Chemoprevention of familial adenomatous polyposis in ApcMin/+ mice by phenethyl isothiocyanate (PEITC)

Molecular Carcinogenesis

Volumn 47, Issue 5, 2008, Pages 321-325

  Tin, Oo Khor ^a,b   Cheung, William Ka Lung ^a,b   Prawan, Auemduan ^a,b   Reddy, Bandaru S ^a,b   Kong, Ah Ng Tony ^a,b  

^a RUTGERS UNIVERSITY   (United States)

^b RUTGERS UNIVERSITY   (United States)

Author keywords

ApcMin +; Chemoprevention; Colon cancer; PEITC; Polyps

Indexed keywords

APC PROTEIN; CASPASE 3; CASPASE 7; CYCLIN A; CYCLIN D1; CYCLIN E; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PHENETHYL ISOTHIOCYANATE; ANTINEOPLASTIC AGENT; CASPASE; ISOTHIOCYANIC ACID DERIVATIVE; MITOGEN ACTIVATED PROTEIN KINASE;

ADENOMATOUS POLYP; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CANCER CHEMOTHERAPY; CANCER PREVENTION; CELL CYCLE ARREST; COLON CANCER; CONTROLLED STUDY; DIET SUPPLEMENTATION; DRUG EFFICACY; ENZYME ACTIVATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; TUMOR VOLUME; WESTERN BLOTTING; ANIMAL; CELL CYCLE; CHEMOPROPHYLAXIS; COLON POLYPOSIS; DRUG EFFECT; GENETICS; INTESTINE TUMOR; METABOLISM; MOUSE MUTANT; PHYSIOLOGY; TUMOR SUPPRESSOR GENE;

MUS; NASTURTIUM OFFICINALE; RODENTIA;

ADENOMATOUS POLYPOSIS COLI; ANIMALS; ANTICARCINOGENIC AGENTS; APOPTOSIS; BLOTTING, WESTERN; CASPASES; CELL CYCLE; CHEMOPREVENTION; DIETARY SUPPLEMENTS; GENES, APC; INTESTINAL NEOPLASMS; ISOTHIOCYANATES; MICE; MICE, KNOCKOUT; MITOGEN-ACTIVATED PROTEIN KINASES;

EID: 42949121566     PISSN: 08991987     EISSN: 10982744     Source Type: Journal    
DOI: 10.1002/mc.20390     Document Type: Article

References (23)

1. Galiatsatos P, Foulkes WD. Familial adenomatous polyposis. Am J Gastroenterol 2006;1012:385-398.
2. Steinmetz KA, Potter JD. Vegetables, fruit, and cancer. I. Epidemiology. Cancer Causes Control 1991;25:325-357.
3. Zhang Y, Kensler TW, Cho CG, et al. Anticarcinogenic activities of sulforaphane and structurally related synthetic norbornyl isothiocyanates. Proc Natl Acad Sci USA 1994;918:3147-3150.
4. Hu R, Khor TO, Shen G, et al. Cancer chemoprevention of intestinal polyposis in ApcMin/+ mice by sulforaphane, a natural product derived from cruciferous vegetable. Carcinogenesis 2006;2710:2038-2046.
5. Chung FL, Conaway CC, Rao CV, et al. Chemoprevention of colonic aberrant crypt foci in Fischer rats by sulforaphane and phenethyl isothiocyanate. Carcinogenesis 2000;2112:2287-2291.
6. Hu R, Kim BR, Chen C, et al. The roles of JNK and apoptotic signaling pathways in PEITC-mediated responses in human HT-29 colon adenocarcinoma cells. Carcinogenesis 2003;248:1361-1367.
7. Visanji JM, Duthie SJ, Pirie L, et al. Dietary isothiocyanates inhibit Caco-2 cell proliferation and induce G2/M phase cell cycle arrest, DNA damage, and G2/M checkpoint activation. J Nutr 2004;13411:3121-3126.
8. Hecht SS, Upadhyaya P, Wang M, et al. Inhibition of lung tumorigenesis in A/J mice by N-acetyl-S-(N-2-phenethylthiocarbamoyl)-L- cysteine and myo-inositol, individually and in combination. Carcinogenesis 2002;239:1455-1461.
9. Khor TO, Keum YS, Lin W, et al. Combined inhibitory effects of curcumin and phenethyl isothiocyanate on the growth of human PC-3 prostate xenografts in immunodeficient mice. Cancer Res 2006;662:613-621.
10. Xiao D, Zeng Y, Choi S, et al. Caspase-dependent apoptosis induction by phenethyl isothiocyanate, a cruciferous vegetable-derived cancer chemopreventive agent, is mediated by Bak and Bax. Clin Cancer Res 2005;117:2670-2679.
11. Conaway CC, Wang CX, Pittman B, et al. Phenethyl isothiocyanate and sulforaphane and their N-acetylcysteine conjugates inhibit malignant progression of lung adenomas induced by tobacco carcinogens in A/J mice. Cancer Res 2005;6518:8548-8557.
12. Plate AY, Gallaher DD. Effects of indole-3-carbinol and phenethyl isothiocyanate on colon carcinogenesis induced by azoxymethane in rats. Carcinogenesis 2006;272:287-292.
13. Moser AR, Pitot HC, Dove WF. A dominant mutation that predisposes to multiple intestinal neoplasia in the mouse. Science 1990;2474940:322-324.
14. Powell SM, Zilz N, Beazer-Barclay Y, et al. APC mutations occur early during colorectal tumorigenesis. Nature 1992;3596392:235-237.
15. Zhurinsky J, Shtutman M, Ben-Ze'ev A. Plakoglobin and beta-catenin: Protein interactions, regulation and biological roles. J Cell Sci 2000;113:3127-3139.
16. Tetsu O, McCormick F. Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells. Nature 1999;3986726:422-426.
17. Xu C, Shen G, Chen C, et al. Suppression of NF-kappaB and NF-kappaB-regulated gene expression by sulforaphane and PEITC through IkappaBalpha, IKK pathway in human prostate cancer PC-3 cells. Oncogene 2005;2428:4486-4495.
18. Chiao JW, Wu H, Ramaswamy G, et al. Ingestion of an isothiocyanate metabolite from cruciferous vegetables inhibits growth of human prostate cancer cell xenografts by apoptosis and cell cycle arrest. Carcinogenesis 2004;258:1403-1408.
19. Yang YM, Jhanwar-Uniyal M, Schwartz J, et al. N-Acetylcysteine conjugate of phenethyl isothiocyanate enhances apoptosis in growth-stimulated human lung cells. Cancer Res 2005;6518:8538-8547.
20. Tang L, Zhang Y. Mitochondria are the primary target in isothiocyanate-induced apoptosis in human bladder cancer cells. Mol Cancer Ther 2005;48:1250-1259.
21. Kuang YF, Chen YH. Induction of apoptosis in a non-small cell human lung cancer cell line by isothiocyanates is associated with P53 and P21. Food Chem Toxicol 2004;4210:1711-1718.
22. Myzak MC, Dashwood WM, Orner GA, et al. Sulforaphane inhibits histone deacetylase in vivo and suppresses tumorigenesis in Apc-minus mice. FASEB J 2006;20:506-508.
23. Wang LG, Beklemisheva A, Liu XM, et al. Dual action on promoter demethylation and chromatin by an isothiocyanate restored GSTP1 silenced in prostate cancer. Mol Carcinog 2007;46:24-31.