-
1
-
-
70450187617
-
The regulation of TGFβ signal transduction
-
A. Moustakas, and C.-H. Heldin The regulation of TGFβ signal transduction Development 136 2009 3699 3714
-
(2009)
Development
, vol.136
, pp. 3699-3714
-
-
Moustakas, A.1
Heldin, C.-H.2
-
2
-
-
47549090432
-
TGFβ in cancer
-
J. Massagué TGFβ in cancer Cell 134 2008 215 230
-
(2008)
Cell
, vol.134
, pp. 215-230
-
-
Massagué, J.1
-
3
-
-
40849133772
-
Role of transforming growth factor-β superfamily signaling pathways in human disease
-
K.J. Gordon, and G.C. Blobe Role of transforming growth factor-β superfamily signaling pathways in human disease Biochim. Biophys. Acta 1782 2008 197 228
-
(2008)
Biochim. Biophys. Acta
, vol.1782
, pp. 197-228
-
-
Gordon, K.J.1
Blobe, G.C.2
-
4
-
-
30944444113
-
Alterations in components of the TGF-β superfamily signaling pathways in human cancer
-
L. Levy, and C.S. Hill Alterations in components of the TGF-β superfamily signaling pathways in human cancer Cytokine Growth Factor Rev. 17 2006 41 58
-
(2006)
Cytokine Growth Factor Rev.
, vol.17
, pp. 41-58
-
-
Levy, L.1
Hill, C.S.2
-
5
-
-
70450198396
-
Epithelial-mesenchymal transitions in development and disease
-
J.P. Thiery, H. Acloque, R.Y. Huang, and M.A. Nieto Epithelial- mesenchymal transitions in development and disease Cell 139 2009 871 890
-
(2009)
Cell
, vol.139
, pp. 871-890
-
-
Thiery, J.P.1
Acloque, H.2
Huang, R.Y.3
Nieto, M.A.4
-
6
-
-
68549123472
-
New regulatory mechanisms of TGF-β receptor function
-
J.S. Kang, C. Liu, and R. Derynck New regulatory mechanisms of TGF-β receptor function Trends Cell Biol. 19 2009 385 394
-
(2009)
Trends Cell Biol.
, vol.19
, pp. 385-394
-
-
Kang, J.S.1
Liu, C.2
Derynck, R.3
-
7
-
-
53349164136
-
The type i TGF-β receptor engages TRAF6 to activate TAK1 in a receptor kinase-independent manner
-
A. Sorrentino, N. Thakur, S. Grimsby, A. Marcusson, V. von Bulow, N. Schuster, S. Zhang, C.-H. Heldin, and M. Landström The type I TGF-β receptor engages TRAF6 to activate TAK1 in a receptor kinase-independent manner Nat. Cell Biol. 10 2008 1199 1207
-
(2008)
Nat. Cell Biol.
, vol.10
, pp. 1199-1207
-
-
Sorrentino, A.1
Thakur, N.2
Grimsby, S.3
Marcusson, A.4
Von Bulow, V.5
Schuster, N.6
Zhang, S.7
Heldin, C.-H.8
Landström, M.9
-
8
-
-
52049111663
-
TRAF6 mediates Smad-independent activation of JNK and p38 by TGF-β
-
M. Yamashita, K. Fatyol, C. Jin, X. Wang, Z. Liu, and Y.E. Zhang TRAF6 mediates Smad-independent activation of JNK and p38 by TGF-β Mol. Cell 31 2008 918 924
-
(2008)
Mol. Cell
, vol.31
, pp. 918-924
-
-
Yamashita, M.1
Fatyol, K.2
Jin, C.3
Wang, X.4
Liu, Z.5
Zhang, Y.E.6
-
9
-
-
79958698402
-
TRAF6 ubiquitinates TGFβ type i receptor to promote its cleavage and nuclear translocation in cancer
-
Y. Mu, R. Sundar, N. Thakur, M. Ekman, S.K. Gudey, M. Yakymovych, A. Hermansson, H. Dimitriou, M.T. Bengoechea-Alonso, J. Ericsson, C.-H. Heldin, and M. Landström TRAF6 ubiquitinates TGFβ type I receptor to promote its cleavage and nuclear translocation in cancer Nat. Commun. 2 2011 330
-
(2011)
Nat. Commun.
, vol.2
, pp. 330
-
-
Mu, Y.1
Sundar, R.2
Thakur, N.3
Ekman, M.4
Gudey, S.K.5
Yakymovych, M.6
Hermansson, A.7
Dimitriou, H.8
Bengoechea-Alonso, M.T.9
Ericsson, J.10
Heldin, C.-H.11
Landström, M.12
-
10
-
-
0028603343
-
TGF-β induced transdifferentiation of mammary epithelial cells to mesenchymal cells: Involvement of type i receptors
-
P.J. Miettinen, R. Ebner, A.R. Lopez, and R. Derynck TGF-β induced transdifferentiation of mammary epithelial cells to mesenchymal cells: Involvement of type I receptors J. Cell Biol. 127 1994 2021 2036
-
(1994)
J. Cell Biol.
, vol.127
, pp. 2021-2036
-
-
Miettinen, P.J.1
Ebner, R.2
Lopez, A.R.3
Derynck, R.4
-
11
-
-
70450142560
-
Inflammation and EMT: An alliance towards organ fibrosis and cancer progression
-
J.M. López-Novoa, and M.A. Nieto Inflammation and EMT: an alliance towards organ fibrosis and cancer progression EMBO Mol. Med. 1 2009 303 314
-
(2009)
EMBO Mol. Med.
, vol.1
, pp. 303-314
-
-
López-Novoa, J.M.1
Nieto, M.A.2
-
12
-
-
0036322007
-
Evidence that fibroblasts derive from epithelium during tissue fibrosis
-
M. Iwano, D. Plieth, T.M. Danoff, C. Xue, H. Okada, and E.G. Neilson Evidence that fibroblasts derive from epithelium during tissue fibrosis J. Clin. Invest. 110 2002 341 350
-
(2002)
J. Clin. Invest.
, vol.110
, pp. 341-350
-
-
Iwano, M.1
Plieth, D.2
Danoff, T.M.3
Xue, C.4
Okada, H.5
Neilson, E.G.6
-
13
-
-
34548145815
-
Fibroblasts derive from hepatocytes in liver fibrosis via epithelial to mesenchymal transition
-
M. Zeisberg, C. Yang, M. Martino, M.B. Duncan, F. Rieder, H. Tanjore, and R. Kalluri Fibroblasts derive from hepatocytes in liver fibrosis via epithelial to mesenchymal transition J. Biol. Chem. 282 2007 23337 23347
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 23337-23347
-
-
Zeisberg, M.1
Yang, C.2
Martino, M.3
Duncan, M.B.4
Rieder, F.5
Tanjore, H.6
Kalluri, R.7
-
14
-
-
33748375828
-
Alveolar epithelial cell mesenchymal transition develops in vivo during pulmonary fibrosis and is regulated by the extracellular matrix
-
K.K. Kim, M.C. Kugler, P.J. Wolters, L. Robillard, M.G. Galvez, A.N. Brumwell, D. Sheppard, and H.A. Chapman Alveolar epithelial cell mesenchymal transition develops in vivo during pulmonary fibrosis and is regulated by the extracellular matrix Proc. Natl. Acad. Sci. USA 103 2006 13180 13185
-
(2006)
Proc. Natl. Acad. Sci. USA
, vol.103
, pp. 13180-13185
-
-
Kim, K.K.1
Kugler, M.C.2
Wolters, P.J.3
Robillard, L.4
Galvez, M.G.5
Brumwell, A.N.6
Sheppard, D.7
Chapman, H.A.8
-
15
-
-
34547676391
-
Endothelial-to-mesenchymal transition contributes to cardiac fibrosis
-
E.M. Zeisberg, O. Tarnavski, M. Zeisberg, A.L. Dorfman, J.R. McMullen, E. Gustafsson, A. Chandraker, X. Yuan, W.T. Pu, A.B. Roberts, E.G. Neilson, M.H. Sayegh, S. Izumo, and R. Kalluri Endothelial-to-mesenchymal transition contributes to cardiac fibrosis Nat. Med. 13 2007 952 961
-
(2007)
Nat. Med.
, vol.13
, pp. 952-961
-
-
Zeisberg, E.M.1
Tarnavski, O.2
Zeisberg, M.3
Dorfman, A.L.4
McMullen, J.R.5
Gustafsson, E.6
Chandraker, A.7
Yuan, X.8
Pu, W.T.9
Roberts, A.B.10
Neilson, E.G.11
Sayegh, M.H.12
Izumo, S.13
Kalluri, R.14
-
16
-
-
55249103431
-
Fibroblasts in kidney fibrosis emerge via endothelial-to-mesenchymal transition
-
E.M. Zeisberg, S.E. Potenta, H. Sugimoto, M. Zeisberg, and R. Kalluri Fibroblasts in kidney fibrosis emerge via endothelial-to-mesenchymal transition J. Am. Soc. Nephrol. 19 2008 2282 2287
-
(2008)
J. Am. Soc. Nephrol.
, vol.19
, pp. 2282-2287
-
-
Zeisberg, E.M.1
Potenta, S.E.2
Sugimoto, H.3
Zeisberg, M.4
Kalluri, R.5
-
17
-
-
68549106083
-
E-cadherin, beta-catenin, and ZEB1 in malignant progression of cancer
-
O. Schmalhofer, S. Brabletz, and T. Brabletz E-cadherin, beta-catenin, and ZEB1 in malignant progression of cancer Cancer Metastasis Rev. 28 2009 151 166
-
(2009)
Cancer Metastasis Rev.
, vol.28
, pp. 151-166
-
-
Schmalhofer, O.1
Brabletz, S.2
Brabletz, T.3
-
18
-
-
33645758275
-
Tumor invasion in the absence of epithelial-mesenchymal transition: Podoplanin-mediated remodeling of the actin cytoskeleton
-
A. Wicki, F. Lehembre, N. Wick, B. Hantusch, D. Kerjaschki, and G. Christofori Tumor invasion in the absence of epithelial-mesenchymal transition: podoplanin-mediated remodeling of the actin cytoskeleton Cancer Cell 9 2006 261 272
-
(2006)
Cancer Cell
, vol.9
, pp. 261-272
-
-
Wicki, A.1
Lehembre, F.2
Wick, N.3
Hantusch, B.4
Kerjaschki, D.5
Christofori, G.6
-
19
-
-
34249289041
-
Snail, Zeb and bHLH factors in tumour progression: An alliance against the epithelial phenotype?
-
H. Peinado, D. Olmeda, and A. Cano Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype? Nat. Rev. Cancer 7 2007 415 428
-
(2007)
Nat. Rev. Cancer
, vol.7
, pp. 415-428
-
-
Peinado, H.1
Olmeda, D.2
Cano, A.3
-
20
-
-
34547141894
-
Mesenchyme Forkhead 1 (FOXC2) plays a key role in metastasis and is associated with aggressive basal-like breast cancers
-
S.A. Mani, J. Yang, M. Brooks, G. Schwaninger, A. Zhou, N. Miura, J.L. Kutok, K. Hartwell, A.L. Richardson, and R.A. Weinberg Mesenchyme Forkhead 1 (FOXC2) plays a key role in metastasis and is associated with aggressive basal-like breast cancers Proc. Natl. Acad. Sci. USA 104 2007 10069 10074
-
(2007)
Proc. Natl. Acad. Sci. USA
, vol.104
, pp. 10069-10074
-
-
Mani, S.A.1
Yang, J.2
Brooks, M.3
Schwaninger, G.4
Zhou, A.5
Miura, N.6
Kutok, J.L.7
Hartwell, K.8
Richardson, A.L.9
Weinberg, R.A.10
-
21
-
-
33746034613
-
Transforming growth factor-β employs HMGA2 to elicit epithelial-mesenchymal transition
-
S. Thuault, U. Valcourt, M. Petersen, G. Manfioletti, C.-H. Heldin, and A. Moustakas Transforming growth factor-β employs HMGA2 to elicit epithelial-mesenchymal transition J. Cell Biol. 174 2006 175 183
-
(2006)
J. Cell Biol.
, vol.174
, pp. 175-183
-
-
Thuault, S.1
Valcourt, U.2
Petersen, M.3
Manfioletti, G.4
Heldin, C.-H.5
Moustakas, A.6
-
22
-
-
57749114754
-
HMGA2 and Smads coregulate SNAIL1 expression during induction of epithelial-to-mesenchymal transition
-
S. Thuault, E.-J. Tan, H. Peinado, A. Cano, C.-H. Heldin, and A. Moustakas HMGA2 and Smads coregulate SNAIL1 expression during induction of epithelial-to-mesenchymal transition J. Biol. Chem. 283 2008 33437 33446
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 33437-33446
-
-
Thuault, S.1
Tan, E.-J.2
Peinado, H.3
Cano, A.4
Heldin, C.-H.5
Moustakas, A.6
-
23
-
-
67650045932
-
A Twist-Snail axis critical for TrkB-induced epithelial-mesenchymal transition-like transformation, anoikis resistance, and metastasis
-
M.A. Smit, T.R. Geiger, J.Y. Song, I. Gitelman, and D.S. Peeper A Twist-Snail axis critical for TrkB-induced epithelial-mesenchymal transition-like transformation, anoikis resistance, and metastasis Mol. Cell. Biol. 29 2009 3722 3737
-
(2009)
Mol. Cell. Biol.
, vol.29
, pp. 3722-3737
-
-
Smit, M.A.1
Geiger, T.R.2
Song, J.Y.3
Gitelman, I.4
Peeper, D.S.5
-
24
-
-
79953325707
-
Functional cooperation between Snail1 and twist in the regulation of ZEB1 expression during epithelial to mesenchymal transition
-
N. Dave, S. Guaita-Esteruelas, S. Gutarra, A. Frias, M. Beltran, S. Peiro, and A.G. de Herreros Functional cooperation between Snail1 and twist in the regulation of ZEB1 expression during epithelial to mesenchymal transition J. Biol. Chem. 286 2011 12024 12032
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 12024-12032
-
-
Dave, N.1
Guaita-Esteruelas, S.2
Gutarra, S.3
Frias, A.4
Beltran, M.5
Peiro, S.6
De Herreros, A.G.7
-
25
-
-
0037131409
-
Snail induction of epithelial to mesenchymal transition in tumor cells is accompanied by MUC1 repression and ZEB1 expression
-
S. Guaita, I. Puig, C. Franci, M. Garrido, D. Dominguez, E. Batlle, E. Sancho, S. Dedhar, A.G. de Herreros, and J. Baulida Snail induction of epithelial to mesenchymal transition in tumor cells is accompanied by MUC1 repression and ZEB1 expression J. Biol. Chem. 277 2002 39209 39216
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 39209-39216
-
-
Guaita, S.1
Puig, I.2
Franci, C.3
Garrido, M.4
Dominguez, D.5
Batlle, E.6
Sancho, E.7
Dedhar, S.8
De Herreros, A.G.9
Baulida, J.10
-
26
-
-
78651401992
-
Snail2 is an essential mediator of Twist1-induced epithelial mesenchymal transition and metastasis
-
E. Casas, J. Kim, A. Bendesky, L. Ohno-Machado, C.J. Wolfe, and J. Yang Snail2 is an essential mediator of Twist1-induced epithelial mesenchymal transition and metastasis Cancer Res. 71 2011 245 254
-
(2011)
Cancer Res.
, vol.71
, pp. 245-254
-
-
Casas, E.1
Kim, J.2
Bendesky, A.3
Ohno-Machado, L.4
Wolfe, C.J.5
Yang, J.6
-
27
-
-
33644534795
-
The tumor suppressor Smad4 is required for transforming growth factor β-induced epithelial to mesenchymal transition and bone metastasis of breast cancer cells
-
M. Deckers, M. van Dinther, J. Buijs, I. Que, C. Lowik, G. van der Pluijm, and P. ten Dijke The tumor suppressor Smad4 is required for transforming growth factor β-induced epithelial to mesenchymal transition and bone metastasis of breast cancer cells Cancer Res. 66 2006 2202 2209
-
(2006)
Cancer Res.
, vol.66
, pp. 2202-2209
-
-
Deckers, M.1
Van Dinther, M.2
Buijs, J.3
Que, I.4
Lowik, C.5
Van Der Pluijm, G.6
Ten Dijke, P.7
-
28
-
-
16344378397
-
TGF-β and the Smad signaling pathway support transcriptomic reprogramming during epithelial mesenchymal cell transition
-
U. Valcourt, M. Kowanetz, H. Niimi, C.-H. Heldin, and A. Moustakas TGF-β and the Smad signaling pathway support transcriptomic reprogramming during epithelial mesenchymal cell transition Mol. Biol. Cell 16 2005 1987 2002
-
(2005)
Mol. Biol. Cell
, vol.16
, pp. 1987-2002
-
-
Valcourt, U.1
Kowanetz, M.2
Niimi, H.3
Heldin, C.-H.4
Moustakas, A.5
-
29
-
-
30944466813
-
Smad3 is key to TGF-β-mediated epithelial-to-mesenchymal transition, fibrosis, tumor suppression and metastasis
-
A.B. Roberts, F. Tian, S.D. Byfield, C. Stuelten, A. Ooshima, S. Saika, and K.C. Flanders Smad3 is key to TGF-β-mediated epithelial-to-mesenchymal transition, fibrosis, tumor suppression and metastasis Cytokine Growth Factor Rev. 17 2006 19 27
-
(2006)
Cytokine Growth Factor Rev.
, vol.17
, pp. 19-27
-
-
Roberts, A.B.1
Tian, F.2
Byfield, S.D.3
Stuelten, C.4
Ooshima, A.5
Saika, S.6
Flanders, K.C.7
-
30
-
-
0033377867
-
TGF-β type i receptor/ALK5 and SMAD proteins mediate epithelial to mesenchymal transdifferentiation in NMuMG breast epithelial cells
-
E. Piek, A. Moustakas, A. Kurisaki, C.-H. Heldin, and P. ten Dijke TGF-β type I receptor/ALK5 and SMAD proteins mediate epithelial to mesenchymal transdifferentiation in NMuMG breast epithelial cells J. Cell Sci. 112 1999 4557 4568
-
(1999)
J. Cell Sci.
, vol.112
, pp. 4557-4568
-
-
Piek, E.1
Moustakas, A.2
Kurisaki, A.3
Heldin, C.-H.4
Ten Dijke, P.5
-
31
-
-
48749122568
-
Keratinocyte-specific Smad2 ablation results in increased epithelial-mesenchymal transition during skin cancer formation and progression
-
K.E. Hoot, J. Lighthall, G. Han, S.L. Lu, A. Li, W. Ju, M. Kulesz-Martin, E. Bottinger, and X.J. Wang Keratinocyte-specific Smad2 ablation results in increased epithelial-mesenchymal transition during skin cancer formation and progression J. Clin. Invest. 118 2008 2722 2732
-
(2008)
J. Clin. Invest.
, vol.118
, pp. 2722-2732
-
-
Hoot, K.E.1
Lighthall, J.2
Han, G.3
Lu, S.L.4
Li, A.5
Ju, W.6
Kulesz-Martin, M.7
Bottinger, E.8
Wang, X.J.9
-
32
-
-
69949136772
-
Role of SARA (SMAD anchor for receptor activation) in maintenance of epithelial cell phenotype
-
C.E. Runyan, T. Hayashida, S. Hubchak, J.F. Curley, and H.W. Schnaper Role of SARA (SMAD anchor for receptor activation) in maintenance of epithelial cell phenotype J. Biol. Chem. 284 2009 25181 25189
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 25181-25189
-
-
Runyan, C.E.1
Hayashida, T.2
Hubchak, S.3
Curley, J.F.4
Schnaper, H.W.5
-
33
-
-
79957596419
-
Selective targeting of activating and inhibitory Smads by distinct WWP2 ubiquitin ligase isoforms differentially modulates TGFβ signalling and EMT
-
S.M. Soond, and A. Chantry Selective targeting of activating and inhibitory Smads by distinct WWP2 ubiquitin ligase isoforms differentially modulates TGFβ signalling and EMT Oncogene 30 2011 2451 2462
-
(2011)
Oncogene
, vol.30
, pp. 2451-2462
-
-
Soond, S.M.1
Chantry, A.2
-
34
-
-
58149093172
-
FAM/USP9x, a deubiquitinating enzyme essential for TGFβ signaling, controls Smad4 monoubiquitination
-
S. Dupont, A. Mamidi, M. Cordenonsi, M. Montagner, L. Zacchigna, M. Adorno, G. Martello, M.J. Stinchfield, S. Soligo, L. Morsut, M. Inui, S. Moro, N. Modena, F. Argenton, S.J. Newfeld, and S. Piccolo FAM/USP9x, a deubiquitinating enzyme essential for TGFβ signaling, controls Smad4 monoubiquitination Cell 136 2009 123 135
-
(2009)
Cell
, vol.136
, pp. 123-135
-
-
Dupont, S.1
Mamidi, A.2
Cordenonsi, M.3
Montagner, M.4
Zacchigna, L.5
Adorno, M.6
Martello, G.7
Stinchfield, M.J.8
Soligo, S.9
Morsut, L.10
Inui, M.11
Moro, S.12
Modena, N.13
Argenton, F.14
Newfeld, S.J.15
Piccolo, S.16
-
35
-
-
33646876973
-
Hematopoiesis controlled by distinct TIF1γ and Smad4 branches of the TGFβ pathway
-
W. He, D.C. Dorn, H. Erdjument-Bromage, P. Tempst, M.A. Moore, and J. Massagué Hematopoiesis controlled by distinct TIF1γ and Smad4 branches of the TGFβ pathway Cell 125 2006 929 941
-
(2006)
Cell
, vol.125
, pp. 929-941
-
-
He, W.1
Dorn, D.C.2
Erdjument-Bromage, H.3
Tempst, P.4
Moore, M.A.5
Massagué, J.6
-
36
-
-
79959969184
-
Antagonistic regulation of EMT by TIF1γ and Smad4 in mammary epithelial cells
-
C. Hesling, L. Fattet, G. Teyre, D. Jury, P. Gonzalo, J. Lopez, C. Vanbelle, A.P. Morel, G. Gillet, I. Mikaelian, and R. Rimokh Antagonistic regulation of EMT by TIF1γ and Smad4 in mammary epithelial cells EMBO Rep. 12 2011 665 672
-
(2011)
EMBO Rep.
, vol.12
, pp. 665-672
-
-
Hesling, C.1
Fattet, L.2
Teyre, G.3
Jury, D.4
Gonzalo, P.5
Lopez, J.6
Vanbelle, C.7
Morel, A.P.8
Gillet, G.9
Mikaelian, I.10
Rimokh, R.11
-
37
-
-
84857761971
-
Regulation of transcription factor Twist expression by the DNA architectural protein high mobility group A2 during epithelial-to-mesenchymal transition
-
in press
-
Tan, E.-J., Thuault, S., Caja, L., Carletti, T., Heldin, C.-H., and Moustakas, A. (in press). Regulation of transcription factor Twist expression by the DNA architectural protein high mobility group A2 during epithelial-to-mesenchymal transition. J. Biol. Chem.
-
J. Biol. Chem.
-
-
Tan, E.-J.1
Thuault, S.2
Caja, L.3
Carletti, T.4
Heldin, C.-H.5
Moustakas, A.6
-
38
-
-
0038756636
-
Transforming growth factor β-1 induces snail transcription factor in epithelial cell lines: Mechanisms for epithelial mesenchymal transitions
-
H. Peinado, M. Quintanilla, and A. Cano Transforming growth factor β-1 induces snail transcription factor in epithelial cell lines: mechanisms for epithelial mesenchymal transitions J. Biol. Chem. 278 2003 21113 21123
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 21113-21123
-
-
Peinado, H.1
Quintanilla, M.2
Cano, A.3
-
39
-
-
77957868981
-
ATF3, an adaptive-response gene, enhances TGFβ signaling and cancer-initiating cell features in breast cancer cells
-
X. Yin, C.C. Wolford, Y.S. Chang, S.J. McConoughey, S.A. Ramsey, A. Aderem, and T. Hai ATF3, an adaptive-response gene, enhances TGFβ signaling and cancer-initiating cell features in breast cancer cells J. Cell Sci. 123 2010 3558 3565
-
(2010)
J. Cell Sci.
, vol.123
, pp. 3558-3565
-
-
Yin, X.1
Wolford, C.C.2
Chang, Y.S.3
McConoughey, S.J.4
Ramsey, S.A.5
Aderem, A.6
Hai, T.7
-
40
-
-
4344612243
-
NF-κB is essential for epithelial-mesenchymal transition and metastasis in a model of breast cancer progression
-
M.A. Huber, N. Azoitei, B. Baumann, S. Grunert, A. Sommer, H. Pehamberger, N. Kraut, H. Beug, and T. Wirth NF-κB is essential for epithelial-mesenchymal transition and metastasis in a model of breast cancer progression J. Clin. Invest. 114 2004 569 581
-
(2004)
J. Clin. Invest.
, vol.114
, pp. 569-581
-
-
Huber, M.A.1
Azoitei, N.2
Baumann, B.3
Grunert, S.4
Sommer, A.5
Pehamberger, H.6
Kraut, N.7
Beug, H.8
Wirth, T.9
-
41
-
-
76249084838
-
Smad signaling is required to maintain epigenetic silencing during breast cancer progression
-
P. Papageorgis, A.W. Lambert, S. Ozturk, F. Gao, H. Pan, U. Manne, Y.O. Alekseyev, A. Thiagalingam, H.M. Abdolmaleky, M. Lenburg, and S. Thiagalingam Smad signaling is required to maintain epigenetic silencing during breast cancer progression Cancer Res. 70 2010 968 978
-
(2010)
Cancer Res.
, vol.70
, pp. 968-978
-
-
Papageorgis, P.1
Lambert, A.W.2
Ozturk, S.3
Gao, F.4
Pan, H.5
Manne, U.6
Alekseyev, Y.O.7
Thiagalingam, A.8
Abdolmaleky, H.M.9
Lenburg, M.10
Thiagalingam, S.11
-
42
-
-
79961023271
-
Genome-scale epigenetic reprogramming during epithelial-to-mesenchymal transition
-
O.G. McDonald, H. Wu, W. Timp, A. Doi, and A.P. Feinberg Genome-scale epigenetic reprogramming during epithelial-to-mesenchymal transition Nat. Struct. Mol. Biol. 18 2011 867 874
-
(2011)
Nat. Struct. Mol. Biol.
, vol.18
, pp. 867-874
-
-
McDonald, O.G.1
Wu, H.2
Timp, W.3
Doi, A.4
Feinberg, A.P.5
-
43
-
-
80052221592
-
Interplay between HDAC3 and WDR5 is essential for hypoxia-induced epithelial-mesenchymal transition
-
M.Z. Wu, Y.P. Tsai, M.H. Yang, C.H. Huang, S.Y. Chang, C.C. Chang, S.C. Teng, and K.J. Wu Interplay between HDAC3 and WDR5 is essential for hypoxia-induced epithelial-mesenchymal transition Mol. Cell 43 2011 811 822
-
(2011)
Mol. Cell
, vol.43
, pp. 811-822
-
-
Wu, M.Z.1
Tsai, Y.P.2
Yang, M.H.3
Huang, C.H.4
Chang, S.Y.5
Chang, C.C.6
Teng, S.C.7
Wu, K.J.8
-
44
-
-
51049100212
-
Requirement of HDAC6 for transforming growth factor-β1-induced epithelial-mesenchymal transition
-
B. Shan, T.P. Yao, H.T. Nguyen, Y. Zhuo, D.R. Levy, R.C. Klingsberg, H. Tao, M.L. Palmer, K.N. Holder, and J.A. Lasky Requirement of HDAC6 for transforming growth factor-β1-induced epithelial-mesenchymal transition J. Biol. Chem. 283 2008 21065 21073
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 21065-21073
-
-
Shan, B.1
Yao, T.P.2
Nguyen, H.T.3
Zhuo, Y.4
Levy, D.R.5
Klingsberg, R.C.6
Tao, H.7
Palmer, M.L.8
Holder, K.N.9
Lasky, J.A.10
-
45
-
-
39149135251
-
Downregulation of Par-3 expression and disruption of Par complex integrity by TGF-β during the process of epithelial to mesenchymal transition in rat proximal epithelial cells
-
X. Wang, J. Nie, Q. Zhou, W. Liu, F. Zhu, W. Chen, H. Mao, N. Luo, X. Dong, and X. Yu Downregulation of Par-3 expression and disruption of Par complex integrity by TGF-β during the process of epithelial to mesenchymal transition in rat proximal epithelial cells Biochim. Biophys. Acta 1782 2008 51 59
-
(2008)
Biochim. Biophys. Acta
, vol.1782
, pp. 51-59
-
-
Wang, X.1
Nie, J.2
Zhou, Q.3
Liu, W.4
Zhu, F.5
Chen, W.6
Mao, H.7
Luo, N.8
Dong, X.9
Yu, X.10
-
46
-
-
14844364701
-
Regulation of the polarity protein Par6 by TGFβ receptors controls epithelial cell plasticity
-
B. Ozdamar, R. Bose, M. Barrios-Rodiles, H.R. Wang, Y. Zhang, and J.L. Wrana Regulation of the polarity protein Par6 by TGFβ receptors controls epithelial cell plasticity Science 307 2005 1603 1609
-
(2005)
Science
, vol.307
, pp. 1603-1609
-
-
Ozdamar, B.1
Bose, R.2
Barrios-Rodiles, M.3
Wang, H.R.4
Zhang, Y.5
Wrana, J.L.6
-
47
-
-
39049160267
-
The transcriptional repressor ZEB1 promotes metastasis and loss of cell polarity in cancer
-
S. Spaderna, O. Schmalhofer, M. Wahlbuhl, A. Dimmler, K. Bauer, A. Sultan, F. Hlubek, A. Jung, D. Strand, A. Eger, T. Kirchner, J. Behrens, and T. Brabletz The transcriptional repressor ZEB1 promotes metastasis and loss of cell polarity in cancer Cancer Res. 68 2008 537 544
-
(2008)
Cancer Res.
, vol.68
, pp. 537-544
-
-
Spaderna, S.1
Schmalhofer, O.2
Wahlbuhl, M.3
Dimmler, A.4
Bauer, K.5
Sultan, A.6
Hlubek, F.7
Jung, A.8
Strand, D.9
Eger, A.10
Kirchner, T.11
Behrens, J.12
Brabletz, T.13
-
48
-
-
44649163918
-
A reciprocal repression between ZEB1 and members of the miR-200 family promotes EMT and invasion in cancer cells
-
U. Burk, J. Schubert, U. Wellner, O. Schmalhofer, E. Vincan, S. Spaderna, and T. Brabletz A reciprocal repression between ZEB1 and members of the miR-200 family promotes EMT and invasion in cancer cells EMBO Rep. 9 2008 582 589
-
(2008)
EMBO Rep.
, vol.9
, pp. 582-589
-
-
Burk, U.1
Schubert, J.2
Wellner, U.3
Schmalhofer, O.4
Vincan, E.5
Spaderna, S.6
Brabletz, T.7
-
49
-
-
43049103824
-
The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1
-
P.A. Gregory, A.G. Bert, E.L. Paterson, S.C. Barry, A. Tsykin, G. Farshid, M.A. Vadas, Y. Khew-Goodall, and G.J. Goodall The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1 Nat. Cell Biol. 10 2008 593 601
-
(2008)
Nat. Cell Biol.
, vol.10
, pp. 593-601
-
-
Gregory, P.A.1
Bert, A.G.2
Paterson, E.L.3
Barry, S.C.4
Tsykin, A.5
Farshid, G.6
Vadas, M.A.7
Khew-Goodall, Y.8
Goodall, G.J.9
-
50
-
-
47249091921
-
The miR-200 family inhibits epithelial-mesenchymal transition and cancer cell migration by direct targeting of E-cadherin transcriptional repressors ZEB1 and ZEB2
-
M. Korpal, E.S. Lee, G. Hu, and Y. Kang The miR-200 family inhibits epithelial-mesenchymal transition and cancer cell migration by direct targeting of E-cadherin transcriptional repressors ZEB1 and ZEB2 J. Biol. Chem. 283 2008 14910 14914
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 14910-14914
-
-
Korpal, M.1
Lee, E.S.2
Hu, G.3
Kang, Y.4
-
51
-
-
41649091906
-
The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2
-
S.M. Park, A.B. Gaur, E. Lengyel, and M.E. Peter The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2 Genes Dev. 22 2008 894 907
-
(2008)
Genes Dev.
, vol.22
, pp. 894-907
-
-
Park, S.M.1
Gaur, A.B.2
Lengyel, E.3
Peter, M.E.4
-
52
-
-
73349099030
-
MicroRNAs differentially regulated by Akt isoforms control EMT and stem cell renewal in cancer cells
-
Iliopoulos, D., Polytarchou, C., Hatziapostolou, M., Kottakis, F., Maroulakou, I.G., Struhl, K., and Tsichlis, P.N. (2009). MicroRNAs differentially regulated by Akt isoforms control EMT and stem cell renewal in cancer cells. Sci. Signal. 2, ra62.
-
(2009)
Sci. Signal.
, vol.2
-
-
Iliopoulos, D.1
Polytarchou, C.2
Hatziapostolou, M.3
Kottakis, F.4
Maroulakou, I.G.5
Struhl, K.6
Tsichlis, P.N.7
-
53
-
-
41149112564
-
A natural antisense transcript regulates Zeb2/Sip1 gene expression during Snail1-induced epithelial-mesenchymal transition
-
M. Beltran, I. Puig, C. Pena, J.M. Garcia, A.B. Alvarez, R. Pena, F. Bonilla, and A.G. de Herreros A natural antisense transcript regulates Zeb2/Sip1 gene expression during Snail1-induced epithelial-mesenchymal transition Genes Dev. 22 2008 756 769
-
(2008)
Genes Dev.
, vol.22
, pp. 756-769
-
-
Beltran, M.1
Puig, I.2
Pena, C.3
Garcia, J.M.4
Alvarez, A.B.5
Pena, R.6
Bonilla, F.7
De Herreros, A.G.8
-
54
-
-
79955954699
-
An autocrine TGF-β/ZEB/miR-200 signaling network regulates establishment and maintenance of epithelial-mesenchymal transition
-
P.A. Gregory, C.P. Bracken, E. Smith, A.G. Bert, J.A. Wright, S. Roslan, M. Morris, L. Wyatt, G. Farshid, Y.Y. Lim, G.J. Lindeman, M.F. Shannon, P.A. Drew, Y. Khew-Goodall, and G.J. Goodall An autocrine TGF-β/ZEB/miR-200 signaling network regulates establishment and maintenance of epithelial-mesenchymal transition Mol. Biol. Cell 22 2011 1686 1698
-
(2011)
Mol. Biol. Cell
, vol.22
, pp. 1686-1698
-
-
Gregory, P.A.1
Bracken, C.P.2
Smith, E.3
Bert, A.G.4
Wright, J.A.5
Roslan, S.6
Morris, M.7
Wyatt, L.8
Farshid, G.9
Lim, Y.Y.10
Lindeman, G.J.11
Shannon, M.F.12
Drew, P.A.13
Khew-Goodall, Y.14
Goodall, G.J.15
-
55
-
-
79960391940
-
MiR-200a regulates SIRT1 expression and epithelial to mesenchymal transition (EMT)-like transformation in mammary epithelial cells
-
G. Eades, Y. Yao, M. Yang, Y. Zhang, S. Chumsri, and Q. Zhou MiR-200a regulates SIRT1 expression and epithelial to mesenchymal transition (EMT)-like transformation in mammary epithelial cells J. Biol. Chem. 286 2011 25992 26002
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 25992-26002
-
-
Eades, G.1
Yao, Y.2
Yang, M.3
Zhang, Y.4
Chumsri, S.5
Zhou, Q.6
-
56
-
-
55849123946
-
MicroRNA-155 is regulated by the transforming growth factor β/Smad pathway and contributes to epithelial cell plasticity by targeting RhoA
-
W. Kong, H. Yang, L. He, J.J. Zhao, D. Coppola, W.S. Dalton, and J.Q. Cheng MicroRNA-155 is regulated by the transforming growth factor β/Smad pathway and contributes to epithelial cell plasticity by targeting RhoA Mol. Cell. Biol. 28 2008 6773 6784
-
(2008)
Mol. Cell. Biol.
, vol.28
, pp. 6773-6784
-
-
Kong, W.1
Yang, H.2
He, L.3
Zhao, J.J.4
Coppola, D.5
Dalton, W.S.6
Cheng, J.Q.7
-
57
-
-
78650038626
-
TGF-β-induced MiR-491-5p expression promotes Par-3 degradation in rat proximal tubular epithelial cells
-
Q. Zhou, J. Fan, X. Ding, W. Peng, X. Yu, Y. Chen, and J. Nie TGF-β-induced MiR-491-5p expression promotes Par-3 degradation in rat proximal tubular epithelial cells J. Biol. Chem. 285 2010 40019 40027
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 40019-40027
-
-
Zhou, Q.1
Fan, J.2
Ding, X.3
Peng, W.4
Yu, X.5
Chen, Y.6
Nie, J.7
-
58
-
-
35148886434
-
Tumour invasion and metastasis initiated by microRNA-10b in breast cancer
-
L. Ma, J. Teruya-Feldstein, and R.A. Weinberg Tumour invasion and metastasis initiated by microRNA-10b in breast cancer Nature 449 2007 682 688
-
(2007)
Nature
, vol.449
, pp. 682-688
-
-
Ma, L.1
Teruya-Feldstein, J.2
Weinberg, R.A.3
-
59
-
-
79951813692
-
TGF-β regulates isoform switching of FGF receptors and epithelial-mesenchymal transition
-
T. Shirakihara, K. Horiguchi, K. Miyazawa, S. Ehata, T. Shibata, I. Morita, K. Miyazono, and M. Saitoh TGF-β regulates isoform switching of FGF receptors and epithelial-mesenchymal transition EMBO J. 30 2011 783 795
-
(2011)
EMBO J.
, vol.30
, pp. 783-795
-
-
Shirakihara, T.1
Horiguchi, K.2
Miyazawa, K.3
Ehata, S.4
Shibata, T.5
Morita, I.6
Miyazono, K.7
Saitoh, M.8
-
60
-
-
84863203049
-
TGF-β drives epithelial-mesenchymal transition through δeF1-mediated downregulation of ESRP
-
in press
-
Horiguchi, K., Sakamoto, K., Koinuma, D., Semba, K., Inoue, A., Inoue, S., Fujii, H., Yamaguchi, A., Miyazawa, K., Miyazono, K., and Saitoh, M. (in press). TGF-β drives epithelial-mesenchymal transition through δEF1-mediated downregulation of ESRP. Oncogene.
-
Oncogene
-
-
Horiguchi, K.1
Sakamoto, K.2
Koinuma, D.3
Semba, K.4
Inoue, A.5
Inoue, S.6
Fujii, H.7
Yamaguchi, A.8
Miyazawa Miyazono K, K.9
Saitoh, M.10
-
61
-
-
61649087689
-
ESRP1 and ESRP2 are epithelial cell-type-specific regulators of FGFR2 splicing
-
C.C. Warzecha, T.K. Sato, B. Nabet, J.B. Hogenesch, and R.P. Carstens ESRP1 and ESRP2 are epithelial cell-type-specific regulators of FGFR2 splicing Mol. Cell 33 2009 591 601
-
(2009)
Mol. Cell
, vol.33
, pp. 591-601
-
-
Warzecha, C.C.1
Sato, T.K.2
Nabet, B.3
Hogenesch, J.B.4
Carstens, R.P.5
-
62
-
-
77950552549
-
The epithelial splicing factors ESRP1 and ESRP2 positively and negatively regulate diverse types of alternative splicing events
-
C.C. Warzecha, S. Shen, Y. Xing, and R.P. Carstens The epithelial splicing factors ESRP1 and ESRP2 positively and negatively regulate diverse types of alternative splicing events RNA Biol. 6 2009 546 562
-
(2009)
RNA Biol.
, vol.6
, pp. 546-562
-
-
Warzecha, C.C.1
Shen, S.2
Xing, Y.3
Carstens, R.P.4
-
63
-
-
77649261101
-
TGF-β-mediated phosphorylation of hnRNP E1 induces EMT via transcript-selective translational induction of Dab2 and ILEI
-
A. Chaudhury, G.S. Hussey, P.S. Ray, G. Jin, P.L. Fox, and P.H. Howe TGF-β-mediated phosphorylation of hnRNP E1 induces EMT via transcript-selective translational induction of Dab2 and ILEI Nat. Cell Biol. 12 2010 286 293
-
(2010)
Nat. Cell Biol.
, vol.12
, pp. 286-293
-
-
Chaudhury, A.1
Hussey, G.S.2
Ray, P.S.3
Jin, G.4
Fox, P.L.5
Howe, P.H.6
-
64
-
-
79951472098
-
Identification of an mRNP complex regulating tumorigenesis at the translational elongation step
-
G.S. Hussey, A. Chaudhury, A.E. Dawson, D.J. Lindner, C.R. Knudsen, M.C. Wilce, W.C. Merrick, and P.H. Howe Identification of an mRNP complex regulating tumorigenesis at the translational elongation step Mol. Cell 41 2011 419 431
-
(2011)
Mol. Cell
, vol.41
, pp. 419-431
-
-
Hussey, G.S.1
Chaudhury, A.2
Dawson, A.E.3
Lindner, D.J.4
Knudsen, C.R.5
Wilce, M.C.6
Merrick, W.C.7
Howe, P.H.8
-
65
-
-
24644480749
-
Molecular requirements for epithelial-mesenchymal transition during tumor progression
-
M.A. Huber, N. Kraut, and H. Beug Molecular requirements for epithelial-mesenchymal transition during tumor progression Curr. Opin. Cell Biol. 17 2005 548 558
-
(2005)
Curr. Opin. Cell Biol.
, vol.17
, pp. 548-558
-
-
Huber, M.A.1
Kraut, N.2
Beug, H.3
-
66
-
-
33751514601
-
A Wnt-Axin2-GSK3β cascade regulates Snail1 activity in breast cancer cells
-
J.I. Yook, X.Y. Li, I. Ota, C. Hu, H.S. Kim, N.H. Kim, S.Y. Cha, J.K. Ryu, Y.J. Choi, J. Kim, E.R. Fearon, and S.J. Weiss A Wnt-Axin2-GSK3β cascade regulates Snail1 activity in breast cancer cells Nat. Cell Biol. 8 2006 1398 1406
-
(2006)
Nat. Cell Biol.
, vol.8
, pp. 1398-1406
-
-
Yook, J.I.1
Li, X.Y.2
Ota, I.3
Hu, C.4
Kim, H.S.5
Kim, N.H.6
Cha, S.Y.7
Ryu, J.K.8
Choi, Y.J.9
Kim, J.10
Fearon, E.R.11
Weiss, S.J.12
-
67
-
-
34249674558
-
TGFβ3 inhibits E-cadherin gene expression in palate medial-edge epithelial cells through a Smad2-Smad4-LEF1 transcription complex
-
A. Nawshad, D. Medici, C.C. Liu, and E.D. Hay TGFβ3 inhibits E-cadherin gene expression in palate medial-edge epithelial cells through a Smad2-Smad4-LEF1 transcription complex J. Cell Sci. 120 2007 1646 1653
-
(2007)
J. Cell Sci.
, vol.120
, pp. 1646-1653
-
-
Nawshad, A.1
Medici, D.2
Liu, C.C.3
Hay, E.D.4
-
68
-
-
68249092353
-
A SNAIL1-SMAD3/4 transcriptional repressor complex promotes TGF-β mediated epithelial-mesenchymal transition
-
T. Vincent, E.P.A. Neve, J.R. Johnson, A. Kukalev, F. Rojo, J. Albanell, K. Pietras, I. Virtanen, L. Philipson, P.L. Leopold, R.G. Crystal, A.G. de Herreros, A. Moustakas, R.F. Pettersson, and J. Fuxe A SNAIL1-SMAD3/4 transcriptional repressor complex promotes TGF-β mediated epithelial-mesenchymal transition Nat. Cell Biol. 11 2009 943 950
-
(2009)
Nat. Cell Biol.
, vol.11
, pp. 943-950
-
-
Vincent, T.1
Neve, E.P.A.2
Johnson, J.R.3
Kukalev, A.4
Rojo, F.5
Albanell, J.6
Pietras, K.7
Virtanen, I.8
Philipson, L.9
Leopold, P.L.10
Crystal, R.G.11
De Herreros, A.G.12
Moustakas, A.13
Pettersson, R.F.14
Fuxe, J.15
-
69
-
-
61749102618
-
Epithelial cell α3β1 integrin links β-catenin and Smad signaling to promote myofibroblast formation and pulmonary fibrosis
-
K.K. Kim, Y. Wei, C. Szekeres, M.C. Kugler, P.J. Wolters, M.L. Hill, J.A. Frank, A.N. Brumwell, S.E. Wheeler, J.A. Kreidberg, and H.A. Chapman Epithelial cell α3β1 integrin links β-catenin and Smad signaling to promote myofibroblast formation and pulmonary fibrosis J. Clin. Invest. 119 2009 213 224
-
(2009)
J. Clin. Invest.
, vol.119
, pp. 213-224
-
-
Kim, K.K.1
Wei, Y.2
Szekeres, C.3
Kugler, M.C.4
Wolters, P.J.5
Hill, M.L.6
Frank, J.A.7
Brumwell, A.N.8
Wheeler, S.E.9
Kreidberg, J.A.10
Chapman, H.A.11
-
70
-
-
84872499171
-
β-catenin/CBP-dependent regulation of TGF-β-mediated epithelial-mesenchymal transition (EMT) by smad3
-
in press
-
Zhou, B., Liu, Y., Kahn, M., Ann, D.K., Han, A., Wang, H., Nguyen, C., Flodby, P., Zhong, Q., Krishnaveni, M.S., Liebler, J.M., Minoo, P., Crandall, E.D., and Borok, Z. (in press). β-catenin/CBP-dependent regulation of TGF-β-mediated epithelial-mesenchymal transition (EMT) by smad3. J. Biol. Chem.
-
J. Biol. Chem.
-
-
Zhou, B.1
Liu, Y.2
Kahn, M.3
Ann, D.K.4
Han, A.5
Wang, H.6
Nguyen, C.7
Flodby, P.8
Zhong, Q.9
Krishnaveni, M.S.10
Liebler, J.M.11
Minoo, P.12
Crandall, E.D.13
Borok, Z.14
-
71
-
-
34447326176
-
WNT5A-target of CUTL1 and potent modulator of tumor cell migration and invasion in pancreatic cancer
-
S. Ripka, A. Konig, M. Buchholz, M. Wagner, B. Sipos, G. Kloppel, J. Downward, T. Gress, and P. Michl WNT5A-target of CUTL1 and potent modulator of tumor cell migration and invasion in pancreatic cancer Carcinogenesis 28 2007 1178 1187
-
(2007)
Carcinogenesis
, vol.28
, pp. 1178-1187
-
-
Ripka, S.1
Konig, A.2
Buchholz, M.3
Wagner, M.4
Sipos, B.5
Kloppel, G.6
Downward, J.7
Gress, T.8
Michl, P.9
-
72
-
-
79958265710
-
Paracrine and autocrine signals induce and maintain mesenchymal and stem cell states in the breast
-
C. Scheel, E.N. Eaton, S.H. Li, C.L. Chaffer, F. Reinhardt, K.J. Kah, G. Bell, W. Guo, J. Rubin, A.L. Richardson, and R.A. Weinberg Paracrine and autocrine signals induce and maintain mesenchymal and stem cell states in the breast Cell 145 2011 926 940
-
(2011)
Cell
, vol.145
, pp. 926-940
-
-
Scheel, C.1
Eaton, E.N.2
Li, S.H.3
Chaffer, C.L.4
Reinhardt, F.5
Kah, K.J.6
Bell, G.7
Guo, W.8
Rubin, J.9
Richardson, A.L.10
Weinberg, R.A.11
-
73
-
-
34548175512
-
Signaling networks guiding epithelial-mesenchymal transitions during embryogenesis and cancer progression
-
A. Moustakas, and C.-H. Heldin Signaling networks guiding epithelial-mesenchymal transitions during embryogenesis and cancer progression Cancer Sci. 98 2007 1512 1520
-
(2007)
Cancer Sci.
, vol.98
, pp. 1512-1520
-
-
Moustakas, A.1
Heldin, C.-H.2
-
74
-
-
9144246932
-
Notch promotes epithelial-mesenchymal transition during cardiac development and oncogenic transformation
-
L.A. Timmerman, J. Grego-Bessa, A. Raya, E. Bertran, J.M. Perez-Pomares, J. Diez, S. Aranda, S. Palomo, F. McCormick, J.C. Izpisua-Belmonte, and J.L. de la Pompa Notch promotes epithelial-mesenchymal transition during cardiac development and oncogenic transformation Genes Dev. 18 2004 99 115
-
(2004)
Genes Dev.
, vol.18
, pp. 99-115
-
-
Timmerman, L.A.1
Grego-Bessa, J.2
Raya, A.3
Bertran, E.4
Perez-Pomares, J.M.5
Diez, J.6
Aranda, S.7
Palomo, S.8
McCormick, F.9
Izpisua-Belmonte, J.C.10
De La Pompa, J.L.11
-
75
-
-
48249103470
-
Slug is a direct Notch target required for initiation of cardiac cushion cellularization
-
K. Niessen, Y. Fu, L. Chang, P.A. Hoodless, D. McFadden, and A. Karsan Slug is a direct Notch target required for initiation of cardiac cushion cellularization J. Cell Biol. 182 2008 315 325
-
(2008)
J. Cell Biol.
, vol.182
, pp. 315-325
-
-
Niessen, K.1
Fu, Y.2
Chang, L.3
Hoodless, P.A.4
McFadden, D.5
Karsan, A.6
-
76
-
-
77957847171
-
Integration of a Notch-dependent mesenchymal gene program and Bmp2-driven cell invasiveness regulates murine cardiac valve formation
-
L. Luna-Zurita, B. Prados, J. Grego-Bessa, G. Luxan, G. del Monte, A. Benguria, R.H. Adams, J.M. Perez-Pomares, and J.L. de la Pompa Integration of a Notch-dependent mesenchymal gene program and Bmp2-driven cell invasiveness regulates murine cardiac valve formation J. Clin. Invest. 120 2010 3493 3507
-
(2010)
J. Clin. Invest.
, vol.120
, pp. 3493-3507
-
-
Luna-Zurita, L.1
Prados, B.2
Grego-Bessa, J.3
Luxan, G.4
Del Monte, G.5
Benguria, A.6
Adams, R.H.7
Perez-Pomares, J.M.8
De La Pompa, J.L.9
-
77
-
-
33847403486
-
Notch signaling is necessary for epithelial growth arrest by TGF-β
-
H. Niimi, K. Pardali, M. Vanlandewijck, C.-H. Heldin, and A. Moustakas Notch signaling is necessary for epithelial growth arrest by TGF-β J. Cell Biol. 176 2007 695 707
-
(2007)
J. Cell Biol.
, vol.176
, pp. 695-707
-
-
Niimi, H.1
Pardali, K.2
Vanlandewijck, M.3
Heldin, C.-H.4
Moustakas, A.5
-
78
-
-
77957790485
-
Jagged/Notch signalling is required for a subset of TGFβ1 responses in human kidney epithelial cells
-
K.C. Nyhan, N. Faherty, G. Murray, L.B. Cooey, C. Godson, J.K. Crean, and D.P. Brazil Jagged/Notch signalling is required for a subset of TGFβ1 responses in human kidney epithelial cells Biochim. Biophys. Acta 1803 2010 1386 1395
-
(2010)
Biochim. Biophys. Acta
, vol.1803
, pp. 1386-1395
-
-
Nyhan, K.C.1
Faherty, N.2
Murray, G.3
Cooey, L.B.4
Godson, C.5
Crean, J.K.6
Brazil, D.P.7
-
79
-
-
1842524153
-
Integration of TGF-β/Smad and Jagged1/Notch signalling in epithelial-to-mesenchymal transition
-
J. Zavadil, L. Cermak, N. Soto-Nieves, and E.P. Bottinger Integration of TGF-β/Smad and Jagged1/Notch signalling in epithelial-to-mesenchymal transition EMBO J. 23 2004 1155 1165
-
(2004)
EMBO J.
, vol.23
, pp. 1155-1165
-
-
Zavadil, J.1
Cermak, L.2
Soto-Nieves, N.3
Bottinger, E.P.4
-
80
-
-
84856309973
-
The notch and TGF-β signaling pathways contribute to the aggressiveness of clear cell renal cell carcinoma
-
J. Sjölund, A.-K. Boström, D. Lindgren, S. Manna, A. Moustakas, B. Ljungberg, M. Johansson, E. Fredlund, and H. Axelson The notch and TGF-β signaling pathways contribute to the aggressiveness of clear cell renal cell carcinoma PLoS ONE 6 2011 e23057
-
(2011)
PLoS ONE
, vol.6
, pp. 23057
-
-
Sjölund, J.1
Boström, A.-K.2
Lindgren, D.3
Manna, S.4
Moustakas, A.5
Ljungberg, B.6
Johansson, M.7
Fredlund, E.8
Axelson, H.9
-
81
-
-
80051502369
-
Notch induces myofibroblast differentiation of alveolar epithelial cells via transforming growth factor-β-Smad3 pathway
-
K. Aoyagi-Ikeda, T. Maeno, H. Matsui, M. Ueno, K. Hara, Y. Aoki, F. Aoki, T. Shimizu, H. Doi, K. Kawai-Kowase, T. Iso, T. Suga, M. Arai, and M. Kurabayashi Notch induces myofibroblast differentiation of alveolar epithelial cells via transforming growth factor-β-Smad3 pathway Am. J. Respir. Cell Mol. Biol. 45 2011 136 144
-
(2011)
Am. J. Respir. Cell Mol. Biol.
, vol.45
, pp. 136-144
-
-
Aoyagi-Ikeda, K.1
Maeno, T.2
Matsui, H.3
Ueno, M.4
Hara, K.5
Aoki, Y.6
Aoki, F.7
Shimizu, T.8
Doi, H.9
Kawai-Kowase, K.10
Iso, T.11
Suga, T.12
Arai, M.13
Kurabayashi, M.14
-
82
-
-
80155126639
-
A NOTCH3-mediated squamous cell differentiation program limits expansion of EMT-competent cells that express the ZEB transcription factors
-
S. Ohashi, M. Natsuizaka, S. Naganuma, S. Kagawa, S. Kimura, H. Itoh, R.A. Kalman, M. Nakagawa, D.S. Darling, D. Basu, P.A. Gimotty, A.J. Klein-Szanto, J.A. Diehl, M. Herlyn, and H. Nakagawa A NOTCH3-mediated squamous cell differentiation program limits expansion of EMT-competent cells that express the ZEB transcription factors Cancer Res. 71 2011 6836 6847
-
(2011)
Cancer Res.
, vol.71
, pp. 6836-6847
-
-
Ohashi, S.1
Natsuizaka, M.2
Naganuma, S.3
Kagawa, S.4
Kimura, S.5
Itoh, H.6
Kalman, R.A.7
Nakagawa, M.8
Darling, D.S.9
Basu, D.10
Gimotty, P.A.11
Klein-Szanto, A.J.12
Diehl, J.A.13
Herlyn, M.14
Nakagawa, H.15
-
83
-
-
33745107179
-
A crucial function of PDGF in TGF-β-mediated cancer progression of hepatocytes
-
J. Gotzmann, A.N. Fischer, M. Zojer, M. Mikula, V. Proell, H. Huber, M. Jechlinger, T. Waerner, A. Weith, H. Beug, and W. Mikulits A crucial function of PDGF in TGF-β-mediated cancer progression of hepatocytes Oncogene 25 2006 3170 3185
-
(2006)
Oncogene
, vol.25
, pp. 3170-3185
-
-
Gotzmann, J.1
Fischer, A.N.2
Zojer, M.3
Mikula, M.4
Proell, V.5
Huber, H.6
Jechlinger, M.7
Waerner, T.8
Weith, A.9
Beug, H.10
Mikulits, W.11
-
84
-
-
34249028607
-
PDGF essentially links TGF-β signaling to nuclear β-catenin accumulation in hepatocellular carcinoma progression
-
A.N. Fischer, E. Fuchs, M. Mikula, H. Huber, H. Beug, and W. Mikulits PDGF essentially links TGF-β signaling to nuclear β-catenin accumulation in hepatocellular carcinoma progression Oncogene 26 2007 3395 3405
-
(2007)
Oncogene
, vol.26
, pp. 3395-3405
-
-
Fischer, A.N.1
Fuchs, E.2
Mikula, M.3
Huber, H.4
Beug, H.5
Mikulits, W.6
-
85
-
-
70449636444
-
Hepatic tumor-stroma crosstalk guides epithelial to mesenchymal transition at the tumor edge
-
F. van Zijl, M. Mair, A. Csiszar, D. Schneller, G. Zulehner, H. Huber, R. Eferl, H. Beug, H. Dolznig, and W. Mikulits Hepatic tumor-stroma crosstalk guides epithelial to mesenchymal transition at the tumor edge Oncogene 28 2009 4022 4033
-
(2009)
Oncogene
, vol.28
, pp. 4022-4033
-
-
Van Zijl, F.1
Mair, M.2
Csiszar, A.3
Schneller, D.4
Zulehner, G.5
Huber, H.6
Eferl, R.7
Beug, H.8
Dolznig, H.9
Mikulits, W.10
-
86
-
-
59649107672
-
ILEI requires oncogenic Ras for the epithelial to mesenchymal transition of hepatocytes and liver carcinoma progression
-
C. Lahsnig, M. Mikula, M. Petz, G. Zulehner, D. Schneller, F. van Zijl, H. Huber, A. Csiszar, H. Beug, and W. Mikulits ILEI requires oncogenic Ras for the epithelial to mesenchymal transition of hepatocytes and liver carcinoma progression Oncogene 28 2009 638 650
-
(2009)
Oncogene
, vol.28
, pp. 638-650
-
-
Lahsnig, C.1
Mikula, M.2
Petz, M.3
Zulehner, G.4
Schneller, D.5
Van Zijl, F.6
Huber, H.7
Csiszar, A.8
Beug, H.9
Mikulits, W.10
-
87
-
-
33745192635
-
Autocrine PDGFR signaling promotes mammary cancer metastasis
-
M. Jechlinger, A. Sommer, R. Moriggl, P. Seither, N. Kraut, P. Capodiecci, M. Donovan, C. Cordon-Cardo, H. Beug, and S. Grunert Autocrine PDGFR signaling promotes mammary cancer metastasis J. Clin. Invest. 116 2006 1561 1570
-
(2006)
J. Clin. Invest.
, vol.116
, pp. 1561-1570
-
-
Jechlinger, M.1
Sommer, A.2
Moriggl, R.3
Seither, P.4
Kraut, N.5
Capodiecci, P.6
Donovan, M.7
Cordon-Cardo, C.8
Beug, H.9
Grunert, S.10
-
88
-
-
79952284127
-
Hallmarks of cancer: The next generation
-
D. Hanahan, and R.A. Weinberg Hallmarks of cancer: the next generation Cell 144 2011 646 674
-
(2011)
Cell
, vol.144
, pp. 646-674
-
-
Hanahan, D.1
Weinberg, R.A.2
-
89
-
-
43049165453
-
The epithelial-mesenchymal transition generates cells with properties of stem cells
-
S.A. Mani, W. Guo, M.J. Liao, E.N. Eaton, A. Ayyanan, A.Y. Zhou, M. Brooks, F. Reinhard, C.C. Zhang, M. Shipitsin, L.L. Campbell, K. Polyak, C. Brisken, J. Yang, and R.A. Weinberg The epithelial-mesenchymal transition generates cells with properties of stem cells Cell 133 2008 704 715
-
(2008)
Cell
, vol.133
, pp. 704-715
-
-
Mani, S.A.1
Guo, W.2
Liao, M.J.3
Eaton, E.N.4
Ayyanan, A.5
Zhou, A.Y.6
Brooks, M.7
Reinhard, F.8
Zhang, C.C.9
Shipitsin, M.10
Campbell, L.L.11
Polyak, K.12
Brisken, C.13
Yang, J.14
Weinberg, R.A.15
-
90
-
-
51449085561
-
Generation of breast cancer stem cells through epithelial-mesenchymal transition
-
A.P. Morel, M. Lievre, C. Thomas, G. Hinkal, S. Ansieau, and A. Puisieux Generation of breast cancer stem cells through epithelial-mesenchymal transition PLoS ONE 3 2008 e2888
-
(2008)
PLoS ONE
, vol.3
, pp. 2888
-
-
Morel, A.P.1
Lievre, M.2
Thomas, C.3
Hinkal, G.4
Ansieau, S.5
Puisieux, A.6
-
91
-
-
77955811853
-
Epithelial-mesenchymal transition-derived cells exhibit multilineage differentiation potential similar to mesenchymal stem cells
-
V.L. Battula, K.W. Evans, B.G. Hollier, Y. Shi, F.C. Marini, A. Ayyanan, R.Y. Wang, C. Brisken, R. Guerra, M. Andreeff, and S.A. Mani Epithelial-mesenchymal transition-derived cells exhibit multilineage differentiation potential similar to mesenchymal stem cells Stem Cells 28 2010 1435 1445
-
(2010)
Stem Cells
, vol.28
, pp. 1435-1445
-
-
Battula, V.L.1
Evans, K.W.2
Hollier, B.G.3
Shi, Y.4
Marini, F.C.5
Ayyanan, A.6
Wang, R.Y.7
Brisken, C.8
Guerra, R.9
Andreeff, M.10
Mani, S.A.11
-
92
-
-
79951797048
-
The transforming growth factor-β (TGF-β) mediates acquisition of a mesenchymal stem cell-like phenotype in human liver cells
-
L. Caja, E. Bertran, J. Campbell, N. Fausto, and I. Fabregat The transforming growth factor-β (TGF-β) mediates acquisition of a mesenchymal stem cell-like phenotype in human liver cells J. Cell. Physiol. 226 2011 1214 1223
-
(2011)
J. Cell. Physiol.
, vol.226
, pp. 1214-1223
-
-
Caja, L.1
Bertran, E.2
Campbell, J.3
Fausto, N.4
Fabregat, I.5
-
93
-
-
79959863770
-
TGFβ/TNF(α)-mediated epithelial-mesenchymal transition generates breast cancer stem cells with a claudin-low phenotype
-
M.K. Asiedu, J.N. Ingle, M.D. Behrens, D.C. Radisky, and K.L. Knutson TGFβ/TNF(α)-mediated epithelial-mesenchymal transition generates breast cancer stem cells with a claudin-low phenotype Cancer Res. 71 2011 4707 4719
-
(2011)
Cancer Res.
, vol.71
, pp. 4707-4719
-
-
Asiedu, M.K.1
Ingle, J.N.2
Behrens, M.D.3
Radisky, D.C.4
Knutson, K.L.5
-
94
-
-
77957551870
-
A mesenchymal-to-epithelial transition initiates and is required for the nuclear reprogramming of mouse fibroblasts
-
R. Li, J. Liang, S. Ni, T. Zhou, X. Qing, H. Li, W. He, J. Chen, F. Li, Q. Zhuang, B. Qin, J. Xu, W. Li, J. Yang, Y. Gan, D. Qin, S. Feng, H. Song, D. Yang, B. Zhang, L. Zeng, L. Lai, M.A. Esteban, and D. Pei A mesenchymal-to- epithelial transition initiates and is required for the nuclear reprogramming of mouse fibroblasts Cell Stem Cell 7 2010 51 63
-
(2010)
Cell Stem Cell
, vol.7
, pp. 51-63
-
-
Li, R.1
Liang, J.2
Ni, S.3
Zhou, T.4
Qing, X.5
Li, H.6
He, W.7
Chen, J.8
Li, F.9
Zhuang, Q.10
Qin, B.11
Xu, J.12
Li, W.13
Yang, J.14
Gan, Y.15
Qin, D.16
Feng, S.17
Song, H.18
Yang, D.19
Zhang, B.20
Zeng, L.21
Lai, L.22
Esteban, M.A.23
Pei, D.24
more..
-
95
-
-
63049090100
-
Metastasis: From dissemination to organ-specific colonization
-
D.X. Nguyen, P.D. Bos, and J. Massagué Metastasis: from dissemination to organ-specific colonization Nat. Rev. Cancer 9 2009 274 284
-
(2009)
Nat. Rev. Cancer
, vol.9
, pp. 274-284
-
-
Nguyen, D.X.1
Bos, P.D.2
Massagué, J.3
-
96
-
-
33745515023
-
Tumour microenvironment: TGFβ: The molecular Jekyll and Hyde of cancer
-
B. Bierie, and H.L. Moses Tumour microenvironment: TGFβ: the molecular Jekyll and Hyde of cancer Nat. Rev. Cancer 6 2006 506 520
-
(2006)
Nat. Rev. Cancer
, vol.6
, pp. 506-520
-
-
Bierie, B.1
Moses, H.L.2
-
97
-
-
77952568396
-
Hallmarks of cancer: Interactions with the tumor stroma
-
K. Pietras, and A. Östman Hallmarks of cancer: interactions with the tumor stroma Exp. Cell Res. 316 2010 1324 1331
-
(2010)
Exp. Cell Res.
, vol.316
, pp. 1324-1331
-
-
Pietras, K.1
Östman, A.2
-
98
-
-
0027136742
-
Inhibition of mammary duct development but not alveolar outgrowth during pregnancy in transgenic mice expressing active TGF-β1
-
D. Pierce Jr., M.D. Johnson, Y. Matsui, S.D. Robinson, L.I. Gold, A.F. Purchio, C.W. Daniel, B. Hogan, and H.L. Moses Inhibition of mammary duct development but not alveolar outgrowth during pregnancy in transgenic mice expressing active TGF-β1 Genes Dev. 7 1993 2308 2317
-
(1993)
Genes Dev.
, vol.7
, pp. 2308-2317
-
-
Pierce, Jr.D.1
Johnson, M.D.2
Matsui, Y.3
Robinson, S.D.4
Gold, L.I.5
Purchio, A.F.6
Daniel, C.W.7
Hogan, B.8
Moses, H.L.9
-
99
-
-
0242552529
-
Increased malignancy of Neu-induced mammary tumors overexpressing active transforming growth factor β1
-
R.S. Muraoka, Y. Koh, L.R. Roebuck, M.E. Sanders, D. Brantley-Sieders, A.E. Gorska, H.L. Moses, and C.L. Arteaga Increased malignancy of Neu-induced mammary tumors overexpressing active transforming growth factor β1 Mol. Cell. Biol. 23 2003 8691 8703
-
(2003)
Mol. Cell. Biol.
, vol.23
, pp. 8691-8703
-
-
Muraoka, R.S.1
Koh, Y.2
Roebuck, L.R.3
Sanders, M.E.4
Brantley-Sieders, D.5
Gorska, A.E.6
Moses, H.L.7
Arteaga, C.L.8
-
100
-
-
10844224603
-
Conditional overexpression of active transforming growth factor β1 in vivo accelerates metastases of transgenic mammary tumors
-
R.S. Muraoka-Cook, H. Kurokawa, Y. Koh, J.T. Forbes, L.R. Roebuck, M.H. Barcellos-Hoff, S.E. Moody, L.A. Chodosh, and C.L. Arteaga Conditional overexpression of active transforming growth factor β1 in vivo accelerates metastases of transgenic mammary tumors Cancer Res. 64 2004 9002 9011
-
(2004)
Cancer Res.
, vol.64
, pp. 9002-9011
-
-
Muraoka-Cook, R.S.1
Kurokawa, H.2
Koh, Y.3
Forbes, J.T.4
Roebuck, L.R.5
Barcellos-Hoff, M.H.6
Moody, S.E.7
Chodosh, L.A.8
Arteaga, C.L.9
-
101
-
-
0037816160
-
Transforming growth factor β signaling impairs Neu-induced mammary tumorigenesis while promoting pulmonary metastasis
-
P.M. Siegel, W. Shu, R.D. Cardiff, W.J. Muller, and J. Massagué Transforming growth factor β signaling impairs Neu-induced mammary tumorigenesis while promoting pulmonary metastasis Proc. Natl. Acad. Sci. USA 100 2003 8430 8435
-
(2003)
Proc. Natl. Acad. Sci. USA
, vol.100
, pp. 8430-8435
-
-
Siegel, P.M.1
Shu, W.2
Cardiff, R.D.3
Muller, W.J.4
Massagué, J.5
-
102
-
-
16844373628
-
Effect of conditional knockout of the type II TGF-β receptor gene in mammary epithelia on mammary gland development and polyomavirus middle T antigen induced tumor formation and metastasis
-
E. Forrester, A. Chytil, B. Bierie, M. Aakre, A.E. Gorska, A.R. Sharif-Afshar, W.J. Muller, and H.L. Moses Effect of conditional knockout of the type II TGF-β receptor gene in mammary epithelia on mammary gland development and polyomavirus middle T antigen induced tumor formation and metastasis Cancer Res. 65 2005 2296 2302
-
(2005)
Cancer Res.
, vol.65
, pp. 2296-2302
-
-
Forrester, E.1
Chytil, A.2
Bierie, B.3
Aakre, M.4
Gorska, A.E.5
Sharif-Afshar, A.R.6
Muller, W.J.7
Moses, H.L.8
-
103
-
-
0030598681
-
TGFβ1 inhibits the formation of benign skin tumors, but enhances progression to invasive spindle carcinomas in transgenic mice
-
W. Cui, D.J. Fowlis, S. Bryson, E. Duffie, H. Ireland, A. Balmain, and R.J. Akhurst TGFβ1 inhibits the formation of benign skin tumors, but enhances progression to invasive spindle carcinomas in transgenic mice Cell 86 1996 531 542
-
(1996)
Cell
, vol.86
, pp. 531-542
-
-
Cui, W.1
Fowlis, D.J.2
Bryson, S.3
Duffie, E.4
Ireland, H.5
Balmain, A.6
Akhurst, R.J.7
-
104
-
-
0035887461
-
Inducible expression of transforming growth factor β1 in papillomas causes rapid metastasis
-
B.H. Weeks, W. He, K.L. Olson, and X.J. Wang Inducible expression of transforming growth factor β1 in papillomas causes rapid metastasis Cancer Res. 61 2001 7435 7443
-
(2001)
Cancer Res.
, vol.61
, pp. 7435-7443
-
-
Weeks, B.H.1
He, W.2
Olson, K.L.3
Wang, X.J.4
-
105
-
-
22144490495
-
Distinct mechanisms of TGF-β1-mediated epithelial-to mesenchymal transition and metastasis during skin carcinogenesis
-
G. Han, S.L. Lu, A.G. Li, W. He, C.L. Corless, M. Kulesz-Martin, and X.J. Wang Distinct mechanisms of TGF-β1-mediated epithelial-to mesenchymal transition and metastasis during skin carcinogenesis J. Clin. Invest. 115 2005 1714 1723
-
(2005)
J. Clin. Invest.
, vol.115
, pp. 1714-1723
-
-
Han, G.1
Lu, S.L.2
Li, A.G.3
He, W.4
Corless, C.L.5
Kulesz-Martin, M.6
Wang, X.J.7
-
106
-
-
0032500010
-
Expression of a dominant negative type II TGF-β receptor in mouse skin results in an increase in carcinoma incidence and an acceleration of carcinoma development
-
C. Amendt, P. Schirmacher, H. Weber, and M. Blessing Expression of a dominant negative type II TGF-β receptor in mouse skin results in an increase in carcinoma incidence and an acceleration of carcinoma development Oncogene 17 1998 25 34
-
(1998)
Oncogene
, vol.17
, pp. 25-34
-
-
Amendt, C.1
Schirmacher, P.2
Weber, H.3
Blessing, M.4
-
107
-
-
33646537475
-
Loss of transforming growth factor-β type II receptor promotes metastatic head-and-neck squamous cell carcinoma
-
S.L. Lu, H. Herrington, D. Reh, S. Weber, S. Bornstein, D. Wang, A.G. Li, C.F. Tang, Y. Siddiqui, J. Nord, P. Andersen, C.L. Corless, and X.J. Wang Loss of transforming growth factor-β type II receptor promotes metastatic head-and-neck squamous cell carcinoma Genes Dev. 20 2006 1331 1342
-
(2006)
Genes Dev.
, vol.20
, pp. 1331-1342
-
-
Lu, S.L.1
Herrington, H.2
Reh, D.3
Weber, S.4
Bornstein, S.5
Wang, D.6
Li, A.G.7
Tang, C.F.8
Siddiqui, Y.9
Nord, J.10
Andersen, P.11
Corless, C.L.12
Wang, X.J.13
-
108
-
-
35148832173
-
Loss of TGFβ signaling destabilizes homeostasis and promotes squamous cell carcinomas in stratified epithelia
-
G. Guasch, M. Schober, H.A. Pasolli, E.B. Conn, L. Polak, and E. Fuchs Loss of TGFβ signaling destabilizes homeostasis and promotes squamous cell carcinomas in stratified epithelia Cancer Cell 12 2007 313 327
-
(2007)
Cancer Cell
, vol.12
, pp. 313-327
-
-
Guasch, G.1
Schober, M.2
Pasolli, H.A.3
Conn, E.B.4
Polak, L.5
Fuchs, E.6
-
109
-
-
0842288323
-
TGF-β signaling in fibroblasts modulates the oncogenic potential of adjacent epithelia
-
N.A. Bhowmick, A. Chytil, D. Plieth, A.E. Gorska, N. Dumont, S. Shappell, M.K. Washington, E.G. Neilson, and H.L. Moses TGF-β signaling in fibroblasts modulates the oncogenic potential of adjacent epithelia Science 303 2004 848 851
-
(2004)
Science
, vol.303
, pp. 848-851
-
-
Bhowmick, N.A.1
Chytil, A.2
Plieth, D.3
Gorska, A.E.4
Dumont, N.5
Shappell, S.6
Washington, M.K.7
Neilson, E.G.8
Moses, H.L.9
-
110
-
-
0345601083
-
Met, metastasis, motility and more
-
C. Birchmeier, W. Birchmeier, E. Gherardi, and G.F. Vande Woude Met, metastasis, motility and more Nat. Rev. Mol. Cell Biol. 4 2003 915 925
-
(2003)
Nat. Rev. Mol. Cell Biol.
, vol.4
, pp. 915-925
-
-
Birchmeier, C.1
Birchmeier, W.2
Gherardi, E.3
Vande Woude, G.F.4
-
111
-
-
34250321214
-
Enhanced hepatocyte growth factor signaling by type II transforming growth factor-β receptor knockout fibroblasts promotes mammary tumorigenesis
-
N. Cheng, A. Chytil, Y. Shyr, A. Joly, and H.L. Moses Enhanced hepatocyte growth factor signaling by type II transforming growth factor-β receptor knockout fibroblasts promotes mammary tumorigenesis Cancer Res. 67 2007 4869 4877
-
(2007)
Cancer Res.
, vol.67
, pp. 4869-4877
-
-
Cheng, N.1
Chytil, A.2
Shyr, Y.3
Joly, A.4
Moses, H.L.5
-
112
-
-
37349100945
-
Abrogation of TGF β signaling in mammary carcinomas recruits Gr-1+CD11b+ myeloid cells that promote metastasis
-
L. Yang, J. Huang, X. Ren, A.E. Gorska, A. Chytil, M. Aakre, D.P. Carbone, L.M. Matrisian, A. Richmond, P.C. Lin, and H.L. Moses Abrogation of TGF β signaling in mammary carcinomas recruits Gr-1+CD11b+ myeloid cells that promote metastasis Cancer Cell 13 2008 23 35
-
(2008)
Cancer Cell
, vol.13
, pp. 23-35
-
-
Yang, L.1
Huang, J.2
Ren, X.3
Gorska, A.E.4
Chytil, A.5
Aakre, M.6
Carbone, D.P.7
Matrisian, L.M.8
Richmond, A.9
Lin, P.C.10
Moses, H.L.11
-
113
-
-
40949144957
-
Transforming growth factor-β regulates mammary carcinoma cell survival and interaction with the adjacent microenvironment
-
B. Bierie, D.G. Stover, T.W. Abel, A. Chytil, A.E. Gorska, M. Aakre, E. Forrester, L. Yang, K.U. Wagner, and H.L. Moses Transforming growth factor-β regulates mammary carcinoma cell survival and interaction with the adjacent microenvironment Cancer Res. 68 2008 1809 1819
-
(2008)
Cancer Res.
, vol.68
, pp. 1809-1819
-
-
Bierie, B.1
Stover, D.G.2
Abel, T.W.3
Chytil, A.4
Gorska, A.E.5
Aakre, M.6
Forrester, E.7
Yang, L.8
Wagner, K.U.9
Moses, H.L.10
-
114
-
-
67651005826
-
Abrogation of TGF-β signaling enhances chemokine production and correlates with prognosis in human breast cancer
-
B. Bierie, C.H. Chung, J.S. Parker, D.G. Stover, N. Cheng, A. Chytil, M. Aakre, Y. Shyr, and H.L. Moses Abrogation of TGF-β signaling enhances chemokine production and correlates with prognosis in human breast cancer J. Clin. Invest. 119 2009 1571 1582
-
(2009)
J. Clin. Invest.
, vol.119
, pp. 1571-1582
-
-
Bierie, B.1
Chung, C.H.2
Parker, J.S.3
Stover, D.G.4
Cheng, N.5
Chytil, A.6
Aakre, M.7
Shyr, Y.8
Moses, H.L.9
-
115
-
-
0029662049
-
TGF-β1 and Ha-Ras collaborate in modulating the phenotypic plasticity and invasiveness of epithelial tumor cells
-
M. Oft, J. Peli, C. Rudaz, H. Schwarz, H. Beug, and E. Reichmann TGF-β1 and Ha-Ras collaborate in modulating the phenotypic plasticity and invasiveness of epithelial tumor cells Genes Dev. 10 1996 2462 2477
-
(1996)
Genes Dev.
, vol.10
, pp. 2462-2477
-
-
Oft, M.1
Peli, J.2
Rudaz, C.3
Schwarz, H.4
Beug, H.5
Reichmann, E.6
-
116
-
-
0032547895
-
TGFβ signaling is necessary for carcinoma cell invasiveness and metastasis
-
M. Oft, K.H. Heider, and H. Beug TGFβ signaling is necessary for carcinoma cell invasiveness and metastasis Curr. Biol. 8 1998 1243 1252
-
(1998)
Curr. Biol.
, vol.8
, pp. 1243-1252
-
-
Oft, M.1
Heider, K.H.2
Beug, H.3
-
117
-
-
0037148532
-
Ras and TGFβ cooperatively regulate epithelial cell plasticity and metastasis: Dissection of Ras signaling pathways
-
E. Janda, K. Lehmann, I. Killisch, M. Jechlinger, M. Herzig, J. Downward, H. Beug, and S. Grunert Ras and TGFβ cooperatively regulate epithelial cell plasticity and metastasis: dissection of Ras signaling pathways J. Cell Biol. 156 2002 299 313
-
(2002)
J. Cell Biol.
, vol.156
, pp. 299-313
-
-
Janda, E.1
Lehmann, K.2
Killisch, I.3
Jechlinger, M.4
Herzig, M.5
Downward, J.6
Beug, H.7
Grunert, S.8
-
118
-
-
33748168727
-
ILEI: A cytokine essential for EMT, tumor formation, and late events in metastasis in epithelial cells
-
T. Waerner, M. Alacakaptan, I. Tamir, R. Oberauer, A. Gal, T. Brabletz, M. Schreiber, M. Jechlinger, and H. Beug ILEI: a cytokine essential for EMT, tumor formation, and late events in metastasis in epithelial cells Cancer Cell 10 2006 227 239
-
(2006)
Cancer Cell
, vol.10
, pp. 227-239
-
-
Waerner, T.1
Alacakaptan, M.2
Tamir, I.3
Oberauer, R.4
Gal, A.5
Brabletz, T.6
Schreiber, M.7
Jechlinger, M.8
Beug, H.9
-
119
-
-
69049109696
-
Role of CXCR4/SDF-1 α in the migratory phenotype of hepatoma cells that have undergone epithelial-mesenchymal transition in response to the transforming growth factor-β
-
E. Bertran, L. Caja, E. Navarro, P. Sancho, J. Mainez, M.M. Murillo, A. Vinyals, A. Fabra, and I. Fabregat Role of CXCR4/SDF-1 α in the migratory phenotype of hepatoma cells that have undergone epithelial-mesenchymal transition in response to the transforming growth factor-β Cell. Signal. 21 2009 1595 1606
-
(2009)
Cell. Signal.
, vol.21
, pp. 1595-1606
-
-
Bertran, E.1
Caja, L.2
Navarro, E.3
Sancho, P.4
Mainez, J.5
Murillo, M.M.6
Vinyals, A.7
Fabra, A.8
Fabregat, I.9
-
120
-
-
80053336355
-
Mesenchymal transition and dissemination of cancer cells is driven by myeloid-derived suppressor cells infiltrating the primary tumor
-
B. Toh, X. Wang, J. Keeble, W.J. Sim, K. Khoo, W.C. Wong, M. Kato, A. Prevost-Blondel, J.P. Thiery, and J.P. Abastado Mesenchymal transition and dissemination of cancer cells is driven by myeloid-derived suppressor cells infiltrating the primary tumor PLoS Biol. 9 2011 e1001162
-
(2011)
PLoS Biol.
, vol.9
, pp. 1001162
-
-
Toh, B.1
Wang, X.2
Keeble, J.3
Sim, W.J.4
Khoo, K.5
Wong, W.C.6
Kato, M.7
Prevost-Blondel, A.8
Thiery, J.P.9
Abastado, J.P.10
-
121
-
-
77950903213
-
Annexin A1 regulates TGF-β signaling and promotes metastasis formation of basal-like breast cancer cells
-
M. de Graauw, M.H. van Miltenburg, M.K. Schmidt, C. Pont, R. Lalai, J. Kartopawiro, E. Pardali, S.E. Le Devedec, V.T. Smit, A. van der Wal, L.J. Van't Veer, A.M. Cleton-Jansen, P. ten Dijke, and B. van de Water Annexin A1 regulates TGF-β signaling and promotes metastasis formation of basal-like breast cancer cells Proc. Natl. Acad. Sci. USA 107 2010 6340 6345
-
(2010)
Proc. Natl. Acad. Sci. USA
, vol.107
, pp. 6340-6345
-
-
De Graauw, M.1
Van Miltenburg, M.H.2
Schmidt, M.K.3
Pont, C.4
Lalai, R.5
Kartopawiro, J.6
Pardali, E.7
Le Devedec, S.E.8
Smit, V.T.9
Van Der Wal, A.10
Van'T Veer, L.J.11
Cleton-Jansen, A.M.12
Ten Dijke, P.13
Van De Water, B.14
-
122
-
-
79960315242
-
Down-regulation of epithelial cadherin is required to initiate metastatic outgrowth of breast cancer
-
M.K. Wendt, M.A. Taylor, B.J. Schiemann, and W.P. Schiemann Down-regulation of epithelial cadherin is required to initiate metastatic outgrowth of breast cancer Mol. Biol. Cell 22 2011 2423 2435
-
(2011)
Mol. Biol. Cell
, vol.22
, pp. 2423-2435
-
-
Wendt, M.K.1
Taylor, M.A.2
Schiemann, B.J.3
Schiemann, W.P.4
-
123
-
-
70449526719
-
Localized and reversible TGFβ signalling switches breast cancer cells from cohesive to single cell motility
-
S. Giampieri, C. Manning, S. Hooper, L. Jones, C.S. Hill, and E. Sahai Localized and reversible TGFβ signalling switches breast cancer cells from cohesive to single cell motility Nat. Cell Biol. 11 2009 1287 1296
-
(2009)
Nat. Cell Biol.
, vol.11
, pp. 1287-1296
-
-
Giampieri, S.1
Manning, C.2
Hooper, S.3
Jones, L.4
Hill, C.S.5
Sahai, E.6
-
124
-
-
77951728283
-
Intravital imaging illuminates transforming growth factor β signaling switches during metastasis
-
S. Giampieri, S. Pinner, and E. Sahai Intravital imaging illuminates transforming growth factor β signaling switches during metastasis Cancer Res. 70 2010 3435 3439
-
(2010)
Cancer Res.
, vol.70
, pp. 3435-3439
-
-
Giampieri, S.1
Pinner, S.2
Sahai, E.3
-
125
-
-
41149157649
-
TGFβ primes breast tumors for lung metastasis seeding through angiopoietin-like 4
-
D. Padua, X.H. Zhang, Q. Wang, C. Nadal, W.L. Gerald, R.R. Gomis, and J. Massagué TGFβ primes breast tumors for lung metastasis seeding through angiopoietin-like 4 Cell 133 2008 66 77
-
(2008)
Cell
, vol.133
, pp. 66-77
-
-
Padua, D.1
Zhang, X.H.2
Wang, Q.3
Nadal, C.4
Gerald, W.L.5
Gomis, R.R.6
Massagué, J.7
-
126
-
-
68849126304
-
Multimodality imaging of TGFβ signaling in breast cancer metastases
-
I. Serganova, E. Moroz, J. Vider, G. Gogiberidze, M. Moroz, N. Pillarsetty, M. Doubrovin, A. Minn, H.T. Thaler, J. Massagué, J. Gelovani, and R. Blasberg Multimodality imaging of TGFβ signaling in breast cancer metastases FASEB J. 23 2009 2662 2672
-
(2009)
FASEB J.
, vol.23
, pp. 2662-2672
-
-
Serganova, I.1
Moroz, E.2
Vider, J.3
Gogiberidze, G.4
Moroz, M.5
Pillarsetty, N.6
Doubrovin, M.7
Minn, A.8
Thaler, H.T.9
Massagué, J.10
Gelovani, J.11
Blasberg, R.12
-
127
-
-
68349160814
-
Imaging transforming growth factor-β signaling dynamics and therapeutic response in breast cancer bone metastasis
-
M. Korpal, J. Yan, X. Lu, S. Xu, D.A. Lerit, and Y. Kang Imaging transforming growth factor-β signaling dynamics and therapeutic response in breast cancer bone metastasis Nat. Med. 15 2009 960 966
-
(2009)
Nat. Med.
, vol.15
, pp. 960-966
-
-
Korpal, M.1
Yan, J.2
Lu, X.3
Xu, S.4
Lerit, D.A.5
Kang, Y.6
-
128
-
-
0038488950
-
A multigenic program mediating breast cancer metastasis to bone
-
Y. Kang, P.M. Siegel, W. Shu, M. Drobnjak, S.M. Kakonen, C. Cordon-Cardo, T.A. Guise, and J. Massagué A multigenic program mediating breast cancer metastasis to bone Cancer Cell 3 2003 537 549
-
(2003)
Cancer Cell
, vol.3
, pp. 537-549
-
-
Kang, Y.1
Siegel, P.M.2
Shu, W.3
Drobnjak, M.4
Kakonen, S.M.5
Cordon-Cardo, C.6
Guise, T.A.7
Massagué, J.8
-
129
-
-
25444479744
-
Breast cancer bone metastasis mediated by the Smad tumor suppressor pathway
-
Y. Kang, W. He, S. Tulley, G.P. Gupta, I. Serganova, C.R. Chen, K. Manova-Todorova, R. Blasberg, W.L. Gerald, and J. Massagué Breast cancer bone metastasis mediated by the Smad tumor suppressor pathway Proc. Natl. Acad. Sci. USA 102 2005 13909 13914
-
(2005)
Proc. Natl. Acad. Sci. USA
, vol.102
, pp. 13909-13914
-
-
Kang, Y.1
He, W.2
Tulley, S.3
Gupta, G.P.4
Serganova, I.5
Chen, C.R.6
Manova-Todorova, K.7
Blasberg, R.8
Gerald, W.L.9
Massagué, J.10
-
131
-
-
79960364782
-
Exploring anti-TGF-β therapies in cancer and fibrosis
-
L.J.A.C. Hawinkels, and P. ten Dijke Exploring anti-TGF-β therapies in cancer and fibrosis Growth Factors 29 2011 140 152
-
(2011)
Growth Factors
, vol.29
, pp. 140-152
-
-
Hawinkels, L.J.A.C.1
Ten Dijke, P.2
-
132
-
-
0036086409
-
Blockade of TGF-β inhibits mammary tumor cell viability, migration, and metastases
-
R.S. Muraoka, N. Dumont, C.A. Ritter, T.C. Dugger, D.M. Brantley, J. Chen, E. Easterly, L.R. Roebuck, S. Ryan, P.J. Gotwals, V. Koteliansky, and C.L. Arteaga Blockade of TGF-β inhibits mammary tumor cell viability, migration, and metastases J. Clin. Invest. 109 2002 1551 1559
-
(2002)
J. Clin. Invest.
, vol.109
, pp. 1551-1559
-
-
Muraoka, R.S.1
Dumont, N.2
Ritter, C.A.3
Dugger, T.C.4
Brantley, D.M.5
Chen, J.6
Easterly, E.7
Roebuck, L.R.8
Ryan, S.9
Gotwals, P.J.10
Koteliansky, V.11
Arteaga, C.L.12
-
133
-
-
0036087521
-
Lifetime exposure to a soluble TGF-β antagonist protects mice against metastasis without adverse side effects
-
Y.A. Yang, O. Dukhanina, B. Tang, M. Mamura, J.J. Letterio, J. MacGregor, S.C. Patel, S. Khozin, Z.Y. Liu, J. Green, M.R. Anver, G. Merlino, and L.M. Wakefield Lifetime exposure to a soluble TGF-β antagonist protects mice against metastasis without adverse side effects J. Clin. Invest. 109 2002 1607 1615
-
(2002)
J. Clin. Invest.
, vol.109
, pp. 1607-1615
-
-
Yang, Y.A.1
Dukhanina, O.2
Tang, B.3
Mamura, M.4
Letterio, J.J.5
MacGregor, J.6
Patel, S.C.7
Khozin, S.8
Liu, Z.Y.9
Green, J.10
Anver, M.R.11
Merlino, G.12
Wakefield, L.M.13
-
134
-
-
34248185926
-
Inhibition of TGF-β with neutralizing antibodies prevents radiation-induced acceleration of metastatic cancer progression
-
S. Biswas, M. Guix, C. Rinehart, T.C. Dugger, A. Chytil, H.L. Moses, M.L. Freeman, and C.L. Arteaga Inhibition of TGF-β with neutralizing antibodies prevents radiation-induced acceleration of metastatic cancer progression J. Clin. Invest. 117 2007 1305 1313
-
(2007)
J. Clin. Invest.
, vol.117
, pp. 1305-1313
-
-
Biswas, S.1
Guix, M.2
Rinehart, C.3
Dugger, T.C.4
Chytil, A.5
Moses, H.L.6
Freeman, M.L.7
Arteaga, C.L.8
-
135
-
-
45549085803
-
An anti-transforming growth factor β antibody suppresses metastasis via cooperative effects on multiple cell compartments
-
J.S. Nam, M. Terabe, M. Mamura, M.J. Kang, H. Chae, C. Stuelten, E. Kohn, B. Tang, H. Sabzevari, M.R. Anver, S. Lawrence, D. Danielpour, S. Lonning, J.A. Berzofsky, and L.M. Wakefield An anti-transforming growth factor β antibody suppresses metastasis via cooperative effects on multiple cell compartments Cancer Res. 68 2008 3835 3843
-
(2008)
Cancer Res.
, vol.68
, pp. 3835-3843
-
-
Nam, J.S.1
Terabe, M.2
Mamura, M.3
Kang, M.J.4
Chae, H.5
Stuelten, C.6
Kohn, E.7
Tang, B.8
Sabzevari, H.9
Anver, M.R.10
Lawrence, S.11
Danielpour, D.12
Lonning, S.13
Berzofsky, J.A.14
Wakefield, L.M.15
-
136
-
-
78650450648
-
Peroxisome proliferator-activated receptor-γ activation inhibits tumor metastasis by antagonizing Smad3-mediated epithelial-mesenchymal transition
-
A.K. Reka, H. Kurapati, V.R. Narala, G. Bommer, J. Chen, T.J. Standiford, and V.G. Keshamouni Peroxisome proliferator-activated receptor-γ activation inhibits tumor metastasis by antagonizing Smad3-mediated epithelial-mesenchymal transition Mol. Cancer Ther. 9 2010 3221 3232
-
(2010)
Mol. Cancer Ther.
, vol.9
, pp. 3221-3232
-
-
Reka, A.K.1
Kurapati, H.2
Narala, V.R.3
Bommer, G.4
Chen, J.5
Standiford, T.J.6
Keshamouni, V.G.7
-
137
-
-
79953138206
-
Klotho inhibits transforming growth factor-β1 (TGF-β1) signaling and suppresses renal fibrosis and cancer metastasis in mice
-
S. Doi, Y. Zou, O. Togao, J.V. Pastor, G.B. John, L. Wang, K. Shiizaki, R. Gotschall, S. Schiavi, N. Yorioka, M. Takahashi, D.A. Boothman, and M. Kuro-o Klotho inhibits transforming growth factor-β1 (TGF-β1) signaling and suppresses renal fibrosis and cancer metastasis in mice J. Biol. Chem. 286 2011 8655 8665
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 8655-8665
-
-
Doi, S.1
Zou, Y.2
Togao, O.3
Pastor, J.V.4
John, G.B.5
Wang, L.6
Shiizaki, K.7
Gotschall, R.8
Schiavi, S.9
Yorioka, N.10
Takahashi, M.11
Boothman, D.A.12
Kuro-O, M.13
-
138
-
-
42249099019
-
LY2109761, a novel transforming growth factor β receptor type i and type II dual inhibitor, as a therapeutic approach to suppressing pancreatic cancer metastasis
-
D. Melisi, S. Ishiyama, G.M. Sclabas, J.B. Fleming, Q. Xia, G. Tortora, J.L. Abbruzzese, and P.J. Chiao LY2109761, a novel transforming growth factor β receptor type I and type II dual inhibitor, as a therapeutic approach to suppressing pancreatic cancer metastasis Mol. Cancer Ther. 7 2008 829 840
-
(2008)
Mol. Cancer Ther.
, vol.7
, pp. 829-840
-
-
Melisi, D.1
Ishiyama, S.2
Sclabas, G.M.3
Fleming, J.B.4
Xia, Q.5
Tortora, G.6
Abbruzzese, J.L.7
Chiao, P.J.8
-
139
-
-
77952609184
-
Targeting the transforming growth factor-β pathway inhibits human basal-like breast cancer metastasis
-
V. Ganapathy, R. Ge, A. Grazioli, W. Xie, W. Banach-Petrosky, Y. Kang, S.
-
(2010)
Mol. Cancer
, vol.9
, pp. 122
-
-
Ganapathy, V.1
Ge, R.2
Grazioli, A.3
Xie, W.4
Banach-Petrosky, W.5
Kang, Y.6
Lonning, S.7
McPherson, J.8
Yingling, J.M.9
Biswas, S.10
Mundy, G.R.11
Reiss, M.12
-
140
-
-
79952771133
-
Outgrowth of drug-resistant carcinomas expressing markers of tumor aggression after long-term TβRI/II kinase inhibition with LY2109761
-
E.C. Connolly, E.F. Saunier, D. Quigley, M.T. Luu, A. De Sapio, B. Hann, J.M. Yingling, and R.J. Akhurst Outgrowth of drug-resistant carcinomas expressing markers of tumor aggression after long-term TβRI/II kinase inhibition with LY2109761 Cancer Res. 71 2011 2339 2349
-
(2011)
Cancer Res.
, vol.71
, pp. 2339-2349
-
-
Connolly, E.C.1
Saunier, E.F.2
Quigley, D.3
Luu, M.T.4
De Sapio, A.5
Hann, B.6
Yingling, J.M.7
Akhurst, R.J.8
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