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Volumn 1823, Issue 2, 2012, Pages 451-457

Autophagy inhibition enhances ursolic acid-induced apoptosis in PC3 cells

Author keywords

Akt mTOR; Apoptosis; Autophagy; Prostate cancer; Ursolic acid

Indexed keywords

3 METHYLADENINE; ANTINEOPLASTIC AGENT; AUTOPHAGY PROTEIN 5; BECLIN 1; DANSYLCADAVERINE; MAMMALIAN TARGET OF RAPAMYCIN; MICROTUBULE ASSOCIATED PROTEIN 1; MICROTUBULE ASSOCIATED PROTEIN 1 LIGHT CHAIN 3; PROTEIN KINASE B; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; URSOLIC ACID;

EID: 84862798150     PISSN: 01674889     EISSN: 18792596     Source Type: Journal    
DOI: 10.1016/j.bbamcr.2011.10.014     Document Type: Article
Times cited : (88)

References (56)
  • 1
    • 0242692456 scopus 로고    scopus 로고
    • Molecular pathways to prostate cancer
    • Gonzalo M.L., Isaacs W.B. Molecular pathways to prostate cancer. J. Urol. 2003, 170:2444-2452.
    • (2003) J. Urol. , vol.170 , pp. 2444-2452
    • Gonzalo, M.L.1    Isaacs, W.B.2
  • 2
    • 33846436108 scopus 로고    scopus 로고
    • Cancer statistics, trends, and multiple primary cancer analyses from the Surveillance, Epidemiology, and End Results (SEER) program
    • Hayat M.J., Howlader N., Reichman M.E., Edwards B.K. Cancer statistics, trends, and multiple primary cancer analyses from the Surveillance, Epidemiology, and End Results (SEER) program. Oncologist 2007, 12:20-37.
    • (2007) Oncologist , vol.12 , pp. 20-37
    • Hayat, M.J.1    Howlader, N.2    Reichman, M.E.3    Edwards, B.K.4
  • 4
    • 0032761807 scopus 로고    scopus 로고
    • Chemotherapy for advanced hormone refractory prostate cancer
    • Petrylak D.P. Chemotherapy for advanced hormone refractory prostate cancer. Urology 1997, 54:30-35.
    • (1997) Urology , vol.54 , pp. 30-35
    • Petrylak, D.P.1
  • 5
    • 0032953362 scopus 로고    scopus 로고
    • The challenge of locally advanced prostate cancer
    • Pisters L.L. The challenge of locally advanced prostate cancer. Semin. Oncol. 1999, 26:202-216.
    • (1999) Semin. Oncol. , vol.26 , pp. 202-216
    • Pisters, L.L.1
  • 6
    • 0032777144 scopus 로고    scopus 로고
    • Anti-androgens and other hormonal therapies for prostate cancer
    • Richie J.P. Anti-androgens and other hormonal therapies for prostate cancer. Urology 1999, 54:15-18.
    • (1999) Urology , vol.54 , pp. 15-18
    • Richie, J.P.1
  • 7
    • 0029567968 scopus 로고
    • Pharmacology of oleanolic acid and ursolic acid
    • Liu J. Pharmacology of oleanolic acid and ursolic acid. J. Ethnopharmacol. 1995, 49:57-68.
    • (1995) J. Ethnopharmacol. , vol.49 , pp. 57-68
    • Liu, J.1
  • 9
    • 33646028804 scopus 로고    scopus 로고
    • Molecular targets of dietary agents for prevention and therapy of cancer
    • Aggarwal B.B., Shishodia S. Molecular targets of dietary agents for prevention and therapy of cancer. Biochem. Pharmacol. 2006, 71:1397-1421.
    • (2006) Biochem. Pharmacol. , vol.71 , pp. 1397-1421
    • Aggarwal, B.B.1    Shishodia, S.2
  • 10
    • 63449089496 scopus 로고    scopus 로고
    • Downregulation of survivin and activation of caspase-3 through the PI3K/Akt pathway in ursolic acid-induced HepG2 cell apoptosis
    • Tang C., Lu Y.H., Xie J.H., Wang F., Zou J.N., Yang J.S., Xing Y.Y., Xi T. Downregulation of survivin and activation of caspase-3 through the PI3K/Akt pathway in ursolic acid-induced HepG2 cell apoptosis. Anticancer Drugs 2009, 20:249-258.
    • (2009) Anticancer Drugs , vol.20 , pp. 249-258
    • Tang, C.1    Lu, Y.H.2    Xie, J.H.3    Wang, F.4    Zou, J.N.5    Yang, J.S.6    Xing, Y.Y.7    Xi, T.8
  • 11
    • 79953153877 scopus 로고    scopus 로고
    • Ursolic acid, a pentacyclin triterpene, potentiates TRAIL-induced apoptosis through p53-independent up-regulation of death receptors: evidence for the role of reactive oxygen species and JNK
    • Prasad S., Yadav V.R., Kannappan R., Aggarwal B.B. Ursolic acid, a pentacyclin triterpene, potentiates TRAIL-induced apoptosis through p53-independent up-regulation of death receptors: evidence for the role of reactive oxygen species and JNK. J. Biol. Chem. 2010, 286:5546-5557.
    • (2010) J. Biol. Chem. , vol.286 , pp. 5546-5557
    • Prasad, S.1    Yadav, V.R.2    Kannappan, R.3    Aggarwal, B.B.4
  • 13
    • 0032510164 scopus 로고    scopus 로고
    • Ursolic acid-induced down-regulation of MMP-9 gene is mediated through the nuclear translocation of glucocorticoid receptor in HT1080 human fibrosarcoma cells
    • Cha H., Park M.T., Chung H.Y., Kim N.D., Sato H., Seiki M., Kim K.W. Ursolic acid-induced down-regulation of MMP-9 gene is mediated through the nuclear translocation of glucocorticoid receptor in HT1080 human fibrosarcoma cells. Oncogene 1998, 16:771-778.
    • (1998) Oncogene , vol.16 , pp. 771-778
    • Cha, H.1    Park, M.T.2    Chung, H.Y.3    Kim, N.D.4    Sato, H.5    Seiki, M.6    Kim, K.W.7
  • 14
    • 67650097012 scopus 로고    scopus 로고
    • Triterpenes augment the inhibitory effects of anticancer drugs on growth of human esophageal carcinoma cells in vitro and suppress experimental metastasis in vivo
    • Yamai H., Sawada N., Yoshida T., Seike J., Takizawa H., Kenzaki K., Miyoshi T., Kondo K., Bando Y., Ohnishi Y., Tangoru A. Triterpenes augment the inhibitory effects of anticancer drugs on growth of human esophageal carcinoma cells in vitro and suppress experimental metastasis in vivo. Int. J. Cancer 2009, 125:952-960.
    • (2009) Int. J. Cancer , vol.125 , pp. 952-960
    • Yamai, H.1    Sawada, N.2    Yoshida, T.3    Seike, J.4    Takizawa, H.5    Kenzaki, K.6    Miyoshi, T.7    Kondo, K.8    Bando, Y.9    Ohnishi, Y.10    Tangoru, A.11
  • 15
    • 0036791348 scopus 로고    scopus 로고
    • How death shapes life during development
    • Baehrecke E.H. How death shapes life during development. Nat. Rev. Mol. Cell Biol. 2002, 3:779-787.
    • (2002) Nat. Rev. Mol. Cell Biol. , vol.3 , pp. 779-787
    • Baehrecke, E.H.1
  • 16
  • 17
    • 1842583789 scopus 로고    scopus 로고
    • Development by self-digestion: molecular mechanisms and biological functions of autophagy
    • Levine B., Klionsky D.J. Development by self-digestion: molecular mechanisms and biological functions of autophagy. Dev. Cell 2004, 6:463-477.
    • (2004) Dev. Cell , vol.6 , pp. 463-477
    • Levine, B.1    Klionsky, D.J.2
  • 19
    • 25444440875 scopus 로고    scopus 로고
    • The role of autophagy in cancer development and response to therapy
    • Kondo Y., Kanzawa T., Sawaya R., Kondo S. The role of autophagy in cancer development and response to therapy. Nat. Rev. Cancer 2005, 5:726-734.
    • (2005) Nat. Rev. Cancer , vol.5 , pp. 726-734
    • Kondo, Y.1    Kanzawa, T.2    Sawaya, R.3    Kondo, S.4
  • 21
    • 0034757896 scopus 로고    scopus 로고
    • A novel assay to study autophagy: regulation of autophagosome vacuole size by amino acid deprivation
    • Munafo D.B., Colombo M.I. A novel assay to study autophagy: regulation of autophagosome vacuole size by amino acid deprivation. J. Cell Sci. 2001, 114:3619-3630.
    • (2001) J. Cell Sci. , vol.114 , pp. 3619-3630
    • Munafo, D.B.1    Colombo, M.I.2
  • 24
    • 38949119423 scopus 로고    scopus 로고
    • Hypoxia induces autophagic cell death in apoptosis-competent cells through a mechanism involving BNIP3
    • Azad M.B., Chen Y., Henson E.S., Cizeau J., McMillan-Ward E., Israels S.J., Gibson S.B. Hypoxia induces autophagic cell death in apoptosis-competent cells through a mechanism involving BNIP3. Autophagy 2008, 4:195-204.
    • (2008) Autophagy , vol.4 , pp. 195-204
    • Azad, M.B.1    Chen, Y.2    Henson, E.S.3    Cizeau, J.4    McMillan-Ward, E.5    Israels, S.J.6    Gibson, S.B.7
  • 25
    • 0037205048 scopus 로고    scopus 로고
    • The phosphoinositide 3-kinase pathway
    • Cantley L.C. The phosphoinositide 3-kinase pathway. Science 2002, 296:1655-1657.
    • (2002) Science , vol.296 , pp. 1655-1657
    • Cantley, L.C.1
  • 26
    • 0036185848 scopus 로고    scopus 로고
    • The protein kinase B/Akt signalling pathway in human malignancy
    • Nicholson K.M., Anderson N.G. The protein kinase B/Akt signalling pathway in human malignancy. Cell. Signal. 2002, 14:381-395.
    • (2002) Cell. Signal. , vol.14 , pp. 381-395
    • Nicholson, K.M.1    Anderson, N.G.2
  • 27
    • 0345276609 scopus 로고    scopus 로고
    • Targeting PI3K-AKT pathway for cancer therapy
    • Lu Y., Wang H., Mills G.B. Targeting PI3K-AKT pathway for cancer therapy. Rev. Clin. Exp. Hematol. 2003, 7:205-228.
    • (2003) Rev. Clin. Exp. Hematol. , vol.7 , pp. 205-228
    • Lu, Y.1    Wang, H.2    Mills, G.B.3
  • 28
    • 24044551995 scopus 로고    scopus 로고
    • PI3K/Akt/mTOR pathway as a target for cancer therapy
    • Morgensztern D., McLeod H.L. PI3K/Akt/mTOR pathway as a target for cancer therapy. Anticancer Drugs 2005, 16:797-803.
    • (2005) Anticancer Drugs , vol.16 , pp. 797-803
    • Morgensztern, D.1    McLeod, H.L.2
  • 29
    • 0036632368 scopus 로고    scopus 로고
    • The phosphatidylinositol 3-kinase-Akt pathway in human cancer
    • Vivanco I., Sawyers C.L. The phosphatidylinositol 3-kinase-Akt pathway in human cancer. Nat. Rev. Cancer 2002, 2:489-501.
    • (2002) Nat. Rev. Cancer , vol.2 , pp. 489-501
    • Vivanco, I.1    Sawyers, C.L.2
  • 31
    • 0035929650 scopus 로고    scopus 로고
    • The tumor suppressor PTEN positively regulates macroautophagy by inhibiting the phosphatidylinositol 3-kinase/protein kinase B pathway
    • Arico S., Petiot A., Bauvy C., Dubbelhuis P.F., Meijer A.J., Codogno P., Ogier-Denis E. The tumor suppressor PTEN positively regulates macroautophagy by inhibiting the phosphatidylinositol 3-kinase/protein kinase B pathway. J. Biol. Chem. 2001, 276:35243-35246.
    • (2001) J. Biol. Chem. , vol.276 , pp. 35243-35246
    • Arico, S.1    Petiot, A.2    Bauvy, C.3    Dubbelhuis, P.F.4    Meijer, A.J.5    Codogno, P.6    Ogier-Denis, E.7
  • 32
    • 24944480788 scopus 로고    scopus 로고
    • The Akt-mTOR tango and its relevance to cancer
    • Hay N. The Akt-mTOR tango and its relevance to cancer. Cancer Cell 2005, 8:179-183.
    • (2005) Cancer Cell , vol.8 , pp. 179-183
    • Hay, N.1
  • 33
    • 0034626708 scopus 로고    scopus 로고
    • MMAC1/PTEN inhibits cell growth and induces chemosensitivity to doxorubicin in human bladder cancer cells
    • Tanaka M., Koul D., Davies M.A., Liebert M., Steck P.A., Grossman H.B. MMAC1/PTEN inhibits cell growth and induces chemosensitivity to doxorubicin in human bladder cancer cells. Oncogene 2000, 19:5406-5412.
    • (2000) Oncogene , vol.19 , pp. 5406-5412
    • Tanaka, M.1    Koul, D.2    Davies, M.A.3    Liebert, M.4    Steck, P.A.5    Grossman, H.B.6
  • 35
    • 52049125696 scopus 로고    scopus 로고
    • Suppression of autophagy enhances the cytotoxicity of the DNA-damaging aromatic amine p-anilinoaniline
    • Elliott A., Reiners J.J. Suppression of autophagy enhances the cytotoxicity of the DNA-damaging aromatic amine p-anilinoaniline. Toxicol. Appl. Pharmacol. 2008, 232:169-179.
    • (2008) Toxicol. Appl. Pharmacol. , vol.232 , pp. 169-179
    • Elliott, A.1    Reiners, J.J.2
  • 38
    • 33750284176 scopus 로고    scopus 로고
    • Autophagy in cancer: good, bad, or both?
    • Hippert M.M., O'Toole P.S., Thorburn A. Autophagy in cancer: good, bad, or both?. Cancer Res. 2006, 66:9349-9351.
    • (2006) Cancer Res. , vol.66 , pp. 9349-9351
    • Hippert, M.M.1    O'Toole, P.S.2    Thorburn, A.3
  • 40
    • 2342545519 scopus 로고    scopus 로고
    • Target of rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression
    • Fingar D.C., Blenis J. Target of rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression. Oncogene 2004, 23:3151-3171.
    • (2004) Oncogene , vol.23 , pp. 3151-3171
    • Fingar, D.C.1    Blenis, J.2
  • 41
    • 34247120977 scopus 로고    scopus 로고
    • Nutrient sensing in the mTOR/S6K1 signalling pathway
    • Gulati P., Thomas G. Nutrient sensing in the mTOR/S6K1 signalling pathway. Biochem. Soc. Trans. 2007, 35:236-238.
    • (2007) Biochem. Soc. Trans. , vol.35 , pp. 236-238
    • Gulati, P.1    Thomas, G.2
  • 42
    • 0033978633 scopus 로고    scopus 로고
    • Distinct classes of phosphatidylinositol 3'-kinases are involved in signaling pathways that control macroautophagy in HT-29 cells
    • Petiot A., Ogier-Denis E., Blommaart E.F., Meijer A.J., Codogno P. Distinct classes of phosphatidylinositol 3'-kinases are involved in signaling pathways that control macroautophagy in HT-29 cells. J. Biol. Chem. 2000, 275:992-998.
    • (2000) J. Biol. Chem. , vol.275 , pp. 992-998
    • Petiot, A.1    Ogier-Denis, E.2    Blommaart, E.F.3    Meijer, A.J.4    Codogno, P.5
  • 44
    • 27644484061 scopus 로고    scopus 로고
    • Autophagy: molecular machinery for self-eating
    • Yorimitsu T., Klionsky D.J. Autophagy: molecular machinery for self-eating. Cell Death Differ. 2005, 12:1542-1552.
    • (2005) Cell Death Differ. , vol.12 , pp. 1542-1552
    • Yorimitsu, T.1    Klionsky, D.J.2
  • 45
  • 46
    • 0036160679 scopus 로고    scopus 로고
    • Mammalian target of rapamycin (mTOR): pro- and anti-apoptotic
    • Castedo M., Ferri K.F., Kroemer G. Mammalian target of rapamycin (mTOR): pro- and anti-apoptotic. Cell Death Differ. 2002, 9:99-100.
    • (2002) Cell Death Differ. , vol.9 , pp. 99-100
    • Castedo, M.1    Ferri, K.F.2    Kroemer, G.3
  • 50
    • 8344242220 scopus 로고    scopus 로고
    • Autophagy in health and disease: a double-edged sword
    • Shintani T., Klionsky D.J. Autophagy in health and disease: a double-edged sword. Science 2004, 306:990-995.
    • (2004) Science , vol.306 , pp. 990-995
    • Shintani, T.1    Klionsky, D.J.2
  • 51
    • 77956898610 scopus 로고    scopus 로고
    • Autophagy is a critical mechanism for the induction of the antileukemic effects of arsenic trioxide
    • Goussetis D.J., Altman J.K., Glaser H., McNeer J.L., Tallman M.S., Platanias L.C. Autophagy is a critical mechanism for the induction of the antileukemic effects of arsenic trioxide. J. Biol. Chem. 2010, 285:29989-29997.
    • (2010) J. Biol. Chem. , vol.285 , pp. 29989-29997
    • Goussetis, D.J.1    Altman, J.K.2    Glaser, H.3    McNeer, J.L.4    Tallman, M.S.5    Platanias, L.C.6
  • 52
    • 34147193472 scopus 로고    scopus 로고
    • Autophagy and cancer
    • Levine B. Autophagy and cancer. Nature 2007, 446:745-747.
    • (2007) Nature , vol.446 , pp. 745-747
    • Levine, B.1
  • 54
    • 37649005234 scopus 로고    scopus 로고
    • Autophagy in the pathogenesis of disease
    • Levine B., Kroemer G. Autophagy in the pathogenesis of disease. Cell 2008, 132:27-42.
    • (2008) Cell , vol.132 , pp. 27-42
    • Levine, B.1    Kroemer, G.2
  • 55
    • 33745282435 scopus 로고    scopus 로고
    • Sulforaphane causes autophagy to inhibit release of cytochrome C and apoptosis in human prostate cancer cells
    • Herman-Antosiewicz A., Johnson D.E., Singh S.V. Sulforaphane causes autophagy to inhibit release of cytochrome C and apoptosis in human prostate cancer cells. Cancer Res. 2006, 66:5828-5835.
    • (2006) Cancer Res. , vol.66 , pp. 5828-5835
    • Herman-Antosiewicz, A.1    Johnson, D.E.2    Singh, S.V.3
  • 56
    • 37549056216 scopus 로고    scopus 로고
    • The roles of therapy-induced autophagy and necrosis in cancer treatment
    • Amaravadi R.K., Thompson C.B. The roles of therapy-induced autophagy and necrosis in cancer treatment. Clin. Cancer Res. 2007, 13:7271-7279.
    • (2007) Clin. Cancer Res. , vol.13 , pp. 7271-7279
    • Amaravadi, R.K.1    Thompson, C.B.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.