In vitro and in vivo anti-inflammatory activity of a seed preparation containing phenethylisothiocyanate

Journal of Pharmacology and Experimental Therapeutics

Volumn 317, Issue 1, 2006, Pages 326-333

  Dey, Moul ^a   Ribnicky, David ^a   Kurmukov, Anvar G ^a,b   Raskin, Ilya ^a  

^a RUTGERS UNIVERSITY   (United States)

^b Ministry of Health Uzbekistan   (Uzbekistan)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; CYTOKINE; INTERLEUKIN 1; NITRIC OXIDE SYNTHASE; PHENETHYL ISOTHIOCYANATE; PROSTAGLANDIN SYNTHASE;

ANIMAL CELL; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BARBAREA; CONTROLLED STUDY; DRUG INHIBITION; DRUG MECHANISM; DRUG MIXTURE; EDEMA; HYPERALGESIA; IN VITRO STUDY; IN VIVO STUDY; MACROPHAGE; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RAT;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BARBAREA; CELL LINE; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; EDEMA; GENE EXPRESSION; ISOTHIOCYANATES; MACROPHAGE ACTIVATION; MACROPHAGES; MICE; PLANT PREPARATIONS; RATS; RNA, MESSENGER; SEEDS;

EID: 33645112858     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.105.096511     Document Type: Article

References (34)

1. Baeuerle PA and Baltimore D (1996) NF-kappa B: ten years after. Cell 87:13-20.
2. Ben-Av P, Crofford LJ, Wilder RL, and Hla T (1995) Induction of vascular endothelial growth factor expression in synovial fibroblasts by prostaglandin E. and interleukin-1: a potential mechanism for inflammatory angiogenesis. FEBS Lett 372:83-87.
3. Callejas NA, Fernández-Martínez A, Castrillo A, Boscá L, and Martín-Sanz P (2003) Selective inhibitors of cyclooxygenase-2 delay the activation of nuclear factor κB and attenuate the expression of inflammatory genes in murine macrophages treated with lipopolysaccharide. Mol Pharmacol 63:671-677.
4. Chen YH, Dail HJ, and Chang HP (2003) Suppression of inducible nitric oxide production by indole and isothiocyanate derivatives from Brassica plants in stimulated macrophages. Planta Med 69:696-700.
5. Esposito K and Giugliano D (2004) The metabolic syndrome and inflammation: association or causation? Nutr Metab Cardiovasc Dis 14:228-232.
6. Gerhauser C, Klimo K, Heiss E, Neumann I, Gamal-Eldeen A, Knauft J, Liu GY, Sitthimonchai S, and Frank N (2003) Mechanism-based in vitro screening of potential cancer chemopreventive agents. Mutat Res 523-524:163-172.
7. Goodwin JS and Ceuppens J (1983) Regulation of the immune response by prostaglandins. J Clin Immunol 3:295-314.
8. Hantraye P, Brouillet E, Ferrante R, Palfi S, Dolan R, Matthews RT, and Beal MF (1996) Inhibition of neuronal nitric oxide synthase prevents MPTP-induced parkinsonism in baboons. Nat Med 2:1017-1021.
9. Hecht SS (1997) Tobacco and cancer: approaches using carcinogen biomarkers and chemoprevention. Ann NY Acad Sci 833:91-111.
10. Heiss E, Herhaus C, Klimo K, Bartsch H, and Gerhäuser C (2001) Nuclear factor kappa B is a molecular target for sulforaphane-mediated anti-inflammatory mechanisms. J Biol Chem 276:32008-32015.
11. Hooper DC, Bagasra O, Marini JC, Zborek A, Ohnishi ST, Kean R, Champion JM, Sarker AB, Bobroski L, Farber JL, et al. (1997) Prevention of experimental allergic encephalomyelitis by targeting nitric oxide and peroxynitrite: implications for the treatment of multiple sclerosis. Proc Natl Acad Sci USA 94:2328-2333.
12. Juni P, Reichenbach S, and Egger M (2005) COX2 inhibitors, traditional NSAIDs and the heart. Br Med J 330:1342-1343.
13. Krakauer T (2004) Molecular therapeutic targets in inflammation: cyclooxygenase and NFκβ. Curr Drug Targets 3:317-324.
14. Kwon G, Hill JR, Corbett JA, and McDaniel ML (1997) Effects of aspirin on nitric oxide formation and de novo protein synthesis by RINm5F cells and rat islets. Mol Pharmacol 52:398-405.
15. Langman MJS (1998) Ulcer complications and NSAIDs. Am J Med 84 (Suppl):15-19.
16. Lee AK, Sung SH, Kim YC, and Kim SG (2003) Inhibition of lipopolysaccharide-inducible nitric oxide synthase, TNF-alpha and COX-2 expression by sauchinone effects on I-kappaBalpha phosphorylation, C/EBP and AP-1 activation. Br J Pharmacol 139: 11-20.
17. Martin D and Near SL (1995) Protective effect of the interleukin-1 receptor antagonist (IL-1ra) on experimental allergic encephalomyelitis in rats. J Neuroimmunol 61:241-246.
18. Mosmann T (1983) Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods 65:55-63.
19. Ohshima H and Bartsch H (1994) Chronic infections and inflammatory processes as cancer risk factors: possible role of nitric oxide in carcinogenesis. Mutat Res 305:253-264.
20. Pathak SK, Sharma RA, Steward WP, Mellon JK, Griffiths TR, and Gescher AJ (2005) Oxidative stress and cyclooxygenase activity in prostate carcinogenesis: targets for chemopreventive strategies. Eur J Cancer 41:61-70.
21. Press WH, Teukolsky SA, Vetterling WT, and Flannery BP (1992) Numerical Recipes, 2nd ed, Cambridge University Press, Cambridge, UK.
22. Ribnicky DM, Poulev A, Henry E, and Raskin I (2001) Seed of Barbarea verna as a rich source of phenethyl isothiocyanate to provide natural protection from environmental and dietary toxins. J Nutraceuticals Funct Med Foods 3:43-65.
23. Rose P, Won YK, Ong CN, and Whiteman M (2005) β-Phenylethyl and 8-methylsulphinyloctyl isothiocyanates, constituents of watercress, suppress LPS induced production of nitric oxide and prostaglandin E2 in RAW 264.7 macrophages. Nitric Oxide 12:237-243.
24. Sheng H, Shao J, Morrow JD, Beauchamp RD, and DuBois RN (1998) Modulation of apoptosis and Bcl-2 expression by prostaglandin E2 in human colon cancer cells. Cancer Res 58:362-366.
25. Simonian NA and Coyle JT (1996) Oxidative stress in neurodegenerative diseases. Annu Rev Pharmacol Toxicol 36:83-106.
26. Sporn MB and Roberts AB (1986) Peptide growth factors and inflammation, tissue repair and cancer. J Clin Investig 78:329-332.
27. Steinbach G, Lynch PM, Phillips RK, Wallace MH, Hawk E, and Gordon GB (2000) The effect of celecoxib, a cyclooxygenase-2 inhibitor, in familial adenomatous polyposis. N Engl J Med 342:1946-1952.
28. Stoewsand GS (1995) Bioactive organosulfur phytochemicals in Brassica oleracea vegetables - a review. Food Chem Toxicol 33:537-543.
29. Subbaramaiah K, Zakim D, Weksler BB, and Dannenberg AJ (1997) Inhibition of cyclooxygenase: a novel approach to cancer prevention. Proc Soc Exp Biol Med 216:201-210.
30. Takahashi M, Fukuda K, Ohata T, Sugimura T, and Wakabayashi K (1997) Increased expression of inducible and endothelial constitutive nitric oxide synthases in rat colon tumors induced by azoxymethane. Cancer Res 57:1233-1237.
31. Tukey JW (1972) Robust Estimates of Location: Survey and Advances, Princeton University Press, Princeton, NJ.
32. von Knethen A and Brune B (2000) Superinduction of cyclooxygenase-2 by NO(*) and agonist challenge involves transcriptional regulation mediated by AP-1 activation. Biochemistry 39:1532-1540.
33. Winer J, Jung CK, Shackel I, and Williams PM (1999) Development and validation of real-time quantitative reverse transcriptase-polymerase chain reaction for monitoring gene expression in cardiac myocytes in vitro. Anal Biochem 270:41-49.
34. Yamamoto Y and Gaynor RB (2004) IkappaB kinases: key regulators of the NF-kappaB pathway. Trends Biochem Sci 29:72-79.