메뉴 건너뛰기




Volumn 12, Issue 9, 2012, Pages 1132-1142

Dual roles of sulforaphane in cancer treatment

Author keywords

Anti Cancer; Chemopreventive agent; Chemoresistance; Combination therapy; Isothiocyanates; Signaling pathway; Sulforaphane; Systemic toxicity

Indexed keywords

3 INDOLEMETHANOL; CISPLATIN; CYTOCHROME P450; CYTOCHROME P450 1A2; CYTOCHROME P450 3A4; DOXORUBICIN; ETOPOSIDE; GEMCITABINE; GLUCURONOSYLTRANSFERASE; GLUTATHIONE TRANSFERASE; HISTONE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; SELENIUM; SULFORAPHANE; TRANSCRIPTION FACTOR NRF1; TRANSCRIPTION FACTOR NRF2;

EID: 84872249486     PISSN: 18715206     EISSN: 18755992     Source Type: Journal    
DOI: 10.2174/187152012803529691     Document Type: Article
Times cited : (20)

References (162)
  • 1
    • 0027993707 scopus 로고
    • Efficacy and safety profile of gemcitabine in nonsmall-cell lung cancer: A phase II study
    • Abratt, R.P.; Bezwoda, W.R.; Falkson, G.; Goedhals, L.; Hacking, D.; Rugg, T.A. Efficacy and safety profile of gemcitabine in nonsmall-cell lung cancer: a phase II study. J. Clin. Oncol., 1994, 12, 1535-1540.
    • (1994) J. Clin. Oncol. , vol.12 , pp. 1535-1540
    • Abratt, R.P.1    Bezwoda, W.R.2    Falkson, G.3    Goedhals, L.4    Hacking, D.5    Rugg, T.A.6
  • 2
    • 0026577605 scopus 로고
    • A major inducer of anticarcinogenic protective enzymes from broccoli: Isolation and elucidation of structure
    • Zhang, Y.; Talalay, P.; Cho, CG.; Posner, G.H. A major inducer of anticarcinogenic protective enzymes from broccoli: isolation and elucidation of structure. Proc. Natl. Acad. Sci., U.S.A.,1992, 89, 2399-2403.
    • (1992) Proc. Natl. Acad. Sci., U.S.A. , vol.89 , pp. 2399-2403
    • Zhang, Y.1    Talalay, P.2    Cho, C.G.3    Posner, G.H.4
  • 3
    • 0032841203 scopus 로고    scopus 로고
    • Antioxidant functions of sulforaphane: A potent inducer of phase II detoxication enzymes
    • Fahey, J.W.; Talalay, P. Antioxidant functions of sulforaphane: a potent inducer of phase II detoxication enzymes. Food. Chem. Toxicol., 1999, 37, 973-979.
    • (1999) Food. Chem. Toxicol. , vol.37 , pp. 973-979
    • Fahey, J.W.1    Talalay, P.2
  • 4
    • 34548445866 scopus 로고    scopus 로고
    • Discovery and development of sulforaphane as a cancer chemopreventive phytochemical
    • Zhang, Y.; Tang, L. Discovery and development of sulforaphane as a cancer chemopreventive phytochemical. Acta. Pharmacol. Sin., 2007, 28, 1343-1354.
    • (2007) Acta. Pharmacol. Sin. , vol.28 , pp. 1343-1354
    • Zhang, Y.1    Tang, L.2
  • 5
    • 33644646401 scopus 로고    scopus 로고
    • Chemoprotection by sulforaphane: Keep one eye beyond Keap1
    • Myzak, MC.; Dashwood, R.H. Chemoprotection by sulforaphane: Keep one eye beyond Keap1. Cancer. Lett., 2006, 233, 208-218.
    • (2006) Cancer. Lett. , vol.233 , pp. 208-218
    • Myzak, M.C.1    Dashwood, R.H.2
  • 6
    • 23344431898 scopus 로고    scopus 로고
    • Isothiocyanates induce cell cycle arrest, apoptosis and mitochondrial potential depolarization in HL-60 and multidrug-resistant cell lines
    • Jakubikova, J.; Bao, Y.P.; Sedlak, J. Isothiocyanates induce cell cycle arrest, apoptosis and mitochondrial potential depolarization in HL-60 and multidrug-resistant cell lines. Anticancer Research., 2005, 25, 3375-3386.
    • (2005) Anticancer Research. , vol.25 , pp. 3375-3386
    • Jakubikova, J.1    Bao, Y.P.2    Sedlak, J.3
  • 7
    • 34247606510 scopus 로고    scopus 로고
    • Molecular basis for chemoprevention by sulforaphane: A comprehensive review
    • Juge N.; Mithen, R.F.; Traka, M. Molecular basis for chemoprevention by sulforaphane: a comprehensive review. Cell Mol. Life Sci., 2007, 64, 1105-1127.
    • (2007) Cell Mol. Life Sci. , vol.64 , pp. 1105-1127
    • Juge, N.1    Mithen, R.F.2    Traka, M.3
  • 8
    • 23844505236 scopus 로고    scopus 로고
    • Mitochondria are the primary target in isothiocyanate-induced apoptosis in human bladder cancer cells
    • Tang, L.; Zhang, Y.S. Mitochondria are the primary target in isothiocyanate-induced apoptosis in human bladder cancer cells. Mol. Cancer Ther., 2005, 4, 1250-1259.
    • (2005) Mol. Cancer Ther. , vol.4 , pp. 1250-1259
    • Tang, L.1    Zhang, Y.S.2
  • 9
    • 67651155826 scopus 로고    scopus 로고
    • Chemopreventive functions of sulforaphane: A potent inducer of antioxidant enzymes and apoptosis
    • Yeh, C.T.; Yen, G.C. Chemopreventive functions of sulforaphane: A potent inducer of antioxidant enzymes and apoptosis. J. Funct. Food., 2009, 1, 23-32.
    • (2009) J. Funct. Food. , vol.1 , pp. 23-32
    • Yeh, C.T.1    Yen, G.C.2
  • 10
    • 9744283511 scopus 로고    scopus 로고
    • Transcription factor nrf2 is essential for induction of NAD(P)H: Quinone oxidoreductase 1, glutathione S-transferases, and glutamate cysteine ligase by broccoli seeds and isothiocyanates
    • McWalter, G.K.; Higgins, L.G.; McLellan, L.I.; Henderson, C.J.; Song, L.J.; Thornalley, P.J.; Itoh, K.; Yamamoto, M.; Hayes, J.D. Transcription factor nrf2 is essential for induction of NAD(P)H: quinone oxidoreductase 1, glutathione S-transferases, and glutamate cysteine ligase by broccoli seeds and isothiocyanates. J. Nutr., 2004, 134, 3499s-3506s.
    • (2004) J. Nutr. , vol.134
    • McWalter, G.K.1    Higgins, L.G.2    McLellan, L.I.3    Henderson, C.J.4    Song, L.J.5    Thornalley, P.J.6    Itoh, K.7    Yamamoto, M.8    Hayes, J.D.9
  • 11
    • 0141567455 scopus 로고    scopus 로고
    • Involvement of Nrf2 and JNK1 in the activation of antioxidant responsive element (ARE) by chemopreventive agent phenethyl isothiocyanate (PEITC)
    • Keum, Y.S.; Owuor, E.D.; Kim, B.R.; Hu, R.; Kong, A.N.T. Involvement of Nrf2 and JNK1 in the activation of antioxidant responsive element (ARE) by chemopreventive agent phenethyl isothiocyanate (PEITC). Pharmaceut. Res., 2003, 20, 1351-1356.
    • (2003) Pharmaceut. Res. , vol.20 , pp. 1351-1356
    • Keum, Y.S.1    Owuor, E.D.2    Kim, B.R.3    Hu, R.4    Kong, A.N.T.5
  • 14
    • 0034525122 scopus 로고    scopus 로고
    • Chemoprevention of colonic aberrant crypt foci in Fischer rats by sulforaphane and phenethyl isothiocyanate
    • Chung, F.L.; Conaway, C.C.; Rao, C.V.; Reddy, B.S. Chemoprevention of colonic aberrant crypt foci in Fischer rats by sulforaphane and phenethyl isothiocyanate. Carcinogenesis. 2000, 21, 2287-2291.
    • (2000) Carcinogenesis. , vol.21 , pp. 2287-2291
    • Chung, F.L.1    Conaway, C.C.2    Rao, C.V.3    Reddy, B.S.4
  • 15
    • 51349088974 scopus 로고    scopus 로고
    • Multi-targeted prevention of cancer by sulforaphane
    • Clarke, J.D.; Dashwood, R.H.; Ho, E. Multi-targeted prevention of cancer by sulforaphane. Cancer Lett., 2008, 269, 291-304.
    • (2008) Cancer Lett. , vol.269 , pp. 291-304
    • Clarke, J.D.1    Dashwood, R.H.2    Ho, E.3
  • 16
    • 2442587889 scopus 로고    scopus 로고
    • Breast cancer risk in premenopausal women is inversely associated with consumption of broccoli, a source of isothiocyanates, but is not modified by GST genotype
    • Ambrosone, C.B.; McCann, S.E.; Freudenheim, J.L.; Marshall, J.R.; Zhang, Y.S.; Shields, P.G. Breast cancer risk in premenopausal women is inversely associated with consumption of broccoli, a source of isothiocyanates, but is not modified by GST genotype. J. Nutr., 2004, 134, 1134-1138.
    • (2004) J. Nutr. , vol.134 , pp. 1134-1138
    • Ambrosone, C.B.1    McCann, S.E.2    Freudenheim, J.L.3    Marshall, J.R.4    Zhang, Y.S.5    Shields, P.G.6
  • 18
    • 12744278308 scopus 로고    scopus 로고
    • Ambrosone CB, Cruciferous vegetables, genetic polymorphisms in glutathione Stransferases M1 and T1, and prostate cancer risk
    • Joseph, M.A.; Moysich, K.B.; Freudenheim, J.L.; Shields, P.G.; Bowman, ED.; Zhang, Y.S.; Marshall, J.R. Ambrosone CB, Cruciferous vegetables, genetic polymorphisms in glutathione Stransferases M1 and T1, and prostate cancer risk. Nutr. Cancer., 2004, 50, 206-213.
    • (2004) Nutr. Cancer. , vol.50 , pp. 206-213
    • Joseph, M.A.1    Moysich, K.B.2    Freudenheim, J.L.3    Shields, P.G.4    Bowman, E.D.5    Zhang, Y.S.6    Marshall, J.R.7
  • 19
    • 0035155096 scopus 로고    scopus 로고
    • Glucosinolates-biochemistry, genetics and biological activity
    • Mithen, R. Glucosinolates-biochemistry, genetics and biological activity. Plant Growth Regul., 2001, 34, 91-103.
    • (2001) Plant Growth Regul. , vol.34 , pp. 91-103
    • Mithen, R.1
  • 20
    • 0037008887 scopus 로고    scopus 로고
    • Identification of the major glucosinolate (4-mercaptobutyl glucosinolate) in leaves of Eruca sativa L. (salad rocket)
    • Bennett, R.N.; Mellon, F.A.; Botting, N.P.; Eagles, J.; Rosa, E.A.S.; Williamson, G. Identification of the major glucosinolate (4-mercaptobutyl glucosinolate) in leaves of Eruca sativa L. (salad rocket). Phytochemistry., 2002, 61, 25-30.
    • (2002) Phytochemistry. , vol.61 , pp. 25-30
    • Bennett, R.N.1    Mellon, F.A.2    Botting, N.P.3    Eagles, J.4    Rosa, E.A.S.5    Williamson, G.6
  • 22
    • 0036252496 scopus 로고    scopus 로고
    • Growth inhibition, cell-cycle arrest and apoptosis in human T-cell leukemia by the isothiocyanate sulforaphane
    • Fimognari, C.; Nusse, M.; Cesari, R.; Iori, R.; Cantelli-Forti, G.; Hrelia, P. Growth inhibition, cell-cycle arrest and apoptosis in human T-cell leukemia by the isothiocyanate sulforaphane. Carcinogenesis., 2002, 23, 581-586.
    • (2002) Carcinogenesis. , vol.23 , pp. 581-586
    • Fimognari, C.1    Nusse, M.2    Cesari, R.3    Iori, R.4    Cantelli-Forti, G.5    Hrelia, P.6
  • 23
    • 0030852501 scopus 로고    scopus 로고
    • Inhibition of cytochromes P-450 and induction of glutathione S-transferases by sulforaphane in primary human and rat hepatocytes
    • Maheo, K.; Morel, F.; Langouet, S.; Kramer, H.; LeFerrec, E.; Ketterer, B.; Guillouzo, A. Inhibition of cytochromes P-450 and induction of glutathione S-transferases by sulforaphane in primary human and rat hepatocytes. Cancer. Res., 1997, 57, 3649-3652.
    • (1997) Cancer. Res. , vol.57 , pp. 3649-3652
    • Maheo, K.1    Morel, F.2    Langouet, S.3    Kramer, H.4    LeFerrec, E.5    Ketterer, B.6    Guillouzo, A.7
  • 24
    • 0035543010 scopus 로고    scopus 로고
    • Comparison of the bioactivity of two glucoraphanin hydrolysis products found in broccoli, sulforaphane and sulforaphane nitrile
    • Matusheski, N.V.; Jeffery, E.H. Comparison of the bioactivity of two glucoraphanin hydrolysis products found in broccoli, sulforaphane and sulforaphane nitrile. J. Agr. Food Chem., 2001, 49, 5743-5749.
    • (2001) J. Agr. Food Chem. , vol.49 , pp. 5743-5749
    • Matusheski, N.V.1    Jeffery, E.H.2
  • 25
    • 34547770863 scopus 로고    scopus 로고
    • Quantitative combination effects between sulforaphane and 3, 3'-diindolylmethane on proliferation of human colon cancer cells in vitro
    • Pappa, G.; Strathmann, J.; Lowinger, M.; Bartsch, H.; Gerhauser, C. Quantitative combination effects between sulforaphane and 3, 3'-diindolylmethane on proliferation of human colon cancer cells in vitro. Carcinogenesis., 2007, 28, 1471-1477.
    • (2007) Carcinogenesis. , vol.28 , pp. 1471-1477
    • Pappa, G.1    Strathmann, J.2    Lowinger, M.3    Bartsch, H.4    Gerhauser, C.5
  • 26
    • 5144230473 scopus 로고    scopus 로고
    • Cancer-preventive isothiocyanates: Measurement of human exposure and mechanism of action
    • Zhang, Y.S. Cancer-preventive isothiocyanates: measurement of human exposure and mechanism of action. Mutat. Res-Fund. Mol., 2004, 555, 173-190.
    • (2004) Mutat. Res-Fund. Mol. , vol.555 , pp. 173-190
    • Zhang, Y.S.1
  • 28
    • 0028326168 scopus 로고
    • Anticarcinogenic activities of organic isothiocyanates: Chemistry and mechanisms
    • Zhang, Y.; Talalay, P. Anticarcinogenic activities of organic isothiocyanates: chemistry and mechanisms. Cancer. Res., 1994, 54, 1976s-1981s.
    • (1994) Cancer. Res. , vol.54
    • Zhang, Y.1    Talalay, P.2
  • 29
    • 0036792160 scopus 로고    scopus 로고
    • Brassica, biotransformation and cancer risk: Genetic polymorphisms alter the preventive effects of cruciferous vegetables
    • Lampe, J.W.; Peterson, S. Brassica, biotransformation and cancer risk: Genetic polymorphisms alter the preventive effects of cruciferous vegetables. J. Nutr., 2002, 132, 2991-2994.
    • (2002) J. Nutr. , vol.132 , pp. 2991-2994
    • Lampe, J.W.1    Peterson, S.2
  • 30
    • 0028203252 scopus 로고
    • Anticarcinogenic activities of sulforaphane and structurally related synthetic norbornyl isothiocyanates
    • Zhang, Y.; Kensler, T.W.; Cho, C.G.; Posner, G.H.; Talalay, P. Anticarcinogenic activities of sulforaphane and structurally related synthetic norbornyl isothiocyanates. Proc. Natl. Acad. Sci. U.S.A., 1994, 91, 3147-3150.
    • (1994) Proc. Natl. Acad. Sci. U.S.A. , vol.91 , pp. 3147-3150
    • Zhang, Y.1    Kensler, T.W.2    Cho, C.G.3    Posner, G.H.4    Talalay, P.5
  • 31
    • 0034525122 scopus 로고    scopus 로고
    • Chemoprevention of colonic aberrant crypt foci in Fischer rats by sulforaphane and phenethyl isothiocyanate
    • Chung, F.L.; Conaway, C.C.; Rao, C.V.; Reddy, B.S. Chemoprevention of colonic aberrant crypt foci in Fischer rats by sulforaphane and phenethyl isothiocyanate. Carcinogenesis, 2000, 21, 2287-2291.
    • (2000) Carcinogenesis , vol.21 , pp. 2287-2291
    • Chung, F.L.1    Conaway, C.C.2    Rao, C.V.3    Reddy, B.S.4
  • 32
    • 33749581701 scopus 로고    scopus 로고
    • Cancer chemoprevention of intestinal polyposis in ApcMin/+ mice by sulforaphane, a natural product derived from cruciferous vegetable
    • Hu. R.; Khor, T.O.; Shen, G.X.; Jeong, W.S.; Hebbar, V.; Chen, C.; Xu, C.J.; Reddy, B.; Chada, K.; Kong, A.N.T. Cancer chemoprevention of intestinal polyposis in ApcMin/+ mice by sulforaphane, a natural product derived from cruciferous vegetable. Carcinogenesis, 2006, 27, 2038-2046.
    • (2006) Carcinogenesis , vol.27 , pp. 2038-2046
    • Hu, R.1    Khor, T.O.2    Shen, G.X.3    Jeong, W.S.4    Hebbar, V.5    Chen, C.6    Xu, C.J.7    Reddy, B.8    Chada, K.9    Kong, A.N.T.10
  • 33
    • 33645825587 scopus 로고    scopus 로고
    • Sulforaphane inhibits histone deacetylase in vivo and suppresses tumorigenesis in Apc-minus mice
    • Myzak, M.C.; Dashwood, W.M.; Orner, G.A.; Ho, E.; Dashwood, R.H. Sulforaphane inhibits histone deacetylase in vivo and suppresses tumorigenesis in Apc-minus mice. Faseb. J., 2006, 20, 506-508.
    • (2006) Faseb. J. , vol.20 , pp. 506-508
    • Myzak, M.C.1    Dashwood, W.M.2    Orner, G.A.3    Ho, E.4    Dashwood, R.H.5
  • 34
    • 7444229836 scopus 로고    scopus 로고
    • The dietary isothiocyanate sulforaphane targets pathways of apoptosis, cell cycle arrest, and oxidative stress in human pancreatic cancer cells and inhibits tumor growth in severe combined immunodeficient mice
    • Pham, N.A.; Jacobberger, J.W.; Schimmer, A.D.; Cao, P.; Gronda, M.; Hedley, D.W. The dietary isothiocyanate sulforaphane targets pathways of apoptosis, cell cycle arrest, and oxidative stress in human pancreatic cancer cells and inhibits tumor growth in severe combined immunodeficient mice. Mol. Cancer. Ther., 2004, 3, 1239-1248.
    • (2004) Mol. Cancer. Ther. , vol.3 , pp. 1239-1248
    • Pham, N.A.1    Jacobberger, J.W.2    Schimmer, A.D.3    Cao, P.4    Gronda, M.5    Hedley, D.W.6
  • 35
    • 1642545614 scopus 로고    scopus 로고
    • Sulforaphane induces caspase-mediated apoptosis in cultured PC-3 human prostate cancer cells and retards growth of PC-3 xenografts in vivo
    • Singh, A.V.; Xiao, D.; Lew, K.L.; Dhir, R.; Singh, S.V. Sulforaphane induces caspase-mediated apoptosis in cultured PC-3 human prostate cancer cells and retards growth of PC-3 xenografts in vivo. Carcinogenesis, 2004, 25, 83-90.
    • (2004) Carcinogenesis , vol.25 , pp. 83-90
    • Singh, A.V.1    Xiao, D.2    Lew, K.L.3    Dhir, R.4    Singh, S.V.5
  • 36
    • 0032841203 scopus 로고    scopus 로고
    • Antioxidant functions of sulforaphane: A potent inducer of Phase II detoxication enzymes
    • Fahey, J.W.; Talalay, P. Antioxidant functions of sulforaphane: a potent inducer of Phase II detoxication enzymes. Food. Chem. Toxicol., 1999, 37, 973-979.
    • (1999) Food. Chem. Toxicol. , vol.37 , pp. 973-979
    • Fahey, J.W.1    Talalay, P.2
  • 37
    • 34548445866 scopus 로고    scopus 로고
    • Discovery and development of sulforaphane as a cancer chemopreventive phytochemical
    • Zhang, Y.; Tang, L. Discovery and development of sulforaphane as a cancer chemopreventive phytochemical. Acta. Pharmacol. Sin., 2007, 28, 1343-1354.
    • (2007) Acta. Pharmacol. Sin. , vol.28 , pp. 1343-1354
    • Zhang, Y.1    Tang, L.2
  • 38
    • 0034854057 scopus 로고    scopus 로고
    • Potent induction of phase 2 enzymes in human prostate cells by sulforaphane
    • Brooks, J.D.; Paton, V.G.; Vidanes, G. Potent induction of phase 2 enzymes in human prostate cells by sulforaphane. Cancer. Epidemiol. Biomarkers. Prev., 2001, 10, 949-954.
    • (2001) Cancer. Epidemiol. Biomarkers. Prev. , vol.10 , pp. 949-954
    • Brooks, J.D.1    Paton, V.G.2    Vidanes, G.3
  • 39
    • 79956040609 scopus 로고    scopus 로고
    • Anti-carcinogenic effects of sulforaphane in association with its apoptosis-inducing and anti-inflammatory properties in human cervical cancer cells
    • Sharma, C.; Sadrieh, L.; Priyani, A.; Ahmed, M.; Hassan, A.H.; Hussain, A. Anti-carcinogenic effects of sulforaphane in association with its apoptosis-inducing and anti-inflammatory properties in human cervical cancer cells. Cancer. Epidemiol., 2010, 35(3), 272-278.
    • (2010) Cancer. Epidemiol. , vol.35 , Issue.3 , pp. 272-278
    • Sharma, C.1    Sadrieh, L.2    Priyani, A.3    Ahmed, M.4    Hassan, A.H.5    Hussain, A.6
  • 40
    • 38449089515 scopus 로고    scopus 로고
    • Sulforaphane induces cell cycle arrest and apoptosis in murine osteosarcoma cells in vitro and inhibits tumor growth in vivo
    • Matsui, T.A.; Murata, H.; Sakabe, T.; Sowa, Y.; Horie, N.; Nakanishi, R.; Sakai, T.; Kubo, T. Sulforaphane induces cell cycle arrest and apoptosis in murine osteosarcoma cells in vitro and inhibits tumor growth in vivo. Oncol. Rep., 2007, 18, 1263-1268.
    • (2007) Oncol. Rep. , vol.18 , pp. 1263-1268
    • Matsui, T.A.1    Murata, H.2    Sakabe, T.3    Sowa, Y.4    Horie, N.5    Nakanishi, R.6    Sakai, T.7    Kubo, T.8
  • 41
    • 0037188518 scopus 로고    scopus 로고
    • Sulforaphane inhibits extracellular, intracellular, and antibiotic-resistant strains of Helicobacter pylori and prevents benzo[a]pyrene-induced stomach tumors
    • Fahey, J.W.; Haristoy, X.; Dolan, P.M.; Kensler, T.W.; Scholtus, I.; Stephenson, K.K.; Talalay, P.; Lozniewski, A. Sulforaphane inhibits extracellular, intracellular, and antibiotic-resistant strains of Helicobacter pylori and prevents benzo[a]pyrene-induced stomach tumors. P. Natl. Acad. Sci. USA., 2002, 99, 7610-7615.
    • (2002) P. Natl. Acad. Sci. USA. , vol.99 , pp. 7610-7615
    • Fahey, J.W.1    Haristoy, X.2    Dolan, P.M.3    Kensler, T.W.4    Scholtus, I.5    Stephenson, K.K.6    Talalay, P.7    Lozniewski, A.8
  • 42
    • 78650323904 scopus 로고    scopus 로고
    • Anticancer activity of a broccoli derivative, sulforaphane, in barrett adenocarcinoma: Potential use in chemoprevention and as adjuvant in chemotherapy
    • Qazi, A.; Pal, J.; Maitah, M.; Fulciniti, M.; Pelluru, D.; Nanjappa, P.; Lee, S.; Batchu, R.B.; Prasad, M.; Bryant, C.S. Anticancer activity of a broccoli derivative, sulforaphane, in barrett adenocarcinoma: potential use in chemoprevention and as adjuvant in chemotherapy. Transl. Oncol., 2010, 3, 389-399.
    • (2010) Transl. Oncol. , vol.3 , pp. 389-399
    • Qazi, A.1    Pal, J.2    Maitah, M.3    Fulciniti, M.4    Pelluru, D.5    Nanjappa, P.6    Lee, S.7    Batchu, R.B.8    Prasad, M.9    Bryant, C.S.10
  • 44
    • 33748089664 scopus 로고    scopus 로고
    • Inhibition of 7, 12-dimethylbenz(a)anthracene-induced skin tumorigenesis in C57BL/6 mice by sulforaphane is mediated by nuclear factor E2-related factor 2
    • Xu, C.J.; Huang, M.T.; Shen, G.X.; Yuan, X.L.; Lin, W.; Khor, T.O.; Conney, A.H.; Kong, A.N.T. Inhibition of 7, 12-dimethylbenz(a)anthracene-induced skin tumorigenesis in C57BL/6 mice by sulforaphane is mediated by nuclear factor E2-related factor 2. Cancer. Res., 2006, 66, 8293-8296.
    • (2006) Cancer. Res. , vol.66 , pp. 8293-8296
    • Xu, C.J.1    Huang, M.T.2    Shen, G.X.3    Yuan, X.L.4    Lin, W.5    Khor, T.O.6    Conney, A.H.7    Kong, A.N.T.8
  • 45
    • 52449134789 scopus 로고    scopus 로고
    • Interaction of the isothiocyanate sulforaphane with drug disposition and metabolism: Pharmacological and toxicological implications
    • Fimognari, C.; Lenzi, M.; Hrelia, P. Interaction of the isothiocyanate sulforaphane with drug disposition and metabolism: Pharmacological and toxicological implications. Curr. Drug. Metab., 2008, 9, 668-678.
    • (2008) Curr. Drug. Metab. , vol.9 , pp. 668-678
    • Fimognari, C.1    Lenzi, M.2    Hrelia, P.3
  • 46
    • 0029879994 scopus 로고    scopus 로고
    • CYP2E1-mediated mechanism of anti-genotoxicity of the broccoli constituent sulforaphane
    • Barcelo, S.; Gardiner, J.M.; Gescher, A.; Chipman, J.K. CYP2E1-mediated mechanism of anti-genotoxicity of the broccoli constituent sulforaphane. Carcinogenesis, 1996, 17, 277-282.
    • (1996) Carcinogenesis , vol.17 , pp. 277-282
    • Barcelo, S.1    Gardiner, J.M.2    Gescher, A.3    Chipman, J.K.4
  • 47
    • 0036270413 scopus 로고    scopus 로고
    • Modulation of heterocyclic amine-induced mutagenicity and carcinogenicity: An 'A-to-Z' guide to chemopreventive agents, promoters, and transgenic models
    • Dashwood, R.H. Modulation of heterocyclic amine-induced mutagenicity and carcinogenicity: an 'A-to-Z' guide to chemopreventive agents, promoters, and transgenic models. Mutat. Res-Rev. Mutat., 2002, 511, 89-112.
    • (2002) Mutat. Res-Rev. Mutat. , vol.511 , pp. 89-112
    • Dashwood, R.H.1
  • 48
    • 0346888660 scopus 로고    scopus 로고
    • Sulforaphane and quercetin modulate PhIP-DNA adduct formation in human HepG2 cells and hepatocytes
    • Bacon, J.R.; Williamson, G.; Garner, R.C.; Lappin, G.; Langouet, S.; Bao, Y. Sulforaphane and quercetin modulate PhIP-DNA adduct formation in human HepG2 cells and hepatocytes. Carcinogenesis, 2003, 24, 1903-1911.
    • (2003) Carcinogenesis , vol.24 , pp. 1903-1911
    • Bacon, J.R.1    Williamson, G.2    Garner, R.C.3    Lappin, G.4    Langouet, S.5    Bao, Y.6
  • 49
    • 0031025733 scopus 로고    scopus 로고
    • Cancer chemopreventive potential of sulforamate, a novel analogue of sulforaphane that induces phase 2 drug-metabolizing enzymes
    • Gerhauser, C.; You, M.; Liu, J.; Moriarty, R.M.; Hawthorne, M.; Mehta, R.G.; Moon, R.C.; Pezzuto, J.M. Cancer chemopreventive potential of sulforamate, a novel analogue of sulforaphane that induces phase 2 drug-metabolizing enzymes. Cancer. Res., 1997, 57, 272-278.
    • (1997) Cancer. Res. , vol.57 , pp. 272-278
    • Gerhauser, C.1    You, M.2    Liu, J.3    Moriarty, R.M.4    Hawthorne, M.5    Mehta, R.G.6    Moon, R.C.7    Pezzuto, J.M.8
  • 50
    • 0036045433 scopus 로고    scopus 로고
    • Sulforaphane and its glutathione conjugate but not sulforaphane nitrile induce UDP-glucuronosyl transferase (UGT1A1) and glutathione transferase (GSTA1) in cultured cells
    • Basten, G.P.; Bao, Y.; Williamson, G. Sulforaphane and its glutathione conjugate but not sulforaphane nitrile induce UDP-glucuronosyl transferase (UGT1A1) and glutathione transferase (GSTA1) in cultured cells. Carcinogenesis, 2002, 23, 1399-1404.
    • (2002) Carcinogenesis , vol.23 , pp. 1399-1404
    • Basten, G.P.1    Bao, Y.2    Williamson, G.3
  • 51
    • 0037740965 scopus 로고    scopus 로고
    • Induction of hepatic thioredoxin reductase activity by sulforaphane, both in Hepa1c1c7 cells and in male Fisher 344 rats
    • Hintze, K.J.; Keck, A.S.; Finley, J.W.; Jeffery, E.H. Induction of hepatic thioredoxin reductase activity by sulforaphane, both in Hepa1c1c7 cells and in male Fisher 344 rats. J. Nutr. Biochem., 2003, 14, 173-179.
    • (2003) J. Nutr. Biochem. , vol.14 , pp. 173-179
    • Hintze, K.J.1    Keck, A.S.2    Finley, J.W.3    Jeffery, E.H.4
  • 52
    • 0142148111 scopus 로고    scopus 로고
    • Expression of the aflatoxin B1-8, 9-epoxide-metabolizing murine glutathione S-transferase A3 subunit is regulated by the Nrf2 transcription factor through an antioxidant response element
    • Jowsey, I.R.; Jiang, Q.; Itoh, K.; Yamamoto, M.; Hayes, J.D. Expression of the aflatoxin B1-8, 9-epoxide-metabolizing murine glutathione S-transferase A3 subunit is regulated by the Nrf2 transcription factor through an antioxidant response element. Mol. Pharmacol., 2003, 64, 1018-1028.
    • (2003) Mol. Pharmacol. , vol.64 , pp. 1018-1028
    • Jowsey, I.R.1    Jiang, Q.2    Itoh, K.3    Yamamoto, M.4    Hayes, J.D.5
  • 53
    • 1842588301 scopus 로고    scopus 로고
    • Induction of phase II detoxification enzymes in rats by plant-derived isothiocyanates: Comparison of allyl isothiocyanate with sulforaphane and related compounds
    • Munday, R.; Munday, C.M. Induction of phase II detoxification enzymes in rats by plant-derived isothiocyanates: comparison of allyl isothiocyanate with sulforaphane and related compounds. J. Agric. Food. Chem., 2004, 52, 1867-1871.
    • (2004) J. Agric. Food. Chem. , vol.52 , pp. 1867-1871
    • Munday, R.1    Munday, C.M.2
  • 54
    • 4544247421 scopus 로고    scopus 로고
    • Interactions between sulforaphane and apigenin in the induction of UGT1A1 and GSTA1 in CaCo-2 cells
    • Svehlikova, V.; Wang, S.R.; Jakubikova, J.; Williamson, G.; Mithen, R.; Bao, Y.P. Interactions between sulforaphane and apigenin in the induction of UGT1A1 and GSTA1 in CaCo-2 cells. Carcinogenesis, 2004, 25, 1629-1637.
    • (2004) Carcinogenesis , vol.25 , pp. 1629-1637
    • Svehlikova, V.1    Wang, S.R.2    Jakubikova, J.3    Williamson, G.4    Mithen, R.5    Bao, Y.P.6
  • 56
    • 33645472584 scopus 로고    scopus 로고
    • Inhibition of angiogenesis and endothelial cell functions are novel sulforaphane-mediated mechanisms in chemoprevention
    • Bertl, E.; Bartsch, H.; Gerhauser, C. Inhibition of angiogenesis and endothelial cell functions are novel sulforaphane-mediated mechanisms in chemoprevention. Mol. Cancer. Ther., 2006, 5, 575-585.
    • (2006) Mol. Cancer. Ther. , vol.5 , pp. 575-585
    • Bertl, E.1    Bartsch, H.2    Gerhauser, C.3
  • 57
    • 45749117896 scopus 로고    scopus 로고
    • Protective effects of an extract of young radish (Raphanus sativus L) cultivated with sulfur (sulfur-radish extract) and of sulforaphane on carbon tetrachloride-induced hepatotoxicity
    • Baek, S.H.; Park, M.; Suh, J.H.; Choi, H.S. Protective effects of an extract of young radish (Raphanus sativus L) cultivated with sulfur (sulfur-radish extract) and of sulforaphane on carbon tetrachloride-induced hepatotoxicity. Biosci. Biotech. Bioch., 2008, 72, 1176-1182.
    • (2008) Biosci. Biotech. Bioch. , vol.72 , pp. 1176-1182
    • Baek, S.H.1    Park, M.2    Suh, J.H.3    Choi, H.S.4
  • 58
    • 24744453945 scopus 로고    scopus 로고
    • Specific patterns of electrophile adduction trigger Keap1 ubiquitination and Nrf2 activation
    • Hong, F.; Sekhar, K.R.; Freeman, M.L.; Liebler, D.C. Specific patterns of electrophile adduction trigger Keap1 ubiquitination and Nrf2 activation. J. Biol. Chem., 2005, 280, 31768-31775.
    • (2005) J. Biol. Chem. , vol.280 , pp. 31768-31775
    • Hong, F.1    Sekhar, K.R.2    Freeman, M.L.3    Liebler, D.C.4
  • 60
    • 36349019109 scopus 로고    scopus 로고
    • Identification of the highly reactive cysteine 151 in the chemopreventive agent-sensor Keap1 protein is method-dependent
    • Eggler, A.L.; Luo, Y.; van Breemen, R.B.; Mesecar, A.D. Identification of the highly reactive cysteine 151 in the chemopreventive agent-sensor Keap1 protein is method-dependent. Chem. Res. Toxicol., 2007, 20, 1878-1884.
    • (2007) Chem. Res. Toxicol. , vol.20 , pp. 1878-1884
    • Eggler, A.L.1    Luo, Y.2    van Breemen, R.B.3    Mesecar, A.D.4
  • 61
    • 22544464124 scopus 로고    scopus 로고
    • Modifying specific cysteines of the electrophilesensing human Keap1 disrupt binding to the protein is insufficient to Nrf2 domain Neh2
    • Eggler, A.L.; Liu, G.W.; Pezzuto, J.M.; van Breemen, R.B.; Mesecar, A.D. Modifying specific cysteines of the electrophilesensing human Keap1 disrupt binding to the protein is insufficient to Nrf2 domain Neh2. P. Natl. Acad. Sci. USA., 2005, 102, 10070-10075.
    • (2005) P. Natl. Acad. Sci. USA. , vol.102 , pp. 10070-10075
    • Eggler, A.L.1    Liu, G.W.2    Pezzuto, J.M.3    van Breemen, R.B.4    Mesecar, A.D.5
  • 62
    • 0242580049 scopus 로고    scopus 로고
    • Distinct cysteine residues in Keap1 are required for Keap1-dependent ubiquitination of Nrf2 and for stabilization of Nrf2 by chemopreventive agents and oxidative stress
    • Zhang, D.D.; Hannink, M. Distinct cysteine residues in Keap1 are required for Keap1-dependent ubiquitination of Nrf2 and for stabilization of Nrf2 by chemopreventive agents and oxidative stress. Mol. Cell. Biol., 2003, 23, 8137-8151.
    • (2003) Mol. Cell. Biol. , vol.23 , pp. 8137-8151
    • Zhang, D.D.1    Hannink, M.2
  • 63
    • 0037015035 scopus 로고    scopus 로고
    • Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants
    • Dinkova-Kostova, A.T.; Holtzclaw, W.D.; Cole, R.N.; Itoh, K.; Wakabayashi, N.; Katoh, Y.; Yamamoto, M.; Talalay, P. Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants. P. Natl. Acad. Sci. USA., 2002, 99, 11908-11913.
    • (2002) P. Natl. Acad. Sci. USA. , vol.99 , pp. 11908-11913
    • Dinkova-Kostova, A.T.1    Holtzclaw, W.D.2    Cole, R.N.3    Itoh, K.4    Wakabayashi, N.5    Katoh, Y.6    Yamamoto, M.7    Talalay, P.8
  • 64
    • 1642282736 scopus 로고    scopus 로고
    • Cellular mechanisms of redox cell signalling: Role of cysteine modification in controlling antioxidant defences in response to electrophilic lipid oxidation products
    • Levonen, A.L.; Landar, A.; Ramachandran, A.; Ceaser, E.K.; Dickinson, D.A.; Zanoni, G.; Morrow, J.D.; Darley-Usmar, V.M. Cellular mechanisms of redox cell signalling: role of cysteine modification in controlling antioxidant defences in response to electrophilic lipid oxidation products. Biochem. J., 2004, 378, 373-382.
    • (2004) Biochem. J. , vol.378 , pp. 373-382
    • Levonen, A.L.1    Landar, A.2    Ramachandran, A.3    Ceaser, E.K.4    Dickinson, D.A.5    Zanoni, G.6    Morrow, J.D.7    Darley-Usmar, V.M.8
  • 66
    • 0037462651 scopus 로고    scopus 로고
    • Degradation of transcription factor Nrf2 via the ubiquitinproteasome pathway and stabilization by cadmium
    • Stewart, D.; Killeen, E.; Naquin, R.; Alam, S.; Alam, J. Degradation of transcription factor Nrf2 via the ubiquitinproteasome pathway and stabilization by cadmium. J. Biol. Chem., 2003, 278, 2396-2402.
    • (2003) J. Biol. Chem. , vol.278 , pp. 2396-2402
    • Stewart, D.1    Killeen, E.2    Naquin, R.3    Alam, S.4    Alam, J.5
  • 67
    • 0037821802 scopus 로고    scopus 로고
    • Keap1-dependent proteasomal degradation of transcription factor Nrf2 contributes to the negative regulation of antioxidant response element-driven gene expression
    • McMahon, M.; Itoh, K.; Yamamoto, M.; Hayes, J.D. Keap1-dependent proteasomal degradation of transcription factor Nrf2 contributes to the negative regulation of antioxidant response element-driven gene expression. J. Biol. Chem., 2003, 278, 21592-21600.
    • (2003) J. Biol. Chem. , vol.278 , pp. 21592-21600
    • McMahon, M.1    Itoh, K.2    Yamamoto, M.3    Hayes, J.D.4
  • 68
    • 3543008924 scopus 로고    scopus 로고
    • Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate for proteasomal degradation of Nrf2
    • Kobayashi, A.; Kang, M.I.; Okawa, H.; Ohtsuji, M.; Zenke, Y.; Chiba, T.; Igarashi, K.; Yamamoto, M. Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate for proteasomal degradation of Nrf2. Mol. Cell. Biol., 2004, 24, 7130-7139.
    • (2004) Mol. Cell. Biol. , vol.24 , pp. 7130-7139
    • Kobayashi, A.1    Kang, M.I.2    Okawa, H.3    Ohtsuji, M.4    Zenke, Y.5    Chiba, T.6    Igarashi, K.7    Yamamoto, M.8
  • 69
    • 34548772935 scopus 로고    scopus 로고
    • Keap1 controls postinduction repression of the Nrf2-mediated antioxidant response by escorting nuclear export of Nrf2
    • Sun, Z.; Zhang, S.; Chan, J.Y.; Zhang, D.D. Keap1 controls postinduction repression of the Nrf2-mediated antioxidant response by escorting nuclear export of Nrf2. Mol. Cell. Biol., 2007, 27, 6334-6349.
    • (2007) Mol. Cell. Biol. , vol.27 , pp. 6334-6349
    • Sun, Z.1    Zhang, S.2    Chan, J.Y.3    Zhang, D.D.4
  • 70
    • 77958186199 scopus 로고    scopus 로고
    • Role of Nrf2 transcription factor in cellular response to oxidative stress
    • Florczyk, U.; Loboda, A.; Stachurska, A.; Jozkowicz, A.; Dulak, J. [Role of Nrf2 transcription factor in cellular response to oxidative stress]. Postepy. Biochem., 2010, 56, 147-155.
    • (2010) Postepy. Biochem. , vol.56 , pp. 147-155
    • Florczyk, U.1    Loboda, A.2    Stachurska, A.3    Jozkowicz, A.4    Dulak, J.5
  • 71
    • 0033600914 scopus 로고    scopus 로고
    • Role of a mitogen-activated protein kinase pathway in the induction of phase II detoxifying enzymes by chemicals
    • Yu, R.; Lei, W.; Mandlekar, S.; Weber, M.J.; Der, C.J.; Wu, J.; Kong, A.N.T. Role of a mitogen-activated protein kinase pathway in the induction of phase II detoxifying enzymes by chemicals. J. Biol. Chem., 1999, 274, 27545-27552.
    • (1999) J. Biol. Chem. , vol.274 , pp. 27545-27552
    • Yu, R.1    Lei, W.2    Mandlekar, S.3    Weber, M.J.4    Der, C.J.5    Wu, J.6    Kong, A.N.T.7
  • 72
    • 0034704079 scopus 로고    scopus 로고
    • Activation of mitogen-activated protein kinase pathways induces antioxidant response element-mediated gene expression via a Nrf2-dependent mechanism
    • Yu, R.; Chen, C.; Mo, Y.Y.; Hebbar, V.; Owuor, E.D.; Tan, TH.; Kong, A.N. Activation of mitogen-activated protein kinase pathways induces antioxidant response element-mediated gene expression via a Nrf2-dependent mechanism. J. Biol. Chem., 2000, 275, 39907-39913.
    • (2000) J. Biol. Chem. , vol.275 , pp. 39907-39913
    • Yu, R.1    Chen, C.2    Mo, Y.Y.3    Hebbar, V.4    Owuor, E.D.5    Tan, T.H.6    Kong, A.N.7
  • 73
    • 0036235637 scopus 로고    scopus 로고
    • Isothiocyanates: Mechanism of cancer chemopreventive action
    • Thornalley, P.J. Isothiocyanates: mechanism of cancer chemopreventive action. Anti-Cancer. Drug., 2002, 13, 331-338.
    • (2002) Anti-Cancer. Drug. , vol.13 , pp. 331-338
    • Thornalley, P.J.1
  • 74
    • 0034648765 scopus 로고    scopus 로고
    • Angiogenesis in cancer and other diseases
    • Carmeliet, P.; Jain, R.K. Angiogenesis in cancer and other diseases. Nature., 2000, 407, 249-257.
    • (2000) Nature. , vol.407 , pp. 249-257
    • Carmeliet, P.1    Jain, R.K.2
  • 76
    • 0036136731 scopus 로고    scopus 로고
    • 'Angioprevention': Angiogenesis is a common and key target for cancer chemopreventive agents
    • Tosetti, F.; Ferrari, N.; DeFlora, S.; Albini, A. 'Angioprevention': angiogenesis is a common and key target for cancer chemopreventive agents. Faseb. J., 2002, 16, 2-14.
    • (2002) Faseb. J. , vol.16 , pp. 2-14
    • Tosetti, F.1    Ferrari, N.2    DeFlora, S.3    Albini, A.4
  • 77
    • 80355149328 scopus 로고    scopus 로고
    • Inhibition of angiogenic attributes by decursin in endothelial cells and ex vivo rat aortic ring angiogenesis model
    • Bhat, T.A.; Moon, J.S.; Lee, S.; Yim, D.; Singh, R.P. Inhibition of angiogenic attributes by decursin in endothelial cells and ex vivo rat aortic ring angiogenesis model. Indian. J. Exp. Biol., 2011, 49, 848-856.
    • (2011) Indian. J. Exp. Biol. , vol.49 , pp. 848-856
    • Bhat, T.A.1    Moon, J.S.2    Lee, S.3    Yim, D.4    Singh, R.P.5
  • 78
    • 0036512208 scopus 로고    scopus 로고
    • New functions for the matrix metallo proteinases in cancer progression
    • Egeblad, M.; Werb, Z. New functions for the matrix metallo proteinases in cancer progression. Nat. Rev. Cancer., 2002, 2, 161-174.
    • (2002) Nat. Rev. Cancer. , vol.2 , pp. 161-174
    • Egeblad, M.1    Werb, Z.2
  • 79
    • 0037316605 scopus 로고    scopus 로고
    • Matrix metalloproteinases, reduction of wound angiogenesis in patients treated with BMS-275291, a broad spectrum matrix metalloproteinase inhibitor
    • Rundhaug, J.E. Matrix metalloproteinases, reduction of wound angiogenesis in patients treated with BMS-275291, a broad spectrum matrix metalloproteinase inhibitor. Clinical. Cancer. Research., 2003, 9, 551-554.
    • (2003) Clinical. Cancer. Research. , vol.9 , pp. 551-554
    • Rundhaug, J.E.1
  • 80
    • 1942502894 scopus 로고    scopus 로고
    • Transcription factors having impact on vascular endothelial growth factor (VEGF) gene expression in angiogenesis
    • Josko, J.; Mazurek, M. Transcription factors having impact on vascular endothelial growth factor (VEGF) gene expression in angiogenesis. Med, Sci. Monitor., 2004, 10, Ra89-Ra98.
    • (2004) Med, Sci. Monitor. , vol.10
    • Josko, J.1    Mazurek, M.2
  • 81
    • 4344692045 scopus 로고    scopus 로고
    • Constitutive and inducible expression and regulation of vascular endothelial growth factor
    • Xie, K.P.; Wei, D.Y.; Shi, Q.; Huang, S.Y. Constitutive and inducible expression and regulation of vascular endothelial growth factor. Cytokine. Growth. F. R. 2004, 15, 297-324.
    • (2004) Cytokine. Growth. F.R. , vol.15 , pp. 297-324
    • Xie, K.P.1    Wei, D.Y.2    Shi, Q.3    Huang, S.Y.4
  • 82
    • 4143130097 scopus 로고    scopus 로고
    • A novel mechanism of chemoprotection by sulforaphane: Inhibition of histone deacetylase
    • Myzak, M.C.; Karplus, P.A.; Chung, F.L.; Dashwood, R.H. A novel mechanism of chemoprotection by sulforaphane: Inhibition of histone deacetylase. Cancer. Res., 2004, 64, 5767-5774.
    • (2004) Cancer. Res. , vol.64 , pp. 5767-5774
    • Myzak, M.C.1    Karplus, P.A.2    Chung, F.L.3    Dashwood, R.H.4
  • 83
    • 0034596309 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors: Inducers of differentiation or apoptosis of transformed cells
    • Marks, P.A.; Richon, V.M.; Rifkind, R.A. Histone deacetylase inhibitors: inducers of differentiation or apoptosis of transformed cells. J. Natl. Cancer. Inst., 2000, 92, 1210-1216.
    • (2000) J. Natl. Cancer. Inst. , vol.92 , pp. 1210-1216
    • Marks, P.A.1    Richon, V.M.2    Rifkind, R.A.3
  • 84
    • 0037822085 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors in cancer therapy
    • Rosato, R.R.; Grant, S. Histone deacetylase inhibitors in cancer therapy. Cancer. Biol. Ther., 2003, 2, 30-37.
    • (2003) Cancer. Biol. Ther. , vol.2 , pp. 30-37
    • Rosato, R.R.1    Grant, S.2
  • 86
    • 0033868452 scopus 로고    scopus 로고
    • Inhibition of histone deacetylases: A new strategy to target epigenetic modifications for anticancer treatment
    • Weidle, U.H.; Grossmann, A. Inhibition of histone deacetylases: a new strategy to target epigenetic modifications for anticancer treatment. Anticancer. Res., 2000, 20, 1471-1485.
    • (2000) Anticancer. Res. , vol.20 , pp. 1471-1485
    • Weidle, U.H.1    Grossmann, A.2
  • 88
    • 48749118821 scopus 로고    scopus 로고
    • De-repression of the p21 promoter in prostate cancer cells by an isothiocyanate via inhibition of HDACs and c-Myc
    • Wang, L.G.; Liu, X.M.; Fang, Y.; Dai, W.; Chiao, F.B.; Puccio, G.M.; Feng, J.; Liu, D.; Chiao, J.W. De-repression of the p21 promoter in prostate cancer cells by an isothiocyanate via inhibition of HDACs and c-Myc. Int. J. Oncol., 2008, 33, 375-380.
    • (2008) Int. J. Oncol. , vol.33 , pp. 375-380
    • Wang, L.G.1    Liu, X.M.2    Fang, Y.3    Dai, W.4    Chiao, F.B.5    Puccio, G.M.6    Feng, J.7    Liu, D.8    Chiao, J.W.9
  • 89
    • 4143130097 scopus 로고    scopus 로고
    • A novel mechanism of chemoprotection by sulforaphane: Inhibition of histone deacetylase
    • Myzak, M.C.; Karplus, P.A.; Chung, F.L.; Dashwood, R.H. A novel mechanism of chemoprotection by sulforaphane: inhibition of histone deacetylase. Cancer. Res., 2004, 64, 5767-5774.
    • (2004) Cancer. Res. , vol.64 , pp. 5767-5774
    • Myzak, M.C.1    Karplus, P.A.2    Chung, F.L.3    Dashwood, R.H.4
  • 90
    • 4143130097 scopus 로고    scopus 로고
    • A novel mechanism of chemoprotection by sulforaphane: Inhibition of histone deacetylase
    • Myzak, M.C.; Karplus, P.A.; Chung, F.L.; Dashwood, R.H. A novel mechanism of chemoprotection by sulforaphane: inhibition of histone deacetylase. Cancer. Res., 2004, 64, 5767-5774.
    • (2004) Cancer. Res. , vol.64 , pp. 5767-5774
    • Myzak, M.C.1    Karplus, P.A.2    Chung, F.L.3    Dashwood, R.H.4
  • 91
    • 0037169358 scopus 로고    scopus 로고
    • Apoptosis: A link between cancer genetics and chemotherapy
    • Johnstone, R.W.; Ruefli, A.A.; Lowe, S.W. Apoptosis: A link between cancer genetics and chemotherapy. Cell., 2002, 108, 153-164.
    • (2002) Cell. , vol.108 , pp. 153-164
    • Johnstone, R.W.1    Ruefli, A.A.2    Lowe, S.W.3
  • 92
    • 2442561553 scopus 로고    scopus 로고
    • Apoptosis as a novel target for cancer chemoprevention
    • Sun, S.Y.; Hail, N.; Lotan, R. Apoptosis as a novel target for cancer chemoprevention. J. Natl. Cancer. I., 2004, 96, 662-672.
    • (2004) J. Natl. Cancer. I. , vol.96 , pp. 662-672
    • Sun, S.Y.1    Hail, N.2    Lotan, R.3
  • 93
    • 79952723845 scopus 로고    scopus 로고
    • Sulforaphane--a possible agent in prevention and therapy of cancer
    • Tomczyk, J.; Olejnik, A. Sulforaphane--a possible agent in prevention and therapy of cancer. Postepy. Hig. Med. Dosw. (Online), 2010, 64, 590-603.
    • (2010) Postepy. Hig. Med. Dosw. (Online) , vol.64 , pp. 590-603
    • Tomczyk, J.1    Olejnik, A.2
  • 94
    • 34047241356 scopus 로고    scopus 로고
    • Cell-cycle specificity of sulforaphane-mediated apoptosis in Jurkat T-leukemia cells
    • Fimognari, C.; Lenzi, M.; Sciuscio, D.; Cantelli-Forti, G.; Hrelia, P. Cell-cycle specificity of sulforaphane-mediated apoptosis in Jurkat T-leukemia cells. In Vivo., 2007, 21, 377-380.
    • (2007) In Vivo. , vol.21 , pp. 377-380
    • Fimognari, C.1    Lenzi, M.2    Sciuscio, D.3    Cantelli-Forti, G.4    Hrelia, P.5
  • 95
    • 77449106593 scopus 로고    scopus 로고
    • Molecular targets of dietary phenethyl isothiocyanate and sulforaphane for cancer chemoprevention
    • Cheung, K.L.; Kong, A.N. Molecular targets of dietary phenethyl isothiocyanate and sulforaphane for cancer chemoprevention. AAPS. J., 2010, 12, 87-97.
    • (2010) AAPS.J. , vol.12 , pp. 87-97
    • Cheung, K.L.1    Kong, A.N.2
  • 96
    • 34548028505 scopus 로고    scopus 로고
    • Induction of apoptosis by isothiocyanate sulforaphane in human cervical carcinoma HeLa and hepatocarcinoma HepG2 cells through activation of caspase-3
    • Park, S.Y.; Kim, G.Y.; Bae, S.J.; Yoo, Y.H.; Choi, Y.H. Induction of apoptosis by isothiocyanate sulforaphane in human cervical carcinoma HeLa and hepatocarcinoma HepG2 cells through activation of caspase-3. Oncol. Rep., 2007, 18, 181-187.
    • (2007) Oncol. Rep. , vol.18 , pp. 181-187
    • Park, S.Y.1    Kim, G.Y.2    Bae, S.J.3    Yoo, Y.H.4    Choi, Y.H.5
  • 97
    • 41549090011 scopus 로고    scopus 로고
    • Genetic mechanisms and aberrant gene expression during the development of gastric intestinal metaplasia and adenocarcinoma
    • Holmes, K.; Egan, B.; Swan, N.; O'Morain, C. Genetic mechanisms and aberrant gene expression during the development of gastric intestinal metaplasia and adenocarcinoma. Curr. Genomics., 2007, 8, 379-397.
    • (2007) Curr. Genomics. , vol.8 , pp. 379-397
    • Holmes, K.1    Egan, B.2    Swan, N.3    O'Morain, C.4
  • 98
    • 20044385140 scopus 로고    scopus 로고
    • Carcinogenesis, cancer therapy and chemoprevention
    • Blagosklonny, M.V. Carcinogenesis, cancer therapy and chemoprevention. Cell. Death. Differ., 2005, 12, 592-602.
    • (2005) Cell. Death. Differ. , vol.12 , pp. 592-602
    • Blagosklonny, M.V.1
  • 100
    • 27744575798 scopus 로고    scopus 로고
    • Chemoprevention: A primary cancer prevention strategy
    • Smith, J.J.; Tully, P.; Padberg, R.M. Chemoprevention: a primary cancer prevention strategy. Semin. Oncol. Nurs., 2005, 21, 243-251.
    • (2005) Semin. Oncol. Nurs. , vol.21 , pp. 243-251
    • Smith, J.J.1    Tully, P.2    Padberg, R.M.3
  • 101
    • 84872231073 scopus 로고    scopus 로고
    • Inhibiton of benzo[a]pyrene-(BP) and 1, 6-dinitropyrene (DNP)-DNA adduct formation in human mammary epithelial cells by dibenzoylmethane and sulforaphane
    • Singletary, K.; MacDonald, C. Inhibiton of benzo[a]pyrene-(BP) and 1, 6-dinitropyrene (DNP)-DNA adduct formation in human mammary epithelial cells by dibenzoylmethane and sulforaphane. Faseb. J., 2000, 14, A170-A170.
    • (2000) Faseb. J. , vol.14
    • Singletary, K.1    McDonald, C.2
  • 102
    • 0037188518 scopus 로고    scopus 로고
    • Sulforaphane inhibits extracellular, intracellular, and antibiotic-resistant strains of Helicobacter pylori and prevents benzo[a]pyrene-induced stomach tumors
    • Fahey, J.W.; Haristoy, X.; Dolan, P.M.; Kensler, T.W.; Scholtus, I.; Stephenson, K.K.; Talalay, P.; Lozniewski, A. Sulforaphane inhibits extracellular, intracellular, and antibiotic-resistant strains of Helicobacter pylori and prevents benzo[a]pyrene-induced stomach tumors. Proc. Natl. Acad. Sci. U.S.A., 2002, 99, 7610-7615.
    • (2002) Proc. Natl. Acad. Sci. U.S.A. , vol.99 , pp. 7610-7615
    • Fahey, J.W.1    Haristoy, X.2    Dolan, P.M.3    Kensler, T.W.4    Scholtus, I.5    Stephenson, K.K.6    Talalay, P.7    Lozniewski, A.8
  • 103
    • 0036866923 scopus 로고    scopus 로고
    • Cyclin D3 and p53 mediate sulforaphane-induced cell cycle delay and apoptosis in non-transformed human T lymphocytes
    • Fimognari, C.; Nusse, M.; Berti, F.; Iori, R.; Cantelli-Forti, G.; Hrelia, P. Cyclin D3 and p53 mediate sulforaphane-induced cell cycle delay and apoptosis in non-transformed human T lymphocytes. Cell. Mol. Life. Sci., 2002, 59, 2004-2012.
    • (2002) Cell. Mol. Life. Sci. , vol.59 , pp. 2004-2012
    • Fimognari, C.1    Nusse, M.2    Berti, F.3    Iori, R.4    Cantelli-Forti, G.5    Hrelia, P.6
  • 104
    • 7444229836 scopus 로고    scopus 로고
    • The dietary isothiocyanate sulforaphane targets pathways of apoptosis, cell cycle arrest, and oxidative stress in human pancreatic cancer cells and inhibits tumor growth in severe combined immunodeficient mice
    • Pham, N.A.; Jacobberger, J.W.; Schimmer, A.D.; Cao, P.J.; Gronda, M.; Hedley, D.W. The dietary isothiocyanate sulforaphane targets pathways of apoptosis, cell cycle arrest, and oxidative stress in human pancreatic cancer cells and inhibits tumor growth in severe combined immunodeficient mice. Mol. Cancer. Ther., 2004, 3, 1239-1248.
    • (2004) Mol. Cancer. Ther. , vol.3 , pp. 1239-1248
    • Pham, N.A.1    Jacobberger, J.W.2    Schimmer, A.D.3    Cao, P.J.4    Gronda, M.5    Hedley, D.W.6
  • 106
    • 34548028505 scopus 로고    scopus 로고
    • Induction of apoptosis by isothiocyanate sulforaphane in human cervical carcinoma HeLa and hepatocarcinoma HepG2 cells through activation of caspase-3
    • Park, S.Y.; Kim, G.Y.; Bae, S.J.; Yoo, YH.; Choi, Y.H. Induction of apoptosis by isothiocyanate sulforaphane in human cervical carcinoma HeLa and hepatocarcinoma HepG2 cells through activation of caspase-3. Oncology Reports., 2007, 18, 181-187.
    • (2007) Oncology Reports. , vol.18 , pp. 181-187
    • Park, S.Y.1    Kim, G.Y.2    Bae, S.J.3    Yoo, Y.H.4    Choi, Y.H.5
  • 107
    • 34247606510 scopus 로고    scopus 로고
    • Molecular basis for chemoprevention by sulforaphane: A comprehensive review
    • Juge, N.; Mithen, R.F.; Traka, M. Molecular basis for chemoprevention by sulforaphane: a comprehensive review. Cell. Mol. Life. Sci., 2007, 64, 1105-1127.
    • (2007) Cell. Mol. Life. Sci. , vol.64 , pp. 1105-1127
    • Juge, N.1    Mithen, R.F.2    Traka, M.3
  • 108
    • 23844505236 scopus 로고    scopus 로고
    • Mitochondria are the primary target in isothiocyanate-induced apoptosis in human bladder cancer cells
    • Tang, L.; Zhang, Y. Mitochondria are the primary target in isothiocyanate-induced apoptosis in human bladder cancer cells. Mol. Cancer. Ther., 2005, 4, 1250-1259.
    • (2005) Mol. Cancer. Ther. , vol.4 , pp. 1250-1259
    • Tang, L.1    Zhang, Y.2
  • 109
    • 33746422972 scopus 로고    scopus 로고
    • Activation of multiple molecular mechanisms for apoptosis in human malignant glioblastoma T98G and U87MG cells treated with sulforaphane
    • Karmakar, S.; Weinberg, M.S.; Banik, N.L.; Patel, S.J.; Ray, S.K. Activation of multiple molecular mechanisms for apoptosis in human malignant glioblastoma T98G and U87MG cells treated with sulforaphane. Neuroscience., 2006, 141, 1265-1280.
    • (2006) Neuroscience. , vol.141 , pp. 1265-1280
    • Karmakar, S.1    Weinberg, M.S.2    Banik, N.L.3    Patel, S.J.4    Ray, S.K.5
  • 111
    • 27944494853 scopus 로고    scopus 로고
    • Effect of sulforaphane on metallothionein expression and induction of apoptosis in human hepatoma HepG2 cells
    • Yeh, C.T.; Yen, G.C. Effect of sulforaphane on metallothionein expression and induction of apoptosis in human hepatoma HepG2 cells. Carcinogenesis, 2005, 26, 2138-2148.
    • (2005) Carcinogenesis , vol.26 , pp. 2138-2148
    • Yeh, C.T.1    Yen, G.C.2
  • 112
    • 33745875948 scopus 로고    scopus 로고
    • Comparison of growth inhibition profiles and mechanisms of apoptosis induction in human colon cancer cell lines by isothiocyanates and indoles from Brassicaceae
    • Pappa, G.; Lichtenberg, M.; Iori, R.; Barillari, J.; Bartsch, H.; Gerhauser, C. Comparison of growth inhibition profiles and mechanisms of apoptosis induction in human colon cancer cell lines by isothiocyanates and indoles from Brassicaceae. Mutat. Res-Fund. Mol. M., 2006, 599, 76-87.
    • (2006) Mutat. Res-Fund. Mol. M. , vol.599 , pp. 76-87
    • Pappa, G.1    Lichtenberg, M.2    Iori, R.3    Barillari, J.4    Bartsch, H.5    Gerhauser, C.6
  • 113
    • 38449089515 scopus 로고    scopus 로고
    • Sulforaphane induces cell cycle arrest and apoptosis in murine osteosarcoma cells in vitro and inhibits tumor growth in vivo
    • Matsui, T.A.; Murata, H.; Sakabe, T.; Sowa, Y.; Horie, N.; Nakanishi, R.; Sakai, T.; Kubo, T. Sulforaphane induces cell cycle arrest and apoptosis in murine osteosarcoma cells in vitro and inhibits tumor growth in vivo. Oncology Reports., 2007, 18, 1263-1268.
    • (2007) Oncology Reports. , vol.18 , pp. 1263-1268
    • Matsui, T.A.1    Murata, H.2    Sakabe, T.3    Sowa, Y.4    Horie, N.5    Nakanishi, R.6    Sakai, T.7    Kubo, T.8
  • 116
    • 33645324413 scopus 로고    scopus 로고
    • Sulforaphane inhibits histone deacetylase activity in BPH-1, LnCaP and PC-3 prostate epithelial cells
    • Myzak, M.C.; Hardin, K.; Wang, R.; Dashwood, R.H.; Ho, E. Sulforaphane inhibits histone deacetylase activity in BPH-1, LnCaP and PC-3 prostate epithelial cells. Carcinogenesis, 2006, 27, 811-819.
    • (2006) Carcinogenesis , vol.27 , pp. 811-819
    • Myzak, M.C.1    Hardin, K.2    Wang, R.3    Dashwood, R.H.4    Ho, E.5
  • 117
    • 33645743524 scopus 로고    scopus 로고
    • Using chemopreventive agents to enhance the efficacy of cancer therapy
    • Sarkar, F.H.; Li, Y.W. Using chemopreventive agents to enhance the efficacy of cancer therapy. Cancer. Res., 2006, 66, 3347-3350.
    • (2006) Cancer. Res. , vol.66 , pp. 3347-3350
    • Sarkar, F.H.1    Li, Y.W.2
  • 118
    • 8944220720 scopus 로고    scopus 로고
    • Chemotherapy with mitoxantrone plus prednisone or prednisone alone for symptomatic hormone-resistant prostate cancer: A Canadian randomized trial with palliative end points
    • Tannock, I.F.; Osoba, D.; Stockler, M.R.; Ernst, D.S.; Neville, A.J.; Moore, M.J.; Armitage, G.R.; Wilson, J.J.; Venner, P.M.; Coppin, C.M. Chemotherapy with mitoxantrone plus prednisone or prednisone alone for symptomatic hormone-resistant prostate cancer: a Canadian randomized trial with palliative end points. J. Clin. Oncol., 1996, 14, 1756-1764.
    • (1996) J. Clin. Oncol. , vol.14 , pp. 1756-1764
    • Tannock, I.F.1    Osoba, D.2    Stockler, M.R.3    Ernst, D.S.4    Neville, A.J.5    Moore, M.J.6    Armitage, G.R.7    Wilson, J.J.8    Venner, P.M.9    Coppin, C.M.10
  • 121
    • 74549185833 scopus 로고    scopus 로고
    • Use of gemcitabine and ginger extract infusion may improve the efficiency of cervical cancer treatment
    • Sharma, C.; Ahmed, T.; Sasidharan, S.; Ahmed, M.; Hussain, A. Use of gemcitabine and ginger extract infusion may improve the efficiency of cervical cancer treatment. Afr. J. Biotechnol., 2009, 8, 7087-7093.
    • (2009) Afr. J. Biotechnol. , vol.8 , pp. 7087-7093
    • Sharma, C.1    Ahmed, T.2    Sasidharan, S.3    Ahmed, M.4    Hussain, A.5
  • 123
    • 23044498269 scopus 로고    scopus 로고
    • Inactivation of nuclear factor kappaB by soy isoflavone genistein contributes to increased apoptosis induced by chemotherapeutic agents in human cancer cells
    • Li. Y.; Ahmed, F.; Ali, S.; Philip, P.A.; Kucuk, O.; Sarkar, F.H. Inactivation of nuclear factor kappaB by soy isoflavone genistein contributes to increased apoptosis induced by chemotherapeutic agents in human cancer cells. Cancer. Res., 2005, 65, 6934-6942.
    • (2005) Cancer. Res. , vol.65 , pp. 6934-6942
    • Li, Y.1    Ahmed, F.2    Ali, S.3    Philip, P.A.4    Kucuk, O.5    Sarkar, F.H.6
  • 124
    • 25444493107 scopus 로고    scopus 로고
    • Molecular evidence for increased antitumor activity of gemcitabine by genistein in vitro and in vivo using an orthotopic model of pancreatic cancer
    • Banerjee, S.; Zhang, Y.X.; Ali, S.; Bhuiyan, M.; Wang, Z.W.; Chiao, P.J.; Philip, P.A.; Abbruzzese, J.; Sarkar, F.H. Molecular evidence for increased antitumor activity of gemcitabine by genistein in vitro and in vivo using an orthotopic model of pancreatic cancer. Cancer. Res., 2005, 65, 9064-9072.
    • (2005) Cancer. Res. , vol.65 , pp. 9064-9072
    • Banerjee, S.1    Zhang, Y.X.2    Ali, S.3    Bhuiyan, M.4    Wang, Z.W.5    Chiao, P.J.6    Philip, P.A.7    Abbruzzese, J.8    Sarkar, F.H.9
  • 125
    • 2942690157 scopus 로고    scopus 로고
    • Apoptosis-inducing effect of chemotherapeutic agents is potentiated by soy isoflavone genistein, a natural inhibitor of NF-kappa B in BxPC-3 pancreatic cancer cell line
    • Li, Y.W.; Ellis, K.L.; Ali, S.; El-Rayes, B.F.; Nedeljkovic-Kurepa, A.; Kucuk, O.; Philip, P.A.; Sarkar, F.H. Apoptosis-inducing effect of chemotherapeutic agents is potentiated by soy isoflavone genistein, a natural inhibitor of NF-kappa B in BxPC-3 pancreatic cancer cell line. Pancreas., 2004, 28, E90-E95.
    • (2004) Pancreas. , vol.28
    • Li, Y.W.1    Ellis, K.L.2    Ali, S.3    El-Rayes, B.F.4    Nedeljkovic-Kurepa, A.5    Kucuk, O.6    Philip, P.A.7    Sarkar, F.H.8
  • 126
    • 76649128721 scopus 로고    scopus 로고
    • Enhanced anticancer effect of gemcitabine by genistein in osteosarcoma: The role of Akt and nuclear factor-kappa B
    • Zhang, B.; Shi, Z.L.; Liu, B.; Yan, X.B.; Feng, J.; Tao, H.M. Enhanced anticancer effect of gemcitabine by genistein in osteosarcoma: the role of Akt and nuclear factor-kappa B. Anti-Cancer. Drug., 2010, 21, 288-296.
    • (2010) Anti-Cancer. Drug. , vol.21 , pp. 288-296
    • Zhang, B.1    Shi, Z.L.2    Liu, B.3    Yan, X.B.4    Feng, J.5    Tao, H.M.6
  • 127
    • 18744364422 scopus 로고    scopus 로고
    • Inhibition of growth and sensitization to cisplatin-mediated killing of ovarian cancer cells by polyphenolic chemopreventive agents
    • Chan, M.M.; Fong, D.; Soprano, K.J.; Holmes, W.F.; Heverling, H. Inhibition of growth and sensitization to cisplatin-mediated killing of ovarian cancer cells by polyphenolic chemopreventive agents. J. Cell. Physiol., 2003, 194, 63-70.
    • (2003) J. Cell. Physiol. , vol.194 , pp. 63-70
    • Chan, M.M.1    Fong, D.2    Soprano, K.J.3    Holmes, W.F.4    Heverling, H.5
  • 128
    • 0032168673 scopus 로고    scopus 로고
    • Clinical development of platinum complexes in cancer therapy: An historical perspective and an update
    • Lebwohl, D.; Canetta, R. Clinical development of platinum complexes in cancer therapy: an historical perspective and an update. Eur. J. Cancer., 1998, 34, 1522-1534.
    • (1998) Eur. J. Cancer. , vol.34 , pp. 1522-1534
    • Lebwohl, D.1    Canetta, R.2
  • 129
    • 42149187768 scopus 로고    scopus 로고
    • Cisplatin nephrotoxicity: Mechanisms and renoprotective strategies
    • Pabla, N.; Dong, Z. Cisplatin nephrotoxicity: mechanisms and renoprotective strategies. Kidney. Int., 2008, 73, 994-1007.
    • (2008) Kidney. Int. , vol.73 , pp. 994-1007
    • Pabla, N.1    Dong, Z.2
  • 130
    • 70449715208 scopus 로고    scopus 로고
    • Cisplatin overdose: Toxicities and management
    • Tsang, R.Y.; Al-Fayea, T.; Au, H.J. Cisplatin overdose: toxicities and management. Drug. Saf., 2009, 32, 1109-1122.
    • (2009) Drug. Saf. , vol.32 , pp. 1109-1122
    • Tsang, R.Y.1    Al-Fayea, T.2    Au, H.J.3
  • 131
    • 67649197558 scopus 로고    scopus 로고
    • Modulation of Phase II Enzymes by Sulforaphane: Implications for Its Cardioprotective Potential
    • Angeloni, C.; Leoncini, E.; Malaguti, M.; Angelini, S.; Hrelia, P.; Hrelia, S. Modulation of Phase II Enzymes by Sulforaphane: Implications for Its Cardioprotective Potential. J. Agr. Food. Chem., 2009, 57, 5615-5622.
    • (2009) J. Agr. Food. Chem. , vol.57 , pp. 5615-5622
    • Angeloni, C.1    Leoncini, E.2    Malaguti, M.3    Angelini, S.4    Hrelia, P.5    Hrelia, S.6
  • 132
    • 43049117465 scopus 로고    scopus 로고
    • Sulforaphane protects kidneys against ischemia-reperfusion injury through induction of the Nrf2-dependent phase 2 enzyme
    • Yoon, H.Y.; Kang, N.I.; Lee, H.K.; Jang, K.Y.; Park, J.W.; Park, B.H. Sulforaphane protects kidneys against ischemia-reperfusion injury through induction of the Nrf2-dependent phase 2 enzyme. Biochem. Pharmacol., 2008, 75, 2214-2223.
    • (2008) Biochem. Pharmacol. , vol.75 , pp. 2214-2223
    • Yoon, H.Y.1    Kang, N.I.2    Lee, H.K.3    Jang, K.Y.4    Park, J.W.5    Park, B.H.6
  • 134
    • 77957121798 scopus 로고    scopus 로고
    • Protective effect of sulforaphane against cisplatin-induced mitochondrial alterations and impairment in the activity of NAD(P)H: Quinone oxidoreductase 1 and gamma glutamyl cysteine ligase: Studies in mitochondria isolated from rat kidney and in LLC-PK1 cells
    • Guerrero-Beltran, C.E.; Calderon-Oliver, M.; Martinez-Abundis, E.; Tapia, E.; Zarco-Marquez, G.; Zazueta, C.; Pedraza-Chaverri, J. Protective effect of sulforaphane against cisplatin-induced mitochondrial alterations and impairment in the activity of NAD(P)H: Quinone oxidoreductase 1 and gamma glutamyl cysteine ligase: Studies in mitochondria isolated from rat kidney and in LLC-PK1 cells. Toxicol. Lett., 2010, 199, 80-92.
    • (2010) Toxicol. Lett. , vol.199 , pp. 80-92
    • Guerrero-Beltran, C.E.1    Calderon-Oliver, M.2    Martinez-Abundis, E.3    Tapia, E.4    Zarco-Marquez, G.5    Zazueta, C.6    Pedraza-Chaverri, J.7
  • 135
    • 1242321154 scopus 로고    scopus 로고
    • Cruciferous vegetables: Cancer protective mechanisms of glucosinolate hydrolysis products and selenium
    • Keck, A.S.; Finley, J.W. Cruciferous vegetables: cancer protective mechanisms of glucosinolate hydrolysis products and selenium. Integr. Cancer. Ther., 2004, 3, 5-12.
    • (2004) Integr. Cancer. Ther. , vol.3 , pp. 5-12
    • Keck, A.S.1    Finley, J.W.2
  • 136
    • 33749258585 scopus 로고    scopus 로고
    • Part of the series: From dietary antioxidants to regulators in cellular signaling and gene regulation. Sulforaphane and selenium, partners in adaptive response and prevention of cancer
    • Brigelius-Flohe, R.; Banning, A. Part of the series: from dietary antioxidants to regulators in cellular signaling and gene regulation. Sulforaphane and selenium, partners in adaptive response and prevention of cancer. Free. Radic. Res., 2006, 40, 775-787.
    • (2006) Free. Radic. Res. , vol.40 , pp. 775-787
    • Brigelius-Flohe, R.1    Banning, A.2
  • 137
    • 0035875447 scopus 로고    scopus 로고
    • Accelerated DNA adduct formation in the lung of the Nrf2 knockout mouse exposed to diesel exhaust
    • Aoki, Y.; Sato, H.; Nishimura, N.; Takahashi, S.; Itoh, K.; Yamamoto, M. Accelerated DNA adduct formation in the lung of the Nrf2 knockout mouse exposed to diesel exhaust. Toxicol. Appl. Pharm., 2001, 173, 154-160.
    • (2001) Toxicol. Appl. Pharm. , vol.173 , pp. 154-160
    • Aoki, Y.1    Sato, H.2    Nishimura, N.3    Takahashi, S.4    Itoh, K.5    Yamamoto, M.6
  • 138
    • 0036318224 scopus 로고    scopus 로고
    • Nrf2 transcription factor, a novel target of keratinocyte growth factor action which regulates gene expression and inflammation in the healing skin wound
    • Braun, S.; Hanselmann, C.; Gassmann, M.G.; Keller, U.A.D.; Born-Berclaz, C.; Chan, K.M.; Kan, Y.W.; Werner, S. Nrf2 transcription factor, a novel target of keratinocyte growth factor action which regulates gene expression and inflammation in the healing skin wound. Mol. Cell. Biol., 2002, 22, 5492-5505.
    • (2002) Mol. Cell. Biol. , vol.22 , pp. 5492-5505
    • Braun, S.1    Hanselmann, C.2    Gassmann, M.G.3    Keller, U.A.D.4    Born-Berclaz, C.5    Chan, K.M.6    Kan, Y.W.7    Werner, S.8
  • 139
    • 9444249870 scopus 로고    scopus 로고
    • The transcription factor NRF2 protects against pulmonary fibrosis
    • Cho, H.Y.; Reddy, S.P.M.; Yamamoto, M.; Kleeberge, r S.R. The transcription factor NRF2 protects against pulmonary fibrosis. Faseb. J., 2004, 18, 1258-+.
    • (2004) Faseb. J. , vol.18 , pp. 1258-1259
    • Cho, H.Y.1    Reddy, S.P.M.2    Yamamoto, M.3    Kleeberger, S.R.4
  • 140
    • 1542723493 scopus 로고    scopus 로고
    • Decline in transcriptional activity of Nrf2 causes age-related loss of glutathione synthesis, which is reversible with lipoic acid
    • Suh, J.H.; Shenvi, S.V.; Dixon, B.M.; Liu, H.L.; Jaiswal, A.K.; Liu, R.M.; Hagen, T.M. Decline in transcriptional activity of Nrf2 causes age-related loss of glutathione synthesis, which is reversible with lipoic acid. P. Natl. Acad. Sci. U.S.A., 2004, 101, 3381-3386.
    • (2004) P. Natl. Acad. Sci. U.S.A. , vol.101 , pp. 3381-3386
    • Suh, J.H.1    Shenvi, S.V.2    Dixon, B.M.3    Liu, H.L.4    Jaiswal, A.K.5    Liu, R.M.6    Hagen, T.M.7
  • 141
  • 142
    • 20744440945 scopus 로고    scopus 로고
    • Induction of the Nrf2-driven antioxidant response confers neuroprotection during mitochondrial stress in vivo
    • Shih, A.Y.; Imbeault, S.; Barakauskas, V.; Erb, H.; Jiang, L.; Li, P.; Murphy, T.H. Induction of the Nrf2-driven antioxidant response confers neuroprotection during mitochondrial stress in vivo. J. Biol. Chem., 2005, 280, 22925-22936.
    • (2005) J. Biol. Chem. , vol.280 , pp. 22925-22936
    • Shih, A.Y.1    Imbeault, S.2    Barakauskas, V.3    Erb, H.4    Jiang, L.5    Li, P.6    Murphy, T.H.7
  • 143
    • 34250365437 scopus 로고    scopus 로고
    • Chemopreventive promise of targeting the Nrf2 pathway
    • Yates, M.S.; Kensler, T.W. Chemopreventive promise of targeting the Nrf2 pathway. Drug. News. Perspect., 2007, 20, 109-117.
    • (2007) Drug. News. Perspect. , vol.20 , pp. 109-117
    • Yates, M.S.1    Kensler, T.W.2
  • 144
    • 28644450910 scopus 로고    scopus 로고
    • Effects of glucosinolate-rich broccoli sprouts on urinary levels of aflatoxin-DNA adducts and phenanthrene tetraols in a randomized clinical trial in He Zuo township, Qidong, People's Republic of China
    • Kensler, T.W.; Chen, J.G.; Egner, PA.; Fahey, J.W.; Jacobson, L.P.; Stephenson, K.K.; Ye, L.; Coady, J.L.; Wang, J.B.; Wu, Y. Effects of glucosinolate-rich broccoli sprouts on urinary levels of aflatoxin-DNA adducts and phenanthrene tetraols in a randomized clinical trial in He Zuo township, Qidong, People's Republic of China. Cancer Epidemiol. Biomarkers Prev., 2005, 14, 2605-2613.
    • (2005) Cancer Epidemiol. Biomarkers Prev. , vol.14 , pp. 2605-2613
    • Kensler, T.W.1    Chen, J.G.2    Egner, P.A.3    Fahey, J.W.4    Jacobson, L.P.5    Stephenson, K.K.6    Ye, L.7    Coady, J.L.8    Wang, J.B.9    Wu, Y.10
  • 147
    • 33748255958 scopus 로고    scopus 로고
    • Increased expression of nuclear factor E2 p45-related factor 2 (NRF2) in head and neck squamous cell carcinomas
    • Stacy, D.R.; Ely, K.; Massion, P.P.; Yarbrough, W.G.; Hallahan, D.E.; Sekhar, K.R.; Freeman, M.L. Increased expression of nuclear factor E2 p45-related factor 2 (NRF2) in head and neck squamous cell carcinomas. Head Neck., 2006, 28, 813-818.
    • (2006) Head Neck. , vol.28 , pp. 813-818
    • Stacy, D.R.1    Ely, K.2    Massion, P.P.3    Yarbrough, W.G.4    Hallahan, D.E.5    Sekhar, K.R.6    Freeman, M.L.7
  • 149
    • 38149003106 scopus 로고    scopus 로고
    • Role of the Nrf2-antioxidant system in cytotoxicity mediated by anticancer cisplatin: Implication to cancer cell resistance
    • Cho, J.M.; Manandhar, S.; Lee, H.R.; Park, H.M.; Kwak, M.K. Role of the Nrf2-antioxidant system in cytotoxicity mediated by anticancer cisplatin: implication to cancer cell resistance. Cancer Lett., 2008, 260, 96-108.
    • (2008) Cancer Lett. , vol.260 , pp. 96-108
    • Cho, J.M.1    Manandhar, S.2    Lee, H.R.3    Park, H.M.4    Kwak, M.K.5
  • 151
    • 31644436285 scopus 로고    scopus 로고
    • Expression of the steroid and xenobiotic receptor and its possible target gene, organic anion transporting polypeptide-A, in human breast carcinoma
    • Miki, Y.; Suzuki, T.; Kitada, K.; Yabuki, N.; Shibuya, R.; Moriya, T.; Ishida, T.; Ohuchi, N.; Blumberg, B.; Sasano, H. Expression of the steroid and xenobiotic receptor and its possible target gene, organic anion transporting polypeptide-A, in human breast carcinoma. Cancer Res., 2006, 66, 535-542.
    • (2006) Cancer Res. , vol.66 , pp. 535-542
    • Miki, Y.1    Suzuki, T.2    Kitada, K.3    Yabuki, N.4    Shibuya, R.5    Moriya, T.6    Ishida, T.7    Ohuchi, N.8    Blumberg, B.9    Sasano, H.10
  • 152
    • 41649111966 scopus 로고    scopus 로고
    • The antiapoptotic role of pregnane X receptor in human colon cancer cells
    • Zhou, J.; Liu, M.; Zhai, Y.; Xie, W. The antiapoptotic role of pregnane X receptor in human colon cancer cells. Mol. Endocrinol., 2008, 22, 868-880.
    • (2008) Mol. Endocrinol. , vol.22 , pp. 868-880
    • Zhou, J.1    Liu, M.2    Zhai, Y.3    Xie, W.4
  • 155
    • 0141564528 scopus 로고    scopus 로고
    • Expression and potential roles of pregnane X receptor in endometrial cancer
    • Masuyama, H.; Hiramatsu, Y.; Kodama, J.; Kudo, T. Expression and potential roles of pregnane X receptor in endometrial cancer. J. Clin. Endocrinol. Metab., 2003, 88, 4446-4454.
    • (2003) J. Clin. Endocrinol. Metab. , vol.88 , pp. 4446-4454
    • Masuyama, H.1    Hiramatsu, Y.2    Kodama, J.3    Kudo, T.4
  • 156
    • 34748865948 scopus 로고    scopus 로고
    • Down-regulation of pregnane X receptor contributes to cell growth inhibition and apoptosis by anticancer agents in endometrial cancer cells
    • Masuyama, H.; Nakatsukasa, H.; Takamoto, N.; Hiramatsu, Y. Down-regulation of pregnane X receptor contributes to cell growth inhibition and apoptosis by anticancer agents in endometrial cancer cells. Mol. Pharmacol., 2007, 72, 1045-1053.
    • (2007) Mol. Pharmacol. , vol.72 , pp. 1045-1053
    • Masuyama, H.1    Nakatsukasa, H.2    Takamoto, N.3    Hiramatsu, Y.4
  • 157
    • 62749159815 scopus 로고    scopus 로고
    • Pregnane X receptor and its potential role in drug resistance in cancer treatment
    • Chen, Y.; Nie, D. Pregnane X receptor and its potential role in drug resistance in cancer treatment. Recent Pat. Anticancer Drug Discov., 2009, 4, 19-27.
    • (2009) Recent Pat. Anticancer Drug Discov. , vol.4 , pp. 19-27
    • Chen, Y.1    Nie, D.2
  • 158
    • 23444453717 scopus 로고    scopus 로고
    • Regulation of Bcl-2 and Bcl-xL antiapoptotic protein expression by nuclear receptor PXR in primary cultures of human and rat hepatocytes
    • Zucchini, N.; de Sousa, G.; Bailly-Maitre, B.; Gugenheim, J.; Bars, R.; Lemaire, G.; Rahmani, R. Regulation of Bcl-2 and Bcl-xL antiapoptotic protein expression by nuclear receptor PXR in primary cultures of human and rat hepatocytes. Biochim. Biophys. Acta., 2005, 1745, 48-58.
    • (2005) Biochim. Biophys. Acta. , vol.1745 , pp. 48-58
    • Zucchini, N.1    de Sousa, G.2    Bailly-Maitre, B.3    Gugenheim, J.4    Bars, R.5    Lemaire, G.6    Rahmani, R.7
  • 159
    • 33751394970 scopus 로고    scopus 로고
    • Identification of genes controlled by the pregnane X receptor by microarray analysis of mRNAs from pregnenolone 16alpha-carbonitrile-treated rats
    • Guzelian, J.; Barwick, J.L.; Hunter, L.; Phang, T.L.; Quattrochi, L.C.; Guzelian, P.S. Identification of genes controlled by the pregnane X receptor by microarray analysis of mRNAs from pregnenolone 16alpha-carbonitrile-treated rats. Toxicol. Sci., 2006, 94, 379-387.
    • (2006) Toxicol. Sci. , vol.94 , pp. 379-387
    • Guzelian, J.1    Barwick, J.L.2    Hunter, L.3    Phang, T.L.4    Quattrochi, L.C.5    Guzelian, P.S.6
  • 160
    • 0037972688 scopus 로고    scopus 로고
    • Genetic profiling defines the xenobiotic gene network controlled by the nuclear receptor pregnane X receptor
    • Rosenfeld, J.M.; Vargas, R.; Jr.; Xie, W.; Evans, R.M. Genetic profiling defines the xenobiotic gene network controlled by the nuclear receptor pregnane X receptor. Mol. Endocrinol., 2003, 17, 1268-1282.
    • (2003) Mol. Endocrinol. , vol.17 , pp. 1268-1282
    • Rosenfeld, J.M.1    Vargas Jr., R.2    Xie, W.3    Evans, R.M.4
  • 161
    • 33845904129 scopus 로고    scopus 로고
    • The dietary isothiocyanate sulforaphane is an antagonist of the human steroid and xenobiotic nuclear receptor
    • Zhou, C.; Poulton, E.J.; Grun, F.; Bammler, T.K.; Blumberg, B.; Thummel, KE.; Eaton, D.L. The dietary isothiocyanate sulforaphane is an antagonist of the human steroid and xenobiotic nuclear receptor. Mol. Pharmacol., 2007, 71, 220-229.
    • (2007) Mol. Pharmacol. , vol.71 , pp. 220-229
    • Zhou, C.1    Poulton, E.J.2    Grun, F.3    Bammler, T.K.4    Blumberg, B.5    Thummel, K.E.6    Eaton, D.L.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.