Effects of phenethylisothiocyanate on the expression of glutathione S-transferases and hepatotoxicity induced by acetaminophen

Xenobiotica

Volumn 30, Issue 5, 2000, Pages 535-545

  Seo, K W ^a   Kim, J G ^a   Park, M ^a   Kim, T W ^a   Kim, H J ^a  

^a Korea Food and Drug Administration   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

GLUTATHIONE TRANSFERASE; MESSENGER RNA; PARACETAMOL; PHENETHYL ISOTHIOCYANATE; RNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHEMOPROPHYLAXIS; CONTROLLED STUDY; DOSE RESPONSE; DRUG ACTIVATION; DRUG ANTAGONISM; DRUG INDUCED DISEASE; DRUG INHIBITION; ENZYME ACTIVITY; GLUTATHIONE METABOLISM; LETHALITY; LIVER LEVEL; LIVER PROTECTION; LIVER TOXICITY; MALE; MOUSE; NONHUMAN; PROTEIN EXPRESSION; RAT;

EID: 0033899512     PISSN: 00498254     EISSN: None     Source Type: Journal    
DOI: 10.1080/004982500237532     Document Type: Article

References (50)

1. Dietary carcinogens and anticarcinogens
2. Liver necrosis from paracetamol
3. Chemical carcinogens and inhibitors of carcinogenesis in the human diet
4. Laboratory methods; A method for isolation of intact, translationally active ribonucleic acids
5. Methods for the quantitative morphologic analysis of tissues
6. Single-step method of RNa isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
7. 14C-acetaminophen in humans and laboratory animals
8. Evidence that acetaminophen and N-hydroxyacetaminophen form a common arylating intermediate, N-acetyl-p-benzoquinoneimine
9. N-acetyl-p-benzoquinoneimine; A cytochrome P450-mediated oxidation product of acetaminophen
10. Acute liver necrosis followin overdose of paracetamol
11. Species differences in hepatic glutathione depletion, covalent binding and hepatic necrosis after acetaminophen
12. Western blot analysis
13. Effect of phenethyl isothiocyanate on the metabolism of the tobacco-specific nitrosomine 4-(methylnitroamino)-1-(3-pyridyl)-1-butanone by cultured rat lung tissue
14. Species variation in toxication and detoxication of acetaminophen in vivo; a comparative study of biliary and urinary excretion of acetaminophen metabolites
15. Metabolic activation of 4-(methyl-nitrosamine)-1-(3-pyridyl)-1-butanone as measured by DNA alkylation in vitro and its inhibition by isothiocyanates
16. Structure-activity relationships of arylalkyl isothiocyanates for the inhibition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone metabolism and the modulation of xenobiotic-metabolizing enzymes in rats and mice
17. Effects of phenylhexyl isothiocyanate, a carcinogenesis inhibitor, on xenobiotic-metabolizing enzymes and nitrosamine metabolism in rats
18. Glutathione S-transferase; the first enzymatic step in mercapturic acid formation
19. Cytochrome P450 isozymes selectivity in the oxidation of acetaminophen
20. Dietary inhibitors of mutagenesis and carcinogenesis
21. The glutathione S-transferase supergene family. Regulation of GST and the contribution of the isoenzymes to cancer chemoprotection and drug resistance
22. Effect of cysteine pro-drugs on acetaminophen-induced hepatotoxicity
23. Glutathione S-transferase GSTM1 phenotypes and protection against cutaneous malignancy
24. Biochemical toxicology of acetaminophen
25. Paracetamol metabolism following overdosage; application of high performance liquid chromatography
26. Human μ-class glutathione S-transferases present in liver, skeletal muscle and testicular tissue
27. + RNA
28. Biochemical basis for dose response relationships in reactive intermediate toxicity
29. Acetaminophen-induced hepatic necrosis. VI. Metabolic disposition of toxic and nontoxic doses of acetaminophen
30. Cleavage of structural proteins during assembly of the head bacteriophage T4
31. Effect of oltipraz, α-tocopherol, β-carotene and phenethylisothiocyanate on rat oesophageal, gastric, colonic and hepatic glutathione, glutathione S-transferase and peroxidase
32. Protein measurement with the Folin phenol reagent
33. Glutathione transferases; structure and catalytic activity
34. Metabolic activation of drugs to toxic substances
35. Acetaminophen-induced hepatic necrosis. I. Role of drug metabolism
36. Acetaminophen-induced hepatic necrosis. IV. Protective role of glutathione
37. 6-methyluanine formation, and metabolism of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyidyl)-1-butanone in A/J mouse lung
38. Inhibition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced DNA adduct formation and tumorigenicity in the lung of F344 rats by dietary phenethyl isothiocyanate
39. Acetaminophen-induced hepatic necrosis, V. Correlation of hepatic necrosis, covalent binding and glutathione depletion in hamsters
40. An improvement of the single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
41. Studies of Y and Z, two hepatic cytoplasmic organic anion-binding proteins; Effect of drugs, chemicals, hormones, and cholestasis
42. Relations between hepatotoxicity and pharmaco-kinetics of paracetamol in rats and mice
43. The excretory function of bile
44. Mechanisms of inhibition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone bioactivation in mouse by dietary phenethyl isothiocyanate
45. Vegetables, fruit and cancer. I. Epidemiology
46. The human glutathione S-tranferases; a case control study of the incidence of the GST1 0 phenotype in patients with adenocarcinoma
47. Enzymatic method for quantitative determination of nanogram amounts of total and oxidized glutathione; Application to mammalian blood and other tissues
48. Glucosinolates
49. Dietary fiber, vegetables and colon cancer; a critical review and meta-analysis of the epidemiologic evidence
50. The effect of phenobarbital, probenecid and diethyl maleate on the pharmacokinetics and biliary excretion of ethacrynic acid in the rat