Blocking hedgehog survival signaling at the level of the GLI genes induces DNA damage and extensive cell death in human colon carcinoma cells

Cancer Research

Volumn 71, Issue 17, 2011, Pages 5904-5914

  Mazumdar, Tapati ^a   DeVecchio, Jennifer ^a   Agyeman, Akwasi ^a   Shi, Ting ^a   Houghton, Janet A ^a  

^a LERNER RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; CYCLIN A; CYCLIN E; CYCLOPAMINE; GLI SMALL MOLECULE INHIBITOR GANT61; LIPOCORTIN 5; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 1; PROTEIN BCL 2; PROTEIN INHIBITOR; PROTEIN P21; SMALL MOLECULE INHIBITOR; SONIC HEDGEHOG PROTEIN; TRANSCRIPTION FACTOR GLI1; TRANSCRIPTION FACTOR GLI2; TRANSCRIPTION FACTOR INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; CARCINOMA CELL; CELL CYCLE G1 PHASE; CELL CYCLE S PHASE; CELL DEATH; COLON CARCINOMA; CYTOTOXICITY; DNA DAMAGE; ENZYME ACTIVATION; FLOW CYTOMETRY; GENE EXPRESSION; GENE TARGETING; HUMAN; HUMAN CELL; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION;

APOPTOSIS; CARCINOMA; CELL LINE, TUMOR; COLONIC NEOPLASMS; DNA DAMAGE; GENE EXPRESSION; HEDGEHOG PROTEINS; HUMANS; KRUPPEL-LIKE TRANSCRIPTION FACTORS; PYRIDINES; PYRIMIDINES; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS; VERATRUM ALKALOIDS;

EID: 80052225991     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-10-4173     Document Type: Article

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