Ursolic acid-induced apoptosis in K562 cells involving upregulation of PTEN gene expression and inactivation of the PI3K/Akt pathway

Archives of Pharmacal Research

Volumn 35, Issue 3, 2012, Pages 543-548

  Wu, Bin ^a   Wang, Xu ^a   Chi, Zuo Fei ^a   Hu, Rong ^a   Zhang, Rong ^a   Yang, Wei ^a   Liu, Zhuo Gang ^a  

^a CHINA MEDICAL UNIVERSITY   (China)

Author keywords

Apoptosis; K562; PTEN; Ursolic acid

Indexed keywords

ANTINEOPLASTIC AGENT; CASPASE 3; CASPASE 9; CYTOCHROME C; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE B; URSOLIC ACID;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER INHIBITION; CELL DIFFERENTIATION; CELL MIGRATION; CELL PROLIFERATION; CELL STRAIN K 562; CELL SURVIVAL; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INACTIVATION; GENE EXPRESSION; HUMAN; HUMAN CELL; MEMBRANE POTENTIAL; MYELOID LEUKEMIA; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; UPREGULATION;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; CASPASES; CELL PROLIFERATION; CYTOCHROMES C; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; K562 CELLS; LEUKEMIA, MYELOGENOUS, CHRONIC, BCR-ABL POSITIVE; MEMBRANE POTENTIAL, MITOCHONDRIAL; PHOSPHATIDYLINOSITOL 3-KINASE; PROTO-ONCOGENE PROTEINS C-AKT; PTEN PHOSPHOHYDROLASE; SIGNAL TRANSDUCTION; TIME FACTORS; TRITERPENES; UP-REGULATION;

EID: 84862846116     PISSN: 02536269     EISSN: 19763786     Source Type: Journal    
DOI: 10.1007/s12272-012-0318-1     Document Type: Article

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