Role of Ras and Mapks in TGFβ signaling

Cytokine and Growth Factor Reviews

Volumn 11, Issue 1-2, 2000, Pages 23-35

  Mulder, Kathleen M ^a  

^a PENN STATE COLLEGE OF MEDICINE   (United States)

Author keywords

AP 1; Autoinduction; Cell cycle; Cross talk; Epithelial; Fos Jun; Mapk; Ras; Sapk; Signaling; Smad; TGF

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; C-JUN AMINO-TERMINAL KINASE; DNA BINDING PROTEIN; EXTRACELLULAR SIGNAL-REGULATED KINASE 1; MEK KINASE; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN C FOS; PROTEIN C JUN; PROTEIN KINASE; PROTEIN SERINE THREONINE KINASE; PROTEIN SMAD3; RAS PROTEIN; SAPK-ERK KINASE 1; SMAD4 PROTEIN; STRESS ACTIVATED PROTEIN KINASE; TRANSACTIVATOR PROTEIN; TRANSCRIPTION FACTOR AP 1; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL; CARCINOMA CELL; CELL LINE; CELLULAR DISTRIBUTION; CYTOKINE PRODUCTION; EPITHELIUM CELL; HUMAN; METABOLISM; MOLECULAR INTERACTION; NONHUMAN; ONCOGENE RAS; PHOSPHORYLATION; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; REVIEW; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

ANIMALS; DNA-BINDING PROTEINS; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MAP KINASE KINASE 4; MAP KINASE KINASE KINASE 1; MAP KINASE SIGNALING SYSTEM; MITOGEN-ACTIVATED PROTEIN KINASE 3; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PROTEIN KINASES; PROTEIN-SERINE-THREONINE KINASES; RAS PROTEINS; SIGNAL TRANSDUCTION; SMAD3 PROTEIN; SMAD4 PROTEIN; TRANS-ACTIVATORS; TRANSCRIPTION FACTOR AP-1; TRANSFORMING GROWTH FACTOR BETA;

ANIMALIA;

EID: 0034023127     PISSN: 13596101     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1359-6101(99)00026-X     Document Type: Review

References (85)

1. Davis R.J. The mitogen-activated protein kinase signal transduction pathway. J. Biol. Chem. 268:1993;14,553-14,556.
2. Marshall C.J. Mapk kinase kinase, Mapk kinase and Mapk. Curr. Opin. Genet. Dev. 4:1994;82-89.
3. Robinson M.J., Cobb M.H. Mitogen-activated protein kinase pathways. Curr. Opin. Cell. Biol. 9:1997;180-186.
4. Whitmarsh A.J., Davis R.J. Transcription factor AP-1 regulation by mitogen-activated protein kinase signal transduction pathways. J. Mol. Med. 74:1996;589-607.
5. Dérijard B., Hibi M., Wu I.-H., Barrett T., Su B., Deng T., Karin M., Davis R.J. JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain. Cell. 76:1994;1025-1037.
6. Russell M., Lange-Carter C., Johnson G.L. Direct interaction between Ras and the kinase domain of mitogen-activated protein kinase kinase kinase (MEKK1). J. Biol. Chem. 270:1995;11,757-11,760.
7. Weinberg R.A. The cat and mouse games that genes, viruses, and cells play. Cell. 88:1997;573-575.
8. ink4a. Cell. 88:1997;593-602.
9. Mulcahay L.S., Smith M.R., Stacey D.W. Requirement for ras protooncogene function during serum stimulated growth of NIH 3T3 cells. Nature. 313:1985;241-243.
10. Hagag N., Halegoua S., Viola M. Inhibition of growth factor induced differentiation of PC12 cells by microinjection of antibody to ras p21. Nature. 319:1986;680-682.
11. Dikic L., Schlessinger J., Lax I. PC12 cells overexpressing the insulin receptor undergo insulin-dependent neuronal differentiation. Curr. Biol. 4:1994;702-708.
12. Traverse S., Seedorf K., Paterson H., Marshall C.J., Cohen P., Ulrich A. EGF triggers neural differentiation of PC12 cells that overexpress the EGF receptor. Curr. Biol. 4:1994;694-701.
13. Chen C.Y., Faller D.V. Direction of p21ras-generated signals towards cell growth or apoptosis is determined by protein kinase C and Bcl-2. Oncogene. 11:1995;1487-1498.
14. Joneson T., Bar-Sagi D. Suppression of Ras-induced apoptosis by the Rac GTPase. Mol. Cell. Biol. 19:1999;5892-5901.
15. Howe P.H., Dobrowsolski S.F., Reddy K.B., Stacey D.W. Release from G1 growth arrest by transforming growth factor beta 1 requires cellular ras activity. J. Biol. Chem. 268:1993;21,448-21,452.
16. Atfi A., Drobetsky E., Boissonneault M., Chapdelaine A., Chevalier S. Transforming growth factor β down-regulates Src family protein tyrosine kinase signaling pathways. J. Biol. Chem. 269:1994;30,688-30,693.
17. mapk in proliferating cultures of epithelial cells. J. Biol. Chem. 270:1995;7117-7124.
18. Chatani Y., Tanimura S., Miyoshi N., Hattori A., Sato M., Kohno M. Cell type-specific modulation of cell growth by transforming growth factor β1 does not correlate with mitogen-activated protein kinase activation. J. Biol. Chem. 270:1995;30,686-30,692.
19. Hartsough M.T., Mulder K.M. TGFβ signaling in epithelial cells. Pharmacol. and Ther. 75:1997;21-42.
20. Filmus J., Zhao J., Buick R.N. Overexpression of H-ras oncogene induces resistance to the growth-inhibitory action of transforming growth factor beta-1 (TGF-β1) and alters the number and type of TGF-β1 receptors in rat intestinal epithelial cell clones. Oncogene. 7:1992;521-526.
21. cdc2 regulation in ras-transfected epithelial cells. Oncogene. 7:1992;1549-1556.
22. Coppa A., Mincione G., Lazzereschi D., Ranieri A., Turco A., Lucignano B., Scarpa S., Ragano-Caracciolo M., Colletta G. Restored expression of transforming growth factor β Type II receptor in k-ras-transformed thyroid cells, TGFβ-resistant, reverts their malignant phenotype. J. Cell. Physiol. 172:1997;200-208.
23. 1 following their transformation with v-raf. Cancer Res. 50:1990;7468-7475.
24. Oft M., Peli J., Rudaz C., Schwarz H., Beug H., Reichmann E. TGF-β1 and Ha-Ras collaborate in modulating the phenotypic plasticity and invasiveness of epithelial tumor cells. Genes. and Dev. 10:1996;2462-2477.
25. Kerr D.I., Plumb J.A., Freshney R.I., Khan M.Z., Spandidos D.A. The effect of H-ras oncogene transfection on response of mink lung epithelial cells to growth factors and cytotoxic drugs. Anticancer. Res. 11:1991;1349-1352.
26. Brown J.D., DiChiara M.R., Anderson K.R., Gimbrone M.A. Jr, Topper J.N. MEKK-1, a component of the stress (stress-activated protein kinase/c-Jun N-terminal kinase) pathway, can selectively activate Smad2-mediated transcriptional activation in endothelial cells. J. Biol. Chem. 274:1999;8797-8805.
27. Magee T., Marshall C. New insights into the interaction of ras with the plasma membrane. Cell. 98:1999;9-12.
28. ras by transforming growth factor β in epithelial cells. J. Biol. Chem. 267:1992;5029-5031.
29. Yan Z., Winawer S., Friedman E. Two different signal transduction pathways can be activated by transforming growth factor beta 1 in epithelial cells. J. Biol. Chem. 269:1994;13,231-13,237.
30. Bhushan A., Lin H.Y., Lodish H.F., Kintner C.R. The transforming growth factor β type II receptor can replace the activin type II receptor in inducing mesoderm. Molecular and Cellular Biology. 14:1994;4280-4285.
31. Mulder K.M., Segarini P.R., Morris S.L., Ziman J.M., Choi H.G. Role of receptor complexes in resistance or sensitivity to growth inhibition by TGFβ in intestinal epithelial cell clones. J. Cell. Physiol. 154:1993;162-174.
32. Heasley L.E., Johnson G.L. The β-PDGF receptor induces neuronal differentiation of PC12 cells. Molecular Biology of the Cell. 3:1992;545-553.
33. Marshall C.J. Specificity of receptor tyrosine kinase signaling: transient vs sustained extracellular signal-regulated kinase activation. Cell. 80:1995;179-185.
34. Yue J., Mulder K.M. Activation of the mitogen-activated protein kinase pathway by transforming growth factor-β Howe P., Transforming growth factor beta protocols. 2000;The Humana Press Inc. In press.
35. Hill C.S., Treisman R. Transcriptional regulation by extracellular signals: mechanisms and specificity. Cell. 80:1995;199-211.
36. Frey R.S., Mulder K.M. Involvement of ERK2 and Sapk/JNK activation by TGFβ in the negative growth control of breast cancer cells. Cancer Res. 57:1997;628-633.
37. Frey R.S., Mulder K.M. TGFβ regulation of mitogen-activated protein kinases in human breast cancer cells. Cancer Lett. 117:1997;41-50.
38. 1 is an autocrine negative growth regulator of human colon carcinoma FET cells in vivo as revealed by transfection of an anti-sense expression vector. J. Cell. Biol. 116:1992;187-196.
39. Kim S.-J., Angel P., Lafyatis R., Hattori K., Kim K.Y., Sporn M.B., Karin M., Roberts A.B. Autoinduction of transforming growth factor beta 1 is mediated by the AP-1 complex. Mol. Cell. Biol. 10:1990;1492-1497.
40. Barnard J.A., Beauchamp R.D., Coffey R.J., Moses H.L. Regulation of intestinal epithelial cell growth by transforming growth factor type beta. Proc. Natl. Acad. Sci. USA. 86:1989;1578-1582.
41. Pertovaara L., Sistonen L., Bos T., Vogt P.K., Keski-Oja J., Alitalo K. Enhanced jun gene expression is an early genomic response to transforming growth factor beta stimulation. Mol. Cell. Biol. 9:1989;1255-1262.
42. Hsu S., Huang F., Hafez M., Winawer S., Friedman E. Colon carcinoma cells switch their response to transforming growth factor beta 1 with tumor progression. Cell Growth and Differen. 5:1994;267-275.
43. Hartsough M.T., Frey R.S., Zipfel P.A., Buard A., Cook S.J., McCormick F., Mulder K.M. Altered TGFβ signaling in epithelial cells when Ras activation is blocked. J. Biol. Chem. 271:1996;22,368-22,375.
44. Cip1 by expression of RasN17 in epithelial cells. Oncogene. 17:1998;47-55.
45. Buard A., Zipfel P.A., Frey R.S., Mulder K.M. Maintenance of growth factor signaling through Ras in human colon carcinoma cells containing K-ras mutations. Int. J. Cancer. 67:1996;539-546.
46. Mulder K.M., Brattain M.G. Effects of growth stimulatory factors on mitogenicity and c-myc expression in poorly-differentiated and well-differentiated human colon carcinoma cells. Mol. Endocrinol. 3:1989;1215-1222.
47. Mulder K.M., Brattain M.G. Growth factor expression and response in human colon carcinoma cells. Augenlicht L., The cell and molecular biology of colon cancer. 1989;45-67 CRC Press, Boca Raton, FL.
48. Mulder K.M., Humphrey L.E., Choi H.G., Childress-Fields K.E., Brattain M.G. Evidence for c-myc in the signaling pathway for TGF-β in well-differentiated human colon carcinoma cells. J. Cell. Physiol. 145:1990;501-507.
49. Mulder K.M. Differential regulation of c-myc and TGF-β mRNA expression in poorly differentiated and well-differentiated colon carcinoma cells during the establishment of a quiescent state. Cancer Res. 51:1991;2256-2262.
50. 1, EGF, and DMF in human colon carcinoma cells. Cell Growth Differen. 4:1993;637-645.
51. 1 on mitogenic response, transforming growth factor-α, and c-myc in well-differentiated human colon carcinoma cells. Cancer Res. 50:1990;7581-7586.
52. Fearon E.R., Vogelstein B. A genetic model for colorectal tumorigenesis. Cell. 61:1990;759-767.
53. Williams A.C., Hague A., Maning A.M., Van Der Stappen J.W.J., Paraskeva C. In vitro models of human colorectal cancer. Cancer Surv. 16:1993;15-29.
54. Johnson L., Greenbaum D., Cichowski K., Mercer K., Murphy E., Schmitt E., Bronson R.T., Umanoff H., Edelmann W., Kucherlapati R., Jacks T. K-ras is an esssential gene in the mouse with partial functional overlap with N-ras. Genes. and Dev. 11:1997;2468-2481.
55. Chesa P.G., Rettig W.J., Melamed M.R., Old L.J., Niman H.L. Expression of p21ras in normal and malignant human tissues: lack of association with proliferation and malignancy. Proc. Natl. Acad. Sci. USA. 84:1987;3234-3238.
56. Furth M.E., Aldrich T.H., Cordon C.C. Expression of ras proto-oncogene proteins in normal human tissues. Oncogene. 1:1987;47-58.
57. Leon J., Guerrero I., Pellicer A. Differential expression of the ras gene family in mice. Mol. Cell. Biol. 7:1987;1535-1540.
58. Bos J.L. Ras oncogenes in human cancer: a review. Cancer Res. 49:1989;4682-4689.
59. 1 autoinduction in a Smad3-dependent pathway, J Biol Chem, In press
60. Yue J, Mulder KM. Requirement of TGFβ Receptor-dependent Activation of JNKs/Sapks for TGFβ Up-regulation of the Urokinase-type Plasminogen Activator Receptor, 1999, submitted
61. Hocevar B.A., Brown T.L., Howe P.H. TGFβ induces fibronectin synthesis through a c-Jun N-terminal kinase-dependent, Smad4-independent pathway. EMBO J. 18:1999;1345-1356.
62. Yue J., Frey R.S., Hartsough M.T., Frielle T., Mulder K.M. Cloning and expression of a rat Smad1: Regulation by TGFβ and modulation by the Ras/MEK pathways. J. Cell. Physiol. 178:1999;387-396.
63. Yue J., Frey R.S., Mulder K.M. Cross-talk between the Smad1 and Ras/MEK signaling pathways for TGFβ Oncogene. 18:1999;2033-2037.
64. Yan M., Dai T., Deak J.C., Kyriakis J.M., Zon L.I., Woodgett J.R., Templeton D.J. Activation of stress-activated protein kinase by MEKK1 phosphorylation of its activator SEK1. Nature. 372:1994;798-800.
65. Sanchez I., Hughes R.T., Mayer B.J., Yee K., Woodgett J.R., Avruch J. Role of SAPK/ERK kinase-1 in the stress activated pathway regulating transcription factor c-Jun. Nature. 372:1994;794-798.
66. Tibbles L.A., Woodgett J.R. The stress-activated protein kinase pathways. Cell. Mol. Life Sci. 55:1999;1230-1254.
67. Virolle T., Monthouel M.N., Djabari Z., Ortonne J.P., Meneguzzi G., Aberdam D. Three activator protein-1-binding sites bound by the Fra-2-JunD complex cooperate for the regulation of murine laminin α3A (Lamα3A) promoter activity by transforming growth factor β J. Biol. Chem. 273:1998;17,318-17,325.
68. Pfarr C.M., Mechta F., Spyrou G., Lallemand D., Carillo S., Yaniv M. Mouse JunD negatively regulates fibroblast growth and antagonizes transformation by ras. Cell. 76:1994;747-760.
69. Matsui M., Tokuhara M., Konuma Y., Nomura N., Ishizaki R. Isolation of human fos-related genes and their expression during monocyte-macrophage differentiation. Oncogene. 5:1990;249-255.
70. Riesgo-Escovar J.R., Hafen E. Drosophila Jun kinase regulates expression of decapentaplegic via the ETS-domain protein Aop and the AP-1 transcription factor Djun during dorsal closure. Genes. and Dev. 11:1997;1717-1727.
71. Hou X.S., Goldstein E.S., Perrimon N. Drosophila Jun relays the Jun amino-terminal kinase signal transduction pathway to the Decapentaplegic signal transduction pathway in regulating epithelial cell sheet movement. Genes. and Dev. 11:1997;1728-1737.
72. Noselli S. JNK signaling and morphogenesis in Drosophila. Trends Genet. 14:1998;33-38.
73. Witsotzkey R.G., Mehra A., Sutherland D.J., Dobens L.L., Liu X., Dohrmann C., Attisano L., Raftery L.A. Medea is a Drosophila Smad4 homolog that is differentially required to potentiate DPP responses. Development. 125:1998;1433-1445.
74. Hahn S.A., Schutte M., Shamsul Hoque A.T.M., Moskaluk C.A., da Costa L.T., Rozenblum E., Weinstein C.L., Fischer A., Yeo C.J., Hruban R.H., Kern S.E. DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1. Science. 271:1996;350-353.
75. Chen C.Y., Lebrun J.-J., Vale W. Regulation of transforming growth factor-β and activin-induced transcription by mammalian Mad proteins. Proc. Natl. Acad. Sci. USA. 93:1996;12,992-12,997.
76. Liu X., Yue J., Frey R.S., Zhu Q., Mulder K.M. TGFβ signaling through Smad1 in human breast cancer cells. Cancer Res. 58:1998;4752-4757.
77. Liu X, Mulder KM. Enhancement of TGFβ-mediated Transcriptional Activation of the Smad Binding Element by Smad1, 1999, submitted
78. Tsukazaki T., Chiang T.A., Davison A.F., Attisano L., Wrana J.L. SARA, a FYVE domain protein that recruits Smad2 to the TGF beta receptor. Cell. 95:1998;779-791.
79. Peterson B.O., Lukas J., Sorenson C.S., Bartek J., Helin K. Phosphorylation of mammalian CDC6 by cyclin A/CDK2 regulates its subcellular localization. EMBO J. 18:1999;804-816.
80. Biggs W.H. III, Meisenhelder J., Hunter T., Cavenee W.K., Arden K. Protein kinase B/Akt-mediated phosphorylation promotes nuclear exclusion of the winged helix transcription factor FKHR1. Proc. Natl. Acad. Sci. USA. 96:1999;7421-7426.
81. Le Gallic L., Sgouras D., Beal G. Jr, Mavrothalassitis G. Transcriptional repressor ERF is a Ras/mitogen-activated protein kinase target that regulates cellular proliferation. Mol. Cell. Biol. 19:1999;4121-4133.
82. Itoh S., Landstrom M., Hermansson A., Itoh F., Heldin C.H., Heldin N.E., ten Dijke P. Transforming growth factor beta1 induces nuclear export of inhibitory Smad7. J. Biol. Chem. 273:1998;29,195-29,201.
83. Macias-Silva M., Abdollah S., Hoodless P.A., Pirone R., Attisano L., Wrana J.L. MADR2 is a substrate of the TGFbeta receptor and its phosphorylation is required for nuclear accumulation and signaling. Cell. 87:1996;1215-1224.
84. Hoodless P.A., Haerry T., Abdollah S., Stapleton M., O'Connor M.B., Attisano L., Wrana J.L. MADR1, a MAD-related protein that functions in BMP2 signaling pathways. Cell. 85:1996;489-500.
85. Ferreli J.E. Jr. Tripping the switch fantastic: how a protein kinase cascade can convert graded inputs into switch-like outputs. Trends Biochem Sci. 21:1996;460-466.