Quantitation of ursolic acid in human plasma by ultra performance liquid chromatography tandem mass spectrometry and its pharmacokinetic study

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 879, Issue 2, 2011, Pages 219-224

  Xia, Yuanyuan ^a,b   Wei, Guangli ^b   Si, Duanyun ^b   Liu, Changxiao ^b  

^a TIANJIN UNIVERSITY   (China)

^b TIANJIN INSTITUTE OF PHARMACEUTICAL RESEARCH   (China)

Author keywords

Clinical pharmacokinetics; UPLC MS MS; Ursolic acid

Indexed keywords

ACQUITY; AMMONIUM FORMATE; ANTI-INFLAMMATORIES; ANTICANCER ACTIVITIES; ANTIULCER; CLINICAL PHARMACOKINETICS; ETHYL ACETATES; EXTRACTION RECOVERY; HIGH SELECTIVITY; HUMAN PLASMAS; INTERNAL STANDARDS; ION SUPPRESSION; LIQUID CHROMATOGRAPHY/TANDEM MASS SPECTROMETRY; LIQUID-LIQUID EXTRACTION; LOWER LIMIT OF QUANTITATIONS; MATRIX; MOBILE PHASE; MULTIPLE REACTION MONITORING; PHARMACOKINETIC STUDIES; PLASMA SAMPLES; STORAGE PERIODS; TRITERPENES; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; UPLC/MS/MS; URSOLIC ACID; VALIDATED METHODS;

ACETONITRILE; AMMONIUM COMPOUNDS; ELECTROSPRAY IONIZATION; ESTERS; LIPOSOMES; LIQUIDS; MASS SPECTROMETRY; PHARMACOKINETICS; PHOSPHOLIPIDS; PLASMA (HUMAN); PLASMAS; SOLVENT EXTRACTION;

LIQUID CHROMATOGRAPHY;

ACETIC ACID ETHYL ESTER; ACETONITRILE; AMMONIUM FORMATE; GLYCYRRHETINIC ACID; URSOLIC ACID;

ACCURACY; ARTICLE; CONTROLLED STUDY; ELECTROSPRAY MASS SPECTROMETRY; HUMAN; LIQUID LIQUID EXTRACTION; NORMAL HUMAN; PLASMA; PRIORITY JOURNAL; SENSITIVITY ANALYSIS; TANDEM MASS SPECTROMETRY; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY;

CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG STABILITY; HUMANS; LEAST-SQUARES ANALYSIS; LIPOSOMES; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; TANDEM MASS SPECTROMETRY; TRITERPENES;

EID: 78651252487     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2010.11.037     Document Type: Article

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