Vismodegib

Nature Reviews Drug Discovery

Volumn 11, Issue 6, 2012, Pages 437-438

  Dlugosz, Andrzej ^a   Agrawal, Sid ^b   Kirkpatrick, Peter ^c  

^a UNIVERSITY OF MICHIGAN COMPREHENSIVE CANCER CENTER   (United States)

^b Nature Reviews Drug Discovery   (United States)

^c Nature Reviews Drug Discovery ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; CYCLOPAMINE; ERISMODEGIB; N (3 METHOXYBENZYL) 3,3 DIMETHYL N [1 (3,4 METHYLENEDIOXYBENZYL) 2 (1 PIPERAZINYLCARBONYL) 4 PYRROLIDINYL]BUTYRAMIDE; SONIC HEDGEHOG PROTEIN; UNCLASSIFIED DRUG; VISMODEGIB;

ADVANCED CANCER; BASAL CELL CARCINOMA; CANCER CHEMOTHERAPY; CANCER RADIOTHERAPY; CANCER RESISTANCE; CANCER SURGERY; DRUG APPROVAL; DRUG EFFICACY; DRUG MECHANISM; DRUG SAFETY; DRUG STRUCTURE; FATIGUE; HAIR LOSS; HUMAN; MEDULLOBLASTOMA; METASTASIS; MUSCLE SPASM; NAUSEA; PRIORITY JOURNAL; PROTEIN FUNCTION; SHORT SURVEY; SIDE EFFECT; SIGNAL TRANSDUCTION; TASTE DISORDER; TREATMENT DURATION; TREATMENT INDICATION; WEIGHT REDUCTION;

ANILIDES; ANTINEOPLASTIC AGENTS; BREAST NEOPLASMS; CARCINOMA, BASAL CELL; CLINICAL TRIALS AS TOPIC; DEVICE APPROVAL; DRUG DISCOVERY; FEMALE; HEDGEHOG PROTEINS; HUMANS; PYRIDINES; SIGNAL TRANSDUCTION; UNITED STATES; UNITED STATES FOOD AND DRUG ADMINISTRATION;

EID: 84861903142     PISSN: 14741776     EISSN: 14741784     Source Type: Journal    
DOI: 10.1038/nrd3753     Document Type: Short Survey

References (6)

1. Rubin, A. I., Chen, E. H. & Ratner, D. R. Basal-cell carcinoma. N. Engl. J. Med. 353, 2262-2269 (2005).
2. Barakat, M. T., Humke, E. W. & Scott, M. P. Learning from Jekyll to control Hyde: Hedgehog signaling in development and cancer. Trends Mol. Med. 16, 337-348 (2010).
3. Robarge, K. D. et al. GDC-0449 - a potent inhibitor of the hedgehog pathway. Bioorg. Med. Chem. Lett. 19, 5576-5581 (2009).
4. US Food and Drug Administration. FDA labeling information - Erivedge. FDA website [online], http://www.accessdata.fda.gov/drugsatfdadocs/label/2012/ 203388lbl.pdf (2012).
5. Von Hoff, D. D. et al. Inhibition of the hedgehog pathway in advanced basal-cell carcinoma. N. Engl. J. Med. 361, 1164-1172 (2009).
6. Skvara, H. et al. Topical treatment of basal cell carcinomas in nevoid basal cell carcinoma syndrome with a Smoothened inhibitor. J. Invest. Dermatol. 131, 1735-1744 (2011).