Delivery of ursolic acid (UA) in polymeric nanoparticles effectively promotes the apoptosis of gastric cancer cells through enhanced inhibition of cyclooxygenase 2 (COX-2)

International Journal of Pharmaceutics

Volumn 441, Issue 1-2, 2013, Pages 261-268

  Zhang, Hao ^a   Li, Xiaolin ^a   Ding, Jing ^a   Xu, Huae ^a   Dai, Xinzheng ^a   Hou, Zhibo ^b   Zhang, Kai ^a   Sun, Kun ^a   Sun, Weihao ^a  

^a NANJING MEDICAL UNIVERSITY   (China)

^b NANJING CHEST HOSPITAL   (China)

Author keywords

COX 2; Gastric cancer; mPEG PCL; Nanoparticle; Ursolic acid

Indexed keywords

ANTINEOPLASTIC AGENT; CASPASE 3; CYCLOOXYGENASE 2; MACROGOL; NANOPARTICLE; POLYCAPROLACTONE; URSOLIC ACID;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL DEATH; CYTOPLASM; CYTOTOXICITY; DRUG DELIVERY SYSTEM; HUMAN; HUMAN CELL; HYDROPHOBICITY; IN VITRO STUDY; INCUBATION TIME; LIGHT SCATTERING; PRECIPITATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; STOMACH CANCER; TRANSMISSION ELECTRON MICROSCOPY; ZETA POTENTIAL;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; CASPASE 3; CELL LINE, TUMOR; CELL MEMBRANE; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG CARRIERS; DRUG DELIVERY SYSTEMS; HUMANS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; NANOPARTICLES; POLYESTERS; POLYETHYLENE GLYCOLS; STOMACH NEOPLASMS; TIME FACTORS; TRITERPENES;

EID: 84872777588     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2012.11.034     Document Type: Article

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