Nutrient isothiocyanates covalently modify and inhibit the inflammatory cytokine macrophage migration inhibitory factor (MIF)

Biochemical Journal

Volumn 423, Issue 3, 2009, Pages 315-321

  Cross, Janet V ^a   Rady, Joshua M ^a   Foss Jr , Frank W ^b,c   Lyons, Charles E ^a   Macdonald, Timothy L ^a   Templeton, Dennis J ^a  

^a UNIVERSITY OF VIRGINIA   (United States)

^b UNIVERSITY OF VIRGINIA   (United States)

^c UNIVERSITY OF TEXAS AT ARLINGTON   (United States)

Author keywords

Cancer; Cytokine; Inflammation; Isothiocyanate (ITC); Macrophage migration inhibitory factor (MIF)Tautomerase

Indexed keywords

CANCER; CELLULAR PROTEINS; CYTOKINE; CYTOKINES; ELECTROPHILES; IN-VIVO; INFLAMMATION; INFLAMMATORY DISEASE; INTACT CELLS; ISOTHIOCYANATE (ITC); ISOTHIOCYANATES; MALIGNANT CELLS; MIGRATION INHIBITORY FACTORS; N-TERMINALS; PROLINE RESIDUES; PROTEOMICS; TAUTOMERASE; THERAPEUTIC STRATEGY;

CELL MEMBRANES; GENE EXPRESSION; GROWTH KINETICS; MOLECULAR BIOLOGY; NUTRIENTS; PATHOLOGY; PROTEINS;

MACROPHAGES;

ISOMERASE; ISOTHIOCYANIC ACID DERIVATIVE; MIGRATION INHIBITION FACTOR; PROLINE; TAUTOMERASE; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER INHIBITION; ENZYME INHIBITION; GENE EXPRESSION; HUMAN; HUMAN CELL; INFLAMMATION; INFLAMMATORY DISEASE; MALIGNANT NEOPLASTIC DISEASE; PRIORITY JOURNAL; PROTEIN MODIFICATION; PROTEOMICS;

HELA CELLS; HUMANS; INFLAMMATION; INTRAMOLECULAR OXIDOREDUCTASES; ISOTHIOCYANATES; MACROPHAGE MIGRATION-INHIBITORY FACTORS; NEOPLASMS; PROTEIN PROCESSING, POST-TRANSLATIONAL;

EID: 70350112583     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20091170     Document Type: Article

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