The dietary isothiocyanate sulforaphane targets pathways of apoptosis, cell cycle arrest, and oxidative stress in human pancreatic cancer cells and inhibits tumor growth in severe combined immunodeficient mice

Molecular Cancer Therapeutics

Volumn 3, Issue 10, 2004, Pages 1239-1248

  Pham, Nhu An ^a,b   Jacobberger, James W ^c   Schimmer, Aaron D ^a,b   Cao, Pinjiang ^b   Gronda, Marcella ^b   Hedley, David W ^a,b  

^a UNIVERSITY OF TORONTO   (Canada)

^b PRINCESS MARGARET HOSPITAL   (Canada)

^c CASE WESTERN RESERVE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

7 HYDROXYSTAUROSPORINE; ACETYLCYSTEINE; ANTINEOPLASTIC AGENT; CASPASE 3; CASPASE 8; CELL DNA; CYCLIN A; CYCLIN B1; DRUG VEHICLE; GLUTATHIONE; HISTONE H3; ISOTHIOCYANIC ACID DERIVATIVE; PROTEIN KINASE; SERINE; SULFORAPHANE; TYROSINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL; CANCER CELL CULTURE; CANCER INHIBITION; CANCER PREVENTION; CANCER RESISTANCE; CELL CYCLE; CELL CYCLE G2 PHASE; CELL LEVEL; CELL MEMBRANE; CELL MEMBRANE POTENTIAL; CELL NUCLEUS; CELL STRUCTURE; CELL SUBPOPULATION; COMBINED IMMUNODEFICIENCY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORRELATION ANALYSIS; CYTOTOXICITY; DIETARY INTAKE; DNA CONTENT; DOSE TIME EFFECT RELATION; DRUG DOSE REGIMEN; DRUG TARGETING; ENZYME ACTIVATION; ENZYME DEGRADATION; FLOW CYTOMETRY; HUMAN; HUMAN CELL; MALE; METAPHASE; MITOCHONDRIAL MEMBRANE; MITOSIS INHIBITION; MOUSE; NONHUMAN; OXIDATIVE STRESS; PANCREAS CANCER; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; REGULATORY MECHANISM; SUBCUTANEOUS TISSUE TUMOR; TUMOR VOLUME;

ANIMALS; ANTICARCINOGENIC AGENTS; ANTIGENS; APOPTOSIS; BLOTTING, WESTERN; CASPASE 3; CASPASE 8; CASPASES; CELL CYCLE; CELL LINE, TUMOR; CELL MEMBRANE; CELL NUCLEUS; DNA; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; FLOW CYTOMETRY; GLUTATHIONE; HUMANS; MALE; MEMBRANE POTENTIALS; MICE; MICE, SCID; MICROSCOPY, FLUORESCENCE; MITOCHONDRIA; MITOSIS; NEOPLASM TRANSPLANTATION; NEOPLASMS; OXIDATIVE STRESS; PANCREATIC NEOPLASMS; REACTIVE OXYGEN SPECIES; STAUROSPORINE; THIOCYANATES; TIME FACTORS; TYROSINE;

EID: 7444229836     PISSN: 15357163     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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