Expression of transforming-growth-factor (TGF)-β receptors and Smad proteins in glioblastoma cell lines with distinct responses to TGF-β1

International Journal of Cancer

Volumn 80, Issue 5, 1999, Pages 756-763

  Piek, Ester ^a,b,d   Westermark, Ulrica ^c   Kastemar, Marianne ^c   Heldin, Carl Henrik ^b   Van Zoelen, E Joop ^a   Nistér, Monica ^c   Ten Dijke, Peter ^b  

^a RADBOUD UNIVERSITY NIJMEGEN   (Netherlands)

^b LUDWIG INSTITUTE FOR CANCER RESEARCH   (Sweden)

^c UPPSALA UNIVERSITY HOSPITAL   (Sweden)

^d UPPSALA UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

TRANSFORMING GROWTH FACTOR BETA RECEPTOR; TRANSFORMING GROWTH FACTOR BETA1;

ARTICLE; CELL PROLIFERATION; GLIOBLASTOMA; GROWTH INHIBITION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SYNTHESIS;

DNA, NEOPLASM; DNA-BINDING PROTEINS; GENES, REPORTER; GLIOBLASTOMA; GLIOMA; HUMANS; LUCIFERASES; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; RECOMBINANT FUSION PROTEINS; SMAD2 PROTEIN; SMAD3 PROTEIN; SMAD4 PROTEIN; TRANS-ACTIVATORS; TRANSCRIPTION, GENETIC; TRANSFECTION; TRANSFORMING GROWTH FACTOR BETA; TUMOR CELLS, CULTURED;

EID: 0032943080     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0215(19990301)80:5<756::AID-IJC21>3.0.CO;2-N     Document Type: Article

References (21)

1. AFRAKHTE, M., MORÉN, A., JOSSAN, S., ITOH, S., SAMPATH, K., WESTERMARK, B., HELDIN, C.-H., HELDIN, N.-E. and TEN DIJKE, P., Induction of inhibitory Smad6 and Smad7 mRNA by TGF-β family members. Biochem. biophys. Res. Comm., 249, 505-511 (1998).
2. CENTRELLA, M., CASINGHINO, S., KIM, J., PHAM, T., ROSEN, V., WOZNEY, J. and MCCARTHY, T.L., Independent changes in type I and type II receptors for transforming growth factor β induced by bone morphogenetic protein 2 parallel expression of the osteoblast phenotype. Mol. cell. Biol., 15, 3273-3281 (1995).
3. CHEN, R.-H., EBNER, R. and DERYNCK, R., Inactivation of the type II receptor reveals two receptor pathways for the diverse TGF-β activities. Science, 260, 1335-1338 (1993).
4. CUI, W., FOWLIS, D.J., BRYSON, S., DUFFIE, E., IRELAND, H., BALMAIN, A. and AKHURST, R.J., TGF-β1 inhibits the formation of benign skin tumors, but enhances progression to invasive spindle carcinomas in transgenic mice. Cell, 86, 531-542 (1996).
5. DENNLER, S., ITOH, S., VIVIEN, D., TEN DIJKE, P., HUET, S. and GAUTHIER, J.-M., Direct binding of Smad3 and Smad4 to critical TGFβ-inducible elements in the promoter of human plasminogen activator inhibitor-type 1 gene. EMBO J., 17, 3091-3100 (1998).
6. HELDIN, C.-H., MIYAZONO, K. and TEN DIJKE, P., TGF-β signalling from cell membrane to nucleus through SMAD proteins. Nature (Lond.), 390, 465-471 (1997).
7. ISOE, S., NAGANUMA, H., NAKANO, S., SASAKI, A., SATOH, E., NAGASAKA, M., MAEDA, S. and NUKUI, H., Resistance to growth inhibition by transforming growth factor-β in malignant glioma cells with functional receptors. J. Neurosurg., 88, 529-534 (1998).
8. IZUMOTO, S., ARITA, N., OHNISHI, T., HIRAGA, S., TAKI, T., TOMITA, N., OHUE, M. and HAYAKAWA, T., Microsatellite instability and mutated type II transforming growth factor-β receptor gene in gliomas. Cancer Lett., 112, 251-256 (1997).
9. 2 are potential growth regulators for low-grade and malignant gliomas in vitro: evidence in support of an autocrine hypothesis. Int. J. Cancer, 49, 129-139 (1991).
10. JENNINGS, M.T. and PIETENPOL, J.A., The role of transforming growth factor β in glioma progression. J. Neurooncol., 36, 123-140 (1998).
11. LAIHO, M., RÖNNSTRAND, L., HEINO, J., DECAPRIO, J.A., LUDLOW, J.W., LIVINGSTON, D.M. and MASSAGUÉ, J., Control of junB and extracellular matrix protein expression by transforming growth factor-β1 is independent of simian virus 40 T antigen-sensitive growth-inhibitory events. Mol. Cell. Biol., 11, 972-978 (1991).
12. 1. Brit. J. Cancer, 70, 199-203 (1994).
13. NAKAO, A., AFRAKHTE, M., MORÉN, A., NAKAYAMA, T., CHRISTIAN, J.L., HEUCHEL, R., ITOH, S., KAWABATA, M., HELDIN, N.-E., HELDIN, C.-H. and TEN DIJKE, P., Identification of Smad7, a TGFβ-inducible antagonist of TGF-β signalling. Nature (Lond.), 389, 631-635 (1997a).
14. NAKAO, A., IMAMURA, T., SOUCHELNYTSKYI, S., KAWABATA, M., ISHISAKI, A., OEDA, E., TAMAKI, K., HANAI, J.-I., HELDIN, C.-H., MIYAZONO, K. and TEN DIJKE, P., TGF-β receptor-mediated signalling through Smad2, Smad3 and Smad4. EMBO J., 16, 5353-5362 (1997b).
15. NISTÉR, M., CLAESSON-WELSH, L., ERIKSSON, A., HELDIN, C.-H. and WESTERMARK, B., Differential expression of platelet-derived growth factor receptors in human malignant glioma cell lines. J. biol. Chem., 266, 16755-16763 (1991).
16. NISTÉR, M., WEDELL, B., BETSHOLTZ, C., BYWATER, M., PETTERSSON, M., WESTERMARK, B. and MARK, J., Evidence for progressional changes in the human malignant glioma cell line U-343 MGa: analysis of karyotype and expression of genes encoding the sub-unit chains of platelet-derived growth factor. Cancer Res., 47, 4953-4960 (1987).
17. PIEK, E., FRANZÉN, P., HELDIN, C.-H. and TEN DIJKE, P., Characterization of a 60-kDa cell surface-associated transforming growth factor-β binding protein that can interfere with transforming growth factor-β receptor binding. J. cell. Physiol., 173, 447-459 (1997).
18. ROBERTS, A.B. and SPORN, M.B., Transforming growth factor-βs. In M.B. Sporn and A.B. Roberts (eds.), Peptide growth factors and their receptors: part 1, pp. 419-472, Springer, Berlin (1990).
19. TAKEUCHI, Y., FUKUMOTO, S. and MATSUMOTO, T., Relationship between actions of transforming growth factor (TGF)-β and cell surface expression of its receptors in clonal osteoblastic cells. J. cell. Physiol., 162, 315-321 (1995).
20. WANG, J., HAN, W., ZBOROWSKA, E., LIANG, J., WANG, X., WILLSON, J.K.V., SUN, L. and BRATTAIN, M.G., Reduced expression of transforming growth factor β type I receptor contributes to the malignancy of human colon carcinoma cells. J. biol. Chem., 271, 17366-17371 (1996).
21. YAMASHITA, H., TEN DIJKE, P., HUYLEBROECK, D., SAMPATH, T.K., ANDRIES, M., SMITH, J.C., HELDIN, C.-H. and MIYAZONO, K., Osteogenic protein-1 binds to activin type II receptors and induces certain activin-like effects. J. Cell Biol., 130, 217-226 (1995).