메뉴 건너뛰기




Volumn 44, Issue 3, 2000, Pages 253-265

Functional analysis of the TGFβ receptor/Smad pathway through gene ablation in mice

Author keywords

Gene ablation; Mouse; Serine threonine kinase receptors; Smads; TGF ligands

Indexed keywords

PROTEIN SERINE THREONINE KINASE; RECEPTOR PROTEIN; SMAD PROTEIN; TRANSFORMING GROWTH FACTOR BETA RECEPTOR; DNA BINDING PROTEIN; TRANSACTIVATOR PROTEIN;

EID: 0033625416     PISSN: 02146282     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (323)

References (91)
  • 3
    • 0032054574 scopus 로고    scopus 로고
    • Mads and Smads in TGF β signalling
    • ATTISANO, L. and WRANA, J.L. (1998). Mads and Smads in TGF β signalling. Curr. Opin. Cell Biol. 10:188-194.
    • (1998) Curr. Opin. Cell Biol. , vol.10 , pp. 188-194
    • Attisano, L.1    Wrana, J.L.2
  • 4
    • 0029829230 scopus 로고    scopus 로고
    • A novel mesoderm inducer, Madr2, functions in the activin signal transduction pathway
    • BAKER, J.C. and HARLAND, R.M. (1996). A novel mesoderm inducer, Madr2, functions in the activin signal transduction pathway. Genes Dev. 10:1880-1889.
    • (1996) Genes Dev. , vol.10 , pp. 1880-1889
    • Baker, J.C.1    Harland, R.M.2
  • 5
    • 0033966734 scopus 로고    scopus 로고
    • Combinatorial signaling through BMP receptor IB and GDF5: Shaping of the distal mouse limb and the genetics of distal limb diversity
    • BAUR, ST., MAI, J.J. and DYMECKI, S.M. (2000). Combinatorial signaling through BMP receptor IB and GDF5: shaping of the distal mouse limb and the genetics of distal limb diversity. Development 127:605-619.
    • (2000) Development , vol.127 , pp. 605-619
    • Baur, S.T.1    Mai, J.J.2    Dymecki, S.M.3
  • 7
    • 0032720393 scopus 로고    scopus 로고
    • A murine model of hereditary hemorrhagic telangiectasia
    • BOURDEAU, A., DUMONT, D.J. and LETARTE, M. (1999). A murine model of hereditary hemorrhagic telangiectasia. J. Clin. Invest. 104:1343-1351.
    • (1999) J. Clin. Invest. , vol.104 , pp. 1343-1351
    • Bourdeau, A.1    Dumont, D.J.2    Letarte, M.3
  • 8
    • 0032908432 scopus 로고    scopus 로고
    • Smad5 knockout mice die at mid-gestation due to multiple embryonic and extraembryonic defects
    • CHANG, H., HUYLEBROECK, D., VERSCHUEREN, K., GUO, Q., MATZUK, M.M. and ZWIJSEN, A. (1999). Smad5 knockout mice die at mid-gestation due to multiple embryonic and extraembryonic defects. Development 126:1631-1642.
    • (1999) Development , vol.126 , pp. 1631-1642
    • Chang, H.1    Huylebroeck, D.2    Verschueren, K.3    Guo, Q.4    Matzuk, M.M.5    Zwijsen, A.6
  • 10
    • 0033524945 scopus 로고    scopus 로고
    • Smad1 recognition and activation by the ALK1 group of transforming growth factor-β family receptors
    • CHEN, Y.G. and MASSAGUÉ, J. (1999). Smad1 recognition and activation by the ALK1 group of transforming growth factor-β family receptors. J. Biol. Chem. 274:3672-3677.
    • (1999) J. Biol. Chem. , vol.274 , pp. 3672-3677
    • Chen, Y.G.1    Massagué, J.2
  • 11
    • 0033134805 scopus 로고    scopus 로고
    • Can't get no SMADisfaction: Smad proteins as positive and negative regulators of TGF-β family signals
    • CHRISTIAN, J.L. and NAKAYAMA, T. (1999). Can't get no SMADisfaction: Smad proteins as positive and negative regulators of TGF-β family signals. BioEssays 21:382-390.
    • (1999) BioEssays , vol.21 , pp. 382-390
    • Christian, J.L.1    Nakayama, T.2
  • 12
    • 0029993646 scopus 로고    scopus 로고
    • Relationship between asymmetric nodal expression and the direction of embryonic turning
    • COLLIGNON, J., VARLET, I. and ROBERTSON, E.J. (1996). Relationship between asymmetric nodal expression and the direction of embryonic turning. Nature 381:155-158.
    • (1996) Nature , vol.381 , pp. 155-158
    • Collignon, J.1    Varlet, I.2    Robertson, E.J.3
  • 13
    • 0028180752 scopus 로고
    • A primary requirement for nodal in the formation and maintenance of the primitive streak in the mouse
    • CONLON, F.L., LYONS, K.M., TAKAESU, N., BARTH, K.S., KISPERT, A., HERRMANN, B. and ROBERTSON, EJ. (1994). A primary requirement for nodal in the formation and maintenance of the primitive streak in the mouse. Development 120:1919-1928.
    • (1994) Development , vol.120 , pp. 1919-1928
    • Conlon, F.L.1    Lyons, K.M.2    Takaesu, N.3    Barth, K.S.4    Kispert, A.5    Herrmann, B.6    Robertson, E.J.7
  • 14
    • 0032934979 scopus 로고    scopus 로고
    • Targeted disruption of Smad3 reveals an essential role in transforming growth factor β-mediated signal transduction
    • DATTO, M.B., FREDERICK, J.P., PAN, L., BORTON, A J., ZHUANG, Y. and WANG, X.F. (1999). Targeted disruption of Smad3 reveals an essential role in transforming growth factor β-mediated signal transduction. Mol. Cell. Biol. 19:2495-2504.
    • (1999) Mol. Cell. Biol. , vol.19 , pp. 2495-2504
    • Datto, M.B.1    Frederick, J.P.2    Pan, L.3    Borton, A.J.4    Zhuang, Y.5    Wang, X.F.6
  • 16
    • 0029074681 scopus 로고
    • Defective haematopoiesis and vasculogenesis in transforming growth factor-β 1 knock out mice
    • DICKSON, M.C., MARTIN, J.S., COUSINS, F.M., KULKARNI, A.B., KARLSSON, S. and AKHURST, R.J. (1995). Defective haematopoiesis and vasculogenesis in transforming growth factor-β 1 knock out mice. Development 121:1845-1854.
    • (1995) Development , vol.121 , pp. 1845-1854
    • Dickson, M.C.1    Martin, J.S.2    Cousins, F.M.3    Kulkarni, A.B.4    Karlsson, S.5    Akhurst, R.J.6
  • 17
    • 0028832707 scopus 로고
    • A requirement for bone morphogenetic protein-7 during Development of the mammalian kidney and eye
    • DUDLEY, A.T., LYONS, K.M. and ROBERTSON, E.J. (1995). A requirement for bone morphogenetic protein-7 during Development of the mammalian kidney and eye. Genes Dev. 9:2795-2807.
    • (1995) Genes Dev. , vol.9 , pp. 2795-2807
    • Dudley, A.T.1    Lyons, K.M.2    Robertson, E.J.3
  • 18
    • 0031571651 scopus 로고    scopus 로고
    • Haploinsufficient phenotypes in Bmp4 heterozygous null mice and modification by mutations in Gli3 and Alx4
    • DUNN, N.R., WINNIER, G.E., HARGETT, L.K., SCHRICK, J.J., FOGO, A.B. and HOGAN, B.L. (1997). Haploinsufficient phenotypes in Bmp4 heterozygous null mice and modification by mutations in Gli3 and Alx4. Dev. Biol. 188:235-247.
    • (1997) Dev. Biol. , vol.188 , pp. 235-247
    • Dunn, N.R.1    Winnier, G.E.2    Hargett, L.K.3    Schrick, J.J.4    Fogo, A.B.5    Hogan, B.L.6
  • 19
    • 0031025260 scopus 로고    scopus 로고
    • Activin signalling has a necessary function in Xenopus early development
    • DYSON, S. and GURDON, J.B. (1997). Activin signalling has a necessary function in Xenopus early development. Curr. Biol. 7:81-84.
    • (1997) Curr. Biol. , vol.7 , pp. 81-84
    • Dyson, S.1    Gurdon, J.B.2
  • 20
    • 0026451642 scopus 로고
    • Decapentaplegic acts as a morphogen to organize dorsal-ventral pattern in the Drosophila embryo
    • FERGUSON, E.L. and ANDERSON, K.V. (1992). Decapentaplegic acts as a morphogen to organize dorsal-ventral pattern in the Drosophila embryo. Cell 71:451-461.
    • (1992) Cell , vol.71 , pp. 451-461
    • Ferguson, E.L.1    Anderson, K.V.2
  • 21
    • 0027332995 scopus 로고
    • Cloning of a TGF β type I receptor that forms a heteromeric complex with the TGF β type II receptor
    • FRANZEN, P., TEN DIJKE, P., ICHIJO, H., YAMASHITA, H., SCHULZ, P., HELDIN, C.H. and MIYAZONO, K. (1993). Cloning of a TGF β type I receptor that forms a heteromeric complex with the TGF β type II receptor. Cell 75:661-692.
    • (1993) Cell , vol.75 , pp. 661-692
    • Franzen, P.1    Ten Dijke, P.2    Ichijo, H.3    Yamashita, H.4    Schulz, P.5    Heldin, C.H.6    Miyazono, K.7
  • 23
    • 0025310515 scopus 로고
    • Primary structure of endoglin, an RGD-containing glycoprotein of human endothelial cells
    • GOUGOS, A. and LETARTE, M. (1990). Primary structure of endoglin, an RGD-containing glycoprotein of human endothelial cells. J. Biol. Chem. 265:8361-8364.
    • (1990) J. Biol. Chem. , vol.265 , pp. 8361-8364
    • Gougos, A.1    Letarte, M.2
  • 24
    • 0032878468 scopus 로고    scopus 로고
    • Transforming growth factor-β signalling in extraembryonic mesoderm is required for yolk sac vasculogenesis in mice
    • GOUMANS, M.-J., ZWIJSEN, A., VAN ROOIJEN, M.A., HUYLEBROECK, D., ROELEN, B.A. and MUMMERY, C.L. (1999). Transforming growth factor-β signalling in extraembryonic mesoderm is required for yolk sac vasculogenesis in mice. Development 126:3473-3483.
    • (1999) Development , vol.126 , pp. 3473-3483
    • Goumans, M.-J.1    Zwijsen, A.2    Van Rooijen, M.A.3    Huylebroeck, D.4    Roelen, B.A.5    Mummery, C.L.6
  • 25
    • 0026442926 scopus 로고
    • Responses of embryonic Xenopus cells to activin and FGF are separated by multiple dose thresholds and correspond to distinct axes of the mesoderm
    • GREEN, J.B., NEW, H. V. and SMITH, J. C. (1992). Responses of embryonic Xenopus cells to activin and FGF are separated by multiple dose thresholds and correspond to distinct axes of the mesoderm. Cell 71:731-739.
    • (1992) Cell , vol.71 , pp. 731-739
    • Green, J.B.1    New, H.V.2    Smith, J.C.3
  • 28
    • 0028122987 scopus 로고
    • Activin signalling and response to a morphogen gradient
    • GURDON, J.B., HARGER, P., MITCHELL, A. and LEMAIRE, P. (1994). Activin signalling and response to a morphogen gradient. Nature 371:487-492.
    • (1994) Nature , vol.371 , pp. 487-492
    • Gurdon, J.B.1    Harger, P.2    Mitchell, A.3    Lemaire, P.4
  • 29
    • 0031964859 scopus 로고    scopus 로고
    • Smad6 inhibits BMP/Smad1 signaling by specifically competing with the Smad4 tumor suppressor
    • HATA, A., LAGNA, G., MASSAGUÉ, J. and HEMMATI-BRIVANLOU, A. (1998) Smad6 inhibits BMP/Smad1 signaling by specifically competing with the Smad4 tumor suppressor. Genes Dev. 12:186-197.
    • (1998) Genes Dev. , vol.12 , pp. 186-197
    • Hata, A.1    Lagna, G.2    Massagué, J.3    Hemmati-Brivanlou, A.4
  • 30
    • 0031438047 scopus 로고    scopus 로고
    • TGF-β signalling from cell membrane to nucleus through SMAD proteins
    • HELDIN, C.-H., MIYAZONO, K. and TEN DIJKE, P. (1997). TGF-β signalling from cell membrane to nucleus through SMAD proteins. Nature 390:465-471.
    • (1997) Nature , vol.390 , pp. 465-471
    • Heldin, C.-H.1    Miyazono, K.2    Ten Dijke, P.3
  • 32
    • 0033568923 scopus 로고    scopus 로고
    • Xenopus Smad4β is the Co-Smad component of developmentally regulated transcription factor complexes responsible for induction of early mesodermal genes
    • HOWELL, M., ITOH, F., PIERREUX, C.E., VALGEIRSDOTTIR, S., ITOH, S., TEN DIJKE, P. and HILL, C.S. (1999). Xenopus Smad4β is the Co-Smad component of developmentally regulated transcription factor complexes responsible for induction of early mesodermal genes. Dev. Biol. 214:354-369.
    • (1999) Dev. Biol. , vol.214 , pp. 354-369
    • Howell, M.1    Itoh, F.2    Pierreux, C.E.3    Valgeirsdottir, S.4    Itoh, S.5    Ten Dijke, P.6    Hill, C.S.7
  • 36
    • 0028806184 scopus 로고
    • Abnormal lung development and cleft palate in mice lacking TGF-beta 3 indicates defects of epithelial-mesenchymal interaction
    • KAARTINEN, V., VONCKEN, J.W., SHULER, C., WARBURTON, D., BU, D., HEISTERKAMP, N. and GROFFEN, J. (1995). Abnormal lung development and cleft palate in mice lacking TGF-beta 3 indicates defects of epithelial-mesenchymal interaction. Nat. Genet. 11:415-421.
    • (1995) Nat. Genet. , vol.11 , pp. 415-421
    • Kaartinen, V.1    Voncken, J.W.2    Shuler, C.3    Warburton, D.4    Bu, D.5    Heisterkamp, N.6    Groffen, J.7
  • 37
    • 0032588796 scopus 로고    scopus 로고
    • Strain dependency of TGFβ1 function during embryogenesis
    • KALLAPUR, S, ORMSBY, I. and DOETSCHMAN, T. (1999). Strain dependency of TGFβ1 function during embryogenesis. Mol. Reprod. Dev. 52:341 -349.
    • (1999) Mol. Reprod. Dev. , vol.52 , pp. 341-349
    • Kallapur, S.O.I.1    Doetschman, T.2
  • 38
    • 0028180315 scopus 로고
    • The TGF-β superfamily: New members, new receptors and new genetic tests of function in different organisms
    • KINGSLEY, D.M. (1994). The TGF-β superfamily: new members, new receptors and new genetic tests of function in different organisms. Genes Dev. 2:133-146.
    • (1994) Genes Dev. , vol.2 , pp. 133-146
    • Kingsley, D.M.1
  • 44
    • 0026537831 scopus 로고
    • Expression cloning of the TGF-β type II receptor, a functional transmembrane serine/threonine kinase
    • LIN, H.Y., WANG, X.-F., NG-EATON, E., WEINBERG, R.A. and LODISH, H.F. (1992). Expression cloning of the TGF-β type II receptor, a functional transmembrane serine/threonine kinase. Cell 68:775-785.
    • (1992) Cell , vol.68 , pp. 775-785
    • Lin, H.Y.1    Wang, X.-F.2    Ng-Eaton, E.3    Weinberg, R.A.4    Lodish, H.F.5
  • 45
    • 0027276765 scopus 로고
    • Betaglycan presents ligand to the TGF β signaling receptor
    • LOPEZ-CASILLAS, F., WRANA, J.L. and MASSAGUÉ, J. (1993). Betaglycan presents ligand to the TGF β signaling receptor. Cell 73:1435-1444.
    • (1993) Cell , vol.73 , pp. 1435-1444
    • Lopez-Casillas, F.1    Wrana, J.L.2    Massagué, J.3
  • 46
    • 0028882261 scopus 로고
    • BMP-7 is an inducer of nephrogenesis and is also required for eye development and skeletal patterning
    • LUO, G., HOFMANN, C., BRONCKERS, A.L., SOHOCKI, M., BRADLEY, A. and KARSENTY, G. (1995). BMP-7 is an inducer of nephrogenesis and is also required for eye development and skeletal patterning. Genes Dev. 9:2808-2820.
    • (1995) Genes Dev. , vol.9 , pp. 2808-2820
    • Luo, G.1    Hofmann, C.2    Bronckers, A.L.3    Sohocki, M.4    Bradley, A.5    Karsenty, G.6
  • 47
    • 0033537831 scopus 로고    scopus 로고
    • Assignment of transforming growth factor β 1 and β 3 and a third new ligand to the type I receptor ALK-1
    • LUX, A., ATTISANO, L. and MARCHUK, D.A. (1999). Assignment of transforming growth factor β 1 and β 3 and a third new ligand to the type I receptor ALK-1. J. Biol. Chem. 274:9984-9992.
    • (1999) J. Biol. Chem. , vol.274 , pp. 9984-9992
    • Lux, A.1    Attisano, L.2    Marchuk, D.A.3
  • 48
    • 0032475884 scopus 로고    scopus 로고
    • Specific activation of Smad1 signaling pathways by the BMP7 type I receptor, ALK2
    • MACIAS-SILVA, M., HOODLESS, P.A., TANG, S.J., BUCHWALD, M. and WRANA, J.L. (1998). Specific activation of Smad1 signaling pathways by the BMP7 type I receptor, ALK2. J. Biol. Chem. 273: 25628-25636.
    • (1998) J. Biol. Chem. , vol.273 , pp. 25628-25636
    • Macias-Silva, M.1    Hoodless, P.A.2    Tang, S.J.3    Buchwald, M.4    Wrana, J.L.5
  • 49
    • 0031685620 scopus 로고    scopus 로고
    • TGF-β signal transduction
    • MASSAGUÉ, J. (1998). TGF-β signal transduction. Ann. Rev. Biochem. 67:753-791.
    • (1998) Ann. Rev. Biochem. , vol.67 , pp. 753-791
    • Massagué, J.1
  • 50
    • 0033597107 scopus 로고    scopus 로고
    • Identification of two Smad4 proteins in Xenopus. Their common and distinct properties
    • MASUYAMA, N., HANAFUSA, H., KUSAKABE, M., SHIBUYA, H. and NISHIDA, E. (1999). Identification of two Smad4 proteins in Xenopus. Their common and distinct properties. J. Biol. Chem. 274:12163-12170.
    • (1999) J. Biol. Chem. , vol.274 , pp. 12163-12170
    • Masuyama, N.1    Hanafusa, H.2    Kusakabe, M.3    Shibuya, H.4    Nishida, E.5
  • 51
    • 0028929864 scopus 로고
    • Different phenotypes for mice deficient in either activins or activin receptor type II
    • MATZUK, M.M., KUMAR, T.R. and BRADLEY, A. (1995). Different phenotypes for mice deficient in either activins or activin receptor type II. Nature 374:356-360.
    • (1995) Nature , vol.374 , pp. 356-360
    • Matzuk, M.M.1    Kumar, T.R.2    Bradley, A.3
  • 53
    • 0033568445 scopus 로고    scopus 로고
    • Multiple roles for activin-like kinase-2 signaling during mouse embryogenesis
    • MISHINA, Y., CROMBIE, R., BRADLEY, A. and BEHRINGER, R.R. (1999). Multiple roles for activin-like kinase-2 signaling during mouse embryogenesis. Dev. Biol. 213:314-326.
    • (1999) Dev. Biol. , vol.213 , pp. 314-326
    • Mishina, Y.1    Crombie, R.2    Bradley, A.3    Behringer, R.R.4
  • 54
    • 6244256053 scopus 로고
    • Bmpr encodes a type I bone morphogenetic protein receptor that is essential for gastrulation during mouse embryogenesis
    • MISHINA, Y., SUZUKI, A., UENO, N. and BEHRINGER, R.R. (1995). Bmpr encodes a type I bone morphogenetic protein receptor that is essential for gastrulation during mouse embryogenesis. Genes Dev. 9:3027-3037.
    • (1995) Genes Dev. , vol.9 , pp. 3027-3037
    • Mishina, Y.1    Suzuki, A.2    Ueno, N.3    Behringer, R.R.4
  • 55
    • 0032994043 scopus 로고    scopus 로고
    • Signal transduction by bone morphogenetic protein receptors: Functional roles of Smad proteins
    • MIYAZONO, K. (1999). Signal transduction by bone morphogenetic protein receptors: functional roles of Smad proteins. Bone 25:91-93.
    • (1999) Bone , vol.25 , pp. 91-93
    • Miyazono, K.1
  • 56
    • 0033375411 scopus 로고    scopus 로고
    • Developmental tumours, early differentiation and the transforming growth factor beta superfamily
    • MUMMERY, C.L. and VAN DEN EIJNDEN-VAN RAAIJ, A,J. (1999). Developmental tumours, early differentiation and the transforming growth factor beta superfamily. Int. J. Dev. Biol. 43:693-709.
    • (1999) Int. J. Dev. Biol. , vol.43 , pp. 693-709
    • Mummery, C.L.1    Van Den Eijnden-Van Raaij, A.2
  • 58
    • 0032565859 scopus 로고    scopus 로고
    • Smad2 role in mesoderm formation, left-right patterning and craniofacial development
    • NOMURA, M. and LI, E. (1998). Smad2 role in mesoderm formation, left-right patterning and craniofacial development. Nature 393:786-790.
    • (1998) Nature , vol.393 , pp. 786-790
    • Nomura, M.1    Li, E.2
  • 59
    • 0030837018 scopus 로고    scopus 로고
    • The signaling pathway mediated by the type MB activin receptor controls axial patterning and lateral asymmetry in the mouse
    • OH, S.P. and LI, E. (1997). The signaling pathway mediated by the type MB activin receptor controls axial patterning and lateral asymmetry in the mouse. Genes Dev. 11:1812-1826.
    • (1997) Genes Dev. , vol.11 , pp. 1812-1826
    • Oh, S.P.1    Li, E.2
  • 61
    • 0030579203 scopus 로고    scopus 로고
    • TGF-β receptor type II deficiency results in defects of yolk sac hematopoiesis and vasculogenesis
    • OSHIMA, M., OSHIMA, H. and TAKETO, M.M. (1996). TGF-β receptor type II deficiency results in defects of yolk sac hematopoiesis and vasculogenesis. Dev. Biol. 179:297-302.
    • (1996) Dev. Biol. , vol.179 , pp. 297-302
    • Oshima, M.1    Oshima, H.2    Taketo, M.M.3
  • 63
    • 0000116653 scopus 로고
    • The transforming growth factors βs
    • (Eds. M.B. Sporn and A.B. Roberts) Springer-Verlag, New York
    • ROBERTS, A.B. and SPORN, M.B. (1990). The transforming growth factors βs. In Peptide growth factors and their receptors. (Eds. M.B. Sporn and A.B. Roberts) Springer-Verlag, New York. pp. 419-472.
    • (1990) Peptide Growth Factors and Their Receptors , pp. 419-472
    • Roberts, A.B.1    Sporn, M.B.2
  • 64
    • 0031793717 scopus 로고    scopus 로고
    • Identification of two distinct functions for TGF-β in early mouse development
    • ROELEN, B.A., GOUMANS, M.J., ZWIJSEN, A. and MUMMERY, C.L. (1998). Identification of two distinct functions for TGF-β in early mouse development. Differentiation 64:19-31.
    • (1998) Differentiation , vol.64 , pp. 19-31
    • Roelen, B.A.1    Goumans, M.J.2    Zwijsen, A.3    Mummery, C.L.4
  • 66
    • 0028015934 scopus 로고
    • Mice homozygous for a null mutation of activin beta B are viable and fertile
    • SCHREWE, H., GENDRON-MAGUIRE, M., HARBISON, M.L. and GRIDLEY, T. (1994). Mice homozygous for a null mutation of activin beta B are viable and fertile. Mech. Dev. 47:43-51.
    • (1994) Mech. Dev. , vol.47 , pp. 43-51
    • Schrewe, H.1    Gendron-Maguire, M.2    Harbison, M.L.3    Gridley, T.4
  • 67
    • 0027935432 scopus 로고
    • Effects of truncated activin and FGF receptors and of follistatin on the inducing activities of BVg1 and activin: Does activin play a role in mesoderm induction?
    • SCHULTE-MERKER, S., SMITH, U.C. and DALE, L. (1994). Effects of truncated activin and FGF receptors and of follistatin on the inducing activities of BVg1 and activin: does activin play a role in mesoderm induction? E.M.B.O. J. 13:3533-3541.
    • (1994) E.M.B.O. J. , vol.13 , pp. 3533-3541
    • Schulte-Merker, S.1    Smith, U.C.2    Dale, L.3
  • 70
    • 0032915460 scopus 로고    scopus 로고
    • Early embryonic lethality in Brnp5;Bmp7 double mutant mice suggests functional redundancy within the 60A subgroup
    • SOLLOWAY, M.J. and ROBERTSON, E.J. (1999). Early embryonic lethality in Brnp5;Bmp7 double mutant mice suggests functional redundancy within the 60A subgroup. Development 126:1753-1768.
    • (1999) Development , vol.126 , pp. 1753-1768
    • Solloway, M.J.1    Robertson, E.J.2
  • 71
    • 0033198507 scopus 로고    scopus 로고
    • The type II activin receptors are essential for egg cylinder growth, gastrulation and rostral head development in mice
    • SONG, J., OH, S.P., SCHREWE, H., NOMURA, M., LEI, H., OKANO, M., GRIDLEY, T. and LI, E. (1999). The type II activin receptors are essential for egg cylinder growth, gastrulation and rostral head development in mice. Dev. Biol. 213:157-169.
    • (1999) Dev. Biol. , vol.213 , pp. 157-169
    • Song, J.1    Oh, S.P.2    Schrewe, H.3    Nomura, M.4    Lei, H.5    Okano, M.6    Gridley, T.7    Li, E.8
  • 72
    • 0032566611 scopus 로고    scopus 로고
    • Physical and functional interaction of murine and Xenopus Smad7 with bone morphogenetic protein receptors and transforming growth factor-β receptors
    • SOUCHELNYTSKYI, S., NAKAYAMA, T., NAKAO, A., MOREN, A., HELDIN, C.H., CHRISTIAN, J.L. and TEN DIJKE, P. (1998). Physical and functional interaction of murine and Xenopus Smad7 with bone morphogenetic protein receptors and transforming growth factor-β receptors. J. Biol. Chem. 273:25364-25370.
    • (1998) J. Biol. Chem. , vol.273 , pp. 25364-25370
    • Souchelnytskyi, S.1    Nakayama, T.2    Nakao, A.3    Moren, A.4    Heldin, C.H.5    Christian, J.L.6    Ten Dijke, P.7
  • 73
    • 0033956131 scopus 로고    scopus 로고
    • Signaling inputs converge on nuclear effectors in TGFβ signaling
    • TEN DIJKE, P., MIYAZONO, K. and HELDIN, C.H. (2000). Signaling inputs converge on nuclear effectors in TGFβ signaling. Trends Biochem. Sci. 25:64-70.
    • (2000) Trends Biochem. Sci. , vol.25 , pp. 64-70
    • Ten Dijke, P.1    Miyazono, K.2    Heldin, C.H.3
  • 77
    • 0030932236 scopus 로고    scopus 로고
    • Nodal expression in the primitive endoderm is required for specification of the anterior axis during mouse gastrulation
    • VARLET, I., COLLIGNON, J. and ROBERTSON, E.J. (1997). Nodal expression in the primitive endoderm is required for specification of the anterior axis during mouse gastrulation. Development 124:1033-1044.
    • (1997) Development , vol.124 , pp. 1033-1044
    • Varlet, I.1    Collignon, J.2    Robertson, E.J.3
  • 78
    • 0028176755 scopus 로고
    • Activin/inhibin beta B subunit gene disruption leads to defects in eyelid development and female reproduction
    • VASSALLI, A., MATZUK, M.M., GARDNER, H.A., LEE, K.F. and JAENISCH, R. (1994). Activin/inhibin beta B subunit gene disruption leads to defects in eyelid development and female reproduction. Genes Dev. 8:414-427.
    • (1994) Genes Dev. , vol.8 , pp. 414-427
    • Vassalli, A.1    Matzuk, M.M.2    Gardner, H.A.3    Lee, K.F.4    Jaenisch, R.5
  • 79
    • 0033192373 scopus 로고    scopus 로고
    • Remarkable versatility of Smad proteins in the nucleus of transforming growth factor-beta activated cells
    • VERSCHUEREN, K. and HUYLEBROECK, D. (1999). Remarkable versatility of Smad proteins in the nucleus of transforming growth factor-beta activated cells. Cytokine Growth Factor Rev. 10:187-199.
    • (1999) Cytokine Growth Factor Rev. , vol.10 , pp. 187-199
    • Verschueren, K.1    Huylebroeck, D.2
  • 80
    • 0032549806 scopus 로고    scopus 로고
    • Smad2 signaling in extraembryonic tissues deteirmines anterior-posterior polarity of the early mouse embryo
    • WALDRIP, W.R., BIKOFF, E.K., HOODLESS, P.A., WRANA, J.L. and ROBERTSON, E.J. (1998). Smad2 signaling in extraembryonic tissues deteirmines anterior-posterior polarity of the early mouse embryo. Cell 92:797-808.
    • (1998) Cell , vol.92 , pp. 797-808
    • Waldrip, W.R.1    Bikoff, E.K.2    Hoodless, P.A.3    Wrana, J.L.4    Robertson, E.J.5
  • 81
    • 0032482751 scopus 로고    scopus 로고
    • Failure of egg cylinder elongation and mesoderm induction in mouse embryos lacking the tumor suppressor Smad2
    • WEINSTEIN, M., YANG, X., LI, C., XU, X., GOTAY, J. and DENG, C.X. (1998). Failure of egg cylinder elongation and mesoderm induction in mouse embryos lacking the tumor suppressor Smad2. Proc. Natl. Acad. Sci. USA 95:9378-9383.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 9378-9383
    • Weinstein, M.1    Yang, X.2    Li, C.3    Xu, X.4    Gotay, J.5    Deng, C.X.6
  • 82
    • 0025054992 scopus 로고
    • Expression pattern of the mouse T gene and its role in mesoderm formation
    • WILKINSON, D.G., BHATT, S. and HERRMANN, B.G. (1990). Expression pattern of the mouse T gene and its role in mesoderm formation. Nature 343:657-659.
    • (1990) Nature , vol.343 , pp. 657-659
    • Wilkinson, D.G.1    Bhatt, S.2    Herrmann, B.G.3
  • 83
    • 0029149656 scopus 로고
    • Bone morphogenetic protein-4 is required for mesoderm formation and patterning in the mouse
    • WINNIER, G., BLESSING, M., LABOSKY, P.A. and HOGAN, B.L. (1995). Bone morphogenetic protein-4 is required for mesoderm formation and patterning in the mouse. Genes Dev. 9:2105-2116.
    • (1995) Genes Dev. , vol.9 , pp. 2105-2116
    • Winnier, G.1    Blessing, M.2    Labosky, P.A.3    Hogan, B.L.4
  • 86
    • 0033104503 scopus 로고    scopus 로고
    • Targeted disruption of SMAD3 results in impaired mucosal immunity and diminished T cell resporisiveness to TGF-β
    • YANG, X., LETTERIO, J.J., LECHLEIDER. R.J., CHEN, L., HAYMAN, R., GU, H., ROBERTS, A.B. and DENG, C. (1999b). Targeted disruption of SMAD3 results in impaired mucosal immunity and diminished T cell resporisiveness to TGF-β. E.M.B.O. J. 18:1280-1291.
    • (1999) E.M.B.O. J. , vol.18 , pp. 1280-1291
    • Yang, X.1    Letterio, J.J.2    Lechleider, R.J.3    Chen, L.4    Hayman, R.5    Gu, H.6    Roberts, A.B.7    Deng, C.8
  • 87
    • 0032584068 scopus 로고    scopus 로고
    • The tumor suppressor SMAD4/DPC4 is essential for epiblast proliferation and mesoderm induction in mice
    • YANG, X., LI, C., XU, X. and DENG, C. (1998). The tumor suppressor SMAD4/DPC4 is essential for epiblast proliferation and mesoderm induction in mice. Proc. Natl. Acad. Sci. USA 95:3667-3672.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 3667-3672
    • Yang, X.1    Li, C.2    Xu, X.3    Deng, C.4
  • 88
    • 0033960316 scopus 로고    scopus 로고
    • The type I BMP receptor BMPRIB is required for chondrogenesis in the mouse limb
    • YI, S.E., DALUISKI, A., PEDERSON, R., ROSEN, V. and LYONS, K.M. (2000). The type I BMP receptor BMPRIB is required for chondrogenesis in the mouse limb. Development 127:621-630.
    • (2000) Development , vol.127 , pp. 621-630
    • Yi, S.E.1    Daluiski, A.2    Pederson, R.3    Rosen, V.4    Lyons, K.M.5
  • 89
    • 0029850112 scopus 로고    scopus 로고
    • Mice deficient for BMP2 are ncnviable and have defects in amnion/chorion and cardiac development
    • ZHANG, H. and BRADLEY, A. (1996). Mice deficient for BMP2 are ncnviable and have defects in amnion/chorion and cardiac development. Development 122:2977-2986.
    • (1996) Development , vol.122 , pp. 2977-2986
    • Zhang, H.1    Bradley, A.2
  • 90
    • 0027510084 scopus 로고
    • Nodal is a novel TGF-beta-like gene expressed in the mouse node during gastrulation
    • ZHOU, X., SASAKI, H., LOWE, L., HOGAN, B.L. and KUEHN, M.R. (1993). Nodal is a novel TGF-beta-like gene expressed in the mouse node during gastrulation. Nature 361:543-547.
    • (1993) Nature , vol.361 , pp. 543-547
    • Zhou, X.1    Sasaki, H.2    Lowe, L.3    Hogan, B.L.4    Kuehn, M.R.5
  • 91
    • 0032544448 scopus 로고    scopus 로고
    • Smad3 mutant mice develop metastatic colorectal cancer
    • ZHU, Y., RICHARDSON, J.A., PARADA, L.F. and GRAFF, J.M. (1998). Smad3 mutant mice develop metastatic colorectal cancer. Cell 94:703-714.
    • (1998) Cell , vol.94 , pp. 703-714
    • Zhu, Y.1    Richardson, J.A.2    Parada, L.F.3    Graff, J.M.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.