Requirement of TGF β signaling for SMO-mediated carcinogenesis

Journal of Biological Chemistry

Volumn 285, Issue 47, 2010, Pages 36570-36576

  Fan, Qipeng ^a,b   He, Miao ^b,c   Sheng, Tao ^b   Zhang, Xiaoli ^b   Sinha, Mala ^d,e   Luxon, Bruce ^d,e   Zhao, Xingbo ^a   Xie, Jingwu ^b,f  

^a CHINA AGRICULTURAL UNIVERSITY   (China)

^b INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c WUHAN UNIVERSITY   (China)

^d University of Texas Medical Branch School of Medicine   (United States)

^e UNIVERSITY OF TEXAS MEDICAL BRANCH   (United States)

^f NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BASAL CELL CARCINOMA; DOWN-REGULATION; EMBRYONIC DEVELOPMENT; HEDGEHOG SIGNALING; HUMAN CANCER; IMMUNE SUPPRESSION; KERATINOCYTES; MOLECULAR MECHANISM; MOTOR NEURONS; MOUSE MODELS; OSTEOBLAST DIFFERENTIATION; REGULATED GENES; SIGNAL TRANSDUCERS; TUMOR AREAS;

NEURONS; PATHOLOGY; PHOSPHORYLATION; TRANSCRIPTION; TRANSCRIPTION FACTORS; TUMORS;

SIGNALING;

SD 208; SMAD2 PROTEIN; SMAD3 PROTEIN; SMOOTHENED PROTEIN; SONIC HEDGEHOG PROTEIN; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA2; BIOLOGICAL MARKER; CRE RECOMBINASE; G PROTEIN COUPLED RECEPTOR; INTEGRASE; MESSENGER RNA; PROTEIN SERINE THREONINE KINASE; SMO PROTEIN, MOUSE; TGF BETA TYPE I RECEPTOR; TGF-BETA TYPE I RECEPTOR; TRANSFORMING GROWTH FACTOR BETA RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BASAL CELL CARCINOMA; CANCER INHIBITION; CANCER TISSUE; CELL DIFFERENTIATION; CONTROLLED STUDY; DOWN REGULATION; EMBRYO; IMMUNE DEFICIENCY; KERATINOCYTE; LYMPHOCYTE COUNT; MOTONEURON; MOUSE; NONHUMAN; OSTEOBLAST; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; SKIN CARCINOGENESIS; STROMA; ANIMAL; C3H MOUSE; CELL CULTURE; CELL TRANSFORMATION; CYTOLOGY; DNA MICROARRAY; DRUG ANTAGONISM; DRUG EFFECT; EMBRYONIC STEM CELL; FEMALE; GENE EXPRESSION PROFILING; GENETICS; HUMAN; MALE; METABOLISM; PATHOLOGY; PHOSPHORYLATION; PHYSIOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SKIN TUMOR; WESTERN BLOTTING;

ERINACEIDAE; MUS;

ANIMALS; BIOLOGICAL MARKERS; BLOTTING, WESTERN; CARCINOMA, BASAL CELL; CELL DIFFERENTIATION; CELL TRANSFORMATION, NEOPLASTIC; CELLS, CULTURED; EMBRYONIC STEM CELLS; FEMALE; GENE EXPRESSION PROFILING; HEDGEHOG PROTEINS; HUMANS; INTEGRASES; KERATINOCYTES; MALE; MICE; MICE, INBRED C3H; MOTOR NEURONS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; OSTEOBLASTS; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SIGNAL TRANSDUCTION; SKIN NEOPLASMS; SMAD2 PROTEIN; SMAD3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA;

EID: 78449258451     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.C110.164442     Document Type: Article

References (28)

1. Yang, L., Xie, G., Fan, Q., and Xie, J. (2010) Oncogene 29, 469-481
2. Parkin, C. A., and Ingham, P. W. (2008) Am. J. Physiol. Gastrointest. Liver Physiol. 294, G363-G367
3. Jiang, J., and Hui, C. C. (2008) Dev. Cell 15, 801-812
4. McMahon, A. P., Ingham, P. W., and Tabin, C. J. (2003) Curr. Top. Dev. Biol. 53, 1-114
5. Kinzler, K. W., and Vogelstein, B. (1990) Mol. Cell. Biol. 10, 634-642
6. Xie, J. (2008) Acta Biochim. Biophys. Sin. 40, 670-680
7. Rubin, L. L., and de Sauvage, F. J. (2006) Nat. Rev. Drug Discov. 5, 1026-1033
8. Epstein, E. H. (2008) Nat. Rev. Cancer 8, 743-754
9. Theunissen, J. W., and de Sauvage, F. J. (2009) Cancer Res. 69, 6007-6010
10. Owens, P., Han, G., Li, A. G., and Wang, X. J. (2008) J. Invest. Derm. 128, 783-790
11. Stover, D. G., Bierie, B., and Moses, H. L. (2007) J. Cell. Biochem. 101, 851-861
12. Jonkers, J., Meuwissen, R., van der Gulden, H., Peterse, H., van der Valk, M., and Berns, A. (2001) Nat. Genet. 29, 418-425
13. Mao, J., Ligon, K. L., Rakhlin, E. Y., Thayer, S. P., Bronson, R. T., Rowitch, D., and McMahon, A. P. (2006) Cancer Res. 66, 10171-10178
14. Lecanda, J., Ganapathy, V., D'Aquino-Ardalan, C., Evans, B., Cadacio, C., Ayala, A., and Gold, L. I. (2009) Cell Cycle 8, 724-756
15. Xie, J., and Garrossian, M. (August 13, 2009) World Intellectual Property Organization Patent PCT/US2009/000737
16. Athar, M., Li, C., Tang, X., Chi, S., Zhang, X., Kim, A. L., Tyring, S. K., Kopelovich, L., Hebert, J., Epstein, E. H., Jr., Bickers, D. R., and Xie, J. (2004) Cancer Res. 64, 7545-7552
17. He, J., Sheng, T., Stelter, A. A., Li, C., Zhang, X., Sinha, M., Luxon, B. A., and Xie, J. (2006) J. Biol. Chem. 281, 35598-35602
18. Jain, N., Thatte, J., Braciale, T., Ley, K., O'Connell, M., and Lee, J. K. (2003) Bioinformatics 19, 1945-1951
19. Moffat, J., Grueneberg, D. A., Yang, X., Kim, S. Y., Kloepfer, A. M., Hinkle, G., Piqani, B., Eisenhaure, T. M., Luo, B., Grenier, J. K., Carpenter, A. E., Foo, S. Y., Stewart, S. A., Stockwell, B. R., Hacohen, N., Hahn, W. C., Lander, E. S., Sabatini, D. M., and Root, D. E. (2006) Cell 124, 1283-1298
20. Wichterle, H., Lieberam, I., Porter, J. A., and Jessell, T. M. (2002) Cell 110, 385-397
21. Mao, J., Barrow, J., McMahon, J., Vaughan, J., and McMahon, A. P. (2005) Nucleic Acids Res. 33, e155
22. Chen, Y. G., and Wang, X. F. (2009) Cell Res. 19, 1-2
23. Flavell, R. A., Sanjabi, S., Wrzesinski, S. H., and Licona-Limón, P. (2010) Nat. Rev. Immunol. 10, 554-567
24. Guo, X., and Wang, X. F. (2009) Cell Res. 19, 71-88
25. Alvarez, J., Sohn, P., Zeng, X., Doetschman, T., Robbins, D. J., and Serra, R. (2002) Development 129, 1913-1924
26. Dennler, S., André, J., Alexaki, I., Li, A., Magnaldo, T., ten Dijke, P., Wang, X. J., Verrecchia, F., and Mauviel, A. (2007) Cancer Res. 67, 6981-6986
27. Yoo, Y. A., Kang, M. H., Kim, J. S., and Oh, S. C. (2008) Carcinogenesis 29, 480-490
28. Massagué, J. (2008) Cell 134, 215-230