-
1
-
-
23844552405
-
Cooperative requirement of the Gli proteins in neurogenesis
-
Nguyen V, Chokas AL, Stecca B, Ruiz i Altaba A. Cooperative requirement of the Gli proteins in neurogenesis. Development 2005;132(14):3267-79.
-
(2005)
Development
, vol.132
, Issue.14
, pp. 3267-3279
-
-
Nguyen, V.1
Chokas, A.L.2
Stecca, B.3
Ruiz I Altaba, A.4
-
2
-
-
76849102604
-
Smoothened as a new therapeutic target for human osteosarcoma
-
Hirotsu M, Setoguchi T, Sasaki H, et al. Smoothened as a new therapeutic target for human osteosarcoma. Mol Cancer 2010;9:5.
-
(2010)
Mol Cancer
, vol.9
, pp. 5
-
-
Hirotsu, M.1
Setoguchi, T.2
Sasaki, H.3
-
3
-
-
0030844141
-
Activation of the transcription factor Gli1 and the sonic hedgehog signalling pathway in skin tumours
-
Dahmane N, Lee J, Robins P, Heller P, Ruiz i Altaba A. Activation of the transcription factor Gli1 and the sonic hedgehog signalling pathway in skin tumours. Nature 1997;389(6653):876-81.
-
(1997)
Nature
, vol.389
, Issue.6653
, pp. 876-881
-
-
Dahmane, N.1
Lee, J.2
Robins, P.3
Heller, P.4
Ruiz I Altaba, A.5
-
4
-
-
4344586961
-
Hedgehog signaling pathway is a new therapeutic target for patients with breast cancer
-
DOI 10.1158/0008-5472.CAN-04-0416
-
Kubo M, Nakamura M, Tasaki A, et al. Hedgehog signaling pathway is a new therapeutic target for patients with breast cancer. Cancer Res 2004;64(17):6071-4. (Pubitemid 39129406)
-
(2004)
Cancer Research
, vol.64
, Issue.17
, pp. 6071-6074
-
-
Kubo, M.1
Nakamura, M.2
Tasaki, A.3
Yamanaka, N.4
Nakashima, H.5
Nomura, M.6
Kuroki, S.7
Katano, M.8
-
5
-
-
0242669237
-
Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancer
-
DOI 10.1038/nature01493
-
Watkins DN, Berman DM, Burkholder SG, Wang B, Beachy PA, Baylin SB. Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancer. Nature 2003;422(6929):313-7. (Pubitemid 36378358)
-
(2003)
Nature
, vol.422
, Issue.6929
, pp. 313-317
-
-
Watkins, D.N.1
Berman, D.M.2
Burkholder, S.G.3
Wang, B.4
Beachy, P.A.5
Baylin, S.B.6
-
6
-
-
25144461600
-
Aberrant methylation of the Human Hedgehog interacting protein (HHIP) gene in pancreatic neoplasms
-
Martin ST, Sato N, Dhara S, et al. Aberrant methylation of the human hedgehog interacting protein (HHIP) gene in pancreatic neoplasms. Cancer Biol Ther 2005;4(7):728-33. (Pubitemid 41351171)
-
(2005)
Cancer Biology and Therapy
, vol.4
, Issue.7
, pp. 728-733
-
-
Martin, S.T.1
Sato, N.2
Dhara, S.3
Chang, R.4
Hustinx, S.R.5
Abe, T.6
Maitra, A.7
Goggins, M.8
-
7
-
-
27144541492
-
Frequent activation of the hedgehog pathway in advanced gastric adenocarcinomas
-
DOI 10.1093/carcin/bgi130
-
Ma X, Chen K, Huang S, et al. Frequent activation of the hedgehog pathway in advanced gastric adenocarcinomas. Carcinogenesis 2005;26(10):1698-705. (Pubitemid 41487985)
-
(2005)
Carcinogenesis
, vol.26
, Issue.10
, pp. 1698-1705
-
-
Ma, X.1
Chen, K.2
Huang, S.3
Zhang, X.4
Adegboyega, P.A.5
Evers, B.M.6
Zhang, H.7
Xie, J.8
-
8
-
-
33745634379
-
Activation of the hedgehog pathway in human hepatocellular carcinomas
-
DOI 10.1093/carcin/bgi378
-
Huang S, He J, Zhang X, et al. Activation of the hedgehog pathway in human hepatocellular carcinomas. Carcinogenesis 2006;27(7):1334-40. (Pubitemid 43985408)
-
(2006)
Carcinogenesis
, vol.27
, Issue.7
, pp. 1334-1340
-
-
Huang, S.1
He, J.2
Zhang, X.3
Bian, Y.4
Yang, L.5
Xie, G.6
Zhang, K.7
Tang, W.8
Stelter, A.A.9
Wang, Q.10
Zhang, H.11
Xie, J.12
-
9
-
-
17144371524
-
Therapeutic targeting of the hedgehog-GLI pathway in prostate cancer
-
Sanchez P, Clement V, Ruiz i Altaba A. Therapeutic targeting of the hedgehog-GLI pathway in prostate cancer. Cancer Res 2005;65(8):2990-2.
-
(2005)
Cancer Res
, vol.65
, Issue.8
, pp. 2990-2992
-
-
Sanchez, P.1
Clement, V.2
Ruiz I Altaba, A.3
-
10
-
-
0142227025
-
Developmental biology informs cancer: The emerging role of the hedgehog signaling pathway in upper gastrointestinal cancers
-
DOI 10.1016/S1535-6108(03)00246-0
-
Xie K, Abbruzzese JL. Developmental biology informs cancer: the emerging role of the hedgehog signaling pathway in upper gastrointestinal cancers. Cancer Cell 2003;4(4):245-7. (Pubitemid 37329787)
-
(2003)
Cancer Cell
, vol.4
, Issue.4
, pp. 245-247
-
-
Xie, K.1
Abbruzzese, J.L.2
-
11
-
-
77952898697
-
Context-dependent regulation of the GLI code in cancer by HEDGEHOG and non-HEDGEHOG signals
-
Stecca B, Ruiz IAA. Context-dependent regulation of the GLI code in cancer by HEDGEHOG and non-HEDGEHOG signals. J Mol Cell Biol 2010;2(2):84-95.
-
(2010)
J Mol Cell Biol
, vol.2
, Issue.2
, pp. 84-95
-
-
Stecca, B.1
Ruiz, I.A.A.2
-
12
-
-
52949086129
-
Therapeutic inhibition of Hedgehog-GLI signaling in cancer: Epithelial, stromal, or stem cell targets?
-
Ruiz i Altaba A. Therapeutic inhibition of Hedgehog-GLI signaling in cancer: epithelial, stromal, or stem cell targets? Cancer Cell 2008;14(4):281-3.
-
(2008)
Cancer Cell
, vol.14
, Issue.4
, pp. 281-283
-
-
Ruiz I Altaba, A.1
-
13
-
-
77954214394
-
Small molecule modulation of HH-GLI signaling: Current leads, trials and tribulations
-
Mas C, Ruiz IAA. Small molecule modulation of HH-GLI signaling: current leads, trials and tribulations. Biochem Pharmacol 2010;80(5):712-23.
-
(2010)
Biochem Pharmacol
, vol.80
, Issue.5
, pp. 712-723
-
-
Mas, C.1
Ruiz, I.A.A.2
-
14
-
-
0347635451
-
A role of activated Sonic hedgehog signaling for the cellular proliferation of oral squamous cell carcinoma cell line
-
DOI 10.1016/j.bbrc.2003.12.097
-
Nishimaki H, Kasai K, Kozaki K, et al. A role of activated Sonic hedgehog signaling for the cellular proliferation of oral squamous cell carcinoma cell line. Biochem Biophys Res Commun 2004;314(2):313-20. (Pubitemid 38084719)
-
(2004)
Biochemical and Biophysical Research Communications
, vol.314
, Issue.2
, pp. 313-320
-
-
Nishimaki, H.1
Kasai, K.2
Kozaki, K.-I.3
Takeo, T.4
Ikeda, H.5
Saga, S.6
Nitta, M.7
Itoh, G.8
-
15
-
-
0034738979
-
Effects of oncogenic mutations in smoothened and patched can be reversed by cyclopamine
-
Taipale J, Chen JK, Cooper MK, et al. Effects of oncogenic mutations in smoothened and patched can be reversed by cyclopamine. Nature 2000;406(6799):1005-9.
-
(2000)
Nature
, vol.406
, Issue.6799
, pp. 1005-1009
-
-
Taipale, J.1
Chen, J.K.2
Cooper, M.K.3
-
16
-
-
34249867843
-
Inhibition of GLI-mediated transcription and tumor cell growth by small-molecule antagonists
-
DOI 10.1073/pnas.0609699104
-
Lauth M, Bergstrom A, Shimokawa T, Toftgard R. Inhibition of GLI-mediated transcription and tumor cell growth by small-molecule antagonists. Proc Nat Acad Sci USA 2007;104(20):8455-60. (Pubitemid 47175509)
-
(2007)
Proceedings of the National Academy of Sciences of the United States of America
, vol.104
, Issue.20
, pp. 8455-8460
-
-
Lauth, M.1
Bergstrom, A.2
Shimokawa, T.3
Toftgard, R.4
-
17
-
-
69049118160
-
Sonic hedgehog signaling regulates a novel epithelial progenitor domain of the hindbrain choroid plexus
-
Huang X, Ketova T, Fleming JT, et al. Sonic hedgehog signaling regulates a novel epithelial progenitor domain of the hindbrain choroid plexus. Development 2009;136(15):2535-43.
-
(2009)
Development
, vol.136
, Issue.15
, pp. 2535-2543
-
-
Huang, X.1
Ketova, T.2
Fleming, J.T.3
-
18
-
-
0036559186
-
Gli and hedgehog in cancer: Tumours, embryos and stem cells
-
Ruiz i Altaba A, Sanchez P, Dahmane N. Gli and hedgehog in cancer: tumours, embryos and stem cells. Nat Rev Cancer 2002;2(5):361-72.
-
(2002)
Nat Rev Cancer
, vol.2
, Issue.5
, pp. 361-372
-
-
Ruiz I Altaba, A.1
Sanchez, P.2
Dahmane, N.3
-
19
-
-
0037112420
-
Induction of medulloblastomas in mice by sonic hedgehog, independent of Gli1
-
Weiner HL, Bakst R, Hurlbert MS, et al. Induction of medulloblastomas in mice by sonic hedgehog, independent of Gli1. Cancer Res 2002;62(22):6385-9. (Pubitemid 35364091)
-
(2002)
Cancer Research
, vol.62
, Issue.22
, pp. 6385-6389
-
-
Weiner, H.L.1
Bakst, R.2
Hurlbert, M.S.3
Ruggiero, J.4
Ahn, E.5
Lee, W.S.6
Stephen, D.7
Zagzag, D.8
Joyner, A.L.9
Turnbull, D.H.10
-
20
-
-
53249127492
-
GLI2 knockdown using an antisense oligonucleotide induces apoptosis and chemosensitizes cells to paclitaxel in androgen-independent prostate cancer
-
Narita S, So A, Ettinger S, et al. GLI2 knockdown using an antisense oligonucleotide induces apoptosis and chemosensitizes cells to paclitaxel in androgen-independent prostate cancer. Clin Cancer Res 2008;14(18):5769-77.
-
(2008)
Clin Cancer Res
, vol.14
, Issue.18
, pp. 5769-5777
-
-
Narita, S.1
So, A.2
Ettinger, S.3
-
21
-
-
33746951471
-
Selective modulation of hedgehog/GLI target gene expression by epidermal growth factor signaling in human keratinocytes
-
DOI 10.1128/MCB.02317-05
-
Kasper M, Schnidar H, Neill GW, et al. Selective modulation of Hedgehog/GLI target gene expression by epidermal growth factor signaling in human keratinocytes. Mol Cell Biol 2006;26(16):6283-98. (Pubitemid 44204544)
-
(2006)
Molecular and Cellular Biology
, vol.26
, Issue.16
, pp. 6283-6298
-
-
Kasper, M.1
Schnidar, H.2
Neill, G.W.3
Hanneder, M.4
Klingler, S.5
Blaas, L.6
Schmid, C.7
Hauser-Kronberger, C.8
Regl, G.9
Philpott, M.P.10
Aberger, F.11
-
22
-
-
7444247429
-
Activation of the BCL2 promoter in response to Hedgehog/GLI signal transduction is predominantly mediated by GLI2
-
DOI 10.1158/0008-5472.CAN-04-1085
-
Regl G, Kasper M, Schnidar H, et al. Activation of the BCL2 promoter in response to Hedgehog/GLI signal transduction is predominantly mediated by GLI2. Cancer Res 2004;64(21):7724-31. (Pubitemid 39446903)
-
(2004)
Cancer Research
, vol.64
, Issue.21
, pp. 7724-7731
-
-
Regl, G.1
Kasper, M.2
Schnidar, H.3
Eichberger, T.4
Neill, G.W.5
Philpott, M.P.6
Esterbauer, H.7
Hauser-Kronberger, C.8
Frischauf, A.-M.9
Aberger, F.10
-
23
-
-
70350534843
-
Hedgehog target genes: Mechanisms of carcinogenesis induced by aberrant hedgehog signaling activation
-
Katoh Y, Katoh M. Hedgehog target genes: mechanisms of carcinogenesis induced by aberrant hedgehog signaling activation. Curr Mol Med 2009;9(7):873-86.
-
(2009)
Curr Mol Med
, vol.9
, Issue.7
, pp. 873-886
-
-
Katoh, Y.1
Katoh, M.2
-
24
-
-
45149086312
-
Primers on molecular pathways GLI: More than just Hedgehog?
-
Fernandez-Zapico ME. Primers on molecular pathways GLI: more than just Hedgehog? Pancreatology 2008;8(3):227-9.
-
(2008)
Pancreatology
, vol.8
, Issue.3
, pp. 227-229
-
-
Fernandez-Zapico, M.E.1
-
25
-
-
54049156465
-
Integrative genomic analyses on GLI2: Mechanism of Hedgehog priming through basal GLI2 expression, and interaction map of stem cell signaling network with P53
-
Katoh Y, Katoh M. Integrative genomic analyses on GLI2: mechanism of Hedgehog priming through basal GLI2 expression, and interaction map of stem cell signaling network with P53. Int J Oncol 2008;33(4):881-6.
-
(2008)
Int J Oncol
, vol.33
, Issue.4
, pp. 881-886
-
-
Katoh, Y.1
Katoh, M.2
-
26
-
-
67349108318
-
Dysregulated molecular networks in head and neck carcinogenesis
-
Molinolo AA, Amornphimoltham P, Squarize CH, Castilho RM, Patel V, Gutkind JS. Dysregulated molecular networks in head and neck carcinogenesis. Oral Oncol 2009;45(4-5):324-34.
-
(2009)
Oral Oncol
, vol.45
, Issue.4-5
, pp. 324-334
-
-
Molinolo, A.A.1
Amornphimoltham, P.2
Squarize, C.H.3
Castilho, R.M.4
Patel, V.5
Gutkind, J.S.6
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