-
1
-
-
0028953810
-
Transforming growth factor beta and cell cycle regulation
-
Alexandrow MG, Moses HL (1995) Transforming growth factor beta and cell cycle regulation. Cancer Res 55:1452-14577
-
(1995)
Cancer Res
, vol.55
, pp. 1452-14577
-
-
Alexandrow, M.G.1
Moses, H.L.2
-
2
-
-
78649986150
-
TGF-beta receptor inhibitors target the CD44(high)/ Id1(high) glioma-initiating cell population in human glioblastoma
-
Anido J, Saez-Borderias A, Gonzalez-Junca A, Rodon L, Folch G, Carmona MA, Prieto-Sanchez RM, Barba I, Martinez-Saez E, Prudkin L, Cuartas I, Raventos C, Martinez-Ricarte F, Poca MA, Garcia-Dorado D, Lahn MM, Yingling JM, Rodon J, Sahuquillo J, Baselga J, Seoane J (2010) TGF-beta receptor inhibitors target the CD44(high)/ Id1(high) glioma-initiating cell population in human glioblastoma. Cancer Cell 18:655-6688
-
(2010)
Cancer Cell
, vol.18
, pp. 655-6688
-
-
Anido, J.1
Saez-Borderias, A.2
Gonzalez-Junca, A.3
Rodon, L.4
Folch, G.5
Carmona, M.A.6
Prieto-Sanchez, R.M.7
Barba, I.8
Martinez-Saez, E.9
Prudkin, L.10
Cuartas, I.11
Raventos, C.12
Martinez-Ricarte, F.13
Poca, M.A.14
Garcia-Dorado, D.15
Lahn, M.M.16
Yingling, J.M.17
Rodon, J.18
Sahuquillo, J.19
Baselga, J.20
Seoane, J.21
more..
-
3
-
-
2942653435
-
Integrin alphaVbeta6-mediated activation of latent TGF-beta requires the latent TGF-beta binding protein-1
-
Annes JP, Chen Y, Munger JS, Rifkin DB (2004) Integrin alphaVbeta6-mediated activation of latent TGF-beta requires the latent TGF-beta binding protein-1. J Cell Biol 165:723-7344
-
(2004)
J Cell Biol
, vol.165
, pp. 723-7344
-
-
Annes, J.P.1
Chen, Y.2
Munger, J.S.3
Rifkin, D.B.4
-
4
-
-
34248599025
-
The role of versican isoforms V0/ V1 in glioma migration mediated by transforming growth factor-beta2
-
Arslan F, Bosserhoff AK, Nickl-Jockschat T, Doerfelt A, Bogdahn U, Hau P (2007) The role of versican isoforms V0/ V1 in glioma migration mediated by transforming growth factor-beta2. Br J Cancer 96:1560-15688
-
(2007)
Br J Cancer
, vol.96
, pp. 1560-15688
-
-
Arslan, F.1
Bosserhoff, A.K.2
Nickl-Jockschat, T.3
Doerfelt, A.4
Bogdahn, U.5
Hau, P.6
-
5
-
-
0037204990
-
Signal transduction by the TGF-beta superfamily
-
Attisano L, Wrana JL (2002) Signal transduction by the TGF-beta superfamily. Science 296:1646-16477
-
(2002)
Science
, vol.296
, pp. 1646-16477
-
-
Attisano, L.1
Wrana, J.L.2
-
6
-
-
0035865146
-
Role of TGF-beta in immune-evasion of cancer
-
Beck C, Schreiber H, Rowley D (2001) Role of TGF-beta in immune-evasion of cancer. Microsc Res Tech 52:387-3955
-
(2001)
Microsc Res Tech
, vol.52
, pp. 387-3955
-
-
Beck, C.1
Schreiber, H.2
Rowley, D.3
-
7
-
-
0038205926
-
Add-on anti-TGF-beta antibody to ACE inhibitor arrests progressive diabetic nephropathy in the rat
-
Benigni A, Zoja C, Corna D, Zatelli C, Conti S, Campana M, Gagliardini E, Rottoli D, Zanchi C, Abbate M, Ledbetter S, Remuzzi G (2003) Add-on anti-TGF-beta antibody to ACE inhibitor arrests progressive diabetic nephropathy in the rat. J Am Soc Nephrol 14:1816-18244
-
(2003)
J Am Soc Nephrol
, vol.14
, pp. 1816-18244
-
-
Benigni, A.1
Zoja, C.2
Corna, D.3
Zatelli, C.4
Conti, S.5
Campana, M.6
Gagliardini, E.7
Rottoli, D.8
Zanchi, C.9
Abbate, M.10
Ledbetter, S.11
Remuzzi, G.12
-
8
-
-
0035861541
-
Integrin beta 1 signaling is necessary for transforming growth factor-beta activation of p38MAPK and epithelial plasticity
-
Bhowmick NA, Zent R, Ghiassi M, McDonnell M, Moses HL (2001) Integrin beta 1 signaling is necessary for transforming growth factor-beta activation of p38MAPK and epithelial plasticity. J Biol Chem 276:46707-467133
-
(2001)
J Biol Chem
, vol.276
, pp. 46707-467133
-
-
Bhowmick, N.A.1
Zent, R.2
Ghiassi, M.3
McDonnell, M.4
Moses, H.L.5
-
10
-
-
0036566184
-
Adapting a transforming growth factor beta-related tumor protection strategy to enhance antitumor immunity
-
Bollard CM, Rossig C, Calonge MJ, Huls MH, Wagner HJ, Massague J, Brenner MK, Heslop HE, Rooney CM (2002) Adapting a transforming growth factor beta-related tumor protection strategy to enhance antitumor immunity. Blood 99:3179-31877
-
(2002)
Blood
, vol.99
, pp. 3179-31877
-
-
Bollard, C.M.1
Rossig, C.2
Calonge, M.J.3
Huls, M.H.4
Wagner, H.J.5
Massague, J.6
Brenner, M.K.7
Heslop, H.E.8
Rooney, C.M.9
-
11
-
-
0033773180
-
The transforming growth factor-betas: Structure, signaling, and roles in nervous system development and functions
-
Bottner M, Krieglstein K, Unsicker K (2000) The transforming growth factor-betas: structure, signaling, and roles in nervous system development and functions. J Neurochem 75:2227-22400
-
(2000)
J Neurochem
, vol.75
, pp. 2227-22400
-
-
Bottner, M.1
Krieglstein, K.2
Unsicker, K.3
-
12
-
-
33846821916
-
High TGFbeta-Smad activity confers poor prognosis in glioma patients and promotes cell proliferation depending on the methylation of the PDGF-B gene
-
Bruna A, Darken RS, Rojo F, Ocana A, Penuelas S, Arias A, Paris R, Tortosa A, Mora J, Baselga J, Seoane J (2007) High TGFbeta-Smad activity confers poor prognosis in glioma patients and promotes cell proliferation depending on the methylation of the PDGF-B gene. Cancer Cell 11:147-1600
-
(2007)
Cancer Cell
, vol.11
, pp. 147-1600
-
-
Bruna, A.1
Darken, R.S.2
Rojo, F.3
Ocana, A.4
Penuelas, S.5
Arias, A.6
Paris, R.7
Tortosa, A.8
Mora, J.9
Baselga, J.10
Seoane, J.11
-
13
-
-
19544368642
-
Integrin alpha(v)beta8-mediated activation of transforming growth factor-beta by perivascular astrocytes: An angiogenic control switch
-
Cambier S, Gline S, Mu D, Collins R, Araya J, Dolganov G, Einheber S, Boudreau N, Nishimura SL (2005) Integrin alpha(v)beta8-mediated activation of transforming growth factor-beta by perivascular astrocytes: an angiogenic control switch. Am J Pathol 166:1883-18944
-
(2005)
Am J Pathol
, vol.166
, pp. 1883-18944
-
-
Cambier, S.1
Gline, S.2
Mu, D.3
Collins, R.4
Araya, J.5
Dolganov, G.6
Einheber, S.7
Boudreau, N.8
Nishimura, S.L.9
-
14
-
-
0032528055
-
Determinants of specificity in TGF-beta signal transduction
-
Chen YG, Hata A, Lo RS, Wotton D, Shi Y, Pavletich N, Massague J (1998) Determinants of specificity in TGF-beta signal transduction. Genes Dev 12:2144-21522
-
(1998)
Genes Dev
, vol.12
, pp. 2144-21522
-
-
Chen, Y.G.1
Hata, A.2
Lo, R.S.3
Wotton, D.4
Shi, Y.5
Pavletich, N.6
Massague, J.7
-
15
-
-
0037067653
-
E2F4/5 and p107 as Smad cofactors linking the TGFbeta receptor to c-myc repression
-
Chen CR, Kang Y, Siegel PM, Massague J (2002) E2F4/5 and p107 as Smad cofactors linking the TGFbeta receptor to c-myc repression. Cell 110:19-322
-
(2002)
Cell
, vol.110
, pp. 19-322
-
-
Chen, C.R.1
Kang, Y.2
Siegel, P.M.3
Massague, J.4
-
16
-
-
12244285937
-
Regulatory T cells suppress tumor-specific CD8 T cell cytotoxicity through TGF-beta signals in vivo
-
Chen ML, Pittet MJ, Gorelik L, Flavell RA, Weissleder R, von Boehmer H, Khazaie K (2005) Regulatory T cells suppress tumor-specific CD8 T cell cytotoxicity through TGF-beta signals in vivo. Proc Natl Acad Sci U S A 102:419-4244
-
(2005)
Proc Natl Acad Sci U S A
, vol.102
, pp. 419-4244
-
-
Chen, M.L.1
Pittet, M.J.2
Gorelik, L.3
Flavell, R.A.4
Weissleder, R.5
Von Boehmer, H.6
Khazaie, K.7
-
17
-
-
75749136051
-
TGF-beta downregulates the activating receptor NKG2D on NK cells and CD8+ T cells in glioma patients
-
Crane CA, Han SJ, Barry JJ, Ahn BJ, Lanier LL, Parsa AT (2010) TGF-beta downregulates the activating receptor NKG2D on NK cells and CD8+ T cells in glioma patients. Neuro Oncol 12:7-133
-
(2010)
Neuro Oncol
, vol.12
, pp. 7-133
-
-
Crane, C.A.1
Han, S.J.2
Barry, J.J.3
Ahn, B.J.4
Lanier, L.L.5
Parsa, A.T.6
-
18
-
-
1342265719
-
SB-505124 is a selective inhibitor of transforming growth factor-beta type i receptors ALK4, ALK5, and ALK7
-
DaCosta Byfield S, Major C, Laping NJ, Roberts AB (2004) SB-505124 is a selective inhibitor of transforming growth factor-beta type I receptors ALK4, ALK5, and ALK7. Mol Pharmacol 65:744-7522
-
(2004)
Mol Pharmacol
, vol.65
, pp. 744-7522
-
-
Dacosta Byfield, S.1
Major, C.2
Laping, N.J.3
Roberts, A.B.4
-
19
-
-
0142104985
-
Smad-dependent and Smad-independent pathways in TGF-beta family signalling
-
Derynck R, Zhang YE (2003) Smad-dependent and Smad-independent pathways in TGF-beta family signalling. Nature 425:577-5844
-
(2003)
Nature
, vol.425
, pp. 577-5844
-
-
Derynck, R.1
Zhang, Y.E.2
-
20
-
-
0028906190
-
Processing of transforming growth factor beta 1 precursor by human furin convertase
-
Dubois CM, Laprise MH, Blanchette F, Gentry LE, Leduc R (1995) Processing of transforming growth factor beta 1 precursor by human furin convertase. J Biol Chem 270:10618-106244
-
(1995)
J Biol Chem
, vol.270
, pp. 10618-106244
-
-
Dubois, C.M.1
Laprise, M.H.2
Blanchette, F.3
Gentry, L.E.4
Leduc, R.5
-
21
-
-
33846817212
-
Cross-talk between Smad and p38 MAPK signalling in transforming growth factor beta signal transduction in human glioblastoma cells
-
Dziembowska M, Danilkiewicz M, Wesolowska A, Zupanska A, Chouaib S, Kaminska B (2007) Cross-talk between Smad and p38 MAPK signalling in transforming growth factor beta signal transduction in human glioblastoma cells. Biochem Biophys Res Commun 354:1101-11066
-
(2007)
Biochem Biophys Res Commun
, vol.354
, pp. 1101-11066
-
-
Dziembowska, M.1
Danilkiewicz, M.2
Wesolowska, A.3
Zupanska, A.4
Chouaib, S.5
Kaminska, B.6
-
22
-
-
0036197606
-
Transforming growth factor-beta-induced mobilization of actin cytoskeleton requires signaling by small GTPases Cdc42 and RhoA
-
Edlund S, Landstrom M, Heldin CH, Aspenstrom P (2002) Transforming growth factor-beta-induced mobilization of actin cytoskeleton requires signaling by small GTPases Cdc42 and RhoA. Mol Biol Cell 13:902-9144
-
(2002)
Mol Biol Cell
, vol.13
, pp. 902-9144
-
-
Edlund, S.1
Landstrom, M.2
Heldin, C.H.3
Aspenstrom, P.4
-
23
-
-
33751047033
-
Phase i clinical trial of a TGF-beta antisense-modi fied tumor cell vaccine in patients with advanced glioma
-
Fakhrai H, Mantil JC, Liu L, Nicholson GL, Murphy-Satter CS, Ruppert J, Shawler DL (2006) Phase I clinical trial of a TGF-beta antisense-modi fied tumor cell vaccine in patients with advanced glioma. Cancer Gene Ther 13:1052-10600
-
(2006)
Cancer Gene Ther
, vol.13
, pp. 1052-10600
-
-
Fakhrai, H.1
Mantil, J.C.2
Liu, L.3
Nicholson, G.L.4
Murphy-Satter, C.S.5
Ruppert, J.6
Shawler, D.L.7
-
24
-
-
5644248080
-
RNA interference targeting transforming growth factor-beta enhances NKG2D-mediated antiglioma immune response, inhibits glioma cell migration and invasiveness, and abrogates tumorigenicity in vivo
-
Friese MA, Wischhusen J, Wick W, Weiler M, Eisele G, Steinle A, Weller M (2004) RNA interference targeting transforming growth factor-beta enhances NKG2D-mediated antiglioma immune response, inhibits glioma cell migration and invasiveness, and abrogates tumorigenicity in vivo. Cancer Res 64:7596-76033
-
(2004)
Cancer Res
, vol.64
, pp. 7596-76033
-
-
Friese, M.A.1
Wischhusen, J.2
Wick, W.3
Weiler, M.4
Eisele, G.5
Steinle, A.6
Weller, M.7
-
25
-
-
0034770605
-
Immune-mediated eradication of tumors through the blockade of transforming growth factor-beta signaling in T cells
-
Gorelik L, Flavell RA (2001) Immune-mediated eradication of tumors through the blockade of transforming growth factor-beta signaling in T cells. Nat Med 7:1118-11222
-
(2001)
Nat Med
, vol.7
, pp. 1118-11222
-
-
Gorelik, L.1
Flavell, R.A.2
-
26
-
-
0033625416
-
Functional analysis of the TGFbeta receptor/Smad pathway through gene ablation in mice
-
Goumans MJ, Mummery C (2000) Functional analysis of the TGFbeta receptor/Smad pathway through gene ablation in mice. Int J Dev Biol 44:253-2655
-
(2000)
Int J Dev Biol
, vol.44
, pp. 253-2655
-
-
Goumans, M.J.1
Mummery, C.2
-
27
-
-
0037007226
-
Balancing the activation state of the endothelium via two distinct TGF-beta type i receptors
-
Goumans MJ, Valdimarsdottir G, Itoh S, Rosendahl A, Sideras P, ten Dijke P (2002) Balancing the activation state of the endothelium via two distinct TGF-beta type I receptors. EMBO J 21:1743-17533
-
(2002)
EMBO J
, vol.21
, pp. 1743-17533
-
-
Goumans, M.J.1
Valdimarsdottir, G.2
Itoh, S.3
Rosendahl, A.4
Sideras, P.5
Ten Dijke, P.6
-
28
-
-
0029029807
-
Release and activation of platelet latent TGFbeta in blood clots during dissolution with plasmin
-
Grainger DJ, Wakefield L, Bethell HW, Farndale RW, Metcalfe JC (1995) Release and activation of platelet latent TGFbeta in blood clots during dissolution with plasmin. Nat Med 1:932-9377
-
(1995)
Nat Med
, vol.1
, pp. 932-9377
-
-
Grainger, D.J.1
Wakefield, L.2
Bethell, H.W.3
Farndale, R.W.4
Metcalfe, J.C.5
-
29
-
-
38649088246
-
Cooperative assembly of TGF-beta superfamily signaling complexes is mediated by two disparate mechanisms and distinct modes of receptor binding
-
Groppe J, Hinck CS, Samavarchi-Tehrani P, Zubieta C, Schuermann JP, Taylor AB, Schwarz PM, Wrana JL, Hinck AP (2008) Cooperative assembly of TGF-beta superfamily signaling complexes is mediated by two disparate mechanisms and distinct modes of receptor binding. Mol Cell 29:157-1688
-
(2008)
Mol Cell
, vol.29
, pp. 157-1688
-
-
Groppe, J.1
Hinck, C.S.2
Samavarchi-Tehrani, P.3
Zubieta, C.4
Schuermann, J.P.5
Taylor, A.B.6
Schwarz, P.M.7
Wrana, J.L.8
Hinck, A.P.9
-
30
-
-
0033578721
-
Involvement of the p38 mitogen-activated protein kinase pathway in transforming growth factor-beta-induced gene expression
-
Hanafusa H, Ninomiya-Tsuji J, Masuyama N, Nishita M, Fujisawa J, Shibuya H, Matsumoto K, Nishida E (1999) Involvement of the p38 mitogen-activated protein kinase pathway in transforming growth factor-beta-induced gene expression. J Biol Chem 274:27161-271677
-
(1999)
J Biol Chem
, vol.274
, pp. 27161-271677
-
-
Hanafusa, H.1
Ninomiya-Tsuji, J.2
Masuyama, N.3
Nishita, M.4
Fujisawa, J.5
Shibuya, H.6
Matsumoto, K.7
Nishida, E.8
-
31
-
-
33745051928
-
Tenascin-C protein is induced by transforming growth factor-beta1 but does not correlate with time to tumor progression in high-grade gliomas
-
Hau P, Kunz-Schughart LA, Rummele P, Arslan F, Dorfelt A, Koch H, Lohmeier A, Hirschmann B, Muller A, Bogdahn U, Bosserhoff AK (2006) Tenascin-C protein is induced by transforming growth factor-beta1 but does not correlate with time to tumor progression in high-grade gliomas. J Neurooncol 77:1-77
-
(2006)
J Neurooncol
, vol.77
, pp. 1-77
-
-
Hau, P.1
Kunz-Schughart, L.A.2
Rummele, P.3
Arslan, F.4
Dorfelt, A.5
Koch, H.6
Lohmeier, A.7
Hirschmann, B.8
Muller, A.9
Bogdahn, U.10
Bosserhoff, A.K.11
-
32
-
-
34547187636
-
Inhibition of TGF-beta2 with AP 12009 in recurrent malignant gliomas: From preclinical to phase I/II studies
-
Hau P, Jachimczak P, Schlingensiepen R, Schulmeyer F, Jauch T, Steinbrecher A, Brawanski A, Proescholdt M, Schlaier J, Buchroithner J, Pichler J, Wurm G, Mehdorn M, Strege R, Schuierer G, Villarrubia V, Fellner F, Jansen O, Straube T, Nohria V, Goldbrunner M, Kunst M, Schmaus S, Stauder G, Bogdahn U, Schlingensiepen KH (2007) Inhibition of TGF-beta2 with AP 12009 in recurrent malignant gliomas: from preclinical to phase I/II studies. Oligonucleotides 17:201-2122
-
(2007)
Oligonucleotides
, vol.17
, pp. 201-2122
-
-
Hau, P.1
Jachimczak, P.2
Schlingensiepen, R.3
Schulmeyer, F.4
Jauch, T.5
Steinbrecher, A.6
Brawanski, A.7
Proescholdt, M.8
Schlaier, J.9
Buchroithner, J.10
Pichler, J.11
Wurm, G.12
Mehdorn, M.13
Strege, R.14
Schuierer, G.15
Villarrubia, V.16
Fellner, F.17
Jansen, O.18
Straube, T.19
Nohria, V.20
Goldbrunner, M.21
Kunst, M.22
Schmaus, S.23
Stauder, G.24
Bogdahn, U.25
Schlingensiepen, K.H.26
more..
-
34
-
-
0038717313
-
Interaction of transforming growth factorbeta (TGF-beta) and epidermal growth factor (EGF) in human glioma cells
-
Held-Feindt J, Lutjohann B, Ungefroren H, Mehdorn HM, Mentlein R (2003) Interaction of transforming growth factorbeta (TGF-beta) and epidermal growth factor (EGF) in human glioma cells. J Neurooncol 63:117-1277
-
(2003)
J Neurooncol
, vol.63
, pp. 117-1277
-
-
Held-Feindt, J.1
Lutjohann, B.2
Ungefroren, H.3
Mehdorn, H.M.4
Mentlein, R.5
-
35
-
-
4444341835
-
SB-431542, a small molecule transforming growth factor-beta-receptor antagonist, inhibits human glioma cell line proliferation and motility
-
Hjelmeland MD, Hjelmeland AB, Sathornsumetee S, Reese ED, Herbstreith MH, Laping NJ, Friedman HS, Bigner DD, Wang XF, Rich JN (2004) SB-431542, a small molecule transforming growth factor-beta-receptor antagonist, inhibits human glioma cell line proliferation and motility. Mol Cancer Ther 3:737-7455
-
(2004)
Mol Cancer Ther
, vol.3
, pp. 737-7455
-
-
Hjelmeland, M.D.1
Hjelmeland, A.B.2
Sathornsumetee, S.3
Reese, E.D.4
Herbstreith, M.H.5
Laping, N.J.6
Friedman, H.S.7
Bigner, D.D.8
Wang, X.F.9
Rich, J.N.10
-
36
-
-
3042838388
-
Latent TGF-beta binding proteins: Extracellular matrix association and roles in TGF-beta activation
-
Hyytiainen M, Penttinen C, Keski-Oja J (2004) Latent TGF-beta binding proteins: extracellular matrix association and roles in TGF-beta activation. Crit Rev Clin Lab Sci 41:233-2644
-
(2004)
Crit Rev Clin Lab Sci
, vol.41
, pp. 233-2644
-
-
Hyytiainen, M.1
Penttinen, C.2
Keski-Oja, J.3
-
37
-
-
10744224876
-
Smad4-independent regulation of p21/WAF1 by transforming growth factor-beta
-
Ijichi H, Otsuka M, Tateishi K, Ikenoue T, Kawakami T, Kanai F, Arakawa Y, Seki N, Shimizu K, Miyazono K, Kawabe T, Omata M (2004) Smad4-independent regulation of p21/WAF1 by transforming growth factor-beta. Oncogene 23:1043-10511
-
(2004)
Oncogene
, vol.23
, pp. 1043-10511
-
-
Ijichi, H.1
Otsuka, M.2
Tateishi, K.3
Ikenoue, T.4
Kawakami, T.5
Kanai, F.6
Arakawa, Y.7
Seki, N.8
Shimizu, K.9
Miyazono, K.10
Kawabe, T.11
Omata, M.12
-
38
-
-
70350497349
-
Autocrine TGF-beta signaling maintains tumorigenicity of glioma-initiating cells through Sry-related HMG-box factors
-
Ikushima H, Todo T, Ino Y, Takahashi M, Miyazawa K, Miyazono K (2009) Autocrine TGF-beta signaling maintains tumorigenicity of glioma-initiating cells through Sry-related HMG-box factors. Cell Stem Cell 5:504-5144
-
(2009)
Cell Stem Cell
, vol.5
, pp. 504-5144
-
-
Ikushima, H.1
Todo, T.2
Ino, Y.3
Takahashi, M.4
Miyazawa, K.5
Miyazono, K.6
-
39
-
-
33847716712
-
Negative regulation of TGF-beta receptor/Smad signal transduction
-
Itoh S, ten Dijke P (2007) Negative regulation of TGF-beta receptor/Smad signal transduction. Curr Opin Cell Biol 19:176-1844
-
(2007)
Curr Opin Cell Biol
, vol.19
, pp. 176-1844
-
-
Itoh, S.1
Ten Dijke, P.2
-
40
-
-
0027223428
-
The effect of transforming growth factor-beta 2-specific phosphorothioate-anti-sense oligodeoxynucleotides in reversing cellular immunosuppression in malignant glioma
-
Jachimczak P, Bogdahn U, Schneider J, Behl C, Meixensberger J, Apfel R, Dorries R, Schlingensiepen KH, Brysch W (1993) The effect of transforming growth factor-beta 2-specific phosphorothioate-anti-sense oligodeoxynucleotides in reversing cellular immunosuppression in malignant glioma. J Neurosurg 78:944-9511
-
(1993)
J Neurosurg
, vol.78
, pp. 944-9511
-
-
Jachimczak, P.1
Bogdahn, U.2
Schneider, J.3
Behl, C.4
Meixensberger, J.5
Apfel, R.6
Dorries, R.7
Schlingensiepen, K.H.8
Brysch, W.9
-
41
-
-
0030021142
-
Transforming growth factor-beta-mediated autocrine growth regulation of gliomas as detected with phosphorothioate antisense oligonucleotides
-
Jachimczak P, Hessdorfer B, Fabel-Schulte K, Wismeth C, Brysch W, Schlingensiepen KH, Bauer A, Blesch A, Bogdahn U (1996) Transforming growth factor-beta-mediated autocrine growth regulation of gliomas as detected with phosphorothioate antisense oligonucleotides. Int J Cancer 65:332-3377
-
(1996)
Int J Cancer
, vol.65
, pp. 332-3377
-
-
Jachimczak, P.1
Hessdorfer, B.2
Fabel-Schulte, K.3
Wismeth, C.4
Brysch, W.5
Schlingensiepen, K.H.6
Bauer, A.7
Blesch, A.8
Bogdahn, U.9
-
42
-
-
0031930657
-
The role of transforming growth factor beta in glioma progression
-
Jennings MT, Pietenpol JA (1998) The role of transforming growth factor beta in glioma progression. J Neurooncol 36:123-1400
-
(1998)
J Neurooncol
, vol.36
, pp. 123-1400
-
-
Jennings, M.T.1
Pietenpol, J.A.2
-
43
-
-
0025895774
-
TGF beta 1 and TGF beta 2 are potential growth regulators for low-grade and malignant gliomas in vitro: Evidence in support of an autocrine hypothesis
-
Jennings MT, Maciunas RJ, Carver R, Bascom CC, Juneau P, Misulis K, Moses HL (1991) TGF beta 1 and TGF beta 2 are potential growth regulators for low-grade and malignant gliomas in vitro: evidence in support of an autocrine hypothesis. Int J Cancer 49:129-1399
-
(1991)
Int J Cancer
, vol.49
, pp. 129-1399
-
-
Jennings, M.T.1
MacIunas, R.J.2
Carver, R.3
Bascom, C.C.4
Juneau, P.5
Misulis, K.6
Moses, H.L.7
-
44
-
-
67650364197
-
Molecular characterization of in fl ammation-induced JNK/c-Jun signaling pathway in connection with tumorigenesis
-
Kaminska B (2009) Molecular characterization of in fl ammation-induced JNK/c-Jun signaling pathway in connection with tumorigenesis. Methods Mol Biol 512:249-2644
-
(2009)
Methods Mol Biol
, vol.512
, pp. 249-2644
-
-
Kaminska, B.1
-
45
-
-
0242581709
-
Transforming growth factor-beta controls human osteoclastogenesis through the p38 MAPK and regulation of RANK expression
-
Karsdal MA, Hjorth P, Henriksen K, Kirkegaard T, Nielsen KL, Lou H, Delaisse JM, Foged NT (2003) Transforming growth factor-beta controls human osteoclastogenesis through the p38 MAPK and regulation of RANK expression. J Biol Chem 278:44975-449877
-
(2003)
J Biol Chem
, vol.278
, pp. 44975-449877
-
-
Karsdal, M.A.1
Hjorth, P.2
Henriksen, K.3
Kirkegaard, T.4
Nielsen, K.L.5
Lou, H.6
Delaisse, J.M.7
Foged, N.T.8
-
46
-
-
34748861947
-
A phase III study of subconjunctival human anti-transforming growth factor beta(2) monoclonal antibody (CAT-152) to prevent scarring after first-time trabeculectomy
-
Khaw P, Grehn F, Hollo G, Overton B, Wilson R, Vogel R, Smith Z (2007) A phase III study of subconjunctival human anti-transforming growth factor beta(2) monoclonal antibody (CAT-152) to prevent scarring after first-time trabeculectomy. Ophthalmology 114:1822-18300
-
(2007)
Ophthalmology
, vol.114
, pp. 1822-18300
-
-
Khaw, P.1
Grehn, F.2
Hollo, G.3
Overton, B.4
Wilson, R.5
Vogel, R.6
Smith, Z.7
-
47
-
-
0025218491
-
Autoinduction of transforming growth factor beta 1 is mediated by the AP-1 complex
-
Kim SJ, Angel P, Lafyatis R, Hattori K, Kim KY, Sporn MB, Karin M, Roberts AB (1990) Autoinduction of transforming growth factor beta 1 is mediated by the AP-1 complex. Mol Cell Biol 10:1492-14977
-
(1990)
Mol Cell Biol
, vol.10
, pp. 1492-14977
-
-
Kim, S.J.1
Angel, P.2
Lafyatis, R.3
Hattori, K.4
Kim, K.Y.5
Sporn, M.B.6
Karin, M.7
Roberts, A.B.8
-
48
-
-
34548386720
-
TGF-beta activates Erk MAP kinase signalling through direct phosphorylation of ShcA
-
Lee MK, Pardoux C, Hall MC, Lee PS, Warburton D, Qing J, Smith SM, Derynck R (2007) TGF-beta activates Erk MAP kinase signalling through direct phosphorylation of ShcA. EMBO J 26:3957-39677
-
(2007)
EMBO J
, vol.26
, pp. 3957-39677
-
-
Lee, M.K.1
Pardoux, C.2
Hall, M.C.3
Lee, P.S.4
Warburton, D.5
Qing, J.6
Smith, S.M.7
Derynck, R.8
-
49
-
-
24344483878
-
Smad4 dependency defines two classes of transforming growth factor beta (TGF-{beta}) target genes and distinguishes TGF-{beta}-induced epithelial-mesenchymal transition from its antiproliferative and migratory responses
-
Levy L, Hill CS (2005) Smad4 dependency defines two classes of transforming growth factor beta (TGF-{beta}) target genes and distinguishes TGF-{beta}-induced epithelial-mesenchymal transition from its antiproliferative and migratory responses. Mol Cell Biol 25:8108-81255
-
(2005)
Mol Cell Biol
, vol.25
, pp. 8108-81255
-
-
Levy, L.1
Hill, C.S.2
-
50
-
-
0031698247
-
Prolonged survival of rats with intracranial C6 gliomas by treatment with TGFbeta antisense gene
-
Liau LM, Fakhrai H, Black KL (1998) Prolonged survival of rats with intracranial C6 gliomas by treatment with TGFbeta antisense gene. Neurol Res 20:742-7477
-
(1998)
Neurol Res
, vol.20
, pp. 742-7477
-
-
Liau, L.M.1
Fakhrai, H.2
Black, K.L.3
-
51
-
-
4544256756
-
Cytoplasmic PML function in TGF-beta signalling
-
Lin HK, Bergmann S, Pandol fi PP (2004) Cytoplasmic PML function in TGF-beta signalling. Nature 431:205-211
-
(2004)
Nature
, vol.431
, pp. 205-211
-
-
Lin, H.K.1
Bergmann, S.2
Pandolfi, P.P.3
-
52
-
-
0026510668
-
Transforming growth factor-beta 1 in the rat brain: Increase after injury and inhibition of astrocyte proliferation
-
Lindholm D, Castren E, Kiefer R, Zafra F, Thoenen H (1992) Transforming growth factor-beta 1 in the rat brain: increase after injury and inhibition of astrocyte proliferation. J Cell Biol 117:395-4000
-
(1992)
J Cell Biol
, vol.117
, pp. 395-4000
-
-
Lindholm, D.1
Castren, E.2
Kiefer, R.3
Zafra, F.4
Thoenen, H.5
-
53
-
-
33845684545
-
TGF-beta2 inhibition augments the effect of tumor vaccine and improves the survival of animals with pre-established brain tumors
-
Liu Y, Wang Q, Kleinschmidt-DeMasters BK, Franzusoff A, Ng KY, Lillehei KO (2007) TGF-beta2 inhibition augments the effect of tumor vaccine and improves the survival of animals with pre-established brain tumors. J Neurooncol 81:149-1622
-
(2007)
J Neurooncol
, vol.81
, pp. 149-1622
-
-
Liu, Y.1
Wang, Q.2
Kleinschmidt-Demasters, B.K.3
Franzusoff, A.4
Ng, K.Y.5
Lillehei, K.O.6
-
54
-
-
79953045754
-
TGF-beta1 promotes motility and invasiveness of glioma cells through activation of ADAM17
-
Lu Y, Jiang F, Zheng X, Katakowski M, Buller B, To SS, Chopp M (2011) TGF-beta1 promotes motility and invasiveness of glioma cells through activation of ADAM17. Oncol Rep 25:1329-13355
-
(2011)
Oncol Rep
, vol.25
, pp. 1329-13355
-
-
Lu, Y.1
Jiang, F.2
Zheng, X.3
Katakowski, M.4
Buller, B.5
To, S.S.6
Chopp, M.7
-
55
-
-
0028972556
-
TGF-beta enhances macrophage ability to produce IL-10 in normal and tumor-bearing mice
-
Maeda H, Kuwahara H, Ichimura Y, Ohtsuki M, Kurakata S, Shiraishi A (1995) TGF-beta enhances macrophage ability to produce IL-10 in normal and tumor-bearing mice. J Immunol 155:4926-49322
-
(1995)
J Immunol
, vol.155
, pp. 4926-49322
-
-
Maeda, H.1
Kuwahara, H.2
Ichimura, Y.3
Ohtsuki, M.4
Kurakata, S.5
Shiraishi, A.6
-
56
-
-
47549090432
-
TGFbeta in cancer
-
Massague J (2008) TGFbeta in cancer. Cell 134:215-2300
-
(2008)
Cell
, vol.134
, pp. 215-2300
-
-
Massague, J.1
-
57
-
-
0034678908
-
Transcriptional control by the TGF-beta/Smad signaling system
-
Massague J, Wotton D (2000) Transcriptional control by the TGF-beta/Smad signaling system. EMBO J 19:1745-17544
-
(2000)
EMBO J
, vol.19
, pp. 1745-17544
-
-
Massague, J.1
Wotton, D.2
-
59
-
-
0041342109
-
Evaluation of anti-TGF-beta2 antibody as a new postoperative anti-scarring agent in glaucoma surgery
-
Mead AL, Wong TT, Cordeiro MF, Anderson IK, Khaw PT (2003) Evaluation of anti-TGF-beta2 antibody as a new postoperative anti-scarring agent in glaucoma surgery. Invest Ophthalmol Vis Sci 44:3394-34011
-
(2003)
Invest Ophthalmol Vis Sci
, vol.44
, pp. 3394-34011
-
-
Mead, A.L.1
Wong, T.T.2
Cordeiro, M.F.3
Anderson, I.K.4
Khaw, P.T.5
-
60
-
-
42249099019
-
LY2109761, a novel transforming growth factor beta receptor type i and type II dual inhibitor, as a therapeutic approach to suppressing pancreatic cancer metastasis
-
Melisi D, Ishiyama S, Sclabas GM, Fleming JB, Xia Q, Tortora G, Abbruzzese JL, Chiao PJ (2008) LY2109761, a novel transforming growth factor beta receptor type I and type II dual inhibitor, as a therapeutic approach to suppressing pancreatic cancer metastasis. Mol Cancer Ther 7:829-8400
-
(2008)
Mol Cancer Ther
, vol.7
, pp. 829-8400
-
-
Melisi, D.1
Ishiyama, S.2
Sclabas, G.M.3
Fleming, J.B.4
Xia, Q.5
Tortora, G.6
Abbruzzese, J.L.7
Chiao, P.J.8
-
61
-
-
0034462833
-
Hgs (Hrs), a FYVE domain protein, is involved in Smad signaling through cooperation with SARA
-
Miura S, Takeshita T, Asao H, Kimura Y, Murata K, Sasaki Y, Hanai JI, Beppu H, Tsukazaki T, Wrana JL, Miyazono K, Sugamura K (2000) Hgs (Hrs), a FYVE domain protein, is involved in Smad signaling through cooperation with SARA. Mol Cell Biol 20:9346-93555
-
(2000)
Mol Cell Biol
, vol.20
, pp. 9346-93555
-
-
Miura, S.1
Takeshita, T.2
Asao, H.3
Kimura, Y.4
Murata, K.5
Sasaki, Y.6
Hanai, J.I.7
Beppu, H.8
Tsukazaki, T.9
Wrana, J.L.10
Miyazono, K.11
Sugamura, K.12
-
62
-
-
24944497786
-
Non-Smad TGF-beta signals
-
Moustakas A, Heldin CH (2005) Non-Smad TGF-beta signals. J Cell Sci 118:3573-35844
-
(2005)
J Cell Sci
, vol.118
, pp. 3573-35844
-
-
Moustakas, A.1
Heldin, C.H.2
-
64
-
-
79958698402
-
TRAF6 ubiquitinates TGFbeta type i receptor to promote its cleavage and nuclear translocation in cancer
-
Mu Y, Sundar R, Thakur N, Ekman M, Gudey SK, Yakymovych M, Hermansson A, Dimitriou H, Bengoechea-Alonso MT, Ericsson J, Heldin CH, Landstrom M (2011) TRAF6 ubiquitinates TGFbeta type I receptor to promote its cleavage and nuclear translocation in cancer. Nat Commun 2:330
-
(2011)
Nat Commun
, vol.2
, pp. 330
-
-
Mu, Y.1
Sundar, R.2
Thakur, N.3
Ekman, M.4
Gudey, S.K.5
Yakymovych, M.6
Hermansson, A.7
Dimitriou, H.8
Bengoechea-Alonso, M.T.9
Ericsson, J.10
Heldin, C.H.11
Landstrom, M.12
-
65
-
-
0034023127
-
Role of Ras and Mapks in TGFbeta signaling
-
Mulder KM (2000) Role of Ras and Mapks in TGFbeta signaling. Cytokine Growth Factor Rev 11:23-355
-
(2000)
Cytokine Growth Factor Rev
, vol.11
, pp. 23-355
-
-
Mulder, K.M.1
-
66
-
-
26444551181
-
Human glioblastomas overexpress ADAMTS-5 that degrades brevican
-
Nakada M, Miyamori H, Kita D, Takahashi T, Yamashita J, Sato H, Miura R, Yamaguchi Y, Okada Y (2005) Human glioblastomas overexpress ADAMTS-5 that degrades brevican. Acta Neuropathol 110:239-2466
-
(2005)
Acta Neuropathol
, vol.110
, pp. 239-2466
-
-
Nakada, M.1
Miyamori, H.2
Kita, D.3
Takahashi, T.4
Yamashita, J.5
Sato, H.6
Miura, R.7
Yamaguchi, Y.8
Okada, Y.9
-
67
-
-
0030768644
-
TGF-beta receptor-mediated signalling through Smad2, Smad3 and Smad4
-
Nakao A, Imamura T, Souchelnytskyi S, Kawabata M, Ishisaki A, Oeda E, Tamaki K, Hanai J, Heldin CH, Miyazono K, ten Dijke P (1997) TGF-beta receptor-mediated signalling through Smad2, Smad3 and Smad4. EMBO J 16:5353-53622
-
(1997)
EMBO J
, vol.16
, pp. 5353-53622
-
-
Nakao, A.1
Imamura, T.2
Souchelnytskyi, S.3
Kawabata, M.4
Ishisaki, A.5
Oeda, E.6
Tamaki, K.7
Hanai, J.8
Heldin, C.H.9
Miyazono, K.10
Ten Dijke, P.11
-
68
-
-
56649117546
-
Glioblastoma-secreted factors induce IGFBP7 and angiogenesis by modulating Smad-2-dependent TGF-beta signaling
-
Pen A, Moreno MJ, Durocher Y, Deb-Rinker P, Stanimirovic DB (2008) Glioblastoma-secreted factors induce IGFBP7 and angiogenesis by modulating Smad-2-dependent TGF-beta signaling. Oncogene 27:6834-68444
-
(2008)
Oncogene
, vol.27
, pp. 6834-68444
-
-
Pen, A.1
Moreno, M.J.2
Durocher, Y.3
Deb-Rinker, P.4
Stanimirovic, D.B.5
-
69
-
-
0036272313
-
Internalization-dependent and-independent requirements for transforming growth factor beta receptor signaling via the Smad pathway
-
Penheiter SG, Mitchell H, Garamszegi N, Edens M, Dore JJ Jr, Leof EB (2002) Internalization-dependent and-independent requirements for transforming growth factor beta receptor signaling via the Smad pathway. Mol Cell Biol 22:4750-47599
-
(2002)
Mol Cell Biol
, vol.22
, pp. 4750-47599
-
-
Penheiter, S.G.1
Mitchell, H.2
Garamszegi, N.3
Edens, M.4
Dore Jr., J.J.5
Leof, E.B.6
-
70
-
-
63249123273
-
TGF-beta increases glioma-initiating cell self-renewal through the induction of LIF in human glioblastoma
-
Penuelas S, Anido J, Prieto-Sanchez RM, Folch G, Barba I, Cuartas I, Garcia-Dorado D, Poca MA, Sahuquillo J, Baselga J, Seoane J (2009) TGF-beta increases glioma-initiating cell self-renewal through the induction of LIF in human glioblastoma. Cancer Cell 15:315-3277
-
(2009)
Cancer Cell
, vol.15
, pp. 315-3277
-
-
Penuelas, S.1
Anido, J.2
Prieto-Sanchez, R.M.3
Folch, G.4
Barba, I.5
Cuartas, I.6
Garcia-Dorado, D.7
Poca, M.A.8
Sahuquillo, J.9
Baselga, J.10
Seoane, J.11
-
71
-
-
0031106404
-
Transforming growth factor-beta: Vasculogenesis, angiogenesis, and vessel wall integrity
-
Pepper MS (1997) Transforming growth factor-beta: vasculogenesis, angiogenesis, and vessel wall integrity. Cytokine Growth Factor Rev 8:21-433
-
(1997)
Cytokine Growth Factor Rev
, vol.8
, pp. 21-433
-
-
Pepper, M.S.1
-
72
-
-
0032943080
-
Expression of transforminggrowth-factor (TGF)-beta receptors and Smad proteins in glioblastoma cell lines with distinct responses to TGF-beta1
-
Piek E, Westermark U, Kastemar M, Heldin CH, van Zoelen EJ, Nister M, Ten Dijke P (1999) Expression of transforminggrowth-factor (TGF)-beta receptors and Smad proteins in glioblastoma cell lines with distinct responses to TGF-beta1. Int J Cancer 80:756-7633
-
(1999)
Int J Cancer
, vol.80
, pp. 756-7633
-
-
Piek, E.1
Westermark, U.2
Kastemar, M.3
Heldin, C.H.4
Van Zoelen, E.J.5
Nister, M.6
Ten Dijke, P.7
-
73
-
-
0034673243
-
Transforming growth factors beta (1) (TGF-beta(1)) and TGF-beta(2) promote glioma cell migration via Up-regulation of alpha(V)beta(3) integrin expression
-
Platten M, Wick W, Wild-Bode C, Aulwurm S, Dichgans J, Weller M (2000) Transforming growth factors beta(1) (TGF-beta(1)) and TGF-beta(2) promote glioma cell migration via Up-regulation of alpha(V)beta(3) integrin expression. Biochem Biophys Res Commun 268:607-6111
-
(2000)
Biochem Biophys Res Commun
, vol.268
, pp. 607-6111
-
-
Platten, M.1
Wick, W.2
Wild-Bode, C.3
Aulwurm, S.4
Dichgans, J.5
Weller, M.6
-
74
-
-
0035865158
-
Malignant glioma biology: Role for TGF-beta in growth, motility, angiogenesis, and immune escape
-
Platten M, Wick W, Weller M (2001) Malignant glioma biology: role for TGF-beta in growth, motility, angiogenesis, and immune escape. Microsc Res Tech 52:401-4100
-
(2001)
Microsc Res Tech
, vol.52
, pp. 401-4100
-
-
Platten, M.1
Wick, W.2
Weller, M.3
-
75
-
-
0041737535
-
Molecular mechanisms of glioma invasiveness: The role of proteases
-
Rao JS (2003) Molecular mechanisms of glioma invasiveness: the role of proteases. Nat Rev Cancer 3:489-5011
-
(2003)
Nat Rev Cancer
, vol.3
, pp. 489-5011
-
-
Rao, J.S.1
-
76
-
-
0033532054
-
The activation sequence of thrombospondin-1 interacts with the latency-associated peptide to regulate activation of latent transforming growth factorbeta
-
Ribeiro SM, Poczatek M, Schultz-Cherry S, Villain M, Murphy-Ullrich JE (1999) The activation sequence of thrombospondin-1 interacts with the latency-associated peptide to regulate activation of latent transforming growth factorbeta. J Biol Chem 274:13586-135933
-
(1999)
J Biol Chem
, vol.274
, pp. 13586-135933
-
-
Ribeiro, S.M.1
Poczatek, M.2
Schultz-Cherry, S.3
Villain, M.4
Murphy-Ullrich, J.E.5
-
77
-
-
3142730646
-
The role of transforming growth factor-beta in primary brain tumors
-
Rich JN (2003) The role of transforming growth factor-beta in primary brain tumors. Front Biosci 8:e245-e2600
-
(2003)
Front Biosci
, vol.8
-
-
Rich, J.N.1
-
78
-
-
0033521118
-
Transforming growth factor-beta-mediated p15(INK4B) induction and growth inhibition in astrocytes is SMAD3-dependent and a pathway prominently altered in human glioma cell lines
-
Rich JN, Zhang M, Datto MB, Bigner DD, Wang XF (1999) Transforming growth factor-beta-mediated p15(INK4B) induction and growth inhibition in astrocytes is SMAD3-dependent and a pathway prominently altered in human glioma cell lines. J Biol Chem 274:35053-350588
-
(1999)
J Biol Chem
, vol.274
, pp. 35053-350588
-
-
Rich, J.N.1
Zhang, M.2
Datto, M.B.3
Bigner, D.D.4
Wang, X.F.5
-
79
-
-
77954527232
-
Bone morphogenetic protein and growth differentiation factor cytokine families and their protein antagonists
-
Rider CC, Mulloy B (2010) Bone morphogenetic protein and growth differentiation factor cytokine families and their protein antagonists. Biochem J 429:1-122
-
(2010)
Biochem J
, vol.429
, pp. 1-122
-
-
Rider, C.C.1
Mulloy, B.2
-
80
-
-
0035914297
-
Synergistic cooperation between hypoxia and transforming growth factor-beta pathways on human vascular endothelial growth factor gene expression
-
Sanchez-Elsner T, Botella LM, Velasco B, Corbi A, Attisano L, Bernabeu C (2001) Synergistic cooperation between hypoxia and transforming growth factor-beta pathways on human vascular endothelial growth factor gene expression. J Biol Chem 276:38527-385355
-
(2001)
J Biol Chem
, vol.276
, pp. 38527-385355
-
-
Sanchez-Elsner, T.1
Botella, L.M.2
Velasco, B.3
Corbi, A.4
Attisano, L.5
Bernabeu, C.6
-
81
-
-
2942589081
-
Synthesis and activity of new aryl-and heteroaryl-substituted 5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole inhibitors of the transforming growth factor-beta type i receptor kinase domain
-
Sawyer JS, Beight DW, Britt KS, Anderson BD, Campbell RM, Goodson T Jr, Herron DK, Li HY, McMillen WT, Mort N, Parsons S, Smith EC, Wagner JR, Yan L, Zhang F, Yingling JM (2004) Synthesis and activity of new aryl-and heteroaryl-substituted 5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole inhibitors of the transforming growth factor-beta type I receptor kinase domain. Bioorg Med Chem Lett 14:3581-35844
-
(2004)
Bioorg Med Chem Lett
, vol.14
, pp. 3581-35844
-
-
Sawyer, J.S.1
Beight, D.W.2
Britt, K.S.3
Anderson, B.D.4
Campbell, R.M.5
Goodson Jr., T.6
Herron, D.K.7
Li, H.Y.8
McMillen, W.T.9
Mort, N.10
Parsons, S.11
Smith, E.C.12
Wagner, J.R.13
Yan, L.14
Zhang, F.15
Yingling, J.M.16
-
82
-
-
25444497522
-
The TGF-beta1 antisense oligonucleotide AP 11014 for the treatment of non-small cell lung, colorectal and prostate cancer: Preclinical studies
-
Schlingensiepen KH, Bischof A, Egger T, Hafner M, Herrmuth H, Jachimczak P, Kielmanowicz M, Niewel M, Zavadova E, Stauder G (2004) The TGF-beta1 antisense oligonucleotide AP 11014 for the treatment of non-small cell lung, colorectal and prostate cancer: preclinical studies. J Clin Oncol, 2004 ASCO annual meeting proceedings, 22, 14S:31322
-
(2004)
J Clin Oncol, 2004 ASCO Annual Meeting Proceedings
, vol.22
, Issue.14
, pp. 31322
-
-
Schlingensiepen, K.H.1
Bischof, A.2
Egger, T.3
Hafner, M.4
Herrmuth, H.5
Jachimczak, P.6
Kielmanowicz, M.7
Niewel, M.8
Zavadova, E.9
Stauder, G.10
-
83
-
-
30944437585
-
Targeted tumor therapy with the TGF-beta 2 antisense compound AP 12009
-
Schlingensiepen KH, Schlingensiepen R, Steinbrecher A, Hau P, Bogdahn U, Fischer-Blass B, Jachimczak P (2006) Targeted tumor therapy with the TGF-beta 2 antisense compound AP 12009. Cytokine Growth Factor Rev 17:129-1399
-
(2006)
Cytokine Growth Factor Rev
, vol.17
, pp. 129-1399
-
-
Schlingensiepen, K.H.1
Schlingensiepen, R.2
Steinbrecher, A.3
Hau, P.4
Bogdahn, U.5
Fischer-Blass, B.6
Jachimczak, P.7
-
84
-
-
38449103630
-
Antisense therapeutics for tumor treatment: The TGF-beta2 inhibitor AP 12009 in clinical development against malignant tumors
-
Schlingensiepen KH, Fischer-Blass B, Schmaus S, Ludwig S (2008) Antisense therapeutics for tumor treatment: the TGF-beta2 inhibitor AP 12009 in clinical development against malignant tumors. Cancer Res 177:137-1500
-
(2008)
Cancer Res
, vol.177
, pp. 137-1500
-
-
Schlingensiepen, K.H.1
Fischer-Blass, B.2
Schmaus, S.3
Ludwig, S.4
-
85
-
-
36448936383
-
TGFbeta-SMAD signal transduction: Molecular specificity and functional flexibility
-
Schmierer B, Hill CS (2007) TGFbeta-SMAD signal transduction: molecular specificity and functional flexibility. Nat Rev Mol Cell Biol 8:970-9822
-
(2007)
Nat Rev Mol Cell Biol
, vol.8
, pp. 970-9822
-
-
Schmierer, B.1
Hill, C.S.2
-
86
-
-
43249108418
-
The TGFBeta pathway as a therapeutic target in cancer
-
Seoane J (2008) The TGFBeta pathway as a therapeutic target in cancer. Clin Transl Oncol 10:14-199
-
(2008)
Clin Transl Oncol
, vol.10
, pp. 14-199
-
-
Seoane, J.1
-
87
-
-
0034744956
-
TGFbeta influences Myc, Miz-1 and Smad to control the CDK inhibitor p15INK4b
-
Seoane J, Pouponnot C, Staller P, Schader M, Eilers M, Massague J (2001) TGFbeta influences Myc, Miz-1 and Smad to control the CDK inhibitor p15INK4b. Nat Cell Biol 3:400-4088
-
(2001)
Nat Cell Biol
, vol.3
, pp. 400-4088
-
-
Seoane, J.1
Pouponnot, C.2
Staller, P.3
Schader, M.4
Eilers, M.5
Massague, J.6
-
88
-
-
1642332084
-
Integration of Smad and forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferation
-
Seoane J, Le HV, Shen L, Anderson SA, Massague J (2004) Integration of Smad and forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferation. Cell 117:211-2233
-
(2004)
Cell
, vol.117
, pp. 211-2233
-
-
Seoane, J.1
Le Shen, H.V.L.2
Anderson, S.A.3
Massague, J.4
-
89
-
-
0038682002
-
Mechanisms of TGF-beta signaling from cell membrane to the nucleus
-
Shi Y, Massague J (2003) Mechanisms of TGF-beta signaling from cell membrane to the nucleus. Cell 113:685-7000
-
(2003)
Cell
, vol.113
, pp. 685-7000
-
-
Shi, Y.1
Massague, J.2
-
90
-
-
0037816160
-
Transforming growth factor beta signaling impairs Neu-induced mammary tumorigenesis while promoting pulmonary metastasis
-
Siegel PM, Shu W, Cardiff RD, Muller WJ, Massague J (2003a) Transforming growth factor beta signaling impairs Neu-induced mammary tumorigenesis while promoting pulmonary metastasis. Proc Natl Acad Sci U S A 100:8430-84355
-
(2003)
Proc Natl Acad Sci U S A
, vol.100
, pp. 8430-84355
-
-
Siegel, P.M.1
Shu, W.2
Cardiff, R.D.3
Muller, W.J.4
Massague, J.5
-
91
-
-
0042316912
-
Mad upregulation and Id2 repression accompany transforming growth factor (TGF)-beta-mediated epithelial cell growth suppression
-
Siegel PM, Shu W, Massague J (2003b) Mad upregulation and Id2 repression accompany transforming growth factor (TGF)-beta-mediated epithelial cell growth suppression. J Biol Chem 278:35444-354500
-
(2003)
J Biol Chem
, vol.278
, pp. 35444-354500
-
-
Siegel, P.M.1
Shu, W.2
Massague, J.3
-
92
-
-
0025858872
-
Regulation of lymphokine-activated killer activity and pore-forming protein gene expression in human peripheral blood CD8+ T lymphocytes. Inhibition by transforming growth factor-beta
-
Smyth MJ, Strobl SL, Young HA, Ortaldo JR, Ochoa AC (1991) Regulation of lymphokine-activated killer activity and pore-forming protein gene expression in human peripheral blood CD8+ T lymphocytes. Inhibition by transforming growth factor-beta. J Immunol 146:3289-32977
-
(1991)
J Immunol
, vol.146
, pp. 3289-32977
-
-
Smyth, M.J.1
Strobl, S.L.2
Young, H.A.3
Ortaldo, J.R.4
Ochoa, A.C.5
-
93
-
-
53349164136
-
The type i TGF-beta receptor engages TRAF6 to activate TAK1 in a receptor kinase-independent manner
-
Sorrentino A, Thakur N, Grimsby S, Marcusson A, von Bulow V, Schuster N, Zhang S, Heldin CH, Landstrom M (2008) The type I TGF-beta receptor engages TRAF6 to activate TAK1 in a receptor kinase-independent manner. Nat Cell Biol 10:1199-12077
-
(2008)
Nat Cell Biol
, vol.10
, pp. 1199-12077
-
-
Sorrentino, A.1
Thakur, N.2
Grimsby, S.3
Marcusson, A.4
Von Bulow, V.5
Schuster, N.6
Zhang, S.7
Heldin, C.H.8
Landstrom, M.9
-
94
-
-
47349086991
-
MT1-MMP releases latent TGF-beta1 from endothelial cell extracellular matrix via proteolytic processing of LTBP-1
-
Tatti O, Vehvilainen P, Lehti K, Keski-Oja J (2008) MT1-MMP releases latent TGF-beta1 from endothelial cell extracellular matrix via proteolytic processing of LTBP-1. Exp Cell Res 314:2501-25144
-
(2008)
Exp Cell Res
, vol.314
, pp. 2501-25144
-
-
Tatti, O.1
Vehvilainen, P.2
Lehti, K.3
Keski-Oja, J.4
-
95
-
-
80054044019
-
Glioblastoma angiogenesis and tumor cell invasiveness are differentially regulated by {beta}8 integrin
-
Tchaicha JH, Reyes SB, Shin J, Hossain MG, Lang FF, McCarty JH (2011) Glioblastoma angiogenesis and tumor cell invasiveness are differentially regulated by {beta}8 integrin. Cancer Res 71:6371-63811
-
(2011)
Cancer Res
, vol.71
, pp. 6371-63811
-
-
Tchaicha, J.H.1
Reyes, S.B.2
Shin, J.3
Hossain, M.G.4
Lang, F.F.5
McCarty, J.H.6
-
96
-
-
2342488852
-
New insights into TGF-beta-Smad signalling
-
ten Dijke P, Hill CS (2004) New insights into TGF-beta-Smad signalling. Trends Biochem Sci 29:265-2733
-
(2004)
Trends Biochem Sci
, vol.29
, pp. 265-2733
-
-
Ten Dijke, P.1
Hill, C.S.2
-
97
-
-
77952043572
-
RNAi-based therapeutics-current status, challenges and prospects
-
Tiemann K, Rossi JJ (2009) RNAi-based therapeutics-current status, challenges and prospects. EMBO Mol Med 1:142-1511
-
(2009)
EMBO Mol Med
, vol.1
, pp. 142-1511
-
-
Tiemann, K.1
Rossi, J.J.2
-
98
-
-
34547475192
-
Inhibiting TGF-beta signaling restores immune surveillance in the SMA-560 glioma model
-
Tran TT, Uhl M, Ma JY, Janssen L, Sriram V, Aulwurm S, Kerr I, Lam A, Webb HK, Kapoun AM, Kizer DE, McEnroe G, Hart B, Axon J, Murphy A, Chakravarty S, Dugar S, Protter AA, Higgins LS, Wick W, Weller M, Wong DH (2007) Inhibiting TGF-beta signaling restores immune surveillance in the SMA-560 glioma model. Neuro Oncol 9:259-2700
-
(2007)
Neuro Oncol
, vol.9
, pp. 259-2700
-
-
Tran, T.T.1
Uhl, M.2
Ma, J.Y.3
Janssen, L.4
Sriram, V.5
Aulwurm, S.6
Kerr, I.7
Lam, A.8
Webb, H.K.9
Kapoun, A.M.10
Kizer, D.E.11
McEnroe, G.12
Hart, B.13
Axon, J.14
Murphy, A.15
Chakravarty, S.16
Dugar, S.17
Protter, A.A.18
Higgins, L.S.19
Wick, W.20
Weller, M.21
Wong, D.H.22
more..
-
99
-
-
0032428684
-
SARA, a FYVE domain protein that recruits Smad2 to the TGFbeta receptor
-
Tsukazaki T, Chiang TA, Davison AF, Attisano L, Wrana JL (1998) SARA, a FYVE domain protein that recruits Smad2 to the TGFbeta receptor. Cell 95:779-7911
-
(1998)
Cell
, vol.95
, pp. 779-7911
-
-
Tsukazaki, T.1
Chiang, T.A.2
Davison, A.F.3
Attisano, L.4
Wrana, J.L.5
-
100
-
-
70350708139
-
Systemic inhibition of transforming growth factor-beta in glioma-bearing mice improves the therapeutic efficacy of glioma-associated antigen peptide vaccines
-
Ueda R, Fujita M, Zhu X, Sasaki K, Kastenhuber ER, Kohanbash G, McDonald HA, Harper J, Lonning S, Okada H (2009) Systemic inhibition of transforming growth factor-beta in glioma-bearing mice improves the therapeutic efficacy of glioma-associated antigen peptide vaccines. Clin Cancer Res 15:6551-65599
-
(2009)
Clin Cancer Res
, vol.15
, pp. 6551-65599
-
-
Ueda, R.1
Fujita, M.2
Zhu, X.3
Sasaki, K.4
Kastenhuber, E.R.5
Kohanbash, G.6
McDonald, H.A.7
Harper, J.8
Lonning, S.9
Okada, H.10
-
101
-
-
7444226411
-
SD-208, a novel transforming growth factor beta receptor i kinase inhibitor, inhibits growth and invasiveness and enhances immunogenicity of murine and human glioma cells in vitro and in vivo
-
Uhl M, Aulwurm S, Wischhusen J, Weiler M, Ma JY, Almirez R, Mangadu R, Liu YW, Platten M, Herrlinger U, Murphy A, Wong DH, Wick W, Higgins LS, Weller M (2004) SD-208, a novel transforming growth factor beta receptor I kinase inhibitor, inhibits growth and invasiveness and enhances immunogenicity of murine and human glioma cells in vitro and in vivo. Cancer Res 64:7954-79611
-
(2004)
Cancer Res
, vol.64
, pp. 7954-79611
-
-
Uhl, M.1
Aulwurm, S.2
Wischhusen, J.3
Weiler, M.4
Ma, J.Y.5
Almirez, R.6
Mangadu, R.7
Liu, Y.W.8
Platten, M.9
Herrlinger, U.10
Murphy, A.11
Wong, D.H.12
Wick, W.13
Higgins, L.S.14
Weller, M.15
-
102
-
-
0024278715
-
Transforming growth factor beta 1 positively regulates its own expression in normal and transformed cells
-
Van Obberghen-Schilling E, Roche NS, Flanders KC, Sporn MB, Roberts AB (1988) Transforming growth factor beta 1 positively regulates its own expression in normal and transformed cells. J Biol Chem 263:7741-77466
-
(1988)
J Biol Chem
, vol.263
, pp. 7741-77466
-
-
Van Obberghen-Schilling, E.1
Roche, N.S.2
Flanders, K.C.3
Sporn, M.B.4
Roberts, A.B.5
-
103
-
-
0036177427
-
Transforming growth factor-beta signaling through the Smad pathway: Role in extracellular matrix gene expression and regulation
-
Verrecchia F, Mauviel A (2002) Transforming growth factor-beta signaling through the Smad pathway: role in extracellular matrix gene expression and regulation. J Invest Dermatol 118:211-2155
-
(2002)
J Invest Dermatol
, vol.118
, pp. 211-2155
-
-
Verrecchia, F.1
Mauviel, A.2
-
104
-
-
80051471864
-
The specificities of small molecule inhibitors of the TGFss and BMP pathways
-
1831-18422
-
Vogt J, Traynor R, Sapkota GP (2011) The specificities of small molecule inhibitors of the TGFss and BMP pathways. Cell Signal 23:1831-18422
-
(2011)
Cell Signal
, vol.23
-
-
Vogt, J.1
Traynor, R.2
Sapkota, G.P.3
-
105
-
-
0032478791
-
Transforming growth factor-beta1 stimulates protein kinase A in mesangial cells
-
Wang L, Zhu Y, Sharma K (1998) Transforming growth factor-beta1 stimulates protein kinase A in mesangial cells. J Biol Chem 273:8522-85277
-
(1998)
J Biol Chem
, vol.273
, pp. 8522-85277
-
-
Wang, L.1
Zhu, Y.2
Sharma, K.3
-
106
-
-
38949165993
-
Microglia-derived TGF-beta as an important regulator of glioblastoma invasion-an inhibition of TGF-beta-dependent effects by shRNA against human TGF-beta type II receptor
-
Wesolowska A, Kwiatkowska A, Slomnicki L, Dembinski M, Master A, Sliwa M, Franciszkiewicz K, Chouaib S, Kaminska B (2008) Microglia-derived TGF-beta as an important regulator of glioblastoma invasion-an inhibition of TGF-beta-dependent effects by shRNA against human TGF-beta type II receptor. Oncogene 27:918-9300
-
(2008)
Oncogene
, vol.27
, pp. 918-9300
-
-
Wesolowska, A.1
Kwiatkowska, A.2
Slomnicki, L.3
Dembinski, M.4
Master, A.5
Sliwa, M.6
Franciszkiewicz, K.7
Chouaib, S.8
Kaminska, B.9
-
107
-
-
0034765067
-
Glioma cell invasion: Regulation of metalloproteinase activity by TGF-beta
-
Wick W, Platten M, Weller M (2001) Glioma cell invasion: regulation of metalloproteinase activity by TGF-beta. J Neurooncol 53:177-1855
-
(2001)
J Neurooncol
, vol.53
, pp. 177-1855
-
-
Wick, W.1
Platten, M.2
Weller, M.3
-
108
-
-
0242721599
-
Cell-type-specific activation of PAK2 by transforming growth factor beta independent of Smad2 and Smad3
-
Wilkes MC, Murphy SJ, Garamszegi N, Leof EB (2003) Cell-type-specific activation of PAK2 by transforming growth factor beta independent of Smad2 and Smad3. Mol Cell Biol 23:8878-88899
-
(2003)
Mol Cell Biol
, vol.23
, pp. 8878-88899
-
-
Wilkes, M.C.1
Murphy, S.J.2
Garamszegi, N.3
Leof, E.B.4
-
109
-
-
0033559577
-
Tumorigenicity of mouse thymoma is suppressed by soluble type II transforming growth factor beta receptor therapy
-
Won J, Kim H, Park EJ, Hong Y, Kim SJ, Yun Y (1999) Tumorigenicity of mouse thymoma is suppressed by soluble type II transforming growth factor beta receptor therapy. Cancer Res 59:1273-12777
-
(1999)
Cancer Res
, vol.59
, pp. 1273-12777
-
-
Won, J.1
Kim, H.2
Park, E.J.3
Hong, Y.4
Kim, S.J.5
Yun, Y.6
-
110
-
-
0032979988
-
Smad3-Smad4 and AP-1 complexes synergize in transcriptional activation of the c-Jun promoter by transforming growth factor beta
-
Wong C, Rougier-Chapman EM, Frederick JP, Datto MB, Liberati NT, Li JM, Wang XF (1999) Smad3-Smad4 and AP-1 complexes synergize in transcriptional activation of the c-Jun promoter by transforming growth factor beta. Mol Cell Biol 19:1821-18300
-
(1999)
Mol Cell Biol
, vol.19
, pp. 1821-18300
-
-
Wong, C.1
Rougier-Chapman, E.M.2
Frederick, J.P.3
Datto, M.B.4
Liberati, N.T.5
Li, J.M.6
Wang, X.F.7
-
111
-
-
0029551805
-
Identification of a member of the MAPKKK family as a potential mediator of TGF-beta signal transduction
-
Yamaguchi K, Shirakabe K, Shibuya H, Irie K, Oishi I, Ueno N, Taniguchi T, Nishida E, Matsumoto K (1995) Identification of a member of the MAPKKK family as a potential mediator of TGF-beta signal transduction. Science 270:2008-20111
-
(1995)
Science
, vol.270
, pp. 2008-20111
-
-
Yamaguchi, K.1
Shirakabe, K.2
Shibuya, H.3
Irie, K.4
Oishi, I.5
Ueno, N.6
Taniguchi, T.7
Nishida, E.8
Matsumoto, K.9
-
112
-
-
14744292280
-
Downregulation of major histocompatibility complex antigens in invading glioma cells: Stealth invasion of the brain
-
Zagzag D, Salnikow K, Chiriboga L, Yee H, Lan L, Ali MA, Garcia R, Demaria S, Newcomb EW (2005) Downregulation of major histocompatibility complex antigens in invading glioma cells: stealth invasion of the brain. Lab Invest 85:328-3411
-
(2005)
Lab Invest
, vol.85
, pp. 328-3411
-
-
Zagzag, D.1
Salnikow, K.2
Chiriboga, L.3
Yee, H.4
Lan, L.5
Ali, M.A.6
Garcia, R.7
Demaria, S.8
Newcomb, E.W.9
-
113
-
-
58149213801
-
Non-Smad pathways in TGF-beta signaling
-
Zhang YE (2009) Non-Smad pathways in TGF-beta signaling. Cell Res 19:128-1399
-
(2009)
Cell Res
, vol.19
, pp. 128-1399
-
-
Zhang, Y.E.1
-
114
-
-
33745532884
-
Participation of an abnormality in the transforming growth factor-beta signaling pathway in resistance of malignant glioma cells to growth inhibition induced by that factor
-
Zhang L, Sato E, Amagasaki K, Nakao A, Naganuma H (2006) Participation of an abnormality in the transforming growth factor-beta signaling pathway in resistance of malignant glioma cells to growth inhibition induced by that factor. J Neurosurg 105:119-1288
-
(2006)
J Neurosurg
, vol.105
, pp. 119-1288
-
-
Zhang, L.1
Sato, E.2
Amagasaki, K.3
Nakao, A.4
Naganuma, H.5
-
115
-
-
79960801821
-
Temozolomide decreases invasion of glioma stem cells by downregulating TGF-beta2
-
Zhang D, Jing Z, Qiu B, Wu A, Wang Y (2011a) Temozolomide decreases invasion of glioma stem cells by downregulating TGF-beta2. Oncol Rep 26:901-9088
-
(2011)
Oncol Rep
, vol.26
, pp. 901-9088
-
-
Zhang, D.1
Jing, Z.2
Qiu, B.3
Wu, A.4
Wang, Y.5
-
116
-
-
79958082880
-
Trimodal glioblastoma treatment consisting of concurrent radiotherapy, temozolomide, and the novel TGF-beta receptor i kinase inhibitor LY2109761
-
Zhang M, Herion TW, Timke C, Han N, Hauser K, Weber KJ, Peschke P, Wirkner U, Lahn M, Huber PE (2011b) Trimodal glioblastoma treatment consisting of concurrent radiotherapy, temozolomide, and the novel TGF-beta receptor I kinase inhibitor LY2109761. Neoplasia 13:537-5499
-
(2011)
Neoplasia
, vol.13
, pp. 537-5499
-
-
Zhang, M.1
Herion, T.W.2
Timke, C.3
Han, N.4
Hauser, K.5
Weber, K.J.6
Peschke, P.7
Wirkner, U.8
Lahn, M.9
Huber, P.E.10
-
117
-
-
79955924632
-
Increased transforming growth factor-beta2 in epidermal growth factor receptor variant III-positive glioblastoma
-
Zhang X, Wu A, Fan Y, Wang Y (2011c) Increased transforming growth factor-beta2 in epidermal growth factor receptor variant III-positive glioblastoma. J Clin Neurosci 18:821-8266
-
(2011)
J Clin Neurosci
, vol.18
, pp. 821-8266
-
-
Zhang, X.1
Wu, A.2
Fan, Y.3
Wang, Y.4
|