Inhibition of hedgehog signaling antagonizes serous ovarian cancer growth in a primary xenograft model

PLoS ONE

Volumn 6, Issue 11, 2011, Pages

  McCann, Christopher K ^a,b   Growdon, Whitfield B ^a,b   Kulkarni Datar, Kashmira ^a,b   Curley, Michael D ^a,b   Friel, Anne M ^a,b   Proctor, Jennifer L ^c   Sheikh, Hana ^c   Deyneko, Igor ^c   Ferguson, Jeanne A ^c   Vathipadiekal, Vinod ^b,d   Birrer, Michael J ^b,d   Borger, Darrell R ^b,d   Mohapatra, Gayatry ^b,d   Zukerberg, Lawrence R ^a,b   Foster, Rosemary ^a,b   MacDougall, John R ^c   Rueda, Bo R ^a,b  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c Infinity Pharmaceuticals Inc   (United States)

^d MASSACHUSETTS GENERAL HOSPITAL CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; CARBOPLATIN; CYCLOPAMINE; IPI 926; PACLITAXEL; SONIC HEDGEHOG PROTEIN; TRANSCRIPTION FACTOR GLI1; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER COMBINATION CHEMOTHERAPY; CANCER GROWTH; CANCER INHIBITION; CANCER SURVIVAL; CHRONIC DRUG ADMINISTRATION; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; FEMALE; HUMAN; HUMAN TISSUE; IN VIVO STUDY; MAINTENANCE THERAPY; MOLECULAR PATHOLOGY; MOUSE; NONHUMAN; OVARY CANCER; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SINGLE DRUG DOSE; STROMA CELL; TUMOR XENOGRAFT;

ANIMALS; CELL PROLIFERATION; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HEDGEHOG PROTEINS; HUMANS; MAINTENANCE CHEMOTHERAPY; MICE; NEOPLASMS, CYSTIC, MUCINOUS, AND SEROUS; OVARIAN NEOPLASMS; RNA, MESSENGER; SIGNAL TRANSDUCTION; STROMAL CELLS; SURVIVAL ANALYSIS; TRANSCRIPTION FACTORS; VERATRUM ALKALOIDS; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 82255169379     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0028077     Document Type: Article

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