The P2Y 2/Src/p38/COX-2 pathway is involved in the resistance to ursolic acid-induced apoptosis in colorectal and prostate cancer cells

Biochimie

Volumn 94, Issue 8, 2012, Pages 1754-1763

  Limami, Youness ^a   Pinon, Aline ^a   Leger, David Yannick ^a   Pinault, Emilie ^b   Delage, Christiane ^a   Beneytout, Jean Louis ^a   Simon, Alain ^a   Liagre, Bertrand ^a  

^a UNIVERSITÉ DE LIMOGES   (France)

^b UNIVERSITY OF LIMOGES   (France)

Author keywords

Cyclooxygenase 2; P2Y 2; Resistance to apoptosis; Src; Ursolic acid

Indexed keywords

ADENOSINE TRIPHOSPHATE; ARACHIDONIC ACID; CALCIUM ION; CYCLOOXYGENASE 2; PROTEIN KINASE C; PROTEIN KINASE P60; PURINERGIC P2Y2 RECEPTOR; SYNAPTOPHYSIN; URSOLIC ACID; MITOGEN ACTIVATED PROTEIN KINASE P38; PHOSPHOLIPASE A2 GROUP II; PLA2G2D PROTEIN, HUMAN; PROTEIN TYROSINE KINASE; PTGS2 PROTEIN, HUMAN; TRITERPENE;

APOPTOSIS; ARTICLE; CANCER CELL; CANCER RESISTANCE; COLORECTAL CANCER; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME SUBSTRATE; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; INTRACELLULAR SPACE; MALE; MOLECULAR MECHANICS; PROSTATE CANCER; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; BIOSYNTHESIS; CELL STRAIN HT29; COLORECTAL TUMOR; DRUG EFFECT; FEMALE; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; PHOSPHORYLATION; PROSTATE TUMOR;

ADENOSINE TRIPHOSPHATE; APOPTOSIS; ARACHIDONIC ACID; COLORECTAL NEOPLASMS; CYCLOOXYGENASE 2; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GROUP II PHOSPHOLIPASES A2; HT29 CELLS; HUMANS; MALE; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PROSTATIC NEOPLASMS; RECEPTORS, PURINERGIC P2Y2; SIGNAL TRANSDUCTION; SRC-FAMILY KINASES; TRITERPENES;

EID: 84862839832     PISSN: 03009084     EISSN: 61831638     Source Type: Journal    
DOI: 10.1016/j.biochi.2012.04.006     Document Type: Article

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