Accelerated DNA adduct formation in the lung of the Nrf2 knockout mouse exposed to diesel exhaust

Toxicology and Applied Pharmacology

Volumn 173, Issue 3, 2001, Pages 154-160

  Aoki, Yasunobu ^a   Sato, Hiromi ^a   Nishimura, Noriko ^a   Takahashi, Satoru ^b   Itoh, Ken ^b   Yamamoto, Masayuki ^b  

^a NATIONAL INSTITUTE FOR ENVIRONMENTAL STUDIES   (Japan)

^b UNIVERSITY OF TSUKUBA   (Japan)

Author keywords

8 hydroxydeoxyguanosine; Bronchial epithelial cells; Diesel exhaust; DNA adduct; Knockout mouse; Lung; Nrf2; Oxidative stress; Phase II enzyme; Polyaromatic hydrocarbon

Indexed keywords

8 HYDROXYDEOXYGUANOSINE; CYTOCHROME P450 1A1; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRONCHUS MUCOSA; CARCINOGENICITY; CONTROLLED STUDY; DETOXIFICATION; DNA ADDUCT; EXHAUST GAS; IMMUNOHISTOCHEMISTRY; KNOCKOUT MOUSE; LUNG; MOUSE; MUTAGENICITY; NONHUMAN; NORTHERN BLOTTING; OXIDATIVE STRESS; PROTEIN EXPRESSION; SUSPENDED PARTICULATE MATTER; THIN LAYER CHROMATOGRAPHY;

EID: 0035875447     PISSN: 0041008X     EISSN: None     Source Type: Journal    
DOI: 10.1006/taap.2001.9176     Document Type: Article

References (44)

1. Erythroid transcription factor NF-E2 is a haematopoietic-specific basic-leucine zipper protein
2. The ubiquitous subunit of erythroid transcription factor NF-E2 is a small basic-leucine zipper protein related to the v-maf oncogene
3. 32P-postlabeling assay
4. Cloning and functional characterization of LCR-F1: A bZIP transcription factor that activates erythroid-specific, human globin gene expression
5. Isolation of cDNA encoding the human NF-E2 protein
6. Nrf2 is essential for protection against acute pulmonary injury in mice
7. High sensitivity of Nrf2 knockout mice to acetoaminophen hepatotoxicity associated with decreased expression of ARE-regulated drug metabolizing enzyme and antioxidant genes
8. 32P-postlabeling analysis of non-radioactive aromatic carcinogen-DNA adducts
9. Identification of genetic polymorphisms at the glutathione S-transferase Pi locus and association with susceptibility to bladder, testicular and prostate cancer
10. 8-Hydroxy-2′-deoxyguanosine is increased in epidermal cells of hairless mice after chronic ultraviolet B exposure
11. The Nrf2 transcription factor contributes both to the basal expression of glutathione S-transferases in mouse liver and to their induction by the chemopreventive synthetic anti-oxidants, butylated hydroxyanisole and ethoxyquin
12. Glutathione and glutathione-dependent enzymes represent a coordinately regulated defense against oxidative stress
13. Differential protection against benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide-induced DNA damage in HepG2 cells stably transfected with allelic variants of π class human glutathione S-transferase
14. Lung carcinogenesis and formation of 8-hydroxyde-oxyguanosin in mice by diesel exhaust particles
15. Regulation of transcription by dimerization of erythroid factor NF-E2 p45 with small Maf proteins
16. Transcription factor Nrf2 coordinately regulates a group of oxidative stress-inducible genes in macrophages
17. An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements
18. Cloning and characterization of a novel erythroid cell-derived CNC family transcription factor heterodimerizing with the small Maf family proteins
19. Genoprotection by UDP-glucuronosyl-transferases in peroxidase-dependent, reactive oxygen species-mediated micronucleus initiation by the carcinogens 4-(methylnitrosamino)-1-(3-pyridyl)-1-buta and benzo[a]pyrene
20. Molecular cloning and functional characterization of a new Cap'n' collar family transcription factor Nrf3
21. Molecular cloning of a putative novel human bZIP transcription factor on chromosome 17q22
22. Health effects of exposure to diesel exhaust particles
23. Ah receptor and estrogen receptor-dependent modulation of gene expression by extract of diesel exhaust particles
24. Segmentally restricted, cephalic expression of a leucine zipper gene during Drosophila embryogenesis
25. Isolation of NF-E2-related factor 2 (Nrf2), a NF-E2-like basic leucine zipper transcriptional activator that binds to the tandem NF-E2/AP1 repeat of the beta-globin locus control region
26. Single-stranded shuttle phagemid for mutagenesis studies in mammalian cells: 8-Oxoguanine in DNA induces targeted G.C→T.A transversions in simian kidney cells
27. Adjuvant activity of diesel-exhaust particulates for the production of IgE antibody in mice
28. Multiple forms of cytochrome P-450 and the importance of molecular biology and evolution
29. Role of the Ah receptor and the dioxin-inducible [Ah] gene battery in toxicity, cancer, and signal transduction
30. Location of metallothionein in female reproductive organs of rat and guinea pig
31. Bach proteins belong to a novel family of BTB-basic leucine zipper transcription factors that interact with MafK and regulate transcription through the NF-E2 site
32. 32P-post-labelling analysis of DNA adducts formed in the livers of animals treated with safrole, estragole and other naturally-occurring alkenylbenzenes. I. Adult female CD-1 mice
33. 32P-labeling test for DNA damage
34. 32P-postlabeling test for covalent DNA binding of chemicals in vivo: Application to a variety of aromatic carcinogens and methylating agents
35. Nuclease P1-mediated enhancement of sensitivity of 32P-postlabeling test for structurally diverse DNA adducts
36. The antioxidant responsive element. Activation by oxidative stress and identification of the DNA consensus sequence required for functional activity
37. Genotypes of glutathione transferase M1 and P1 and their significance for lung DNA adduct levels and cancer risk
38. Increase in mutation frequency in lung of Big Blue rat by exposure to diesel exhaust
39. Benzo[a]pyrene carcinogenicity is lost in mice lacking the aryl hydrocarbon receptor
40. Epoxides in polycyclic aromatic hydrocarbon metabolism and carcinogenesis
41. Differences in the catalytic efficiencies of allelic variants of glutathione transferase Pl-1 towards carcinogenic diol epoxides of polycyclic aromatic hydrocarbons
42. Diesel-exhaust particulates inoculated by the intranasal route have an adjuvant activity for IgE production in mice
43. Human small Maf proteins form heterodimers with CNC family transcription factors and recognize the NF-E2 motif
44. DNA adduct formation in mammalian cell cultures by polycyclic aromatic hydrocarbons (PAH) and nitro-PAH in coke oven emission extract