Inhibitors of human histone deacetylase: Synthesis and enzyme and cellular activity of straight chain hydroxamates

Journal of Medicinal Chemistry

Volumn 45, Issue 4, 2002, Pages 753-757

  Remiszewski, Stacy W ^a   Sambucetti, Lidia C ^b   Atadja, Peter ^a   Bair, Kenneth W ^a   Cornell, Wendy D ^a   Green, Michael A ^a   Howell, Kobporn Lulu ^a   Jung, Manfred ^c   Kwon, Paul ^b   Trogani, Nancy ^a   Walker, Heather ^a  

^a NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

^b Xenogen Corporation   (United States)

^c UNIVERSITY OF MÜNSTER   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

4 (DIMETHYLAMINO) N [7 (HYDROXYAMINO) 7 OXYHEPTYL]BENZAMIDE; BENZAMIDE DERIVATIVE; HISTONE DEACETYLASE; HISTONE DEACETYLASE INHIBITOR; HYDROXAMIC ACID DERIVATIVE; PROTEIN P21; SUBEROYLANILIDE HYDROXAMIC ACID DERIVATIVE; TRAPOXIN B; TRICHOSTATIN A; TRICHOSTATIN A DERIVATIVE; UNCLASSIFIED DRUG; VORINOSTAT;

ANTINEOPLASTIC ACTIVITY; ARTICLE; ENZYME INHIBITION; GROWTH INHIBITION; HUMAN; HUMAN CELL; MONOLAYER CULTURE; PROMOTER REGION; TUMOR CELL LINE; TUMOR DIFFERENTIATION;

ANTINEOPLASTIC AGENTS; BENZAMIDES; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLINS; DRUG SCREENING ASSAYS, ANTITUMOR; ENZYME INHIBITORS; HISTONE DEACETYLASES; HUMANS; HYDROXAMIC ACIDS; HYDROXYLAMINES; MODELS, MOLECULAR; PROMOTER REGIONS (GENETICS); STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

EID: 0037075081     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm015568c     Document Type: Article

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