Ursolic acid from Oldenlandia diffusa induces apoptosis via activation of caspases and phosphorylation of glycogen synthase kinase 3 beta in SK-OV-3 ovarian cancer cells

Biological and Pharmaceutical Bulletin

Volumn 35, Issue 7, 2012, Pages 1022-1028

  Song, Young Hoon ^a   Jeong, Soo Jin ^b,c   Kwon, Hee Young ^b   Kim, Bonglee ^b   Kim, Sung Hoon ^b   Yoo, Dong Youl ^a  

^a Department of Pathology Daejeon University College of Oriental Medicine   (South Korea)

^b Kyung Hee University   (South Korea)

^c Korea Institute of Oriental Medicine (KIOM)   (South Korea)

Author keywords

Apoptosis; Astrocyte elevated gene 1; Caspase; Glycogen synthase kinase 3 ; SK OV 3; Ursolic acid

Indexed keywords

2,3 BIS(2 METHOXY 4 NITRO 5 SULPHOPHENYL) 2H TETRAZOLIUM 5 CARBOXANILIDE; BETA CATENIN; CASPASE; CASPASE 3; CASPASE 9; ETHIDIUM; GLYCOGEN SYNTHASE KINASE 3BETA; MITOGEN ACTIVATED PROTEIN KINASE; MYC PROTEIN; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN BCL XL; TETRAZOLIUM; UNCLASSIFIED DRUG; URSOLIC ACID;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; ASTROCYTE ELEVATED GENE 1; BCL XL GENE; CANCER SURVIVAL; DOWN REGULATION; DRUG CYTOTOXICITY; DRUG STRUCTURE; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; EXTRACELLULAR SIGNAL REGULATED KINASE GENE; FEMALE; GENE EXPRESSION REGULATION; GENE REPRESSION; HUMAN; HUMAN CELL; IC 50; MITOCHONDRIAL MEMBRANE POTENTIAL; OLDENLANDIA; OLDENLANDIA DIFFUSA; ONCOGENE C MYC; OVARY CANCER; PROTEIN DEGRADATION; SIGNAL TRANSDUCTION; TUMOR GENE; UPREGULATION; WESTERN BLOTTING;

ANTINEOPLASTIC AGENTS; APOPTOSIS; BCL-X PROTEIN; CASPASE 3; CASPASE 9; CELL ADHESION MOLECULES; CELL CYCLE; CELL LINE, TUMOR; CELL SURVIVAL; DNA-BINDING PROTEINS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FEMALE; GLYCOGEN SYNTHASE KINASE 3; HUMANS; INDOLES; MALEIMIDES; OLDENLANDIA; OVARIAN NEOPLASMS; PHOSPHORYLATION; PROTEIN KINASE INHIBITORS; TRANSCRIPTION FACTORS; TRITERPENES;

EID: 84863552204     PISSN: 09186158     EISSN: 13475215     Source Type: Journal    
DOI: 10.1248/bpb.b110660     Document Type: Article

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