, T.3    Nishioka, M.4    Satoh, K.5    Nishino, H.6
  • 184
    • 77949876397 scopus 로고    scopus 로고
    • Dietary lycopene and tomato extract supplementations inhibit nonalcoholic steatohepatitis-promoted hepatocarcinogenesis in rats
    • Wang Y, Ausman LM, Greenberg AS, Russell RM, Wang XD. Dietary lycopene and tomato extract supplementations inhibit nonalcoholic steatohepatitis-promoted hepatocarcinogenesis in rats. Int J Cancer 2010; 126: 1788-1796
    • (2010) Int J Cancer , vol.126 , pp. 1788-1796
    • Wang, Y.1    Ausman, L.M.2    Greenberg, A.S.3    Russell, R.M.4    Wang, X.D.5
  • 185
    • 0345303964 scopus 로고    scopus 로고
    • Farnesyl-O-acetylhydroquinone and geranyl-O-acetylhydroquinone suppress the proliferation of murine B16 melanoma cells, human prostate and colon adenocarcinoma cells, human lung carcinoma cells, and human leukemia cells
    • McAnally JA, Jung M, Mo H. Farnesyl-O-acetylhydroquinone and geranyl-O-acetylhydroquinone suppress the proliferation of murine B16 melanoma cells, human prostate and colon adenocarcinoma cells, human lung carcinoma cells, and human leukemia cells. Cancer Lett 2003; 202: 181-192
    • (2003) Cancer Lett , vol.202 , pp. 181-192
    • McAnally, J.A.1    Jung, M.2    Mo, H.3
  • 186
    • 77954427466 scopus 로고    scopus 로고
    • Potential chemoprevention of diethylnitrosamine- initiated and 2-acetylaminofluorene-promoted hepatocarcinogenesis by zerumbone from the rhizomes of the subtropical ginger (Zingiber zerumbet)
    • Taha MM, Abdul AB, Abdullah R, Ibrahim TA, Abdelwahab SI, Mohan S. Potential chemoprevention of diethylnitrosamine- initiated and 2-acetylaminofluorene-promoted hepatocarcinogenesis by zerumbone from the rhizomes of the subtropical ginger (Zingiber zerumbet). Chem Biol Interact 2010; 186: 295-305
    • (2010) Chem Biol Interact , vol.186 , pp. 295-305
    • Taha, M.M.1    Abdul, A.B.2    Abdullah, R.3    Ibrahim, T.A.4    Abdelwahab, S.I.5    Mohan, S.6
  • 187
    • 9744222928 scopus 로고    scopus 로고
    • Potential synergy of phytochemicals in cancer prevention: mechanism of action
    • Liu RH. Potential synergy of phytochemicals in cancer prevention: mechanism of action. J Nutr 2004; 134: 3479S-3485S
    • (2004) J Nutr , vol.134
    • Liu, R.H.1
  • 188
    • 33745514508 scopus 로고    scopus 로고
    • Beware of pomegranates bearing 40% ellagic Acid
    • Lansky EP. Beware of pomegranates bearing 40% ellagic Acid. J Med Food 2006; 9: 119-122
    • (2006) J Med Food , vol.9 , pp. 119-122
    • Lansky, E.P.1
  • 189
    • 43149091484 scopus 로고    scopus 로고
    • Mechanisms of combined action of different chemopreventive dietary compounds: a review
    • de Kok TM, van Breda SG, Manson MM. Mechanisms of combined action of different chemopreventive dietary compounds: a review. Eur J Nutr 2008; 47 Suppl 2: 51-59
    • (2008) Eur J Nutr , vol.47 , Issue.SUPPL. 2 , pp. 51-59
    • de Kok, T.M.1    van Breda, S.G.2    Manson, M.M.3
  • 190
    • 68949194441 scopus 로고    scopus 로고
    • Epigallocatechin 3-gallate and green tea catechins: United they work, divided they fail
    • Bode AM, Dong Z. Epigallocatechin 3-gallate and green tea catechins: United they work, divided they fail. Cancer Prev Res (Phila) 2009; 2: 514-517
    • (2009) Cancer Prev Res (Phila) , vol.2 , pp. 514-517
    • Bode, A.M.1    Dong, Z.2
  • 191
    • 70450182123 scopus 로고    scopus 로고
    • Plant polyphenols and tumors: from mechanisms to therapies, prevention, and protection against toxicity of anti-cancer treatments
    • Korkina LG, De Luca C, Kostyuk VA, Pastore S. Plant polyphenols and tumors: from mechanisms to therapies, prevention, and protection against toxicity of anti-cancer treatments. Curr Med Chem 2009; 16: 3943-3965
    • (2009) Curr Med Chem , vol.16 , pp. 3943-3965
    • Korkina, L.G.1    De Luca, C.2    Kostyuk, V.A.3    Pastore, S.4
  • 192
    • 0043128840 scopus 로고    scopus 로고
    • Studies on the non-covalent complexes between oleanolic acid and cyclodextrins using electrospray ionization tandem mass spectrometry
    • Guo M, Zhang S, Song F, Wang D, Liu Z, Liu S. Studies on the non-covalent complexes between oleanolic acid and cyclodextrins using electrospray ionization tandem mass spectrometry. J Mass Spectrom 2003; 38: 723-731
    • (2003) J Mass Spectrom , vol.38 , pp. 723-731
    • Guo, M.1    Zhang, S.2    Song, F.3    Wang, D.4    Liu, Z.5    Liu, S.6
  • 193
    • 12344326615 scopus 로고    scopus 로고
    • Oleanolic acid nanosuspensions: preparation, in-vitro characterization and enhanced hepatoprotective effect
    • Chen Y, Liu J, Yang X, Zhao X, Xu H. Oleanolic acid nanosuspensions: preparation, in-vitro characterization and enhanced hepatoprotective effect. J Pharm Pharmacol 2005; 57: 259-264
    • (2005) J Pharm Pharmacol , vol.57 , pp. 259-264
    • Chen, Y.1    Liu, J.2    Yang, X.3    Zhao, X.4    Xu, H.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.