Frequent activation of the hedgehog pathway in advanced gastric adenocarcinomas

Carcinogenesis

Volumn 26, Issue 10, 2005, Pages 1698-1705

  Ma, Xiaoli ^a   Chen, Kai ^b   Huang, Shuhong ^a   Zhang, Xiaoli ^b   Adegboyega, Patrick A ^b   Evers, B Mark ^b   Zhang, Hongwei ^a   Xie, Jingwu ^b  

^a SHANDONG UNIVERSITY   (China)

^b University of Texas Medical Branch School of Medicine   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOPAMINE; PROTEIN INHIBITOR; PROTEIN PATCHED 1; SONIC HEDGEHOG PROTEIN; TRANSCRIPTION FACTOR GLI1; UNCLASSIFIED DRUG;

ADVANCED CANCER; APOPTOSIS; ARTICLE; CANCER GROWTH; CANCER INHIBITION; CANCER TISSUE; CONTROLLED STUDY; CYTOMEGALOVIRUS; ENZYME ACTIVATION; FEMALE; GENE TARGETING; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; MAJOR CLINICAL STUDY; MALE; NUCLEOTIDE SEQUENCE; PREDICTION; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; SIGNAL TRANSDUCTION; STOMACH ADENOCARCINOMA; STOMACH CANCER; STROMA CELL; TUMOR DIFFERENTIATION;

ADENOCARCINOMA; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HEDGEHOG PROTEINS; HUMANS; IN SITU HYBRIDIZATION; MALE; NEOPLASM STAGING; ONCOGENE PROTEINS; RECEPTORS, CELL SURFACE; STOMACH NEOPLASMS; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS;

EID: 27144541492     PISSN: 01433334     EISSN: 14602180     Source Type: Journal    
DOI: 10.1093/carcin/bgi130     Document Type: Article

References (21)

1. Pasca di Magliano,M. and Hebrok,M. (2003) Hedgehog signalling in cancer formation and maintenance. Nat. Rev. Cancer, 3, 903-911.
2. Taipale,J. and Beachy,P.A. (2001) The Hedgehog and Wnt signalling pathways in cancer. Nature, 411, 349-354.
3. Johnson,R.L., Rothman,A.L., Xie,J. et al. (1996) Human homolog of patched, a candidate gene for the basal cell nevus syndrome. Science, 272, 1668-1671.
4. Hahn,H., Wicking,C., Zaphiropoulous,P.G. et al. (1996) Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome. Cell. 85, 841-851.
5. Xie,J., Murone,M., Luoh,S.M. et al. (1998) Activating smoothened mutations in sporadic basal-cell carcinoma. Nature, 391, 90-92.
6. Xie,J., John-on,R.L., Zhang,X. et al. (1997) Mutations of the PATCHED gene in several types of sporadic extracutaneous tumors. Cancer Res., 57. 2369-2372.
7. Berman,D.M., Karhadkar,S.S., Hallahan,A.R. et al. (2002) Medulloblastoma growth inhibition by hedgehog pathway blockade. Science, 297, 1559-1561.
8. Watkins,D.N., Berman,D.M., Burkholder,S.G., Wang,B., Beachy,P.A. and Baylin,S.B. (2003) Hedgehog signaling within airway epithelial progenitors and in small-cell lung cancer. Nature, 422, 313-317.
9. Thayer,S.P., Di Magliano,M.P., Heiser,P.W. et al. (2003) Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis. Nature, 425, 851-856.
10. Berman,D.M., Karhadkar,S.S., Maitra,A. et al. (2003) Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours. Nature, 425, 846-851.
11. Sheng,T., Li,C.-X., Zhang,X., Chi,S., He,N., Chen.K., McCormick,F., Gatalica,Z., and Xie,J. (2004) Activation of the hedgehog pathway in advanced prostate cancer. Mol. Cancer, 3, 29.
12. Sanchez,P., Hernandez,A.M., Stecca,B. et al. (2004) Inhibition of prostate cancer proliferation by interference with SONIC HEDGEHOG-GLI1 signaling. Proc. Natl Acad. Sci. USA, 101, 12561-12566.
13. Fan,L., Pepicelli,C.V., Dibble,C.C. et al. (2004) Hedgehog signaling promotes prostate xenograft tumor growth. Endocrinology, 145, 3961-3970.
14. Karhadkar,S., Bova,G., Abdallah,N. et al. (2004) Hedgehog signaling in prostate regeneration, neoplasia and metastasis. Nature, 2431(7009), 707-712.
15. Pisani,P.. Parkin,D.M., Bray,F. and Ferlay,J. (1999) Estimates of the worldwide mortality from 25 cancers in 1990. Int. J. Cancer, 83, 18-29.
16. Borchard,F. (1990) Classification of gastric carcinoma. Hepatogastroenterology, 37, 223-232.
17. Unden,A.B., Zaphiropoulos,P.G., Bruce,K., Toftgard,R. and Stahle-Backdahl,M. (1997) Human patched (PTCH) mRNA is overexpressed consistently in tumor cells of both familial and sporadic basal cell carcinoma. Cancer Res., 57, 2336-2340.
18. van den Brink,G.R., Hardwick,J.C. Nielsen,C., Xu,C., ten Kate,F.J., Glickman,J., van Deventer,S.J., Roberts,D.J. and Peppelenbosch,M.P. (2002) Sonic hedgehog expression correlates with fundic gland differentiation in the adult gastrointestinal tract. Gut, 51, 628-633.
19. Li,C., Chi,S., He,N., Zhang,X., Guicherit,O., Wagner,R., Tyring,S. and Xie,J. (2004) IFNalpha induces Fas expression and apoptosis in hedgehog pathway activated BCC cells through inhibiting Ras-Erk signaling. Oncogene. 23, 1608-1617.
20. Xie,J., Aszierbaum,M., Zhang,X., Bonifas,J.M., Zachary,C., Epstein,E. and McCormick,F. (2001) A role of PDGFRalpha in basal cell carcinoma proliferation. Proc. Natl Acad. Sci. USA, 98, 9255-9259.
21. Athar,M., Li,C.-X., Chi,S. et al. (2004) Inhibition of smoothened signaling prevents ultraviolet B-induced basal cell carcinomas through induction of fas expression and apoptosis. Cancer Res., 60, 7545-7552.