Ursolic acid inhibits the initiation, progression of prostate cancer and prolongs the survival of TRAMP mice by modulating pro-inflammatory pathways

PLoS ONE

Volumn 7, Issue 3, 2012, Pages

  Shanmugam, Muthu K ^a   Ong, Tina H ^b   Kumar, Alan Prem ^a,c,d   Lun, Chang K ^e   Ho, Paul C ^e   Wong, Peter T H ^a   Hui, Kam M ^b   Sethi, Gautam ^a,c  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^b DIVISION OF MEDICAL ONCOLOGY   (Singapore)

^c NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^d UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^e NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; CYCLIN D1; CYCLOOXYGENASE 2; I KAPPA B ALPHA; I KAPPA B BETA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; PROTEIN KINASE B; STAT3 PROTEIN; TUMOR NECROSIS FACTOR ALPHA; URSOLIC ACID; ANTINEOPLASTIC AGENT; PRIMER DNA; PTGS2 PROTEIN, MOUSE; TRITERPENE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER INHIBITION; CANCER PREVENTION; CONTROLLED STUDY; DOWN REGULATION; GASTROINTESTINAL ABSORPTION; IMMUNOHISTOCHEMISTRY; MALE; MOUSE; NONHUMAN; OVERALL SURVIVAL; PROSTATE ADENOCARCINOMA; PROSTATE CANCER; PROSTATIC INTRAEPITHELIAL NEOPLASIA; PROTEIN PHOSPHORYLATION; TUMOR GROWTH; UPREGULATION; ADENOCARCINOMA; ANIMAL; DRUG EFFECT; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION REGULATION; GENETICS; KAPLAN MEIER METHOD; METABOLISM; PROSTATE TUMOR; SIGNAL TRANSDUCTION; SPECTROPHOTOMETRY; SURVIVAL; TRANSGENIC MOUSE; WESTERN BLOTTING;

MUS;

ADENOCARCINOMA; ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; BLOTTING, WESTERN; CASPASE 3; CYCLIN D1; CYCLOOXYGENASE 2; DNA PRIMERS; ENZYME-LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION REGULATION, NEOPLASTIC; IMMUNOHISTOCHEMISTRY; KAPLAN-MEIER ESTIMATE; MALE; MICE; MICE, TRANSGENIC; PROSTATIC NEOPLASMS; SIGNAL TRANSDUCTION; SPECTROPHOTOMETRY; SURVIVAL ANALYSIS; TRITERPENES;

EID: 84863269717     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0032476     Document Type: Article

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