Mitochondria are the primary target in isothiocyante-induced apoptosis in human bladder cancer cells

Molecular Cancer Therapeutics

Volumn 4, Issue 8, 2005, Pages 1250-1259

  Tang, Li ^a   Zhang, Yuesheng ^a  

^a ROSWELL PARK CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALLYL ISOTHIOCYANATE; BENZYL ISOTHIOCYANATE; CASPASE 9; CYTOCHROME C; GLUTATHIONE; ISOTHIOCYANIC ACID DERIVATIVE; PHENYL ISOTHIOCYANATE; PROTEIN BAK; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BCL XL; SULFORAPHANE;

APOPTOSIS; ARTICLE; BLADDER CANCER; CANCER CELL; CELL DAMAGE; CELL ISOLATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORRELATION FUNCTION; DRUG POTENCY; DRUG TARGETING; ENZYME ACTIVATION; ENZYME RELEASE; GLUTATHIONE METABOLISM; HUMAN; HUMAN CELL; INTRACELLULAR SPACE; LIPOPHILICITY; MITOCHONDRIAL MEMBRANE; MITOCHONDRION; OUTER MEMBRANE; PRIORITY JOURNAL; PROTEIN FAMILY; PROTEIN PHOSPHORYLATION; PROTEIN TRANSPORT;

ANTICARCINOGENIC AGENTS; APOPTOSIS; CASPASE 9; CASPASES; CYTOCHROMES C; ENZYME ACTIVATION; HUMANS; INTRACELLULAR MEMBRANES; ISOTHIOCYANATES; MEMBRANE POTENTIALS; MITOCHONDRIA; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-BCL-2; TUMOR CELLS, CULTURED; URINARY BLADDER NEOPLASMS;

EID: 23844505236     PISSN: 15357163     EISSN: None     Source Type: Journal    
DOI: 10.1158/1535-7163.MCT-05-0041     Document Type: Article

References (55)

1. Zhang Y, Talalay P. Anticarcinogenic activities of organic isothiocyanates: chemistry and mechanisms. Cancer Res 1994;54:1976-81s.
2. Hecht SS. Chemoprevention by isothiocyanates. J Cell Biochem 1995;22:195-209.
3. Hecht SS. Inhibition of carcinogenesis by isothiocyanates. Drug Metab Rev 2000;32:395-411.
4. Conaway CC, Yang Y, Chung FL. Isothiocyanates as cancer chemopreventive agents: their biological activities and metabolism in rodents and humans. Curr Drug Metab 2002;3:233-55.
5. Chiao JW, Chung FL, Kancherla R, Ahmed T, Mittelman A, Conaway CC. Sulforaphane and its metabolite mediate growth arrest and apoptosis in human prostate cancer cells. Int J Oncol 2002;20:631-6.
6. Fimognari C, Nusse M, Cesari R, Iori R, Cantelli-Forti G, Hrelia P. Growth inhibition, cell-cycle arrest and apoptosis in human T-cell leukemia by the isothiocyanate sulforaphane. Carcinogenesis 2002;23:581-6.
7. Xu K, Thornalley PJ. Studies on the mechanism of the inhibition of human leukaemia cell growth by dietary isothiocyanates and their cysteine adducts in vitro. Biochem Pharmacol 2000;60:221-31.
8. Huang C, Ma WY, Li JX, Hecht SS, Dong ZG. Essential role of p53 in phenethyl isothiocyanate-induced apoptosis. Cancer Res 1998;58: 4102-6.
9. Gamet-Payrastre L, Li P, Lumeau S, et al. Sulforaphane, a naturally occurring isothiocyanate, induces cell cycle arrest and apoptosis in HT29 human colon cancer cells. Cancer Res 2000;60:1426-33.
10. Zhang Y, Tang L, Gonzalez V. Selected isothiocyanates rapidly induce growth inhibition of cancer cells. Mol Cancer Ther 2003;2: 1045-52.
11. Gamet-Payrastre L, Lumeau S, Gasc N, Cassar G, Rollin P, Tulliez J. Selective cytostatic and cytotoxic effects of glucosinolates hydrolysis products on human colon cancer cells in vitro. Anticancer Drugs 1998; 9:141-8.
12. 2/M arrest and inducing apoptosis. Carcinogenesis 2003;24:891-7.
13. Musk SR, Johnson IT. Allyl isothiocyanate is selectively toxic to transformed cells of the human colorectal tumour line HT29. Carcinogenesis 1993;14:2079-83.
14. Chung FL, Morse MA, Eklind KI, Lewis J. Quantification of human uptake of the anticarcinogen phenethyl isothiocyanate after a watercress meal. Cancer Epidemiol Biomarkers Prev 1992;1:383-8.
15. Mennicke WH, Gorler K, Krumbiegel G, Lorenz D, Rittmann N. Studies on the metabolism and excretion of benzyl isothiocyanate in man. Xenobiotica 1988;18:441-7.
16. Tang L, Zhang Y. Isothiocyanates in the chemoprevention of bladder cancer. Curr Drug Metab 2004;5:193-201.
17. Jiao D, Ho CT, Fioles P, Chung FL. Identification and quantification of the N-acetylcysteine conjugate of allyl isothiocyanate in human urine after ingestion of mustard. Cancer Epidemiol Biomarkers Prev 1994;3:487-92.
18. Shapiro TA, Fahey JW, Wade KL, Stephenson KK, Talalay P. Chemoprotective glucosinolates and isothiocyanates of broccoli sprouts: metabolism and excretion in humans. Cancer Epidemiol Biomarkers Prev 2001;10:501-8.
19. Ye L, Dinkova-Kostova AT, Wade KL, Zhang Y, Shapiro TA, Talalay P. Quantitative determination of dithiocarbamates in human plasma, serum, erythrocytes and urine: pharmacokinetics of broccoli sprout isothiocyanates in humans. Clin Chim Acta 2002;316:43-53.
20. Ioannou YM, Burka LT, Matthews HB. Allyl isothiocyanate: comparative disposition in rats and mice. Toxicol Appl Pharmacol 1984;75: 173-81.
21. Tang L, Zhang Y. Dietary isothiocyanates inhibit the growth of human bladder carcinoma cells. J Nutr 2004;134:2004-10.
22. Yu R, Mandlekar S, Harvey KJ, Ucker DS, Kong A-NT. Chemopreventive isothiocyanates induce apoptosis and caspase-3-like protease activity. Cancer Res 1998;58:402-8.
23. Nakamura Y, Kawakami M, Yoshihiro A, et al. Involvement of the mitochondrial death pathway in chemopreventive benzyl isothiocyanate-induced apoptosis. J Biol Chem 2002;277:8492-9.
24. Zhang Y. Role of glutathione in the accumulation of anticarcinogenic isothiocyanates and their glutathione conjugates by murine hepatoma cells. Carcinogenesis 2000;21:1175-82.
25. Zhang Y. Molecular mechanism of rapid cellular accumulation of anticarcinogenic isothiocyanates. Carcinogenesis 2001;22:425-31.
26. Liu X, Kim CN, Yang J, et al. Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c. Cell 1996;86: 147-57.
27. Emaus RK, Grunwald R, Lemasters JJ. Rhodamine 123 as a probe of transmembrane potential in isolated rat-liver mitochondria: spectral and metabolic properties. Biochim Biophys Acta 1986;850:436-48.
28. Kolm RH, Danielson UH, Zhang Y, Talalay P, Mannervik B. Isothiocyanates as substrates for human glutathione transferases: structure-activity studies. Biochem J 1995;311:453-9.
29. Zhang Y, Talalay P. Mechanism of differential protencies of isothiocyanates as inducers of anticarcinogenic phase 2 enzymes. Cancer Res 1998;58:4632-9.
30. Finucane DM, Waterhouse NJ, Amarante-Mendes GP, Cotter TG, Green DR. Collapse of the inner mitochondrial transmembrane potential is not required for apoptosis of HL60 cells. Exp Cell Res 1999;251: 166-74.
31. m) in apoptosis; an update. Apoptosis 2003;8:115-28.
32. Henderson PJ, Lardy HA. An inhibitor of the adenine nucleotide translocase of mitochondria. J Biol Chem 1970; 245:1319-26.
33. Broekemeier KM, Dempsey ME, Pfeiffer DR. Cyclosporin A is a potent inhibitor of the inner membrane permeability transition in liver mitochondria. J Biol Chem 1989;264:7826-30.
34. Halestrap AP, Davidson AM. Inhibition of Ca2 +-induced large-amplitude swelling of liver and heart mitochondria by cyclosporin is probably caused by the inhibitor binding to mitochondrial-matrix peptidylprolyl cis-trans isomerase and preventing it interacting with the adenine nucleotide translocase. Biochem J 1990;268:153-60.
35. Narita M, Shimizu S, Ito T, et al. Bax interacts with the permeability transition pore to induce permeability transition and cytochrome c release in isolated mitochondria. Proc Natl Aced Sci U S A 1998;95:14681-6.
36. 2+-induced permeability transition of mitochondria. Free Radic Res 2004;38:27-35.
37. Chinopoulos C, Starkov AA, Fiskum G. Cyclosporin A-insensitive permeability transition in brain mitochondria: inhibition by 2-aminoethoxydiphenyl borate. J Biol Chem 2003;278:27382-9.
38. Zamzami N, Susin SA, Marchetti P, et al. Mitochondrial control of nuclear apoptosis. J Exp Med 1996;183:1533-44.
39. Li M, Xia T, Jiang CS, Li LJ, Fu JL, Zhou ZC. Cadmium directly induced the opening of membrane permeability pore of mitochondria which possibly involved in cadmium-triggered apoptosis. Toxicology 2003;194:19-33.
40. Choi S, Singh SV. Bax and Bak are required for apoptosis induction by sulforaphane, a cruciferous vegetable-derived cancer chemoprevention agent. Cancer Res 2005;65:2035-43.
41. Xu K, Thornalley PJ. Signal transduction activated by the cancer chemopreventive isothiocyanates: cleavage of BID protein, tyrosine phosphorylation and activation of JNK. Br J Cancer 2001;84:670-3.
42. Miyoshi N, Uchida K, Osawa T, Nakamura Y. A link between benzyl isothiocyanate-induced cell cycle arrest and apoptosis: involvement of mitogen-activated protein kinases in the Bcl-2 phosphorylation. Cancer Res 2004;64:2134-42.
43. Rose P, Armstrong JS, Chua YL, Ong CN, Whiteman M. β-phenylethyl isothiocyanate mediated apoptosis; contribution of Bax and the mitochondrial death pathway. Int J Biochem Cell Biol 2005; 37:100-19.
44. Zamzami N, Kroemer G. The mitochondrion in apoptosis: how Pandora's box opens. Nat Rev Mol Cell Biol 2001;2:67-71.
45. Martinou JC, Green DR. Breaking the mitochondrial barrier. Nat Rev Mol Cell Biol 2001;2:63-7.
46. Miko M, Chance B. Isothiocyanates. A new class of uncouplers. Biochim Biophys Acta 1975;396:165-74.
47. Lim MLR, Minamikawa T, Nagley P. The protonophore CCCP induces mitochondrial permeability transition without cytochrome c release in human osteosarcoma cells. FEBS Lett 2001;503:69-74.
48. Nieminen AL, Saylor AK, Tesfai SA, Herman B, Lemasters JJ. Contribution of the mitochondrial permeability transition to lethal injury after exposure of hepatocytes to t-butylhydroperoxide. Biochem J 1995;307:99-106.
49. Nakamura Y, Ohigashi H, Masuda S, et al. Redox regulation of glutathione S-transferase induction by benzyl isothiocyanate: correlation of enzyme induction with the formation of reactive oxygen intermediates. Cancer Res 2000;60:219-25.
50. Rose P, Whiteman M, Huang SH, Halliwell B, Ong CN. β-Phenylethyl isothiocyanate-mediated apoptosis in hepatoma HepG2 cells. Cell Mol Life Sci 2003;60:1489-503.
51. Payen L, Courtois A, Loewert M, Guillouzo A, Fardel O. Reactive oxygen species-related induction of multidrug resistance-associated protein 2 expression in primary hepatocytes exposed to sulforaphane. Biochem Biophys Res Commun 2001;282:257-63.
52. Papa S, Skulachev VP. Reactive oxygen species, mitochondria, apoptosis and aging. Mol Cell Biochem 1997; 174:305-19.
53. Turrens JF, Alexandre A, Lehninger AL. Ubisemiquione is the electron donor for superoxide formation by complex III of heart mitochondria. Arch Biochem Biophys 1985;237:408-14.
54. Fleury C, Mignotte B, Vayssiere JL. Mitochondrial reactive oxygen species in cell death signaling. Biochimie 2002;84:131-41.
55. Palmeira CM, Ferreira FM, Rolo AP, et al. Histological changes and impairment of liver mitochondrial bioenergetics after long-term treatment with α-naphthyl-isothiocyanate (ANIT). Toxicology 2003;190:185-96.