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Volumn 329, Issue , 2013, Pages 179-202

Chemoprotection against cancer by isothiocyanates: A focus on the animal models and the protective mechanisms

Author keywords

Glucosinolate; Keap1; NF B; NQO1; Nrf2; Phenethyl isothiocyanate; Sulforaphane

Indexed keywords

ISOTHIOCYANIC ACID DERIVATIVE;

EID: 84874500431     PISSN: 03401022     EISSN: None     Source Type: Book Series    
DOI: 10.1007/128-2012-337     Document Type: Article
Times cited : (44)

References (174)
  • 1
    • 33745218882 scopus 로고    scopus 로고
    • Biology and biochemistry of glucosinolates
    • Halkier BA, Gershenzon J (2006) Biology and biochemistry of glucosinolates. Annu Rev Plant Biol 57:303-333
    • (2006) Annu Rev Plant Biol , vol.57 , pp. 303-333
    • Halkier, B.A.1    Gershenzon, J.2
  • 2
    • 0035808553 scopus 로고    scopus 로고
    • The chemical diversity and distribution of glucosinolates and isothiocyanates among plants
    • Fahey JW, Zalcmann AT, Talalay P (2001) The chemical diversity and distribution of glucosinolates and isothiocyanates among plants. Phytochemistry 56:5-51
    • (2001) Phytochemistry , vol.56 , pp. 5-51
    • Fahey, J.W.1    Zalcmann, A.T.2    Talalay, P.3
  • 3
  • 4
    • 51249110829 scopus 로고    scopus 로고
    • Distribution of glucosinolates and sulphurrich cells in roots of field-grown canola (Brassica napus
    • McCully ME, Miller C, Sprague SJ et al (2008) Distribution of glucosinolates and sulphurrich cells in roots of field-grown canola (Brassica napus). New Phytol 180:193-205
    • (2008) New Phytol , vol.180 , pp. 193-205
    • McCully, M.E.1    Miller, C.2    Sprague, S.J.3
  • 5
    • 0033794245 scopus 로고    scopus 로고
    • Identification of a new glucosinolate-rich cell type in Arabidopsis flower stalk
    • Koroleva OA, Davies A, Deeken R et al (2000) Identification of a new glucosinolate-rich cell type in Arabidopsis flower stalk. Plant Physiol 124:599-608
    • (2000) Plant Physiol , vol.124 , pp. 599-608
    • Koroleva, O.A.1    Davies, A.2    Deeken, R.3
  • 6
    • 78149417008 scopus 로고    scopus 로고
    • Glucosinolate-accumulating S-cells in Arabidopsis leaves and flower stalks undergo programmed cell death at early stages of differentiation
    • Koroleva OA, Gibson TM, Cramer R et al (2010) Glucosinolate-accumulating S-cells in Arabidopsis leaves and flower stalks undergo programmed cell death at early stages of differentiation. Plant J 64:456-469
    • (2010) Plant J , vol.64 , pp. 456-469
    • Koroleva, O.A.1    Gibson, T.M.2    Cramer, R.3
  • 7
    • 0036017856 scopus 로고    scopus 로고
    • Constitutive plant toxins and their role in defense against herbivores and pathogens
    • Wittstock U, Gershenzon J (2002) Constitutive plant toxins and their role in defense against herbivores and pathogens. Curr Opin Plant Biol 5:300-307
    • (2002) Curr Opin Plant Biol , vol.5 , pp. 300-307
    • Wittstock, U.1    Gershenzon, J.2
  • 8
    • 0035170990 scopus 로고    scopus 로고
    • Phytochemicals from cruciferous plants protect against cancer by modulating carcinogen metabolism
    • Talalay P, Fahey JW (2001) Phytochemicals from cruciferous plants protect against cancer by modulating carcinogen metabolism. J Nutr 131:3027S-3033S
    • (2001) J Nutr , vol.131
    • Talalay, P.1    Fahey, J.W.2
  • 10
    • 80053154634 scopus 로고    scopus 로고
    • Proteins as binding targets of isothiocyanates in cancer prevention
    • Mi L, Di Pasqua AJ, Chung FL (2011) Proteins as binding targets of isothiocyanates in cancer prevention. Carcinogenesis 32:1405-1413
    • (2011) Carcinogenesis , vol.32 , pp. 1405-1413
    • Mi, L.1    Di Pasqua, A.J.2    Chung, F.L.3
  • 11
    • 84855369813 scopus 로고    scopus 로고
    • The molecular basis that unifies the metabolism, cellular uptake and chemopreventive activities of dietary isothiocyanates
    • Zhang Y (2012) The molecular basis that unifies the metabolism, cellular uptake and chemopreventive activities of dietary isothiocyanates. Carcinogenesis 33:2-9
    • (2012) Carcinogenesis , vol.33 , pp. 2-9
    • Zhang, Y.1
  • 12
    • 24744441319 scopus 로고    scopus 로고
    • An electron-sharing network involved in the catalytic mechanism is functionally conserved in different glutathione transferase classes
    • Winayanuwattikun P, Ketterman AJ (2005) An electron-sharing network involved in the catalytic mechanism is functionally conserved in different glutathione transferase classes. J Biol Chem 280:31776-31782
    • (2005) J Biol Chem , vol.280 , pp. 31776-31782
    • Winayanuwattikun, P.1    Ketterman, A.J.2
  • 13
    • 0013966221 scopus 로고
    • Influence of alpha-naphthyl-isothiocyanate on liver tumorigenesis in rats ingesting ethionine and N-2-fluorenylacetamide
    • Sidransky H, Ito N, Verney E (1966) Influence of alpha-naphthyl- isothiocyanate on liver tumorigenesis in rats ingesting ethionine and N-2-fluorenylacetamide. J Natl Cancer Inst 37:677-686
    • (1966) J Natl Cancer Inst , vol.37 , pp. 677-686
    • Sidransky, H.1    Ito, N.2    Verney, E.3
  • 14
    • 18144447213 scopus 로고
    • Inhibition by 2-naphtylisothiocyanates of hepatocarcinogenesis induced by p-dimethylaminoazobenzene (DAB) in rats
    • Lacasagne A, Hurst L, Xuong MD (1970) Inhibition by 2- naphtylisothiocyanates of hepatocarcinogenesis induced by p- dimethylaminoazobenzene (DAB) in rats. C R Seances Soc Biol Fil 164:230-233
    • (1970) C R Seances Soc Biol Fil , vol.164 , pp. 230-233
    • Lacasagne, A.1    Hurst, L.2    Xuong, M.D.3
  • 15
    • 0017328782 scopus 로고
    • Inhibition of carcinogenic effects of polycyclic hydrocarbons by benzyl isothiocyanate and related compounds
    • Wattenberg LW (1977) Inhibition of carcinogenic effects of polycyclic hydrocarbons by benzyl isothiocyanate and related compounds. J Natl Cancer Inst 58:395-398
    • (1977) J Natl Cancer Inst , vol.58 , pp. 395-398
    • Wattenberg, L.W.1
  • 16
    • 0019467613 scopus 로고
    • Inhibition of carcinogen-induced neoplasia by sodium cyanate, tertbutyl isocyanate, and benzyl isothiocyanate administered subsequent to carcinogen exposure
    • Wattenberg LW (1981) Inhibition of carcinogen-induced neoplasia by sodium cyanate, tertbutyl isocyanate, and benzyl isothiocyanate administered subsequent to carcinogen exposure. Cancer Res 41:2991-2994
    • (1981) Cancer Res , vol.41 , pp. 2991-2994
    • Wattenberg, L.W.1
  • 17
    • 0023616165 scopus 로고
    • Inhibitory effects of benzyl isothiocyanate administered shortly before diethylnitrosamine or benzo[a]pyrene on pulmonary and forestomach neoplasia in A/J mice
    • Wattenberg LW (1987) Inhibitory effects of benzyl isothiocyanate administered shortly before diethylnitrosamine or benzo[a]pyrene on pulmonary and forestomach neoplasia in A/J mice. Carcinogenesis 8:1971-1973
    • (1987) Carcinogenesis , vol.8 , pp. 1971-1973
    • Wattenberg, L.W.1
  • 18
    • 0025177898 scopus 로고
    • Inhibition of carcinogenesis by naturally-occurring and synthetic compounds
    • Wattenberg LW (1990) Inhibition of carcinogenesis by naturally-occurring and synthetic compounds. Basic Life Sci 52:155-166
    • (1990) Basic Life Sci , vol.52 , pp. 155-166
    • Wattenberg, L.W.1
  • 19
    • 0025454581 scopus 로고
    • Inhibition of carcinogenesis by minor anutrient constituents of the diet
    • Wattenberg LW (1990) Inhibition of carcinogenesis by minor anutrient constituents of the diet. Proc Nutr Soc 49:173-183
    • (1990) Proc Nutr Soc , vol.49 , pp. 173-183
    • Wattenberg, L.W.1
  • 20
    • 0024589128 scopus 로고
    • Inhibition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced DNA adduct formation and tumorigenicity in the lung of F344 rats by dietary phenethyl isothiocyanate
    • MorseMA, Wang CX, Stoner GD et al (1989) Inhibition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced DNA adduct formation and tumorigenicity in the lung of F344 rats by dietary phenethyl isothiocyanate. Cancer Res 49:549-553
    • (1989) Cancer Res , vol.49 , pp. 549-553
    • Morsema Wang, C.X.1    Stoner, G.D.2
  • 21
    • 0024360557 scopus 로고
    • Effects of aromatic isothiocyanates on tumorigenicity O6-methylguanine formation, and metabolism of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in A/J mouse lung
    • Morse MA, Amin SG, Hecht SS et al (1989) Effects of aromatic isothiocyanates on tumorigenicity, O6-methylguanine formation, and metabolism of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in A/J mouse lung. Cancer Res 49:2894-2897
    • (1989) Cancer Res , vol.49 , pp. 2894-2897
    • Morse, M.A.1    Amin, S.G.2    Hecht, S.S.3
  • 22
    • 0024458427 scopus 로고
    • Effects of alkyl chain length on the inhibition of NNK-induced lung neoplasia in A/J mice by arylalkyl isothiocyanates
    • Morse MA, Eklind KI, Amin SG et al (1989) Effects of alkyl chain length on the inhibition of NNK-induced lung neoplasia in A/J mice by arylalkyl isothiocyanates. Carcinogenesis 10:1757-1759
    • (1989) Carcinogenesis , vol.10 , pp. 1757-1759
    • Morse, M.A.1    Eklind, K.I.2    Amin, S.G.3
  • 23
    • 0025267078 scopus 로고
    • Effect of dietary aromatic isothiocyanates fed subsequent to the administration of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone on lung tumorigenicity in mice
    • Morse MA, Reinhardt JC, Amin SG et al (1990) Effect of dietary aromatic isothiocyanates fed subsequent to the administration of 4-(methylnitrosamino)-1- (3-pyridyl)-1-butanone on lung tumorigenicity in mice. Cancer Lett 49:225-230
    • (1990) Cancer Lett , vol.49 , pp. 225-230
    • Morse, M.A.1    Reinhardt, J.C.2    Amin, S.G.3
  • 24
    • 0025809376 scopus 로고
    • Structure-activity relationships for inhibition of 4-(methylnitrosamino)- 1-(3-pyridyl)-1-butanone lung tumorigenesis by arylalkyl isothiocyanates in A/J mice
    • Morse MA, Eklind KI, Hecht SS et al (1991) Structure-activity relationships for inhibition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone lung tumorigenesis by arylalkyl isothiocyanates in A/J mice. Cancer Res 51:1846-1850
    • (1991) Cancer Res , vol.51 , pp. 1846-1850
    • Morse, M.A.1    Eklind, K.I.2    Hecht, S.S.3
  • 25
    • 0025937347 scopus 로고
    • Inhibition of tobacco-specific nitrosamine 4-(N-nitrosomethylamino)-1-(3- pyridyl)-1-butanone (NNK) tumorigenesis with aromatic isothiocyanates
    • Morse MA, Eklind KI, Hecht SS et al (1991) Inhibition of tobacco-specific nitrosamine 4-(N-nitrosomethylamino)-1-(3-pyridyl)-1-butanone (NNK) tumorigenesis with aromatic isothiocyanates. IARC Sci Publ 105:529-534
    • (1991) IARC Sci Publ , vol.105 , pp. 529-534
    • Morse, M.A.1    Eklind, K.I.2    Hecht, S.S.3
  • 26
    • 0026502758 scopus 로고
    • Effect of frequency of isothiocyanate administration on inhibition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced pulmonary adenoma formation in A/J mice
    • Morse MA, Eklind KI, Amin SG et al (1992) Effect of frequency of isothiocyanate administration on inhibition of 4-(methylnitrosamino)-1-(3- pyridyl)-1-butanone-induced pulmonary adenoma formation in A/J mice. Cancer Lett 62:77-81
    • (1992) Cancer Lett , vol.62 , pp. 77-81
    • Morse, M.A.1    Eklind, K.I.2    Amin, S.G.3
  • 27
    • 0025959673 scopus 로고
    • A/J mouse lung tumorigenesis by the tobaccospecific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and its inhibition by arylalkyl isothiocyanates
    • Hecht SS, Morse MA, Eklind KI et al (1991) A/J mouse lung tumorigenesis by the tobaccospecific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1- butanone and its inhibition by arylalkyl isothiocyanates. Exp Lung Res 17:501-511
    • (1991) Exp Lung Res , vol.17 , pp. 501-511
    • Hecht, S.S.1    Morse, M.A.2    Eklind, K.I.3
  • 28
    • 0026645244 scopus 로고
    • New potential chemopreventive agents for lung carcinogenesis of tobacco-specific nitrosamine
    • Chung FL, Morse MA, Eklind KI (1992) New potential chemopreventive agents for lung carcinogenesis of tobacco-specific nitrosamine. Cancer Res 52:2719s-2722s
    • (1992) Cancer Res , vol.52
    • Chung, F.L.1    Morse, M.A.2    Eklind, K.I.3
  • 29
    • 10744226312 scopus 로고    scopus 로고
    • Effect of dietary constituents with chemopreventive potential on adduct formation of a low dose of the heterocyclic amines PhIP and IQ and phase II hepatic enzymes
    • Dingley KH, Ubick EA, Chiarappa-Zucca ML et al (2003) Effect of dietary constituents with chemopreventive potential on adduct formation of a low dose of the heterocyclic amines PhIP and IQ and phase II hepatic enzymes. Nutr Cancer 46:212-221
    • (2003) Nutr Cancer , vol.46 , pp. 212-221
    • Dingley, K.H.1    Ubick, E.A.2    Chiarappa-Zucca, M.L.3
  • 30
    • 0025846911 scopus 로고
    • Inhibitory effects of phenethyl isothiocyanate on N- nitrosobenzylmethylamine carcinogenesis in the rat esophagus
    • Stoner GD, Morrissey DT, Heur YH et al (1991) Inhibitory effects of phenethyl isothiocyanate on N-nitrosobenzylmethylamine carcinogenesis in the rat esophagus. Cancer Res 51:2063-2068
    • (1991) Cancer Res , vol.51 , pp. 2063-2068
    • Stoner, G.D.1    Morrissey, D.T.2    Heur, Y.H.3
  • 31
    • 0027163281 scopus 로고
    • Dose-related inhibition by dietary phenethyl isothiocyanate of esophageal tumorigenesis and DNA methylation induced by N-nitrosomethylbenzylamine in rats
    • Morse MA, Zu H, Galati AJ et al (1993) Dose-related inhibition by dietary phenethyl isothiocyanate of esophageal tumorigenesis and DNA methylation induced by N-nitrosomethylbenzylamine in rats. Cancer Lett 72:103-110
    • (1993) Cancer Lett , vol.72 , pp. 103-110
    • Morse, M.A.1    Zu, H.2    Galati, A.J.3
  • 32
    • 0028997486 scopus 로고
    • Effect of alkyl chain length on inhibition of N-nitrosomethylbenzylamine- induced esophageal tumorigenesis and DNA methylation by isothiocyanates
    • Wilkinson JT, Morse MA, Kresty LA et al (1995) Effect of alkyl chain length on inhibition of N-nitrosomethylbenzylamine-induced esophageal tumorigenesis and DNA methylation by isothiocyanates. Carcinogenesis 16:1011-1015
    • (1995) Carcinogenesis , vol.16 , pp. 1011-1015
    • Wilkinson, J.T.1    Morse, M.A.2    Kresty, L.A.3
  • 33
    • 0029053406 scopus 로고
    • Effects of dietary phenethyl isothiocyanate, ellagic acid, sulindac and calcium on the induction and progression of N-nitrosomethylbenzylamineinduced esophageal carcinogenesis in rats
    • Siglin JC, Barch DH, Stoner GD (1995) Effects of dietary phenethyl isothiocyanate, ellagic acid, sulindac and calcium on the induction and progression of N-nitrosomethylbenzylamineinduced esophageal carcinogenesis in rats. Carcinogenesis 16:1101-1106
    • (1995) Carcinogenesis , vol.16 , pp. 1101-1106
    • Siglin, J.C.1    Barch, D.H.2    Stoner, G.D.3
  • 34
    • 0032439956 scopus 로고    scopus 로고
    • Inhibition of N0-nitrosonornicotine-induced esophageal tumorigenesis by 3-phenylpropyl isothiocyanate
    • Stoner GD, Adams C, Kresty LA et al (1998) Inhibition of N0-nitrosonornicotine-induced esophageal tumorigenesis by 3-phenylpropyl isothiocyanate. Carcinogenesis 19:2139-2143
    • (1998) Carcinogenesis , vol.19 , pp. 2139-2143
    • Stoner, G.D.1    Adams, C.2    Kresty, L.A.3
  • 35
    • 0028203252 scopus 로고
    • Anticarcinogenic activities of sulforaphane and structurally related synthetic norbornyl isothiocyanates
    • Zhang Y, Kensler TW, Cho CG et al (1994) Anticarcinogenic activities of sulforaphane and structurally related synthetic norbornyl isothiocyanates. Proc Natl Acad Sci USA 91:3147-3150
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 3147-3150
    • Zhang, Y.1    Kensler, T.W.2    Cho, C.G.3
  • 36
    • 0037188518 scopus 로고    scopus 로고
    • Sulforaphane inhibits extracellular, intracellular, and antibiotic-resistant strains of Helicobacter pylori and prevents benzo[a]pyreneinduced stomach tumors
    • Fahey JW, Haristoy X, Dolan PM et al (2002) Sulforaphane inhibits extracellular, intracellular, and antibiotic-resistant strains of Helicobacter pylori and prevents benzo[a]pyreneinduced stomach tumors. Proc Natl Acad Sci USA 99:7610-7615
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 7610-7615
    • Fahey, J.W.1    Haristoy, X.2    Dolan, P.M.3
  • 37
    • 0034525122 scopus 로고    scopus 로고
    • Chemoprevention of colonic aberrant crypt foci in Fischer rats by sulforaphane and phenethyl isothiocyanate
    • Chung FL, Conaway CC, Rao CV et al (2000) Chemoprevention of colonic aberrant crypt foci in Fischer rats by sulforaphane and phenethyl isothiocyanate. Carcinogenesis 21:2287-2291
    • (2000) Carcinogenesis , vol.21 , pp. 2287-2291
    • Chung, F.L.1    Conaway, C.C.2    Rao, C.V.3
  • 38
    • 24944480252 scopus 로고    scopus 로고
    • Phenethyl isothiocyanate and sulforaphane and their N-acetylcysteine conjugates inhibit malignant progression of lung adenomas induced by tobacco carcinogens in A/J mice
    • Conaway CC, Wang CX, Pittman B et al (2005) Phenethyl isothiocyanate and sulforaphane and their N-acetylcysteine conjugates inhibit malignant progression of lung adenomas induced by tobacco carcinogens in A/J mice. Cancer Res 65:8548-8557
    • (2005) Cancer Res , vol.65 , pp. 8548-8557
    • Conaway, C.C.1    Wang, C.X.2    Pittman, B.3
  • 39
    • 33746701934 scopus 로고    scopus 로고
    • Protective effects of benzyl isothiocyanate and sulforaphane but not resveratrol against initiation of pancreatic carcinogenesis in hamsters
    • Kuroiwa Y, Nishikawa A, Kitamura Y et al (2006) Protective effects of benzyl isothiocyanate and sulforaphane but not resveratrol against initiation of pancreatic carcinogenesis in hamsters. Cancer Lett 241:275-280
    • (2006) Cancer Lett , vol.241 , pp. 275-280
    • Kuroiwa, Y.1    Nishikawa, A.2    Kitamura, Y.3
  • 40
    • 33645825587 scopus 로고    scopus 로고
    • Sulforaphane inhibits histone deacetylase in vivo and suppresses tumorigenesis in Apc-minus mice
    • Myzak MC, Dashwood WM, Orner GA et al (2006) Sulforaphane inhibits histone deacetylase in vivo and suppresses tumorigenesis in Apc-minus mice. FASEB J 20:506-508
    • (2006) FASEB J , vol.20 , pp. 506-508
    • Myzak, M.C.1    Dashwood, W.M.2    Orner, G.A.3
  • 41
    • 33749581701 scopus 로고    scopus 로고
    • Cancer chemoprevention of intestinal polyposis in ApcMin/+ mice by sulforaphane, a natural product derived from cruciferous vegetable
    • Hu R, Khor TO, Shen G et al (2006) Cancer chemoprevention of intestinal polyposis in ApcMin/+ mice by sulforaphane, a natural product derived from cruciferous vegetable. Carcinogenesis 27:2038-2046
    • (2006) Carcinogenesis , vol.27 , pp. 2038-2046
    • Hu, R.1    Khor, T.O.2    Shen, G.3
  • 42
    • 42949121566 scopus 로고    scopus 로고
    • Chemoprevention of familial adenomatous polyposis in Apc(Min/+ mice by phenethyl isothiocyanate (PEITC)
    • Khor TO, Cheung WK, Prawan A et al (2008) Chemoprevention of familial adenomatous polyposis in Apc(Min/+) mice by phenethyl isothiocyanate (PEITC). Mol Carcinog 47:321-325
    • (2008) Mol Carcinog , vol.47 , pp. 321-325
    • Khor, T.O.1    Cheung, W.K.2    Prawan, A.3
  • 43
    • 62449233418 scopus 로고    scopus 로고
    • Sulforaphane inhibits prostate carcinogenesis and pulmonary metastasis in TRAMP mice in association with increased cytotoxicity of natural killer cells
    • Singh SV, Warin R, Xiao D et al (2009) Sulforaphane inhibits prostate carcinogenesis and pulmonary metastasis in TRAMP mice in association with increased cytotoxicity of natural killer cells. Cancer Res 69:2117-2125
    • (2009) Cancer Res , vol.69 , pp. 2117-2125
    • Singh, S.V.1    Warin, R.2    Xiao, D.3
  • 44
    • 69949157311 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamics of broccoli sprouts on the suppression of prostate cancer in transgenic adenocarcinoma of mouse prostate (TRAMP) mice: Implication of induction of Nrf2 HO-1 and apoptosis and the suppression of Akt-dependent kinase pathway
    • Keum YS, Khor TO, Lin W et al (2009) Pharmacokinetics and pharmacodynamics of broccoli sprouts on the suppression of prostate cancer in transgenic adenocarcinoma of mouse prostate (TRAMP) mice: implication of induction of Nrf2, HO-1 and apoptosis and the suppression of Akt-dependent kinase pathway. Pharm Res 26:2324-2331
    • (2009) Pharm Res , vol.26 , pp. 2324-2331
    • Keum, Y.S.1    Khor, T.O.2    Lin, W.3
  • 45
    • 78149252563 scopus 로고    scopus 로고
    • Sulforaphane inhibits 4-aminobiphenyl-induced DNA damage in bladder cells and tissues
    • Ding Y, Paonessa JD, Randall KL et al (2010) Sulforaphane inhibits 4-aminobiphenyl-induced DNA damage in bladder cells and tissues. Carcinogenesis 31:1999-2003
    • (2010) Carcinogenesis , vol.31 , pp. 1999-2003
    • Ding, Y.1    Paonessa, J.D.2    Randall, K.L.3
  • 46
    • 40449129950 scopus 로고    scopus 로고
    • Inhibition of urinary bladder carcinogenesis by broccoli sprouts
    • Munday R, Mhawech-Fauceglia P, Munday CM et al (2008) Inhibition of urinary bladder carcinogenesis by broccoli sprouts. Cancer Res 68:1593-1600
    • (2008) Cancer Res , vol.68 , pp. 1593-1600
    • Munday, R.1    Mhawech-Fauceglia, P.2    Munday, C.M.3
  • 47
    • 84863028426 scopus 로고    scopus 로고
    • The principal urinary metabolite of allyl isothiocyanate, N-acetyl-S-(N-allylthiocarbamoyl)cysteine, inhibits the growth and muscle invasion of bladder cancer
    • Bhattacharya A, Li Y, Geng F et al (2012) The principal urinary metabolite of allyl isothiocyanate, N-acetyl-S-(N-allylthiocarbamoyl)cysteine, inhibits the growth and muscle invasion of bladder cancer. Carcinogenesis 33:394-398
    • (2012) Carcinogenesis , vol.33 , pp. 394-398
    • Bhattacharya, A.1    Li, Y.2    Geng, F.3
  • 48
    • 33745393451 scopus 로고    scopus 로고
    • Sulforaphane prevents mouse skin tumorigenesis during the stage of promotion
    • Gills JJ, Jeffery EH, Matusheski NV et al (2006) Sulforaphane prevents mouse skin tumorigenesis during the stage of promotion. Cancer Lett 236:72-79
    • (2006) Cancer Lett , vol.236 , pp. 72-79
    • Gills, J.J.1    Jeffery, E.H.2    Matusheski, N.V.3
  • 49
    • 33748089664 scopus 로고    scopus 로고
    • Inhibition of 7,12-dimethylbenz(a)anthracene-induced skin tumorigenesis in C57BL/6 mice by sulforaphane is mediated by nuclear factor E2-related factor 2
    • Xu C, Huang MT, Shen G et al (2006) Inhibition of 7,12-dimethylbenz(a) anthracene-induced skin tumorigenesis in C57BL/6 mice by sulforaphane is mediated by nuclear factor E2-related factor 2. Cancer Res 66:8293-8296
    • (2006) Cancer Res , vol.66 , pp. 8293-8296
    • Xu, C.1    Huang, M.T.2    Shen, G.3
  • 50
    • 33746239394 scopus 로고    scopus 로고
    • Protection against UV-light-induced skin carcinogenesis in SKH-1 high-risk mice by sulforaphane-containing broccoli sprout extracts
    • Dinkova-Kostova AT, Jenkins SN, Fahey JWet al (2006) Protection against UV-light-induced skin carcinogenesis in SKH-1 high-risk mice by sulforaphane-containing broccoli sprout extracts. Cancer Lett 240:243-252
    • (2006) Cancer Lett , vol.240 , pp. 243-252
    • Dinkova-Kostova, A.T.1    Jenkins, S.N.2    Fahey, J.W.3
  • 51
    • 77951114133 scopus 로고    scopus 로고
    • Dietary glucoraphanin-rich broccoli sprout extracts protect against UV radiation-induced skin carcinogenesis in SKH-1 hairless mice
    • Dinkova-Kostova AT, Fahey JW, Benedict AL et al (2010) Dietary glucoraphanin-rich broccoli sprout extracts protect against UV radiation-induced skin carcinogenesis in SKH-1 hairless mice. Photochem Photobiol Sci 9:597-600
    • (2010) Photochem Photobiol Sci , vol.9 , pp. 597-600
    • Dinkova-Kostova, A.T.1    Fahey, J.W.2    Benedict, A.L.3
  • 52
    • 0142185392 scopus 로고    scopus 로고
    • Allyl isothiocyanate, a constituent of cruciferous vegetables, inhibits growth of PC-3 human prostate cancer xenografts in vivo
    • Srivastava SK, Xiao D, Lew KL et al (2003) Allyl isothiocyanate, a constituent of cruciferous vegetables, inhibits growth of PC-3 human prostate cancer xenografts in vivo. Carcinogenesis 24:1665-1670
    • (2003) Carcinogenesis , vol.24 , pp. 1665-1670
    • Srivastava, S.K.1    Xiao, D.2    Lew, K.L.3
  • 53
    • 31544454684 scopus 로고    scopus 로고
    • Combined inhibitory effects of curcumin and phenethyl isothiocyanate on the growth of human PC-3 prostate xenografts in immunodeficient mice
    • Khor TO, Keum YS, Lin W et al (2006) Combined inhibitory effects of curcumin and phenethyl isothiocyanate on the growth of human PC-3 prostate xenografts in immunodeficient mice. Cancer Res 66:613-621
    • (2006) Cancer Res , vol.66 , pp. 613-621
    • Khor, T.O.1    Keum, Y.S.2    Lin, W.3
  • 54
    • 4344649449 scopus 로고    scopus 로고
    • Ingestion of an isothiocyanate metabolite from cruciferous vegetables inhibits growth of human prostate cancer cell xenografts by apoptosis and cell cycle arrest
    • Chiao JW, Wu H, Ramaswamy G et al (2004) Ingestion of an isothiocyanate metabolite from cruciferous vegetables inhibits growth of human prostate cancer cell xenografts by apoptosis and cell cycle arrest. Carcinogenesis 25:1403-1408
    • (2004) Carcinogenesis , vol.25 , pp. 1403-1408
    • Chiao, J.W.1    Wu, H.2    Ramaswamy, G.3
  • 55
    • 33846838750 scopus 로고    scopus 로고
    • Sulforaphane retards the growth of human PC-3 xenografts and inhibits HDAC activity in human subjects
    • Myzak MC, Tong P, Dashwood WM et al (2007) Sulforaphane retards the growth of human PC-3 xenografts and inhibits HDAC activity in human subjects. Exp Biol Med (Maywood) 232:227-234
    • (2007) Exp Biol Med (Maywood) , vol.232 , pp. 227-234
    • Myzak, M.C.1    Tong, P.2    Dashwood, W.M.3
  • 56
    • 84863371275 scopus 로고    scopus 로고
    • Inhibition of androgen-responsive LNCaP prostate cancer cell tumor xenograft growth by dietary phenethyl isothiocyanate correlates with decreased angiogenesis and inhibition of cell attachment
    • Hudson TS, Perkins SN, Hursting SD et al (2012) Inhibition of androgen-responsive LNCaP prostate cancer cell tumor xenograft growth by dietary phenethyl isothiocyanate correlates with decreased angiogenesis and inhibition of cell attachment. Int J Oncol 40:1113-1121
    • (2012) Int J Oncol , vol.40 , pp. 1113-1121
    • Hudson, T.S.1    Perkins, S.N.2    Hursting, S.D.3
  • 57
    • 79959962141 scopus 로고    scopus 로고
    • Sulforaphane inhibits the growth of KPL-1 human breast cancer cells in vitro and suppresses the growth and metastasis of orthotopically transplanted KPL-1 cells in female athymic mice
    • Kanematsu S, Yoshizawa K, Uehara N et al (2011) Sulforaphane inhibits the growth of KPL-1 human breast cancer cells in vitro and suppresses the growth and metastasis of orthotopically transplanted KPL-1 cells in female athymic mice. Oncol Rep 26:603-608
    • (2011) Oncol Rep , vol.26 , pp. 603-608
    • Kanematsu, S.1    Yoshizawa, K.2    Uehara, N.3
  • 58
    • 80053643906 scopus 로고    scopus 로고
    • Sulforaphane potentiates the efficacy of 17-allylamino 17-demethoxygeldanamycin against pancreatic cancer through enhanced abrogation of Hsp90 chaperone function
    • Li Y, Zhang T, Schwartz SJ et al (2011) Sulforaphane potentiates the efficacy of 17-allylamino 17-demethoxygeldanamycin against pancreatic cancer through enhanced abrogation of Hsp90 chaperone function. Nutr Cancer 63:1151-1159
    • (2011) Nutr Cancer , vol.63 , pp. 1151-1159
    • Li, Y.1    Zhang, T.2    Schwartz, S.J.3
  • 59
    • 80052707191 scopus 로고    scopus 로고
    • Apoptosis induction in primary human colorectal cancer cell lines and retarded tumor growth in SCID mice by sulforaphane
    • Chen MJ, Tang WY, Hsu CW et al (2012) Apoptosis induction in primary human colorectal cancer cell lines and retarded tumor growth in SCID mice by sulforaphane. Evid Based Complement Alternat Med 2012:415231
    • (2012) Evid Based Complement Alternat Med , vol.2012 , pp. 415231
    • Chen, M.J.1    Tang, W.Y.2    Hsu, C.W.3
  • 60
    • 78650323904 scopus 로고    scopus 로고
    • Anticancer activity of a broccoli derivative, sulforaphane, in Barrett adenocarcinoma: Potential use in chemoprevention and as adjuvant in chemotherapy
    • Qazi A, Pal J, Maitah M et al (2010) Anticancer activity of a broccoli derivative, sulforaphane, in Barrett adenocarcinoma: potential use in chemoprevention and as adjuvant in chemotherapy. Transl Oncol 3:389-399
    • (2010) Transl Oncol , vol.3 , pp. 389-399
    • Qazi, A.1    Pal, J.2    Maitah, M.3
  • 61
    • 0018116175 scopus 로고
    • Elevation of hepatic glutathione S-transferase activities and protection against mutagenic metabolites of benzo(a)pyrene by dietary antioxidants
    • Benson AM, Batzinger RP, Ou SY et al (1978) Elevation of hepatic glutathione S-transferase activities and protection against mutagenic metabolites of benzo(a)pyrene by dietary antioxidants. Cancer Res 38:4486-4495
    • (1978) Cancer Res , vol.38 , pp. 4486-4495
    • Benson, A.M.1    Batzinger, R.P.2    Ou, S.Y.3
  • 62
    • 0018760217 scopus 로고
    • Elevation of extrahepatic glutathione S-transferase and epoxide hydratase activities by 2(3)-tert-butyl-4-hydroxyanisole
    • Benson AM, Cha YN, Bueding E et al (1979) Elevation of extrahepatic glutathione S-transferase and epoxide hydratase activities by 2(3)-tert-butyl-4-hydroxyanisole. Cancer Res 39:2971-2977
    • (1979) Cancer Res , vol.39 , pp. 2971-2977
    • Benson, A.M.1    Cha, Y.N.2    Bueding, E.3
  • 63
    • 0019142866 scopus 로고
    • Increase of NAD(P)H:quinone reductase by dietary antioxidants: Possible role in protection against carcinogenesis and toxicity
    • Benson AM, Hunkeler MJ, Talalay P (1980) Increase of NAD(P)H:quinone reductase by dietary antioxidants: possible role in protection against carcinogenesis and toxicity. Proc Natl Acad Sci USA 77:5216-5220
    • (1980) Proc Natl Acad Sci USA , vol.77 , pp. 5216-5220
    • Benson, A.M.1    Hunkeler, M.J.2    Talalay, P.3
  • 64
    • 0022356047 scopus 로고
    • Effects of disulfiram, diethyldithiocarbamate, bisethylxanthogen, and benzyl isothiocyanate on glutathione transferase activities in mouse organs
    • Benson AM, Barretto PB (1985) Effects of disulfiram, diethyldithiocarbamate, bisethylxanthogen, and benzyl isothiocyanate on glutathione transferase activities in mouse organs. Cancer Res 45:4219-4223
    • (1985) Cancer Res , vol.45 , pp. 4219-4223
    • Benson, A.M.1    Barretto, P.B.2
  • 65
    • 0022608501 scopus 로고
    • Induction of DT-diaphorase by anticarcinogenic sulfur compounds in mice
    • Benson AM, Barretto PB, Stanley JS (1986) Induction of DT-diaphorase by anticarcinogenic sulfur compounds in mice. J Natl Cancer Inst 76:467-473
    • (1986) J Natl Cancer Inst , vol.76 , pp. 467-473
    • Benson, A.M.1    Barretto, P.B.2    Stanley, J.S.3
  • 66
    • 0018054313 scopus 로고
    • Biochemical studies on the mechanisms by which dietary antioxidants suppress mutagenic activity
    • Talalay P, Batzinger RP, Benson AM et al (1978) Biochemical studies on the mechanisms by which dietary antioxidants suppress mutagenic activity. Adv Enzyme Regul 17:23-36
    • (1978) Adv Enzyme Regul , vol.17 , pp. 23-36
    • Talalay, P.1    Batzinger, R.P.2    Benson, A.M.3
  • 67
    • 0035965945 scopus 로고    scopus 로고
    • Molecular basis for the contribution of the antioxidant responsive element to cancer chemoprevention
    • Hayes JD, McMahon M (2001) Molecular basis for the contribution of the antioxidant responsive element to cancer chemoprevention. Cancer Lett 174:103-113
    • (2001) Cancer Lett , vol.174 , pp. 103-113
    • Hayes, J.D.1    McMahon, M.2
  • 68
    • 5144232811 scopus 로고    scopus 로고
    • Chemoprevention through the Keap1-Nrf2 signaling pathway by phase 2 enzyme inducers
    • Kwak MK, Wakabayashi N, Kensler TW (2004) Chemoprevention through the Keap1-Nrf2 signaling pathway by phase 2 enzyme inducers. Mutat Res 555:133-148
    • (2004) Mutat Res , vol.555 , pp. 133-148
    • Kwak, M.K.1    Wakabayashi, N.2    Kensler, T.W.3
  • 69
    • 7244253081 scopus 로고    scopus 로고
    • Nrf2-Keap1 defines a physiologically important stress response mechanism
    • Motohashi H, Yamamoto M (2004) Nrf2-Keap1 defines a physiologically important stress response mechanism. Trends Mol Med 10:549-557
    • (2004) Trends Mol Med , vol.10 , pp. 549-557
    • Motohashi, H.1    Yamamoto, M.2
  • 70
    • 3142570440 scopus 로고    scopus 로고
    • The pathways and molecular mechanisms regulating Nrf2 activation in response to chemical stress
    • Nguyen T, Yang CS, Pickett CB (2004) The pathways and molecular mechanisms regulating Nrf2 activation in response to chemical stress. Free Radic Biol Med 37:433-441
    • (2004) Free Radic Biol Med , vol.37 , pp. 433-441
    • Nguyen, T.1    Yang, C.S.2    Pickett, C.B.3
  • 71
    • 14044254798 scopus 로고    scopus 로고
    • Molecular mechanisms activating the Nrf2-Keap1 pathway of antioxidant gene regulation
    • Kobayashi M, Yamamoto M (2005) Molecular mechanisms activating the Nrf2-Keap1 pathway of antioxidant gene regulation. Antioxid Redox Signal 7:385-394
    • (2005) Antioxid Redox Signal , vol.7 , pp. 385-394
    • Kobayashi, M.1    Yamamoto, M.2
  • 72
    • 33748052967 scopus 로고    scopus 로고
    • Nrf2-Keap1 regulation of cellular defense mechanisms against electrophiles and reactive oxygen species
    • Kobayashi M, Yamamoto M (2006) Nrf2-Keap1 regulation of cellular defense mechanisms against electrophiles and reactive oxygen species. Adv Enzyme Regul 46:113-140
    • (2006) Adv Enzyme Regul , vol.46 , pp. 113-140
    • Kobayashi, M.1    Yamamoto, M.2
  • 73
    • 33845442925 scopus 로고    scopus 로고
    • Mechanistic studies of the Nrf2-Keap1 signaling pathway
    • Zhang DD (2006) Mechanistic studies of the Nrf2-Keap1 signaling pathway. Drug Metab Rev 38:769-789
    • (2006) Drug Metab Rev , vol.38 , pp. 769-789
    • Zhang, D.D.1
  • 74
    • 33847050801 scopus 로고    scopus 로고
    • Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway
    • Kensler TW, Wakabayashi N, Biswal S (2007) Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway. Annu Rev Pharmacol Toxicol 47:89-116
    • (2007) Annu Rev Pharmacol Toxicol , vol.47 , pp. 89-116
    • Kensler, T.W.1    Wakabayashi, N.2    Biswal, S.3
  • 75
    • 53449101213 scopus 로고    scopus 로고
    • Molecular mechanisms of natural products in chemoprevention: Induction of cytoprotective enzymes by Nrf2
    • Eggler AL, Gay KA, Mesecar AD (2008) Molecular mechanisms of natural products in chemoprevention: induction of cytoprotective enzymes by Nrf2. Mol Nutr Food Res 52: S84-S94
    • (2008) Mol Nutr Food Res , vol.52
    • Eggler, A.L.1    Gay, K.A.2    Mesecar, A.D.3
  • 76
    • 52449089630 scopus 로고    scopus 로고
    • Direct and indirect antioxidant properties of inducers of cytoprotective proteins
    • Dinkova-Kostova AT, Talalay P (2008) Direct and indirect antioxidant properties of inducers of cytoprotective proteins. Mol Nutr Food Res 52:S128-S138
    • (2008) Mol Nutr Food Res , vol.52
    • Dinkova-Kostova, A.T.1    Talalay, P.2
  • 77
    • 47849083585 scopus 로고    scopus 로고
    • Nrf2 signaling: An adaptive response pathway for protection against environmental toxic insults
    • Osburn WO, Kensler TW (2008) Nrf2 signaling: an adaptive response pathway for protection against environmental toxic insults. Mutat Res 659:31-39
    • (2008) Mutat Res , vol.659 , pp. 31-39
    • Osburn, W.O.1    Kensler, T.W.2
  • 78
    • 56249106571 scopus 로고    scopus 로고
    • Nrf2 as a master redox switch in turning on the cellular signaling involved in the induction of cytoprotective genes by some chemopreventive phytochemicals
    • Surh YJ, Kundu JK, Na HK (2008) Nrf2 as a master redox switch in turning on the cellular signaling involved in the induction of cytoprotective genes by some chemopreventive phytochemicals. Planta Med 74:1526-1539
    • (2008) Planta Med , vol.74 , pp. 1526-1539
    • Surh, Y.J.1    Kundu, J.K.2    Na, H.K.3
  • 79
    • 67649402187 scopus 로고    scopus 로고
    • The Nrf2-antioxidant response element signaling pathway and its activation by oxidative stress
    • Nguyen T, Nioi P, Pickett CB (2009) The Nrf2-antioxidant response element signaling pathway and its activation by oxidative stress. J Biol Chem 284:13291-13295
    • (2009) J Biol Chem , vol.284 , pp. 13291-13295
    • Nguyen, T.1    Nioi, P.2    Pickett, C.B.3
  • 80
    • 59849113546 scopus 로고    scopus 로고
    • Molecular mechanisms of Nrf2-mediated antioxidant response
    • Li W, Kong AN (2009) Molecular mechanisms of Nrf2-mediated antioxidant response. Mol Carcinog 48:91-104
    • (2009) Mol Carcinog , vol.48 , pp. 91-104
    • Li, W.1    Kong, A.N.2
  • 81
    • 63549121490 scopus 로고    scopus 로고
    • NRF2 and KEAP1 mutations: Permanent activation of an adaptive response in cancer
    • Hayes JD, McMahon M (2009) NRF2 and KEAP1 mutations: permanent activation of an adaptive response in cancer. Trends Biochem Sci 34:176-188
    • (2009) Trends Biochem Sci , vol.34 , pp. 176-188
    • Hayes, J.D.1    McMahon, M.2
  • 82
    • 77958130983 scopus 로고    scopus 로고
    • Cancer chemoprevention mechanisms mediated through the Keap1-Nrf2 pathway
    • Hayes JD, McMahon M, Chowdhry S et al (2010) Cancer chemoprevention mechanisms mediated through the Keap1-Nrf2 pathway. Antioxid Redox Signal 13:1713-1748
    • (2010) Antioxid Redox Signal , vol.13 , pp. 1713-1748
    • Hayes, J.D.1    McMahon, M.2    Chowdhry, S.3
  • 83
    • 77649270763 scopus 로고    scopus 로고
    • Targeting NRF2 signaling for cancer chemoprevention
    • Kwak MK, Kensler TW (2010) Targeting NRF2 signaling for cancer chemoprevention. Toxicol Appl Pharmacol 244:66-76
    • (2010) Toxicol Appl Pharmacol , vol.244 , pp. 66-76
    • Kwak, M.K.1    Kensler, T.W.2
  • 84
    • 77958115724 scopus 로고    scopus 로고
    • Regulation of the Nrf2-Keap1 antioxidant response by the ubiquitin proteasome system: An insight into cullin-ring ubiquitin ligases
    • Villeneuve NF, Lau A, Zhang DD (2010) Regulation of the Nrf2-Keap1 antioxidant response by the ubiquitin proteasome system: an insight into cullin-ring ubiquitin ligases. Antioxid Redox Signal 13:1699-1712
    • (2010) Antioxid Redox Signal , vol.13 , pp. 1699-1712
    • Villeneuve, N.F.1    Lau, A.2    Zhang, D.D.3
  • 85
    • 79954424076 scopus 로고    scopus 로고
    • Nrf2: Control of sensitivity to carcinogens
    • Slocum SL, Kensler TW (2011) Nrf2: control of sensitivity to carcinogens. Arch Toxicol 85:273-284
    • (2011) Arch Toxicol , vol.85 , pp. 273-284
    • Slocum, S.L.1    Kensler, T.W.2
  • 86
    • 0037015035 scopus 로고    scopus 로고
    • Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants
    • Dinkova-Kostova AT, Holtzclaw WD, Cole RN et al (2002) Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants. Proc Natl Acad Sci USA 99:11908-11913
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 11908-11913
    • Dinkova-Kostova, A.T.1    Holtzclaw, W.D.2    Cole, R.N.3
  • 87
    • 78650509515 scopus 로고    scopus 로고
    • Keap1 perceives stress via three sensors for the endogenous signaling molecules nitric oxide, zinc, and alkenals
    • McMahon M, Lamont DJ, Beattie KA et al (2010) Keap1 perceives stress via three sensors for the endogenous signaling molecules nitric oxide, zinc, and alkenals. Proc Natl Acad Sci USA 107:18838-18843
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 18838-18843
    • McMahon, M.1    Lamont, D.J.2    Beattie, K.A.3
  • 88
    • 79954489673 scopus 로고    scopus 로고
    • Modification of Keap1 cysteine residues by sulforaphane
    • Hu C, Eggler AL, Mesecar AD et al (2011) Modification of Keap1 cysteine residues by sulforaphane. Chem Res Toxicol 24:515-521
    • (2011) Chem Res Toxicol , vol.24 , pp. 515-521
    • Hu, C.1    Eggler, A.L.2    Mesecar, A.D.3
  • 89
    • 0023930873 scopus 로고
    • Direct measurement of NAD(P)H:quinone reductase from cells cultured in microtiter wells: A screening assay for anticarcinogenic enzyme inducers
    • Prochaska HJ, Santamaria AB (1988) Direct measurement of NAD(P)H:quinone reductase from cells cultured in microtiter wells: a screening assay for anticarcinogenic enzyme inducers. Anal Biochem 169:328-336
    • (1988) Anal Biochem , vol.169 , pp. 328-336
    • Prochaska, H.J.1    Santamaria, A.B.2
  • 90
    • 0026589840 scopus 로고
    • Rapid detection of inducers of enzymes that protect against carcinogens
    • Prochaska HJ, Santamaria AB, Talalay P (1992) Rapid detection of inducers of enzymes that protect against carcinogens. Proc Natl Acad Sci USA 89:2394-2398
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 2394-2398
    • Prochaska, H.J.1    Santamaria, A.B.2    Talalay, P.3
  • 91
    • 1242319547 scopus 로고    scopus 로고
    • The "Prochaska" microtiter plate bioassay for inducers of NQO1
    • Fahey JW, Dinkova-Kostova AT, Stephenson KK et al (2004) The "Prochaska" microtiter plate bioassay for inducers of NQO1. Methods Enzymol 382:243-258
    • (2004) Methods Enzymol , vol.382 , pp. 243-258
    • Fahey, J.W.1    Dinkova-Kostova, A.T.2    Stephenson, K.K.3
  • 92
    • 0026577605 scopus 로고
    • A major inducer of anticarcinogenic protective enzymes from broccoli: Isolation and elucidation of structure
    • Zhang Y, Talalay P, Cho CG et al (1992) A major inducer of anticarcinogenic protective enzymes from broccoli: isolation and elucidation of structure. Proc Natl Acad Sci USA 89:2399-2403
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 2399-2403
    • Zhang, Y.1    Talalay, P.2    Cho, C.G.3
  • 93
    • 34548445866 scopus 로고    scopus 로고
    • Discovery and development of sulforaphane as a cancer chemopreventive phytochemical
    • Zhang Y, Tang L (2007) Discovery and development of sulforaphane as a cancer chemopreventive phytochemical. Acta Pharmacol Sin 28:1343-1354
    • (2007) Acta Pharmacol Sin , vol.28 , pp. 1343-1354
    • Zhang, Y.1    Tang, L.2
  • 94
    • 0035543010 scopus 로고    scopus 로고
    • Comparison of the bioactivity of two glucoraphanin hydrolysis products found in broccoli, sulforaphane and sulforaphane nitrile
    • Matusheski NV, Jeffery EH (2001) Comparison of the bioactivity of two glucoraphanin hydrolysis products found in broccoli, sulforaphane and sulforaphane nitrile. J Agric Food Chem 49:5743-5749
    • (2001) J Agric Food Chem , vol.49 , pp. 5743-5749
    • Matusheski, N.V.1    Jeffery, E.H.2
  • 95
    • 1842588301 scopus 로고    scopus 로고
    • Induction of phase II detoxification enzymes in rats by plantderived isothiocyanates: Comparison of allyl isothiocyanate with sulforaphane and related compounds
    • Munday R, Munday CM (2004) Induction of phase II detoxification enzymes in rats by plantderived isothiocyanates: comparison of allyl isothiocyanate with sulforaphane and related compounds. J Agric Food Chem 52:1867-1871
    • (2004) J Agric Food Chem , vol.52 , pp. 1867-1871
    • Munday, R.1    Munday, C.M.2
  • 96
    • 33846153232 scopus 로고    scopus 로고
    • Induction of GST and NQO1 in cultured bladder cells and in the urinary bladders of rats by an extract of broccoli (Brassica oleracea italica) sprouts
    • Zhang Y, Munday R, Jobson HE et al (2006) Induction of GST and NQO1 in cultured bladder cells and in the urinary bladders of rats by an extract of broccoli (Brassica oleracea italica) sprouts. J Agric Food Chem 54:9370-9376
    • (2006) J Agric Food Chem , vol.54 , pp. 9370-9376
    • Zhang, Y.1    Munday, R.2    Jobson, H.E.3
  • 97
    • 0035870298 scopus 로고    scopus 로고
    • The Cap'n'Collar basic leucine zipper transcription factor Nrf2 (NF-E2 p45-related factor 2) controls both constitutive and inducible expression of intestinal detoxification and glutathione biosynthetic enzymes
    • McMahon M, Itoh K, Yamamoto M et al (2001) The Cap'n'Collar basic leucine zipper transcription factor Nrf2 (NF-E2 p45-related factor 2) controls both constitutive and inducible expression of intestinal detoxification and glutathione biosynthetic enzymes. Cancer Res 61:3299-3307
    • (2001) Cancer Res , vol.61 , pp. 3299-3307
    • McMahon, M.1    Itoh, K.2    Yamamoto, M.3
  • 98
    • 0033899512 scopus 로고    scopus 로고
    • Effects of phenethylisothiocyanate on the expression of glutathione S-transferases and hepatotoxicity induced by acetaminophen
    • Seo KW, Kim JG, Park M et al (2000) Effects of phenethylisothiocyanate on the expression of glutathione S-transferases and hepatotoxicity induced by acetaminophen. Xenobiotica 30:535-545
    • (2000) Xenobiotica , vol.30 , pp. 535-545
    • Seo, K.W.1    Kim, J.G.2    Park, M.3
  • 99
    • 49549124485 scopus 로고    scopus 로고
    • Structure-activity relationships and organ specificity in the induction of GST and NQO1 by alkyl-aryl isothiocyanates
    • Munday R, Zhang Y, Munday CM et al (2008) Structure-activity relationships and organ specificity in the induction of GST and NQO1 by alkyl-aryl isothiocyanates. Pharm Res 25:2164-2170
    • (2008) Pharm Res , vol.25 , pp. 2164-2170
    • Munday, R.1    Zhang, Y.2    Munday, C.M.3
  • 100
    • 0036949429 scopus 로고    scopus 로고
    • Selective induction of phase II enzymes in the urinary bladder of rats by allyl isothiocyanate, a compound derived from Brassica vegetables
    • Munday R, Munday CM (2002) Selective induction of phase II enzymes in the urinary bladder of rats by allyl isothiocyanate, a compound derived from Brassica vegetables. Nutr Cancer 44:52-59
    • (2002) Nutr Cancer , vol.44 , pp. 52-59
    • Munday, R.1    Munday, C.M.2
  • 101
    • 0037106099 scopus 로고    scopus 로고
    • Identification of Nrf2-regulated genes induced by the chemopreventive agent sulforaphane by oligonucleotide microarray
    • Thimmulappa RK, Mai KH, Srisuma S et al (2002) Identification of Nrf2-regulated genes induced by the chemopreventive agent sulforaphane by oligonucleotide microarray. Cancer Res 62:5196-5203
    • (2002) Cancer Res , vol.62 , pp. 5196-5203
    • Thimmulappa, R.K.1    Mai, K.H.2    Srisuma, S.3
  • 102
    • 33746889956 scopus 로고    scopus 로고
    • Gene expression profiles induced by cancer chemopreventive isothiocyanate sulforaphane in the liver of C57BL/6J mice and C57BL/6J/Nrf2 (-/-) mice
    • Hu R, Xu C, Shen G et al (2006) Gene expression profiles induced by cancer chemopreventive isothiocyanate sulforaphane in the liver of C57BL/6J mice and C57BL/6J/Nrf2 (-/-) mice. Cancer Lett 243:170-192
    • (2006) Cancer Lett , vol.243 , pp. 170-192
    • Hu, R.1    Xu, C.2    Shen, G.3
  • 103
    • 34447131494 scopus 로고    scopus 로고
    • Effects of phenylethyl isothiocyanate on early molecular events in N-nitrosomethylbenzylamine-induced cytotoxicity in rat esophagus
    • Reen RK, Dombkowski AA, Kresty LA et al (2007) Effects of phenylethyl isothiocyanate on early molecular events in N-nitrosomethylbenzylamine-induced cytotoxicity in rat esophagus. Cancer Res 67:6484-6492
    • (2007) Cancer Res , vol.67 , pp. 6484-6492
    • Reen, R.K.1    Dombkowski, A.A.2    Kresty, L.A.3
  • 104
    • 51049088182 scopus 로고    scopus 로고
    • Carcinogen-altered genes in rat esophagus positively modulated to normal levels of expression by both black raspberries and phenylethyl isothiocyanate
    • Stoner GD, Dombkowski AA, Reen RK et al (2008) Carcinogen-altered genes in rat esophagus positively modulated to normal levels of expression by both black raspberries and phenylethyl isothiocyanate. Cancer Res 68:6460-6467
    • (2008) Cancer Res , vol.68 , pp. 6460-6467
    • Stoner, G.D.1    Dombkowski, A.A.2    Reen, R.K.3
  • 105
    • 49849087443 scopus 로고    scopus 로고
    • Broccoli consumption interacts with GSTM1 to perturb oncogenic signalling pathways in the prostate
    • Traka M, Gasper AV, Melchini A et al (2008) Broccoli consumption interacts with GSTM1 to perturb oncogenic signalling pathways in the prostate. PLoS One 3:e2568
    • (2008) PLoS One , vol.3
    • Traka, M.1    Gasper, A.V.2    Melchini, A.3
  • 106
    • 34247473917 scopus 로고    scopus 로고
    • Induction of the phase 2 response in mouse and human skin by sulforaphane-containing broccoli sprout extracts
    • Dinkova-Kostova AT, Fahey JW, Wade KL et al (2007) Induction of the phase 2 response in mouse and human skin by sulforaphane-containing broccoli sprout extracts. Cancer Epidemiol Biomarkers Prev 16:847-851
    • (2007) Cancer Epidemiol Biomarkers Prev , vol.16 , pp. 847-851
    • Dinkova-Kostova, A.T.1    Fahey, J.W.2    Wade, K.L.3
  • 107
    • 0035943597 scopus 로고    scopus 로고
    • NFkB is a molecular target for sulforaphanemediated anti-inflammatory mechanisms
    • Heiss E, Herhaus C, Klimo K et al (2001) NFkB is a molecular target for sulforaphanemediated anti-inflammatory mechanisms. J Biol Chem 276:32008-32015
    • (2001) J Biol Chem , vol.276 , pp. 32008-32015
    • Heiss, E.1    Herhaus, C.2    Klimo, K.3
  • 108
    • 28844478899 scopus 로고    scopus 로고
    • Time-dependent modulation of thioredoxin reductase activity might contribute to sulforaphane-mediated inhibition of NFkB binding to DNA
    • Heiss E, Gerhauser C (2005) Time-dependent modulation of thioredoxin reductase activity might contribute to sulforaphane-mediated inhibition of NFkB binding to DNA. Antioxid Redox Signal 7:1601-1611
    • (2005) Antioxid Redox Signal , vol.7 , pp. 1601-1611
    • Heiss, E.1    Gerhauser, C.2
  • 109
    • 35748952490 scopus 로고    scopus 로고
    • Sulforaphane suppresses lipopolysaccharide-induced cyclooxygenase-2 (COX-2) expression through the modulation of multiple targets in COX-2 gene promoter
    • Woo KJ, Kwon TK (2007) Sulforaphane suppresses lipopolysaccharide-induced cyclooxygenase-2 (COX-2) expression through the modulation of multiple targets in COX-2 gene promoter. Int Immunopharmacol 7:1776-1783
    • (2007) Int Immunopharmacol , vol.7 , pp. 1776-1783
    • Woo, K.J.1    Kwon, T.K.2
  • 110
    • 52949139019 scopus 로고    scopus 로고
    • Sulforaphane suppressed LPS-induced inflammation in mouse peritoneal macrophages through Nrf2 dependent pathway
    • Lin W, Wu RT, Wu T (2008) Sulforaphane suppressed LPS-induced inflammation in mouse peritoneal macrophages through Nrf2 dependent pathway. Biochem Pharmacol 76:967-973
    • (2008) Biochem Pharmacol , vol.76 , pp. 967-973
    • Lin, W.1    Wu, R.T.2    Wu, T.3
  • 111
    • 57349116768 scopus 로고    scopus 로고
    • Coordinate regulation of enzyme markers for inflammation and for protection against oxidants and electrophiles
    • Liu H, Dinkova-Kostova AT, Talalay P (2008) Coordinate regulation of enzyme markers for inflammation and for protection against oxidants and electrophiles. Proc Natl Acad Sci USA 105:15926-15931
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 15926-15931
    • Liu, H.1    Dinkova-Kostova, A.T.2    Talalay, P.3
  • 112
    • 62549085979 scopus 로고    scopus 로고
    • Anti-NF-kB and anti-inflammatory activities of synthetic isothiocyanates: Effect of chemical structures and cellular signaling
    • Prawan A, Saw CL, Khor TO et al (2009) Anti-NF-kB and anti-inflammatory activities of synthetic isothiocyanates: effect of chemical structures and cellular signaling. Chem Biol Interact 179:202-211
    • (2009) Chem Biol Interact , vol.179 , pp. 202-211
    • Prawan, A.1    Saw, C.L.2    Khor, T.O.3
  • 113
    • 57749182206 scopus 로고    scopus 로고
    • Synergistic effect of combination of phenethyl isothiocyanate and sulforaphane or curcumin and sulforaphane in the inhibition of inflammation
    • Cheung KL, Khor TO, Kong AN (2009) Synergistic effect of combination of phenethyl isothiocyanate and sulforaphane or curcumin and sulforaphane in the inhibition of inflammation. Pharm Res 26:224-231
    • (2009) Pharm Res , vol.26 , pp. 224-231
    • Cheung, K.L.1    Khor, T.O.2    Kong, A.N.3
  • 114
    • 2342535632 scopus 로고    scopus 로고
    • Dietary approach to attenuate oxidative stress, hypertension, and inflammation in the cardiovascular system
    • Wu L, Noyan Ashraf MH, FacciMet al (2004) Dietary approach to attenuate oxidative stress, hypertension, and inflammation in the cardiovascular system. Proc Natl Acad Sci USA 101:7094-7099
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 7094-7099
    • Wu, L.1    Noyan Ashraf, M.H.2    Facci, M.3
  • 115
    • 22744440329 scopus 로고    scopus 로고
    • Suppression of NF-kB and NF-kB-regulated gene expression by sulforaphane and PEITC through IkBa IKK pathway in human prostate cancer PC-3 cells
    • Xu C, Shen G, Chen C et al (2005) Suppression of NF-kB and NF-kB-regulated gene expression by sulforaphane and PEITC through IkBa, IKK pathway in human prostate cancer PC-3 cells. Oncogene 24:4486-4495
    • (2005) Oncogene , vol.24 , pp. 4486-4495
    • Xu, C.1    Shen, G.2    Chen, C.3
  • 116
    • 67649637824 scopus 로고    scopus 로고
    • Sulforaphane targets pancreatic tumourinitiating cells by NF-B-induced antiapoptotic signalling
    • Kallifatidis G, Rausch V, Baumann B et al (2009) Sulforaphane targets pancreatic tumourinitiating cells by NF-B-induced antiapoptotic signalling. Gut 58:949-963
    • (2009) Gut , vol.58 , pp. 949-963
    • Kallifatidis, G.1    Rausch, V.2    Baumann, B.3
  • 117
    • 57749088548 scopus 로고    scopus 로고
    • Sulforaphane suppresses TNF-A-mediated activation of NF-kB and induces apoptosis through activation of reactive oxygen speciesdependent caspase-3
    • Moon DO, Kim MO, Kang SH et al (2009) Sulforaphane suppresses TNF-a-mediated activation of NF-kB and induces apoptosis through activation of reactive oxygen speciesdependent caspase-3. Cancer Lett 274:132-142
    • (2009) Cancer Lett , vol.274 , pp. 132-142
    • Moon, D.O.1    Kim, M.O.2    Kang, S.H.3
  • 118
    • 59149098593 scopus 로고    scopus 로고
    • Sulforaphane protects against cytokine-and streptozotocin-induced beta-cell damage by suppressing the NF-kB pathway
    • Song MY, Kim EK, Moon WS et al (2009) Sulforaphane protects against cytokine-and streptozotocin-induced beta-cell damage by suppressing the NF-kB pathway. Toxicol Appl Pharmacol 235:57-67
    • (2009) Toxicol Appl Pharmacol , vol.235 , pp. 57-67
    • Song, M.Y.1    Kim, E.K.2    Moon, W.S.3
  • 119
    • 67649417900 scopus 로고    scopus 로고
    • Sulforaphane down-regulates COX-2 expression by activating p38 and inhibiting NF-kB-DNA-binding activity in human bladder T24 cells
    • Shan Y, Wu K, Wang W et al (2009) Sulforaphane down-regulates COX-2 expression by activating p38 and inhibiting NF-kB-DNA-binding activity in human bladder T24 cells. Int J Oncol 34:1129-1134
    • (2009) Int J Oncol , vol.34 , pp. 1129-1134
    • Shan, Y.1    Wu, K.2    Wang, W.3
  • 120
    • 77953324869 scopus 로고    scopus 로고
    • Sulforaphane suppresses LPS-induced inflammation in primary rat microglia
    • Brandenburg LO, Kipp M, Lucius R et al (2010) Sulforaphane suppresses LPS-induced inflammation in primary rat microglia. Inflamm Res 59:443-450
    • (2010) Inflamm Res , vol.59 , pp. 443-450
    • Brandenburg, L.O.1    Kipp, M.2    Lucius, R.3
  • 121
    • 77958488608 scopus 로고    scopus 로고
    • Sulforaphane inhibits endothelial lipase expression through NF-kB in endothelial cells
    • Kivela AM, Makinen PI, Jyrkkanen HK et al (2010) Sulforaphane inhibits endothelial lipase expression through NF-kB in endothelial cells. Atherosclerosis 213:122-128
    • (2010) Atherosclerosis , vol.213 , pp. 122-128
    • Kivela, A.M.1    Makinen, P.I.2    Jyrkkanen, H.K.3
  • 122
    • 78751496311 scopus 로고    scopus 로고
    • Sulforaphane suppresses TARC/CCL17 and MDC/CCL22 expression through heme oxygenase-1 and NF-kB in human keratinocytes
    • Jeong SI, Choi BM, Jang SI (2010) Sulforaphane suppresses TARC/CCL17 and MDC/CCL22 expression through heme oxygenase-1 and NF-kB in human keratinocytes. Arch Pharm Res 33:1867-1876
    • (2010) Arch Pharm Res , vol.33 , pp. 1867-1876
    • Jeong, S.I.1    Choi, B.M.2    Jang, S.I.3
  • 123
    • 82155197554 scopus 로고    scopus 로고
    • Nrf2 and NF-kB Modulation by sulforaphane counteracts multiple manifestations of diabetic neuropathy in rats and high glucose-induced changes
    • Negi G, Kumar A, Sharma SS (2011) Nrf2 and NF-kB Modulation by sulforaphane counteracts multiple manifestations of diabetic neuropathy in rats and high glucose-induced changes. Curr Neurovasc Res 8:294-304
    • (2011) Curr Neurovasc Res , vol.8 , pp. 294-304
    • Negi, G.1    Kumar, A.2    Sharma, S.S.3
  • 124
    • 33645112858 scopus 로고    scopus 로고
    • In vitro and in vivo anti-inflammatory activity of a seed preparation containing phenethylisothiocyanate
    • Dey M, Ribnicky D, Kurmukov AG et al (2006) In vitro and in vivo anti-inflammatory activity of a seed preparation containing phenethylisothiocyanate. J Pharmacol Exp Ther 317:326-333
    • (2006) J Pharmacol Exp Ther , vol.317 , pp. 326-333
    • Dey, M.1    Ribnicky, D.2    Kurmukov, A.G.3
  • 125
    • 77951210052 scopus 로고    scopus 로고
    • Dietary phenethylisothiocyanate attenuates bowel inflammation in mice
    • Dey M, Kuhn P, Ribnicky D et al (2010) Dietary phenethylisothiocyanate attenuates bowel inflammation in mice. BMC Chem Biol 10:4
    • (2010) BMC Chem Biol , vol.10 , pp. 4
    • Dey, M.1    Kuhn, P.2    Ribnicky, D.3
  • 126
    • 36849089479 scopus 로고    scopus 로고
    • Sulforaphane mobilizes cellular defenses that protect skin against damage by UV radiation
    • Talalay P, Fahey JW, Healy ZR et al (2007) Sulforaphane mobilizes cellular defenses that protect skin against damage by UV radiation. Proc Natl Acad Sci USA 104:17500-17505
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 17500-17505
    • Talalay, P.1    Fahey, J.W.2    Healy, Z.R.3
  • 127
    • 79955710308 scopus 로고    scopus 로고
    • Impact of Nrf2 on UVB-induced skin inflammation/photoprotection and photoprotective effect of sulforaphane
    • Saw CL, Huang MT, Liu Y et al (2011) Impact of Nrf2 on UVB-induced skin inflammation/photoprotection and photoprotective effect of sulforaphane. Mol Carcinog 50:479-486
    • (2011) Mol Carcinog , vol.50 , pp. 479-486
    • Saw, C.L.1    Huang, M.T.2    Liu, Y.3
  • 128
    • 77954659992 scopus 로고    scopus 로고
    • Sulforaphane suppresses ultraviolet B-induced inflammation in HaCaT keratinocytes and HR-1 hairless mice
    • Shibata A, Nakagawa K, Yamanoi H et al (2010) Sulforaphane suppresses ultraviolet B-induced inflammation in HaCaT keratinocytes and HR-1 hairless mice. J Nutr Biochem 21:702-709
    • (2010) J Nutr Biochem , vol.21 , pp. 702-709
    • Shibata, A.1    Nakagawa, K.2    Yamanoi, H.3
  • 129
    • 33846094115 scopus 로고    scopus 로고
    • Pharmacogenomics of cancer chemopreventive isothiocyanate compound sulforaphane in the intestinal polyps of ApcMin/+ mice
    • Khor TO, Hu R, Shen G et al (2006) Pharmacogenomics of cancer chemopreventive isothiocyanate compound sulforaphane in the intestinal polyps of ApcMin/+ mice. Biopharm Drug Dispos 27:407-420
    • (2006) Biopharm Drug Dispos , vol.27 , pp. 407-420
    • Khor, T.O.1    Hu, R.2    Shen, G.3
  • 130
    • 70450248452 scopus 로고    scopus 로고
    • Direct modification of the proinflammatory cytokine macrophage migration inhibitory factor by dietary isothiocyanates
    • Brown KK, Blaikie FH, Smith RA et al (2009) Direct modification of the proinflammatory cytokine macrophage migration inhibitory factor by dietary isothiocyanates. J Biol Chem 284:32425-32433
    • (2009) J Biol Chem , vol.284 , pp. 32425-32433
    • Brown, K.K.1    Blaikie, F.H.2    Smith, R.A.3
  • 131
    • 70350112583 scopus 로고    scopus 로고
    • Nutrient isothiocyanates covalently modify and inhibit the inflammatory cytokine macrophage migration inhibitory factor (MIF)
    • Cross JV, Rady JM, Foss FW et al (2009) Nutrient isothiocyanates covalently modify and inhibit the inflammatory cytokine macrophage migration inhibitory factor (MIF). Biochem J 423:315-321
    • (2009) Biochem J , vol.423 , pp. 315-321
    • Cross, J.V.1    Rady, J.M.2    Foss, F.W.3
  • 132
    • 70350062352 scopus 로고    scopus 로고
    • A new class of isothiocyanate-based irreversible inhibitors of macrophage migration inhibitory factor
    • Ouertatani-Sakouhi H, El-Turk F, Fauvet B et al (2009) A new class of isothiocyanate-based irreversible inhibitors of macrophage migration inhibitory factor. Biochemistry 48:9858-9870
    • (2009) Biochemistry , vol.48 , pp. 9858-9870
    • Ouertatani-Sakouhi, H.1    El-Turk, F.2    Fauvet, B.3
  • 133
    • 79960095905 scopus 로고    scopus 로고
    • Inactivation of tautomerase activity of macrophage migration inhibitory factor by sulforaphane: A potential biomarker for antiinflammatory intervention
    • Healy ZR, Liu H, Holtzclaw WD et al (2011) Inactivation of tautomerase activity of macrophage migration inhibitory factor by sulforaphane: a potential biomarker for antiinflammatory intervention. Cancer Epidemiol Biomarkers Prev 20:1516-1523
    • (2011) Cancer Epidemiol Biomarkers Prev , vol.20 , pp. 1516-1523
    • Healy, Z.R.1    Liu, H.2    Holtzclaw, W.D.3
  • 134
    • 4143121370 scopus 로고    scopus 로고
    • Isothiocyanates as novel cytotoxic and cytostatic agents: Molecular pathway on human transformed and non-transformed cells
    • Fimognari C, Nusse M, Berti F et al (2004) Isothiocyanates as novel cytotoxic and cytostatic agents: molecular pathway on human transformed and non-transformed cells. Biochem Pharmacol 68:1133-1138
    • (2004) Biochem Pharmacol , vol.68 , pp. 1133-1138
    • Fimognari, C.1    Nusse, M.2    Berti, F.3
  • 135
    • 33645815069 scopus 로고    scopus 로고
    • Signaling pathways and intracellular targets of sulforaphane mediating cell cycle arrest and apoptosis
    • Gamet-Payrastre L (2006) Signaling pathways and intracellular targets of sulforaphane mediating cell cycle arrest and apoptosis. Curr Cancer Drug Targets 6:135-145
    • (2006) Curr Cancer Drug Targets , vol.6 , pp. 135-145
    • Gamet-Payrastre, L.1
  • 136
    • 34247606510 scopus 로고    scopus 로고
    • Molecular basis for chemoprevention by sulforaphane: A comprehensive review
    • Juge N, Mithen RF, Traka M (2007) Molecular basis for chemoprevention by sulforaphane: a comprehensive review. Cell Mol Life Sci 64:1105-1127
    • (2007) Cell Mol Life Sci , vol.64 , pp. 1105-1127
    • Juge, N.1    Mithen, R.F.2    Traka, M.3
  • 137
    • 56249114165 scopus 로고    scopus 로고
    • Role of reactive oxygen intermediates in cellular responses to dietary cancer chemopreventive agents
    • Antosiewicz J, Ziolkowski W, Kar S et al (2008) Role of reactive oxygen intermediates in cellular responses to dietary cancer chemopreventive agents. Planta Med 74:1570-1579
    • (2008) Planta Med , vol.74 , pp. 1570-1579
    • Antosiewicz, J.1    Ziolkowski, W.2    Kar, S.3
  • 138
    • 51349088974 scopus 로고    scopus 로고
    • Multi-targeted prevention of cancer by sulforaphane
    • Clarke JD, Dashwood RH, Ho E (2008) Multi-targeted prevention of cancer by sulforaphane. Cancer Lett 269:291-304
    • (2008) Cancer Lett , vol.269 , pp. 291-304
    • Clarke, J.D.1    Dashwood, R.H.2    Ho, E.3
  • 139
    • 77449106593 scopus 로고    scopus 로고
    • Molecular targets of dietary phenethyl isothiocyanate and sulforaphane for cancer chemoprevention
    • Cheung KL, Kong AN (2010) Molecular targets of dietary phenethyl isothiocyanate and sulforaphane for cancer chemoprevention. AAPS J 12:87-97
    • (2010) AAPS J , vol.12 , pp. 87-97
    • Cheung, K.L.1    Kong, A.N.2
  • 140
    • 1242307951 scopus 로고    scopus 로고
    • Sulforaphane: A naturally occurring mammary carcinoma mitotic inhibitor, which disrupts tubulin polymerization
    • Jackson SJ, Singletary KW (2004) Sulforaphane: a naturally occurring mammary carcinoma mitotic inhibitor, which disrupts tubulin polymerization. Carcinogenesis 25:219-227
    • (2004) Carcinogenesis , vol.25 , pp. 219-227
    • Jackson, S.J.1    Singletary, K.W.2
  • 141
    • 33845593776 scopus 로고    scopus 로고
    • Sulforaphane suppresses angiogenesis and disrupts endothelial mitotic progression and microtubule polymerization
    • Jackson SJ, Singletary KW, Venema RC (2007) Sulforaphane suppresses angiogenesis and disrupts endothelial mitotic progression and microtubule polymerization. Vascul Pharmacol 46:77-84
    • (2007) Vascul Pharmacol , vol.46 , pp. 77-84
    • Jackson, S.J.1    Singletary, K.W.2    Venema, R.C.3
  • 142
    • 33646201718 scopus 로고    scopus 로고
    • Antimetastatic activity of sulforaphane
    • Thejass P, Kuttan G (2006) Antimetastatic activity of sulforaphane. Life Sci 78:3043-3050
    • (2006) Life Sci , vol.78 , pp. 3043-3050
    • Thejass, P.1    Kuttan, G.2
  • 143
    • 33846417309 scopus 로고    scopus 로고
    • Allyl isothiocyanate (AITC) and phenyl isothiocyanate (PITC) inhibit tumour-specific angiogenesis by downregulating nitric oxide (NO) and tumour necrosis factor-alpha (TNF-A) production
    • Thejass P, Kuttan G (2007) Allyl isothiocyanate (AITC) and phenyl isothiocyanate (PITC) inhibit tumour-specific angiogenesis by downregulating nitric oxide (NO) and tumour necrosis factor-alpha (TNF-a) production. Nitric Oxide 16:247-257
    • (2007) Nitric Oxide , vol.16 , pp. 247-257
    • Thejass, P.1    Kuttan, G.2
  • 144
    • 34447561905 scopus 로고    scopus 로고
    • Immunomodulatory activity of Sulforaphane, a naturally occurring isothiocyanate from broccoli (Brassica oleracea
    • Thejass P, Kuttan G (2007) Immunomodulatory activity of Sulforaphane, a naturally occurring isothiocyanate from broccoli (Brassica oleracea). Phytomedicine 14:538-545
    • (2007) Phytomedicine , vol.14 , pp. 538-545
    • Thejass, P.1    Kuttan, G.2
  • 145
    • 36249018903 scopus 로고    scopus 로고
    • Inhibition of endothelial cell differentiation and proinflammatory cytokine production during angiogenesis by allyl isothiocyanate and phenyl isothiocyanate
    • Thejass P, Kuttan G (2007) Inhibition of endothelial cell differentiation and proinflammatory cytokine production during angiogenesis by allyl isothiocyanate and phenyl isothiocyanate. Integr Cancer Ther 6:389-399
    • (2007) Integr Cancer Ther , vol.6 , pp. 389-399
    • Thejass, P.1    Kuttan, G.2
  • 146
    • 34548564432 scopus 로고    scopus 로고
    • Modulation of cell-mediated immune response in B16F-10 melanoma-induced metastatic tumor-bearing C57BL/6 mice by sulforaphane
    • Thejass P, Kuttan G (2007) Modulation of cell-mediated immune response in B16F-10 melanoma-induced metastatic tumor-bearing C57BL/6 mice by sulforaphane. Immunopharmacol Immunotoxicol 29:173-186
    • (2007) Immunopharmacol Immunotoxicol , vol.29 , pp. 173-186
    • Thejass, P.1    Kuttan, G.2
  • 147
    • 42749088621 scopus 로고    scopus 로고
    • Nrf2 activation by sulforaphane restores the agerelated decrease of T(H)1 immunity: Role of dendritic cells
    • Kim HJ, Barajas B, Wang M et al (2008) Nrf2 activation by sulforaphane restores the agerelated decrease of T(H)1 immunity: role of dendritic cells. J Allergy Clin Immunol 121:1255-1261.e7
    • (2008) J Allergy Clin Immunol , vol.121
    • Kim, H.J.1    Barajas, B.2    Wang, M.3
  • 148
    • 0141453198 scopus 로고    scopus 로고
    • Effect of naturally occurring isothiocyanates on the immune system
    • Manesh C, Kuttan G (2003) Effect of naturally occurring isothiocyanates on the immune system. Immunopharmacol Immunotoxicol 25:451-459
    • (2003) Immunopharmacol Immunotoxicol , vol.25 , pp. 451-459
    • Manesh, C.1    Kuttan, G.2
  • 150
    • 0035755974 scopus 로고    scopus 로고
    • Histone deacetylases and cancer: Causes and therapies
    • Marks P, Rifkind RA, Richon VM et al (2001) Histone deacetylases and cancer: causes and therapies. Nat Rev Cancer 1:194-202
    • (2001) Nat Rev Cancer , vol.1 , pp. 194-202
    • Marks, P.1    Rifkind, R.A.2    Richon, V.M.3
  • 151
    • 4143130097 scopus 로고    scopus 로고
    • A novel mechanism of chemoprotection by sulforaphane: Inhibition of histone deacetylase
    • Myzak MC, Karplus PA, Chung FL et al (2004) A novel mechanism of chemoprotection by sulforaphane: inhibition of histone deacetylase. Cancer Res 64:5767-5774
    • (2004) Cancer Res , vol.64 , pp. 5767-5774
    • Myzak, M.C.1    Karplus, P.A.2    Chung, F.L.3
  • 152
    • 33645324413 scopus 로고    scopus 로고
    • Sulforaphane inhibits histone deacetylase activity in BPH-1 LnCaP and PC-3 prostate epithelial cells
    • Myzak MC, Hardin K, Wang R et al (2006) Sulforaphane inhibits histone deacetylase activity in BPH-1, LnCaP and PC-3 prostate epithelial cells. Carcinogenesis 27:811-819
    • (2006) Carcinogenesis , vol.27 , pp. 811-819
    • Myzak, M.C.1    Hardin, K.2    Wang, R.3
  • 153
    • 34548456881 scopus 로고    scopus 로고
    • Dietary histone deacetylase inhibitors: From cells to mice to man
    • Dashwood RH, Ho E (2007) Dietary histone deacetylase inhibitors: from cells to mice to man. Semin Cancer Biol 17:363-369
    • (2007) Semin Cancer Biol , vol.17 , pp. 363-369
    • Dashwood, R.H.1    Ho, E.2
  • 154
    • 33646823481 scopus 로고    scopus 로고
    • Phenylhexyl isothiocyanate inhibits histone deacetylases and remodels chromatins to induce growth arrest in human leukemia cells
    • Ma X, Fang Y, Beklemisheva A et al (2006) Phenylhexyl isothiocyanate inhibits histone deacetylases and remodels chromatins to induce growth arrest in human leukemia cells. Int J Oncol 28:1287-1293
    • (2006) Int J Oncol , vol.28 , pp. 1287-1293
    • Ma, X.1    Fang, Y.2    Beklemisheva, A.3
  • 155
    • 33645822781 scopus 로고    scopus 로고
    • Epigenetic mechanism of growth inhibition induced by phenylhexyl isothiocyanate in prostate cancer cells
    • Beklemisheva AA, Fang Y, Feng J et al (2006) Epigenetic mechanism of growth inhibition induced by phenylhexyl isothiocyanate in prostate cancer cells. Anticancer Res 26:1225-1230
    • (2006) Anticancer Res , vol.26 , pp. 1225-1230
    • Beklemisheva, A.A.1    Fang, Y.2    Feng, J.3
  • 156
    • 34147135143 scopus 로고    scopus 로고
    • Sulforaphane induces cell typespecific apoptosis in human breast cancer cell lines
    • Pledgie-Tracy A, Sobolewski MD, Davidson NE (2007) Sulforaphane induces cell typespecific apoptosis in human breast cancer cell lines. Mol Cancer Ther 6:1013-1021
    • (2007) Mol Cancer Ther , vol.6 , pp. 1013-1021
    • Pledgie-Tracy, A.1    Sobolewski, M.D.2    Davidson, N.E.3
  • 157
    • 48749118821 scopus 로고    scopus 로고
    • De-repression of the p21 promoter in prostate cancer cells by an isothiocyanate via inhibition of HDACs and c-Myc
    • Wang LG, Liu XM, Fang Y et al (2008) De-repression of the p21 promoter in prostate cancer cells by an isothiocyanate via inhibition of HDACs and c-Myc. Int J Oncol 33:375-380
    • (2008) Int J Oncol , vol.33 , pp. 375-380
    • Wang, L.G.1    Liu, X.M.2    Fang, Y.3
  • 158
    • 78149260516 scopus 로고    scopus 로고
    • Sulforaphane activates heat shock response and enhances proteasome activity through up-regulation of Hsp27
    • Gan N, Wu YC, Brunet M et al (2010) Sulforaphane activates heat shock response and enhances proteasome activity through up-regulation of Hsp27. J Biol Chem 285:35528-35536
    • (2010) J Biol Chem , vol.285 , pp. 35528-35536
    • Gan, N.1    Wu, Y.C.2    Brunet, M.3
  • 159
    • 0032406798 scopus 로고    scopus 로고
    • Human metabolism and excretion of cancer chemoprotective glucosinolates and isothiocyanates of cruciferous vegetables
    • Shapiro TA, Fahey JW, Wade KL et al (1998) Human metabolism and excretion of cancer chemoprotective glucosinolates and isothiocyanates of cruciferous vegetables. Cancer Epidemiol Biomarkers Prev 7:1091-1100
    • (1998) Cancer Epidemiol Biomarkers Prev , vol.7 , pp. 1091-1100
    • Shapiro, T.A.1    Fahey, J.W.2    Wade, K.L.3
  • 160
    • 0032948428 scopus 로고    scopus 로고
    • Conversion of glucosinolates to isothiocyanates in humans after ingestion of cooked watercress
    • Getahun SM, Chung FL (1999) Conversion of glucosinolates to isothiocyanates in humans after ingestion of cooked watercress. Cancer Epidemiol Biomarkers Prev 8:447-451
    • (1999) Cancer Epidemiol Biomarkers Prev , vol.8 , pp. 447-451
    • Getahun, S.M.1    Chung, F.L.2
  • 161
    • 0034434321 scopus 로고    scopus 로고
    • Disposition of glucosinolates and sulforaphane in humans after ingestion of steamed and fresh broccoli
    • Conaway CC, Getahun SM, Liebes LL et al (2000) Disposition of glucosinolates and sulforaphane in humans after ingestion of steamed and fresh broccoli. Nutr Cancer 38:168-178
    • (2000) Nutr Cancer , vol.38 , pp. 168-178
    • Conaway, C.C.1    Getahun, S.M.2    Liebes, L.L.3
  • 162
    • 0034928041 scopus 로고    scopus 로고
    • Chemoprotective glucosinolates and isothiocyanates of broccoli sprouts: Metabolism and excretion in humans
    • Shapiro TA, Fahey JW, Wade KL et al (2001) Chemoprotective glucosinolates and isothiocyanates of broccoli sprouts: metabolism and excretion in humans. Cancer Epidemiol Biomarkers Prev 10:501-508
    • (2001) Cancer Epidemiol Biomarkers Prev , vol.10 , pp. 501-508
    • Shapiro, T.A.1    Fahey, J.W.2    Wade, K.L.3
  • 163
    • 0036135910 scopus 로고    scopus 로고
    • Quantitative determination of dithiocarbamates in human plasma, serum, erythrocytes and urine: Pharmacokinetics of broccoli sprout isothiocyanates in humans
    • Ye L, Dinkova-Kostova AT, Wade KL et al (2002) Quantitative determination of dithiocarbamates in human plasma, serum, erythrocytes and urine: pharmacokinetics of broccoli sprout isothiocyanates in humans. Clin Chim Acta 316:43-53
    • (2002) Clin Chim Acta , vol.316 , pp. 43-53
    • Ye, L.1    Dinkova-Kostova, A.T.2    Wade, K.L.3
  • 164
    • 28644450910 scopus 로고    scopus 로고
    • Effects of glucosinolate-rich broccoli sprouts on urinary levels of aflatoxin-DNA adducts and phenanthrene tetraols in a randomized clinical trial in He Zuo township, Qidong, People's Republic of China
    • Kensler TW, Chen JG, Egner PA et al (2005) Effects of glucosinolate-rich broccoli sprouts on urinary levels of aflatoxin-DNA adducts and phenanthrene tetraols in a randomized clinical trial in He Zuo township, Qidong, People's Republic of China. Cancer Epidemiol Biomarkers Prev 14:2605-2613
    • (2005) Cancer Epidemiol Biomarkers Prev , vol.14 , pp. 2605-2613
    • Kensler, T.W.1    Chen, J.G.2    Egner, P.A.3
  • 165
    • 33644688761 scopus 로고    scopus 로고
    • Glutathione S-transferase M1 polymorphism and metabolism of sulforaphane from standard and high-glucosinolate broccoli
    • Gasper AV, Al-Janobi A, Smith JA et al (2005) Glutathione S-transferase M1 polymorphism and metabolism of sulforaphane from standard and high-glucosinolate broccoli. Am J Clin Nutr 82:1283-1291
    • (2005) Am J Clin Nutr , vol.82 , pp. 1283-1291
    • Gasper, A.V.1    Al-Janobi, A.2    Smith, J.A.3
  • 166
    • 33749165612 scopus 로고    scopus 로고
    • Safety, tolerance, and metabolism of broccoli sprout glucosinolates and isothiocyanates: A clinical phase i study
    • Shapiro TA, Fahey JW, Dinkova-Kostova AT et al (2006) Safety, tolerance, and metabolism of broccoli sprout glucosinolates and isothiocyanates: a clinical phase I study. Nutr Cancer 55:53-62
    • (2006) Nutr Cancer , vol.55 , pp. 53-62
    • Shapiro, T.A.1    Fahey, J.W.2    Dinkova-Kostova, A.T.3
  • 167
    • 34547795788 scopus 로고    scopus 로고
    • Preclinical and clinical evaluation of sulforaphane for chemoprevention in the breast
    • Cornblatt BS, Ye L, Dinkova-Kostova AT et al (2007) Preclinical and clinical evaluation of sulforaphane for chemoprevention in the breast. Carcinogenesis 28:1485-1490
    • (2007) Carcinogenesis , vol.28 , pp. 1485-1490
    • Cornblatt, B.S.1    Ye, L.2    Dinkova-Kostova, A.T.3
  • 168
    • 59249103720 scopus 로고    scopus 로고
    • Oral sulforaphane increases phase II antioxidant enzymes in the human upper airway
    • Riedl MA, Saxon A, Diaz-Sanchez D (2009) Oral sulforaphane increases phase II antioxidant enzymes in the human upper airway. Clin Immunol 130:244-251
    • (2009) Clin Immunol , vol.130 , pp. 244-251
    • Riedl, M.A.1    Saxon, A.2    Diaz-Sanchez, D.3
  • 169
    • 79955834680 scopus 로고    scopus 로고
    • Bioavailability of sulforaphane from two broccoli sprout beverages: Results of a short-term, cross-over clinical trial in Qidong, China
    • Egner PA, Chen JG, Wang JB et al (2011) Bioavailability of sulforaphane from two broccoli sprout beverages: results of a short-term, cross-over clinical trial in Qidong, China. Cancer Prev Res (Phila) 4:384-395
    • (2011) Cancer Prev Res (Phila) , vol.4 , pp. 384-395
    • Egner, P.A.1    Chen, J.G.2    Wang, J.B.3
  • 170
    • 79951939298 scopus 로고    scopus 로고
    • Sulforaphane absorption and excretion following ingestion of a semi-purified broccoli powder rich in glucoraphanin and broccoli sprouts in healthy men
    • Cramer JM, Jeffery EH (2011) Sulforaphane absorption and excretion following ingestion of a semi-purified broccoli powder rich in glucoraphanin and broccoli sprouts in healthy men. Nutr Cancer 63:196-201
    • (2011) Nutr Cancer , vol.63 , pp. 196-201
    • Cramer, J.M.1    Jeffery, E.H.2
  • 171
    • 80052895923 scopus 로고    scopus 로고
    • Variation of glucoraphanin metabolism in vivo and ex vivo by human gut bacteria
    • Li F, Hullar MA, Beresford SA et al (2011) Variation of glucoraphanin
    • (2011) Br J Nutr , vol.106 , pp. 408-416
    • Li, F.1    Hullar, M.A.2    Beresford, S.A.3
  • 172
    • 79954542852 scopus 로고    scopus 로고
    • Targeting Nrf2 signaling improves bacterial clearance by alveolar macrophages in patients with COPD and in a mouse model
    • Harvey CJ, Thimmulappa RK, Sethi S et al (2011) Targeting Nrf2 signaling improves bacterial clearance by alveolar macrophages in patients with COPD and in a mouse model. Sci Transl Med 3:78ra32
    • (2011) Sci Transl Med , vol.3
    • Harvey, C.J.1    Thimmulappa, R.K.2    Sethi, S.3
  • 173
    • 80054979844 scopus 로고    scopus 로고
    • Bioavailability and inter-conversion of sulforaphane and erucin in human subjects consuming broccoli sprouts or broccoli supplement in a crossover study design
    • Clarke JD, Hsu A, Riedl K et al (2011) Bioavailability and inter-conversion of sulforaphane and erucin in human subjects consuming broccoli sprouts or broccoli supplement in a crossover study design. Pharmacol Res 64:456-463
    • (2011) Pharmacol Res , vol.64 , pp. 456-463
    • Clarke, J.D.1    Hsu, A.2    Riedl, K.3
  • 174
    • 84855409443 scopus 로고    scopus 로고
    • Modulation of the metabolism of airborne pollutants by glucoraphanin-rich and sulforaphane-rich broccoli sprout beverages in Qidong
    • Kensler TW, Ng D, Carmella SG et al (2012) Modulation of the metabolism of airborne pollutants by glucoraphanin-rich and sulforaphane-rich broccoli sprout beverages in Qidong, China. Carcinogenesis 33:101-107
    • (2012) China. Carcinogenesis , vol.33 , pp. 101-107
    • Kensler, T.W.1    Ng, D.2    Carmella, S.G.3


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