Ursolic acid, a pentacyclin triterpene, potentiates trail-induced apoptosis through p53-independent up-regulation of death receptors: Evidence for the role of reactive oxygen species and JNK

Journal of Biological Chemistry

Volumn 286, Issue 7, 2011, Pages 5546-5557

  Prasad, Sahdeo ^a   Yadav, Vivek R ^a   Kannappan, Ramaswamy ^a   Aggarwal, Bharat B ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APOPTOSIS; CANCER CELLS; CELL SURFACE EXPRESSION; CELL SURVIVAL; CELL TYPES; COLORECTAL CANCER; CYTOKINES; DEATH-RECEPTOR; DOWN-REGULATION; GENE SILENCING; INDUCED APOPTOSIS; MOLECULAR TARGETS; NUDE MICE; REACTIVE OXYGEN SPECIES; SMALL INTERFERING RNA; TRITERPENES; TRITERPENOIDS; UP-REGULATION; URSOLIC ACID;

ACTIVATION ANALYSIS; CELL DEATH; CELL MEMBRANES; DISEASES; GENES; GENETIC ENGINEERING; OLEFINS; OXYGEN; PROTEINS; RNA;

ECOLOGY;

DEATH RECEPTOR; PROTEIN P53; SMALL INTERFERING RNA; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND; URSOLIC ACID;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CANCER CELL; CANCER RESISTANCE; CELL SURVIVAL; COLORECTAL CANCER; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFICACY; GENE SILENCING; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; UPREGULATION;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; CACO-2 CELLS; CELL SURVIVAL; COLORECTAL NEOPLASMS; DOWN-REGULATION; DRUG SYNERGISM; HUMANS; MAP KINASE KINASE 4; MICE; MICE, NUDE; NEOPLASM TRANSPLANTATION; REACTIVE OXYGEN SPECIES; RECEPTORS, TNF-RELATED APOPTOSIS-INDUCING LIGAND; TNF-RELATED APOPTOSIS-INDUCING LIGAND; TRITERPENES; TUMOR NECROSIS FACTOR DECOY RECEPTORS; TUMOR SUPPRESSOR PROTEIN P53; UP-REGULATION; XENOGRAFT MODEL ANTITUMOR ASSAYS;

MUS MUSCULUS; OCIMUM TENUIFLORUM; ROSMARINUS OFFICINALIS;

EID: 79953153877     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.183699     Document Type: Article

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