Quantitative determination of dithiocarbamates in human plasma, serum, erythrocytes and urine: Pharmacokinetics of broccoli sprout isothiocyanates in humans

Clinica Chimica Acta

Volumn 316, Issue 1-2, 2002, Pages 43-53

  Ye, Lingxiang ^a   Dinkova Kostova, Albena T ^a   Wade, Kristina L ^a   Zhang, Yuesheng ^a   Shapiro, Theresa A ^a   Talalay, Paul ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Broccoli sprouts; Dithiocarbamates; Glucosinolates; Isothiocyanates; Myrosinase; Pharmacokinetics; Sulforaphane

Indexed keywords

BENZENE DERIVATIVE; DITHIOCARBAMIC ACID; FUNGICIDE; GLUCOSINOLATE; INSECTICIDE; ISOTHIOCYANIC ACID DERIVATIVE; MACROGOL; PESTICIDE; PROTEIN; RUBBER; SULFORAPHANE;

ARTICLE; CANCER RISK; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYCLIZATION; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DETERMINATION; DRUG EXCRETION; DRUG HALF LIFE; ERYTHROCYTE; HUMAN; HUMAN CELL; MALE; NORMAL HUMAN; PLANT; PLASMA; POLYMERIZATION; PRECIPITATION; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; SERUM; SOLID PHASE EXTRACTION; ULTRAFILTRATION; URINALYSIS; VEGETABLE;

ANTICARCINOGENIC AGENTS; BRASSICA; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CLINICAL CHEMISTRY TESTS; ERYTHROCYTES; HUMANS; INDICATORS AND REAGENTS; ISOTHIOCYANATES; PLANT EXTRACTS; PLASMA; SENSITIVITY AND SPECIFICITY; SULFHYDRYL COMPOUNDS; THIOCARBAMATES; THIONES; URINE;

BRASSICA OLERACEA VAR. BOTRYTIS;

EID: 0036135910     PISSN: 00098981     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0009-8981(01)00727-6     Document Type: Article

References (28)

1. The chemical diversity and distribution of glucosinolates and isothiocyanates among plants
2. Human metabolism and excretion of cancer chemoprotective glucosinolates and isothiocyanates of cruciferous vegetables
3. Chemoprotective glucosinolates and isothiocyanates of broccoli sprouts: Metabolism and excretion in humans
4. Occupational contact dermatitis from pesticides: Patch testing procedure
5. Frequency, spectrum and occupational relevance to type IV allergies to rubber chemicals
6. Allergic and irritant reactions to rubber gloves in medical health services
7. A major inducer of anticarcinogenic-protective enzymes from broccoli: Isolation and elucidation of structure
8. Anticarcinogenic activities of organic isothiocyanates: Chemistry and mechanisms
9. Chemoprevention by isothiocyanates
10. Inhibition of carcinogenesis by isothiocyanates
11. The metabolism of benzyl isothiocyanate and its cysteine conjugate
12. Metabolism of naturally occurring isothiocyanates in the rat
13. Spectroscopic quantitation of organic isothiocyanates by cyclocondensation with vicinal dithiols
14. Quantitative determination of isothiocyanates, dithiocarbamates, carbon disulfide, and related thiocarbonyl compounds by cyclocondensation with 1,2-benzenedithiol
15. Comprehensive chromatographic and spectroscopic methods for the separation and identification of intact glucosinolates
16. Broccoli sprouts: An exceptionally rich source of inducers of enzymes that protect against chemical carcinogens
17. Total isothiocyanate contents in cooked vegetables frequently consumed in Singapore
18. Using isothiocyanate excretion as a biological marker of Brassica vegetable consumption in epidemiological studies: Evaluating the source of variability
19. Urinary total isothiocyanate (ITC) in a population-based sample of middle-aged and older Chinese in Singapore: Relationship with dietary total ITC and glutathione S-transferase M1/T1/P1 genotypes
20. Isothiocyanates, glutathione S-transferase M1 and T1 polymorphisms, and lung cancer risk: A prospective study of men in Shanghai, China
21. A urinary biomarker for uptake of dietary isothiocyanates in humans
22. An unusual case of 'uncompetitive activation' by ascorbic acid: Purification and kinetic properties of a myrosinase from Raphanus sativus seedlings
23. Spectrophotometric studies: II. Preparation from washed blood cells, nitric oxide hemoglobin and sulfhemoglobin
24. HPLC-based method for measuring total isothiocyanates in human plasma
25. Role of glutathione in the accumulation of anticarcinogenic isothiocyanates and their glutathione conjugates by murine hepatoma cells
26. Mechanism of differential potencies of isothiocyanates as inducers of anticarcinogenic Phase 2 enzymes