-
2
-
-
0034718294
-
Isothiocyanates, glutathione S-transferase M1 and T1 polymorphisms, and lung-cancer risk: a prospective study of men in Shanghai
-
London,S.J. et al. (2000) Isothiocyanates, glutathione S-transferase M1 and T1 polymorphisms, and lung-cancer risk: a prospective study of men in Shanghai, China. Lancet, 356, 724-729.
-
(2000)
China. Lancet
, vol.356
, pp. 724-729
-
-
London, S.J.1
-
3
-
-
34447120145
-
The role of protein binding in induction of apoptosis by phenethyl isothiocyanate and sulforaphane in human non-small lung cancer cells
-
Mi,L. et al. (2007) The role of protein binding in induction of apoptosis by phenethyl isothiocyanate and sulforaphane in human non-small lung cancer cells. Cancer Res., 67, 6409-6416.
-
(2007)
Cancer Res.
, vol.67
, pp. 6409-6416
-
-
Mi, L.1
-
4
-
-
0343517520
-
Genotoxic effects of allyl isothiocyanate (AITC) and phenethyl isothiocyanate (PEITC)
-
Kassie,F. et al. (2000) Genotoxic effects of allyl isothiocyanate (AITC) and phenethyl isothiocyanate (PEITC). Chem. Biol. Interact., 127, 163-180.
-
(2000)
Chem. Biol. Interact.
, vol.127
, pp. 163-180
-
-
Kassie, F.1
-
5
-
-
64549161577
-
Biological redox switches
-
Palumaa,P. (2009) Biological redox switches. Antioxid. Redox Signal, 11, 981-983.
-
(2009)
Antioxid. Redox Signal
, vol.11
, pp. 981-983
-
-
Palumaa, P.1
-
6
-
-
21244461140
-
Sulforaphane-induced cell death in human prostate cancer cells is initiated by reactive oxygen species
-
Singh,S.V. et al. (2005) Sulforaphane-induced cell death in human prostate cancer cells is initiated by reactive oxygen species. J. Biol. Chem., 280, 19911-19924.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 19911-19924
-
-
Singh, S.V.1
-
7
-
-
52049113028
-
Covalent binding to tubulin by isothiocyanates A mechanism of cell growth arrest and apoptosis
-
Mi,L. et al. (2008) Covalent binding to tubulin by isothiocyanates. A mechanism of cell growth arrest and apoptosis. J. Biol. Chem., 283, 22136-22146.
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 22136-22146
-
-
Mi, L.1
-
8
-
-
70350112583
-
Nutrient isothiocyanates covalently modify and inhibit the inflammatory cytokine macrophage migration inhibitory factor (MIF)
-
Cross,J.V. et al. (2009) Nutrient isothiocyanates covalently modify and inhibit the inflammatory cytokine macrophage migration inhibitory factor (MIF). Biochem. J., 423, 315-321.
-
(2009)
Biochem. J.
, vol.423
, pp. 315-321
-
-
Cross, J.V.1
-
9
-
-
70350062352
-
A new class of isothiocyanate-based irreversible inhibitors of macrophage migration inhibitory factor
-
Ouertatani-Sakouhi,H. et al. (2009) A new class of isothiocyanate-based irreversible inhibitors of macrophage migration inhibitory factor. Biochemistry, 48, 9858-9870.
-
(2009)
Biochemistry
, vol.48
, pp. 9858-9870
-
-
Ouertatani-Sakouhi, H.1
-
10
-
-
70450248452
-
Direct modification of the proinflammatory cytokine macrophage migration inhibitory factor by dietary isothiocyanates
-
Brown,K.K. et al. (2009) Direct modification of the proinflammatory cytokine macrophage migration inhibitory factor by dietary isothiocyanates. J. Biol. Chem., 284, 32425-32433.
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 32425-32433
-
-
Brown, K.K.1
-
11
-
-
0028898483
-
Reversible conjugation of isothiocyanates with glutathione catalyzed by human glutathione transferases
-
Zhang,Y. et al. (1995) Reversible conjugation of isothiocyanates with glutathione catalyzed by human glutathione transferases. Biochem. Biophys. Res. Commun., 206, 748-755.
-
(1995)
Biochem. Biophys. Res. Commun.
, vol.206
, pp. 748-755
-
-
Zhang, Y.1
-
12
-
-
0017566779
-
Glutathione S-transferases in the metabolism of foreign compounds
-
Hayakawa,T. (1977) Glutathione S-transferases in the metabolism of foreign compounds. Ecotoxicol. Environ. Saf., 1, 305-309.
-
(1977)
Ecotoxicol. Environ. Saf.
, vol.1
, pp. 305-309
-
-
Hayakawa, T.1
-
13
-
-
0032532317
-
Mechanism of differential potencies of isothiocyanates as inducers of anticarcinogenic Phase 2 enzymes
-
Zhang,Y.S. et al. (1998) Mechanism of differential potencies of isothiocyanates as inducers of anticarcinogenic Phase 2 enzymes. Cancer Res., 58, 4632-4639.
-
(1998)
Cancer Res.
, vol.58
, pp. 4632-4639
-
-
Zhang, Y.S.1
-
14
-
-
0025077076
-
Distribution and metabolism of the natural anticarcinogen phenethyl isothiocyanate in A/J mice
-
Eklind,K.I. et al. (1990) Distribution and metabolism of the natural anticarcinogen phenethyl isothiocyanate in A/J mice. Carcinogenesis, 11, 2033-2036.
-
(1990)
Carcinogenesis
, vol.11
, pp. 2033-2036
-
-
Eklind, K.I.1
-
15
-
-
0032406798
-
Human metabolism and excretion of cancer chemoprotective glucosinolates and isothiocyanates of cruciferous vegetables
-
Shapiro,T.A. et al. (1998) Human metabolism and excretion of cancer chemoprotective glucosinolates and isothiocyanates of cruciferous vegetables. Cancer Epidemiol. Biomarkers Prev., 7, 1091-1100.
-
(1998)
Cancer Epidemiol. Biomarkers Prev.
, vol.7
, pp. 1091-1100
-
-
Shapiro, T.A.1
-
16
-
-
77955563428
-
A cautionary note on using N-acetylcysteine as an antagonist to assess isothiocyanate-induced ROS-mediated apoptosis
-
Mi,L. et al. (2010) A cautionary note on using N-acetylcysteine as an antagonist to assess isothiocyanate-induced ROS-mediated apoptosis. Anal. Biochem., 405, 269-271.
-
(2010)
Anal. Biochem.
, vol.405
, pp. 269-271
-
-
Mi, L.1
-
17
-
-
79251567380
-
Isothiocyanates inhibit proteasome activity and proliferation of multiple myeloma cells
-
Mi,L. et al. (2010) Isothiocyanates inhibit proteasome activity and proliferation of multiple myeloma cells. Carcinogenesis, 32, 216-223.
-
(2010)
Carcinogenesis
, vol.32
, pp. 216-223
-
-
Mi, L.1
-
18
-
-
0034125712
-
Role of glutathione in the accumulation of anticarcinogenic isothiocyanates and their glutathione conjugates by murine hepatoma cells
-
Zhang,Y. (2000) Role of glutathione in the accumulation of anticarcinogenic isothiocyanates and their glutathione conjugates by murine hepatoma cells. Carcinogenesis, 21, 1175-1183.
-
(2000)
Carcinogenesis
, vol.21
, pp. 1175-1183
-
-
Zhang, Y.1
-
19
-
-
0018395934
-
Reaction of Cysteine, its derivatives, glutathione, coenzyme A, and dihydrolipoic acid with isothiocyanates
-
Podhradský,D. et al. (1979) Reaction of Cysteine, its derivatives, glutathione, coenzyme A, and dihydrolipoic acid with isothiocyanates. Experientia, 35, 154-155.
-
(1979)
Experientia
, vol.35
, pp. 154-155
-
-
Podhradský, D.1
-
20
-
-
9544258372
-
Inhibition of N-nitrosodimethylamine demethylase in rat and human liver microsomes by isothiocyanates and their glutathione, L-cysteine, and N-acetyl-L-cysteine conjugates
-
Jiao,D. et al. (1996) Inhibition of N-nitrosodimethylamine demethylase in rat and human liver microsomes by isothiocyanates and their glutathione, L-cysteine, and N-acetyl-L-cysteine conjugates. Chem. Res. Toxicol., 9, 932-938.
-
(1996)
Chem. Res. Toxicol.
, vol.9
, pp. 932-938
-
-
Jiao, D.1
-
21
-
-
24944480252
-
Phenethyl isothiocyanate and sulforaphane and their N-acetylcysteine conjugates inhibit malignant progression of lung adenomas induced by tobacco carcinogens in A/J mice
-
Conaway,C.C. et al. (2005) Phenethyl isothiocyanate and sulforaphane and their N-acetylcysteine conjugates inhibit malignant progression of lung adenomas induced by tobacco carcinogens in A/J mice. Cancer Res., 65, 8548-8557.
-
(2005)
Cancer Res.
, vol.65
, pp. 8548-8557
-
-
Conaway, C.C.1
-
22
-
-
33646087882
-
The principal urinary metabolites of dietary isothiocyanates, N-acetylcysteine conjugates, elicit the same anti-proliferative response as their parent compounds in human bladder cancer cells
-
Tang,L. et al. (2006) The principal urinary metabolites of dietary isothiocyanates, N-acetylcysteine conjugates, elicit the same anti-proliferative response as their parent compounds in human bladder cancer cells. Anticancer Drugs, 17, 297-305.
-
(2006)
Anticancer Drugs
, vol.17
, pp. 297-305
-
-
Tang, L.1
-
23
-
-
0002611256
-
Use of isothiocyanates as reporter groups in modification of enzymes
-
Fox, J.L. et al. (eds) Dekker, New York, NY
-
Drobnica,L. et al. (1976) Use of isothiocyanates as "reporter" groups in modification of enzymes. In Fox,J.L. et al. (eds) Protein Structure and Evolution, Dekker, New York, NY, pp. 105-115.
-
(1976)
Protein Structure and Evolution
, pp. 105-115
-
-
Drobnica, L.1
-
24
-
-
0000311445
-
Interaction of allyl isothiocyanate with mustard 12S protein
-
Murthy,N.V.K.K. et al. (1986) Interaction of allyl isothiocyanate with mustard 12S protein. J. Agric. Food Chem., 34, 448-452.
-
(1986)
J. Agric. Food Chem.
, vol.34
, pp. 448-452
-
-
Murthy, N.V.K.K.1
-
25
-
-
0019877708
-
Electrostatic influence of local cysteine environments on disulfide exchange kinetics
-
Snyder,G.H. et al. (1981) Electrostatic influence of local cysteine environments on disulfide exchange kinetics. Biochemistry, 20, 6509-6519.
-
(1981)
Biochemistry
, vol.20
, pp. 6509-6519
-
-
Snyder, G.H.1
-
26
-
-
0037111511
-
Internal dynamics and ionization states of the macrophage migration inhibitory factor: comparison between wild-type and mutant forms
-
Soares,T.A. et al. (2002) Internal dynamics and ionization states of the macrophage migration inhibitory factor: comparison between wild-type and mutant forms. Biopolymers, 65, 313-323.
-
(2002)
Biopolymers
, vol.65
, pp. 313-323
-
-
Soares, T.A.1
-
27
-
-
72449180503
-
Protein cysteine modifications: (2) reactivity specificity and topics of medicinal chemistry and protein engineering
-
Nagahara,N. et al. (2009) Protein cysteine modifications: (2) reactivity specificity and topics of medicinal chemistry and protein engineering. Curr. Med. Chem., 16, 4490-4501.
-
(2009)
Curr. Med. Chem.
, vol.16
, pp. 4490-4501
-
-
Nagahara, N.1
-
28
-
-
0036852609
-
Covalent modification of amino acid nucleophiles by the lipid peroxidation products 4-hydroxy-2-nonenal and 4-oxo-2-nonenal
-
Doorn,J.A. et al. (2002) Covalent modification of amino acid nucleophiles by the lipid peroxidation products 4-hydroxy-2-nonenal and 4-oxo-2-nonenal. Chem. Res. Toxicol., 15, 1445-1450.
-
(2002)
Chem. Res. Toxicol.
, vol.15
, pp. 1445-1450
-
-
Doorn, J.A.1
-
29
-
-
38949099990
-
Mechanism-based inactivation of human cytochromes p450s: experimental characterization, reactive intermediates, and clinical implications
-
Hollenberg,P.F. et al. (2008) Mechanism-based inactivation of human cytochromes p450s: experimental characterization, reactive intermediates, and clinical implications. Chem. Res. Toxicol., 21, 189-205.
-
(2008)
Chem. Res. Toxicol.
, vol.21
, pp. 189-205
-
-
Hollenberg, P.F.1
-
30
-
-
0021254807
-
Mechanism-based enzymes inactivators
-
Rando,R.R. (1984) Mechanism-based enzymes inactivators. Pharmacol. Rev., 36, 111-142.
-
(1984)
Pharmacol. Rev.
, vol.36
, pp. 111-142
-
-
Rando, R.R.1
-
31
-
-
0035912861
-
Spectral studies of tert-butyl isothiocyanate-inactivated P450 2E1
-
Kent,U.M. et al. (2001) Spectral studies of tert-butyl isothiocyanate-inactivated P450 2E1. Biochemistry, 40, 7253-7261.
-
(2001)
Biochemistry
, vol.40
, pp. 7253-7261
-
-
Kent, U.M.1
-
32
-
-
33645303201
-
Effects of benzyl and phenethyl isothiocyanate on P450s 2A6 and 2A13: potential for chemoprevention in smokers
-
von Weymarn,L.B. et al. (2006) Effects of benzyl and phenethyl isothiocyanate on P450s 2A6 and 2A13: potential for chemoprevention in smokers. Carcinogenesis, 27, 782-790.
-
(2006)
Carcinogenesis
, vol.27
, pp. 782-790
-
-
von Weymarn, L.B.1
-
33
-
-
0029909016
-
Enzyme induction and comparative oxidative desulfuration of isothiocyanates to isocyanates
-
Lee,M.S. (1996) Enzyme induction and comparative oxidative desulfuration of isothiocyanates to isocyanates. Chem. Res. Toxicol., 9, 1072-1078.
-
(1996)
Chem. Res. Toxicol.
, vol.9
, pp. 1072-1078
-
-
Lee, M.S.1
-
34
-
-
55949104371
-
Quantification of sulforaphane mercapturic acid pathway conjugates in human urine by high-performance liquid chromatography and isotope-dilution tandem mass spectrometry
-
Egner,P.A. et al. (2008) Quantification of sulforaphane mercapturic acid pathway conjugates in human urine by high-performance liquid chromatography and isotope-dilution tandem mass spectrometry. Chem. Res. Toxicol., 21, 1991-1996.
-
(2008)
Chem. Res. Toxicol.
, vol.21
, pp. 1991-1996
-
-
Egner, P.A.1
-
35
-
-
33344469643
-
Oxidative and electrophilic stresses activate Nrf2 through inhibition of ubiquitination activity of Keap1
-
Kobayashi,A. et al. (2006) Oxidative and electrophilic stresses activate Nrf2 through inhibition of ubiquitination activity of Keap1. Mol. Cell. Biol., 26, 221-229.
-
(2006)
Mol. Cell. Biol.
, vol.26
, pp. 221-229
-
-
Kobayashi, A.1
-
36
-
-
0037015035
-
Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants
-
Dinkova-Kostova,A.T. et al. (2002) Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants. Proc. Natl Acad. Sci. USA, 99, 11908-11913.
-
(2002)
Proc. Natl Acad. Sci. USA
, vol.99
, pp. 11908-11913
-
-
Dinkova-Kostova, A.T.1
-
37
-
-
33344463325
-
Keap1 recruits Neh2 through binding to ETGE and DLG motifs: characterization of the two-site molecular recognition model
-
Tong,K.I. et al. (2006) Keap1 recruits Neh2 through binding to ETGE and DLG motifs: characterization of the two-site molecular recognition model. Mol. Cell. Biol., 26, 2887-2900.
-
(2006)
Mol. Cell. Biol.
, vol.26
, pp. 2887-2900
-
-
Tong, K.I.1
-
38
-
-
42149196050
-
Physiological significance of reactive cysteine residues of Keap1 in determining Nrf2 activity
-
Yamamoto,T. et al. (2008) Physiological significance of reactive cysteine residues of Keap1 in determining Nrf2 activity. Mol. Cell. Biol., 28, 2758-2770.
-
(2008)
Mol. Cell. Biol.
, vol.28
, pp. 2758-2770
-
-
Yamamoto, T.1
-
39
-
-
58249117780
-
The antioxidant defense system Keap1-Nrf2 comprises a multiple sensing mechanism for responding to a wide range of chemical compounds
-
Kobayashi,M. et al. (2009) The antioxidant defense system Keap1-Nrf2 comprises a multiple sensing mechanism for responding to a wide range of chemical compounds. Mol. Cell. Biol, 29, 493-502.
-
(2009)
Mol. Cell. Biol
, vol.29
, pp. 493-502
-
-
Kobayashi, M.1
-
40
-
-
59849113546
-
Molecular mechanisms of Nrf2-mediated antioxidant response
-
Li,W. et al. (2009) Molecular mechanisms of Nrf2-mediated antioxidant response. Mol. Carcinog., 48, 91-104.
-
(2009)
Mol. Carcinog.
, vol.48
, pp. 91-104
-
-
Li, W.1
-
41
-
-
29644443964
-
Identification of sensor cysteines in human Keap1 modified by the cancer chemopreventive agent sulforaphane
-
Hong,F. et al. (2005) Identification of sensor cysteines in human Keap1 modified by the cancer chemopreventive agent sulforaphane. Chem. Res. Toxicol., 18, 1917-1926.
-
(2005)
Chem. Res. Toxicol.
, vol.18
, pp. 1917-1926
-
-
Hong, F.1
-
42
-
-
23344452360
-
Nrf2 possesses a redox-insensitive nuclear export signal overlapping with the leucine zipper motif
-
Li,W. et al. (2005) Nrf2 possesses a redox-insensitive nuclear export signal overlapping with the leucine zipper motif. J. Biol. Chem., 280, 28430-28438.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 28430-28438
-
-
Li, W.1
-
43
-
-
0036805387
-
Effect of organic isothiocyanates on the P-glycoproteinand MRP1-mediated transport of daunomycin and vinblastine
-
Tseng,E. et al. (2002) Effect of organic isothiocyanates on the P-glycoproteinand MRP1-mediated transport of daunomycin and vinblastine. Pharm. Res., 19, 1509-1515.
-
(2002)
Pharm. Res.
, vol.19
, pp. 1509-1515
-
-
Tseng, E.1
-
44
-
-
17644382339
-
Effect of organic isothiocyanates on breast cancer resistance protein (ABCG2)-mediated transport
-
Ji,Y. et al. (2004) Effect of organic isothiocyanates on breast cancer resistance protein (ABCG2)-mediated transport. Pharm. Res., 21, 2261-2269.
-
(2004)
Pharm. Res.
, vol.21
, pp. 2261-2269
-
-
Ji, Y.1
-
45
-
-
27144442001
-
Membrane transport of dietary phenethyl isothiocyanate by ABCG2 (breast cancer resistance protein)
-
Ji,Y. et al. (2005) Membrane transport of dietary phenethyl isothiocyanate by ABCG2 (breast cancer resistance protein). Mol. Pharm., 2, 414-419.
-
(2005)
Mol. Pharm.
, vol.2
, pp. 414-419
-
-
Ji, Y.1
-
46
-
-
0342953915
-
-
Skou, J. C. and Norby J. G. (eds) Academic Press, London, UK
-
Karlish,S.J. (1979) Na+, K+-ATPase Structure and Kinetics. In Skou, J. C. and Norby J. G. (eds) Academic Press, London, UK, pp. 115-128.
-
(1979)
Na+, K+-ATPase Structure and Kinetics
, pp. 115-128
-
-
Karlish, S.J.1
-
47
-
-
0029049289
-
Inhibition of (Na/K)-ATPase by electrophilic substances: functional implications
-
Breier,A. et al. (1995) Inhibition of (Na/K)-ATPase by electrophilic substances: functional implications. Mol. Cell. Biochem., 147, 187-192.
-
(1995)
Mol. Cell. Biochem.
, vol.147
, pp. 187-192
-
-
Breier, A.1
-
48
-
-
0020490712
-
The active site structure of Na+- andK+-stimulated ATPase. Location of a specific fluorescein isothiocyanate reactive site
-
Carilli,C.T. et al. (1982) The active site structure of Na+- andK+-stimulated ATPase. Location of a specific fluorescein isothiocyanate reactive site. J. Biol. Chem., 257, 5601-5606.
-
(1982)
J. Biol. Chem.
, vol.257
, pp. 5601-5606
-
-
Carilli, C.T.1
-
49
-
-
0023789156
-
Microenvironment of two different extrinsic fluorescence probes in Na+ K1-ATPase changes out of phase during sequential appearance of intermediates
-
Taniguchi,K. et al. (1988) Microenvironment of two different extrinsic fluorescence probes in Na+ K1-ATPase changes out of phase during sequential appearance of intermediates. J. Biol. Chem., 263, 12943-12947.
-
(1988)
J. Biol. Chem.
, vol.263
, pp. 12943-12947
-
-
Taniguchi, K.1
-
50
-
-
0034278728
-
Lysine is the Lord, thought some scientists in regard to the group interacting with fluorescein isothiocyanate in ATPbinding sites of P-type ATPases but, is it not cysteine?
-
Breier,A. et al. (2000) "Lysine is the Lord", thought some scientists in regard to the group interacting with fluorescein isothiocyanate in ATPbinding sites of P-type ATPases but, is it not cysteine? Gen. Physiol. Biophys., 19, 253-263.
-
(2000)
Gen. Physiol. Biophys.
, vol.19
, pp. 253-263
-
-
Breier, A.1
-
51
-
-
0038687152
-
Eight amino acids form the ATP recognition site of Na(+)/K(+)-ATPase
-
Kubala,M. et al. (2003) Eight amino acids form the ATP recognition site of Na(+)/K(+)-ATPase. Biochemistry, 42, 6446-6452.
-
(2003)
Biochemistry
, vol.42
, pp. 6446-6452
-
-
Kubala, M.1
-
52
-
-
0032710681
-
Modulation of microtubule dynamics by drugs: a paradigm for the actions of cellular regulators
-
Wilson,L. et al. (1999)Modulation of microtubule dynamics by drugs: a paradigm for the actions of cellular regulators. Cell Struct. Funct., 24, 329-335.
-
(1999)
Cell Struct. Funct.
, vol.24
, pp. 329-335
-
-
Wilson, L.1
-
53
-
-
67650547972
-
Cancer preventive isothiocyanates induce selective degradation of cellular alpha- and beta-tubulins by proteasomes
-
Mi,L. et al. (2009) Cancer preventive isothiocyanates induce selective degradation of cellular alpha- and beta-tubulins by proteasomes. J. Biol. Chem., 284, 17039-17051.
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 17039-17051
-
-
Mi, L.1
-
54
-
-
69249206518
-
Aggresome-like structure induced by isothiocyanates is novel proteasome-dependent degradation machinery
-
Mi,L. et al. (2009) Aggresome-like structure induced by isothiocyanates is novel proteasome-dependent degradation machinery. Biochem. Biophys. Res. Commun., 388, 456-462.
-
(2009)
Biochem. Biophys. Res. Commun.
, vol.388
, pp. 456-462
-
-
Mi, L.1
-
55
-
-
33845900989
-
TRP channel activation by reversible covalent modification
-
Hinman,A. et al. (2006) TRP channel activation by reversible covalent modification. Proc. Natl. Acad. Sci. USA, 103, 19564-19568.
-
(2006)
Proc. Natl. Acad. Sci. USA
, vol.103
, pp. 19564-19568
-
-
Hinman, A.1
-
56
-
-
0037131419
-
Phenylethyl isothiocyanate induces apoptotic signaling via suppressing phosphatase activity against c-Jun N-terminal kinase
-
Chen,Y.R. et al. (2002) Phenylethyl isothiocyanate induces apoptotic signaling via suppressing phosphatase activity against c-Jun N-terminal kinase. J. Biol. Chem., 277, 39334-39342.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 39334-39342
-
-
Chen, Y.R.1
-
57
-
-
4444239988
-
Proteasome-mediated degradation of cell division cycle 25C and cyclin-dependent kinase 1 in phenethyl isothiocyanateinduced G2-M-phase cell cycle arrest in PC-3 human prostate cancer cells
-
Xiao,D. et al. (2004) Proteasome-mediated degradation of cell division cycle 25C and cyclin-dependent kinase 1 in phenethyl isothiocyanateinduced G2-M-phase cell cycle arrest in PC-3 human prostate cancer cells. Mol. Cancer Ther., 3, 567-575.
-
(2004)
Mol. Cancer Ther.
, vol.3
, pp. 567-575
-
-
Xiao, D.1
-
58
-
-
2942614713
-
Sulforaphane-induced G2/M phase cell cycle arrest involves checkpoint kinase 2-mediated phosphorylation of cell division cycle 25C
-
Singh,S.V. et al. (2004) Sulforaphane-induced G2/M phase cell cycle arrest involves checkpoint kinase 2-mediated phosphorylation of cell division cycle 25C. J. Biol. Chem., 279, 25813-25822.
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 25813-25822
-
-
Singh, S.V.1
-
59
-
-
36048961546
-
The isothiocyanate class of bioactive nutrients covalently inhibit the MEKK1 protein kinase
-
Cross,J.V. et al. (2007) The isothiocyanate class of bioactive nutrients covalently inhibit the MEKK1 protein kinase. BMC Cancer, 7, 183.
-
(2007)
BMC Cancer
, vol.7
, pp. 183
-
-
Cross, J.V.1
-
60
-
-
33644869673
-
Inhibition of EGFR signaling in human prostate cancer PC-3 cells by combination treatment with beta-phenylethyl isothiocyanate and curcumin
-
Kim,J.H. et al. (2006) Inhibition of EGFR signaling in human prostate cancer PC-3 cells by combination treatment with beta-phenylethyl isothiocyanate and curcumin. Carcinogenesis, 27, 475-482.
-
(2006)
Carcinogenesis
, vol.27
, pp. 475-482
-
-
Kim, J.H.1
-
61
-
-
70349734858
-
Alkyl isothiocyanates suppress epidermal growth factor receptor kinase activity but augment tyrosine kinase activity
-
Nomura,T. et al. (2009) Alkyl isothiocyanates suppress epidermal growth factor receptor kinase activity but augment tyrosine kinase activity. Cancer Epidemiol., 33, 288-292.
-
(2009)
Cancer Epidemiol.
, vol.33
, pp. 288-292
-
-
Nomura, T.1
-
62
-
-
73349137931
-
Isothiocyanates sensitize the effect of chemotherapeutic drugs via modulation of protein kinase C and telomerase in cervical cancer cells
-
Mukherjee,S. et al. (2009) Isothiocyanates sensitize the effect of chemotherapeutic drugs via modulation of protein kinase C and telomerase in cervical cancer cells. Mol. Cell. Biochem., 330, 9-22.
-
(2009)
Mol. Cell. Biochem.
, vol.330
, pp. 9-22
-
-
Mukherjee, S.1
-
63
-
-
35348871314
-
Glutathione- and thioredoxin-related enzymes are modulated by sulfur-containing chemopreventive agents
-
Hu,Y. et al. (2007) Glutathione- and thioredoxin-related enzymes are modulated by sulfur-containing chemopreventive agents. Biol. Chem., 388, 1069-1081.
-
(2007)
Biol. Chem.
, vol.388
, pp. 1069-1081
-
-
Hu, Y.1
-
64
-
-
0032491177
-
Role of active site tyrosine residues in catalysis by human glutathione reductase
-
Krauth-Siegel,R.L. et al. (1998) Role of active site tyrosine residues in catalysis by human glutathione reductase. Biochemistry, 37, 13968-13977.
-
(1998)
Biochemistry
, vol.37
, pp. 13968-13977
-
-
Krauth-Siegel, R.L.1
-
65
-
-
0034646457
-
Mammalian thioredoxin reductase: oxidation of the C-terminal cysteine/selenocysteine active site forms a thioselenide, and replacement of selenium with sulfur markedly reduces catalytic activity
-
Lee,S.R. et al. (2000) Mammalian thioredoxin reductase: oxidation of the C-terminal cysteine/selenocysteine active site forms a thioselenide, and replacement of selenium with sulfur markedly reduces catalytic activity. Proc. Natl Acad. Sci. USA, 97, 2521-2526.
-
(2000)
Proc. Natl Acad. Sci. USA
, vol.97
, pp. 2521-2526
-
-
Lee, S.R.1
-
66
-
-
34249790294
-
AP-1 a target for cancer prevention
-
Matthews,C.P. et al. (2007) AP-1 a target for cancer prevention. Curr. Cancer Drug Targets, 7, 317-324.
-
(2007)
Curr. Cancer Drug Targets
, vol.7
, pp. 317-324
-
-
Matthews, C.P.1
-
67
-
-
70149093188
-
Inhibition of activator protein-1 by sulforaphane involves interaction with cysteine in the cFos DNA-binding domain: implications for chemoprevention of UVB-induced skin cancer
-
Dickinson,S.E. et al. (2009) Inhibition of activator protein-1 by sulforaphane involves interaction with cysteine in the cFos DNA-binding domain: implications for chemoprevention of UVB-induced skin cancer. Cancer Res., 69, 7103-7110.
-
(2009)
Cancer Res.
, vol.69
, pp. 7103-7110
-
-
Dickinson, S.E.1
-
68
-
-
4143130097
-
A novel mechanism of chemoprotection by sulforaphane: inhibition of histone deacetylase
-
Myzak,M.C. et al. (2004) A novel mechanism of chemoprotection by sulforaphane: inhibition of histone deacetylase. Cancer Res., 64, 5767-5774.
-
(2004)
Cancer Res.
, vol.64
, pp. 5767-5774
-
-
Myzak, M.C.1
-
69
-
-
59749104966
-
The role of STAT-3 in the induction of apoptosis in pancreatic cancer cells by benzyl isothiocyanate
-
Sahu,R.P. et al. (2009) The role of STAT-3 in the induction of apoptosis in pancreatic cancer cells by benzyl isothiocyanate. J. Natl Cancer Inst., 101, 176-193.
-
(2009)
J. Natl Cancer Inst.
, vol.101
, pp. 176-193
-
-
Sahu, R.P.1
-
70
-
-
68149167106
-
Phenethyl isothiocyanate inhibits STAT3 activation in prostate cancer cells
-
Gong,A. et al. (2009) Phenethyl isothiocyanate inhibits STAT3 activation in prostate cancer cells. Mol. Nutr. Food Res., 53, 878-886.
-
(2009)
Mol. Nutr. Food Res.
, vol.53
, pp. 878-886
-
-
Gong, A.1
-
71
-
-
77950800375
-
Sulforaphane inhibits constitutive and interleukin-6-induced activation of signal transducer and activator of transcription 3 in prostate cancer cells
-
Hahm,E.R. et al. (2010) Sulforaphane inhibits constitutive and interleukin-6-induced activation of signal transducer and activator of transcription 3 in prostate cancer cells. Cancer Prev. Res., 3, 484-494.
-
(2010)
Cancer Prev. Res.
, vol.3
, pp. 484-494
-
-
Hahm, E.R.1
-
72
-
-
80053137469
-
Selective. depletion of mutant p53 by cancer chemopreventive isothiocyanates and its structure-activity relationships
-
in press
-
Wang,X. et al. (2010) Selective. depletion of mutant p53 by cancer chemopreventive isothiocyanates and its structure-activity relationships. J. Med. Chem. in press.
-
(2010)
J. Med. Chem.
-
-
Wang, X.1
-
73
-
-
0001433809
-
Method for the determination of the amino acid sequence in peptides
-
Edman,P. (1950) Method for the determination of the amino acid sequence in peptides. Acta Chem. Scand., 4, 283-293.
-
(1950)
Acta Chem. Scand.
, vol.4
, pp. 283-293
-
-
Edman, P.1
-
74
-
-
65949117445
-
Covalent modification of lysine residues by allyl isothiocyanate in physiological conditions: plausible transformation of isothiocyanate from thiol to amine
-
Nakamura,T. et al. (2009) Covalent modification of lysine residues by allyl isothiocyanate in physiological conditions: plausible transformation of isothiocyanate from thiol to amine. Chem. Res. Toxicol., 22, 536-542.
-
(2009)
Chem. Res. Toxicol.
, vol.22
, pp. 536-542
-
-
Nakamura, T.1
-
75
-
-
77951211975
-
New biomarkers for monitoring the levels of isothiocyanates in humans
-
Kumar,A. et al. (2010) New biomarkers for monitoring the levels of isothiocyanates in humans. Chem. Res. Toxicol., 23, 756-765.
-
(2010)
Chem. Res. Toxicol.
, vol.23
, pp. 756-765
-
-
Kumar, A.1
-
76
-
-
0037379862
-
Protein expression profiling identifies macrophage migration inhibitory factor and cyclophilin a as potential molecular targets in non-small cell lung cancer
-
Campa,M.J. et al. (2003) Protein expression profiling identifies macrophage migration inhibitory factor and cyclophilin a as potential molecular targets in non-small cell lung cancer. Cancer Res., 63, 1652-1656.
-
(2003)
Cancer Res.
, vol.63
, pp. 1652-1656
-
-
Campa, M.J.1
-
77
-
-
0032516444
-
Characterization of the role of the amino-terminal proline in the enzymatic activity catalyzed by macrophage migration inhibitory factor
-
Stamps,S.L. et al. (1998) Characterization of the role of the amino-terminal proline in the enzymatic activity catalyzed by macrophage migration inhibitory factor. Biochemistry, 37, 10195-10202.
-
(1998)
Biochemistry
, vol.37
, pp. 10195-10202
-
-
Stamps, S.L.1
-
78
-
-
19544385612
-
Beta-phenylethyl and 8-methylsulphinyloctyl isothiocyanates, constituents of watercress, suppress LPS induced production of nitric oxide and prostaglandin E2 in RAW 264.7 macrophages
-
Rose,P. et al. (2005) Beta-phenylethyl and 8-methylsulphinyloctyl isothiocyanates, constituents of watercress, suppress LPS induced production of nitric oxide and prostaglandin E2 in RAW 264.7 macrophages. Nitric Oxide, 12, 237-243.
-
(2005)
Nitric Oxide
, vol.12
, pp. 237-243
-
-
Rose, P.1
-
79
-
-
62549085979
-
Anti-NF-kappaB and anti-inflammatory activities of synthetic isothiocyanates: effect of chemical structures and cellular signaling
-
Prawan,A. et al. (2009) Anti-NF-kappaB and anti-inflammatory activities of synthetic isothiocyanates: effect of chemical structures and cellular signaling. Chem. Biol. Interact., 179, 202-211.
-
(2009)
Chem. Biol. Interact.
, vol.179
, pp. 202-211
-
-
Prawan, A.1
-
80
-
-
23844558266
-
A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: a dawn for evolutionary medicine
-
Wallace,D.C. (2005) A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: a dawn for evolutionary medicine. Annu. Rev. Genet., 39, 359-407.
-
(2005)
Annu. Rev. Genet.
, vol.39
, pp. 359-407
-
-
Wallace, D.C.1
-
81
-
-
33748165596
-
Reactive oxygen species in cancer cells: live by the sword, die by the sword
-
Schumacker,P.T. (2006) Reactive oxygen species in cancer cells: live by the sword, die by the sword. Cancer Cell, 10, 175-176.
-
(2006)
Cancer Cell
, vol.10
, pp. 175-176
-
-
Schumacker, P.T.1
-
82
-
-
0037040918
-
Involvement of the mitochondrial death pathway in chemopreventive benzyl isothiocyanate-induced apoptosis
-
Nakamura,Y. et al. (2002) Involvement of the mitochondrial death pathway in chemopreventive benzyl isothiocyanate-induced apoptosis. J. Biol. Chem., 277, 8492-8499.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 8492-8499
-
-
Nakamura, Y.1
-
83
-
-
23844505236
-
Mitochondria are the primary target in isothiocyanateinduced apoptosis in human bladder cancer cells
-
Tang,L. et al. (2005) Mitochondria are the primary target in isothiocyanateinduced apoptosis in human bladder cancer cells. Mol. Cancer Ther., 4, 1250-1259.
-
(2005)
Mol. Cancer Ther.
, vol.4
, pp. 1250-1259
-
-
Tang, L.1
-
84
-
-
57649174596
-
Benzyl isothiocyanate targets mitochondrial respiratory chain to trigger reactive oxygen species-dependent apoptosis in human breast cancer cells
-
Xiao,D. et al. (2008) Benzyl isothiocyanate targets mitochondrial respiratory chain to trigger reactive oxygen species-dependent apoptosis in human breast cancer cells. J. Biol. Chem., 283, 30151-30163.
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 30151-30163
-
-
Xiao, D.1
-
85
-
-
77950370157
-
Mitochondrial respiratory chain involvement in peroxiredoxin 3 oxidation by phenethyl isothiocyanate and auranofin
-
Brown,K.K. et al. (2010) Mitochondrial respiratory chain involvement in peroxiredoxin 3 oxidation by phenethyl isothiocyanate and auranofin. FEBS Lett., 584, 1257-1262.
-
(2010)
FEBS Lett.
, vol.584
, pp. 1257-1262
-
-
Brown, K.K.1
-
86
-
-
77956218104
-
Phenethyl isothiocyanate inhibits oxidative phosphorylation to trigger reactive oxygen species-mediated death of human prostate cancer cells
-
Xiao,D. et al. (2010) Phenethyl isothiocyanate inhibits oxidative phosphorylation to trigger reactive oxygen species-mediated death of human prostate cancer cells. J. Biol. Chem., 285, 26558-26569.
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 26558-26569
-
-
Xiao, D.1
-
87
-
-
58149234401
-
Sulforaphane enhances the therapeutic potential of TRAIL in prostate cancer orthotopic model through regulation of apoptosis, metastasis, and angiogenesis
-
Shankar,S. et al. (2008) Sulforaphane enhances the therapeutic potential of TRAIL in prostate cancer orthotopic model through regulation of apoptosis, metastasis, and angiogenesis. Clin. Cancer Res., 14, 6855-6866.
-
(2008)
Clin. Cancer Res.
, vol.14
, pp. 6855-6866
-
-
Shankar, S.1
-
88
-
-
45149100643
-
Effective killing of Gleevec-resistant CML cells with T315I mutation by a natural compound PEITC through redoxmediated mechanism
-
Zhang,H. et al. (2008) Effective killing of Gleevec-resistant CML cells with T315I mutation by a natural compound PEITC through redoxmediated mechanism. Leukemia, 22, 1191-1199.
-
(2008)
Leukemia
, vol.22
, pp. 1191-1199
-
-
Zhang, H.1
-
89
-
-
78149260516
-
Sulforaphane activates heat shock response and enhances proteasome activity through up-regulation of Hsp27
-
Gan,N. et al. (2010) Sulforaphane activates heat shock response and enhances proteasome activity through up-regulation of Hsp27. J. Biol. Chem., 285, 35528-35536.
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 35528-35536
-
-
Gan, N.1
-
90
-
-
3543117254
-
Dietary isothiocyanates inhibit the growth of human bladder carcinoma cells
-
Tang,L. et al. (2004) Dietary isothiocyanates inhibit the growth of human bladder carcinoma cells. J. Nutr., 134, 2004-2010.
-
(2004)
J. Nutr.
, vol.134
, pp. 2004-2010
-
-
Tang, L.1
-
91
-
-
80053141997
-
Phase I safety and pharmacokinetics clinical trials of PEITC in chronic smokers
-
NCI CN-55120
-
Liebes,L. et al. (2000) Phase I safety and pharmacokinetics clinical trials of PEITC in chronic smokers, Proceedings of the American Association for Cancer Research, 42, 834, NCI CN-55120.
-
(2000)
Proceedings of the American Association for Cancer Research
, vol.42
, pp. 834
-
-
Liebes, L.1
-
92
-
-
0032968691
-
Disposition and pharmacokinetics of phenethyl isothiocyanate and 6-phenylhexyl isothiocyanate in F344 rats
-
Conaway,C.C. et al. (1999) Disposition and pharmacokinetics of phenethyl isothiocyanate and 6-phenylhexyl isothiocyanate in F344 rats. Drug Metab. Dispos., 27, 13-20.
-
(1999)
Drug Metab. Dispos.
, vol.27
, pp. 13-20
-
-
Conaway, C.C.1
-
93
-
-
0041303871
-
Involvement of toxicity as an early event in urinary bladder carcinogenesis induced by phenethyl isothiocyanate, benzyl isothiocyanate, and analogues in F344 rats
-
Akagi,K. et al. (2003) Involvement of toxicity as an early event in urinary bladder carcinogenesis induced by phenethyl isothiocyanate, benzyl isothiocyanate, and analogues in F344 rats. Toxicol. Pathol., 31, 388-396.
-
(2003)
Toxicol. Pathol.
, vol.31
, pp. 388-396
-
-
Akagi, K.1
-
94
-
-
0036182039
-
Proteomic approaches to characterize protein modifications: new tools to study the effects of environmental exposures
-
Liebler,D.C. (2002) Proteomic approaches to characterize protein modifications: new tools to study the effects of environmental exposures. Environ. Health Perspect., 110 (1Suppl), 3-9.
-
(2002)
Environ. Health Perspect.
, vol.110
, Issue.1 SUPPL.
, pp. 3-9
-
-
Liebler, D.C.1
|