Overlapping activities of TGF-β and Hedgehog signaling in cancer: Therapeutic targets for cancer treatment

Pharmacology and Therapeutics

Volumn 137, Issue 2, 2013, Pages 183-199

  Perrot, Carole Y ^a   Javelaud, Delphine ^b   Mauviel, Alain ^b  

^a INSTITUT CURIE   (France)

^b Centre National de la Recherche Scientifique   (France)

Author keywords

Cancer; Cancer stem cells; Clinical trials; GLI proteins; Hedgehog; Metastasis; TGF

Indexed keywords

ALKALOID; ANTINEOPLASTIC AGENT; ANTISENSE OLIGODEOXYNUCLEOTIDE; BMS 833923; CURCUMIN; GANT 58; GANT 61; ISOFLAVONE; LEQ 506; N (3 METHOXYBENZYL) 3,3 DIMETHYL N [1 (3,4 METHYLENEDIOXYBENZYL) 2 (1 PIPERAZINYLCARBONYL) 4 PYRROLIDINYL]BUTYRAMIDE; NATURAL PRODUCT; PF 04449913; POLYPHENOL; RESVERATROL; ROBOTNIKININ; SESQUITERPENE DERIVATIVE; SMAD PROTEIN; SONIC HEDGEHOG PROTEIN; SONIDEGIB; TAK 441; TRANSCRIPTION FACTOR GLI1; TRANSCRIPTION FACTOR GLI2; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG; VITAMIN D; ZEAXANTHIN DIPALMITATE;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; CANCER GROWTH; CANCER INVASION; CANCER STEM CELL; CANCER THERAPY; CARCINOGENESIS; CELL DIFFERENTIATION; CELL PROLIFERATION; CYTOTOXICITY; EPITHELIAL MESENCHYMAL TRANSITION; GENE TARGETING; HUMAN; IMMUNOSURVEILLANCE; METASTASIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; REVIEW; SIGNAL TRANSDUCTION;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTINEOPLASTIC AGENTS; CLINICAL TRIALS AS TOPIC; HEDGEHOG PROTEINS; HUMANS; NEOPLASMS; OLIGONUCLEOTIDES, ANTISENSE; SIGNAL TRANSDUCTION; SMALL MOLECULE LIBRARIES; TRANSFORMING GROWTH FACTOR ALPHA;

EID: 84872827424     PISSN: 01637258     EISSN: 1879016X     Source Type: Journal    
DOI: 10.1016/j.pharmthera.2012.10.002     Document Type: Review

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