Synthesis and activity of new aryl- and heteroaryl-substituted 5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole inhibitors of the transforming growth factor-β type I receptor kinase domain

Bioorganic and Medicinal Chemistry Letters

Volumn 14, Issue 13, 2004, Pages 3581-3584

  Sawyer, J Scott ^a   Beight, Douglas W ^a   Britt, Karen S ^a   Anderson, Bryan D ^a   Campbell, Robert M ^a   Goodson Jr , Theodore ^a   Herron, David K ^a   Li, Hong Yu ^a   McMillen, William T ^a   Mort, Nicholas ^a   Parsons, Stephen ^a   Smith, Edward C R ^a   Wagner, Jill R ^a   Yan, Lei ^a   Zhang, Faming ^a   Yingling, Jonathan M ^a  

^a ELI LILLY AND COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5,6 DIHYDRO 4H PYRROLO[1,2 B]PYRAZOLE DERIVATIVE; ENZYME INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE; TRANSFORMING GROWTH FACTOR BETA RECEPTOR; TRANSFORMING GROWTH FACTOR BETA TYPE 1 RECEPTOR KINASE INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CRYSTALLIZATION; DRUG ACTIVITY; DRUG SELECTIVITY; DRUG SYNTHESIS; NONHUMAN; PROTEIN DOMAIN; STRUCTURE ACTIVITY RELATION; X RAY ANALYSIS;

ACTIVIN RECEPTORS, TYPE I; ADENOSINE TRIPHOSPHATE; ANIMALS; CELLS, CULTURED; CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; INHIBITORY CONCENTRATION 50; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PYRAZOLES; QUINOLINES; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 2942589081     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2004.04.007     Document Type: Article

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