메뉴 건너뛰기




Volumn 64, Issue 20, 2004, Pages 7596-7603

RNA interference targeting transforming growth factor-β enhances NKG2D-mediated antiglioma immune response, inhibits glioma cell migration and invasiveness, and abrogates tumorigenicity in vivo

Author keywords

[No Author keywords available]

Indexed keywords

CD8 ANTIGEN; MICA RECEPTOR; NATURAL KILLER CELL RECEPTOR NKG2D; RECEPTOR PROTEIN; SMALL INTERFERING RNA; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA1; TRANSFORMING GROWTH FACTOR BETA2; UNCLASSIFIED DRUG;

EID: 5644248080     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-04-1627     Document Type: Article
Times cited : (275)

References (46)
  • 1
    • 84902224552 scopus 로고    scopus 로고
    • Primary tumors of the central and peripheral nervous system
    • Brandt T, Caplan LR, Dichgans J, Diener HC, Kennard C, editors. San Diego, CA: Academic Press
    • Weller M, Thomas DGT. Primary tumors of the central and peripheral nervous system. In: Brandt T, Caplan LR, Dichgans J, Diener HC, Kennard C, editors. Course and treatment of neurological disorders, 2nd ed. San Diego, CA: Academic Press; 2003. p. 827-63.
    • (2003) Course and Treatment of Neurological Disorders, 2nd Ed. , pp. 827-863
    • Weller, M.1    Thomas, D.G.T.2
  • 2
    • 0029610610 scopus 로고
    • The failure of current immunotherapy for malignant glioma. Tumor-derived TGF-beta, T-cell apoptosis, and the immune privilege of the brain
    • Weller M, Fontana A. The failure of current immunotherapy for malignant glioma. Tumor-derived TGF-beta, T-cell apoptosis, and the immune privilege of the brain. Brain Res Brain Res Rev 1995;21:128-51.
    • (1995) Brain Res Brain Res Rev , vol.21 , pp. 128-151
    • Weller, M.1    Fontana, A.2
  • 3
    • 0033385442 scopus 로고    scopus 로고
    • Immunobiology of the blood-brain barrier
    • Miller DW. Immunobiology of the blood-brain barrier. J Neurovirol 1999;5:570-8.
    • (1999) J Neurovirol , vol.5 , pp. 570-578
    • Miller, D.W.1
  • 4
    • 0036379786 scopus 로고    scopus 로고
    • All in the head: Obstacles for immune rejection of brain tumours
    • Walker PR, Calzascia T, Dietrich PY. All in the head: obstacles for immune rejection of brain tumours. Immunology 2002;107:28-38.
    • (2002) Immunology , vol.107 , pp. 28-38
    • Walker, P.R.1    Calzascia, T.2    Dietrich, P.Y.3
  • 5
    • 0021344432 scopus 로고
    • Glioblastoma cells release interleukin 1 and factors inhibiting interleukin 2-mediated effects
    • Fontana A, Hengartner H, de Tribolet N, Weber E. Glioblastoma cells release interleukin 1 and factors inhibiting interleukin 2-mediated effects. J Immunol 1984; 132:1837-44.
    • (1984) J Immunol , vol.132 , pp. 1837-1844
    • Fontana, A.1    Hengartner, H.2    De Tribolet, N.3    Weber, E.4
  • 6
    • 0024399070 scopus 로고
    • Immunosuppression and transforming growth factor-beta in glioblastoma. Preferential production of transforming growth factor-beta 2
    • Bodmer S, Strommer K, Frei K, et al. Immunosuppression and transforming growth factor-beta in glioblastoma. Preferential production of transforming growth factor-beta 2. J Immunol 1989;143:3222-9.
    • (1989) J Immunol , vol.143 , pp. 3222-3229
    • Bodmer, S.1    Strommer, K.2    Frei, K.3
  • 7
    • 0035877007 scopus 로고    scopus 로고
    • Processing of immunosuppressive pro-TGF-beta 1,2 by human glioblastoma cells involves cytoplasmic and secreted furin-like proteases
    • Leitlein J, Aulwurm S, Waltereit R, et al. Processing of immunosuppressive pro-TGF-beta 1,2 by human glioblastoma cells involves cytoplasmic and secreted furin-like proteases. J Immunol 2001;166:7238-43.
    • (2001) J Immunol , vol.166 , pp. 7238-7243
    • Leitlein, J.1    Aulwurm, S.2    Waltereit, R.3
  • 8
    • 0027154692 scopus 로고
    • Detection of active form of transforming growth factor-beta in cerebrospinal fluid of patients with glioma
    • Tada T, Yabu K, Kobayashi S. Detection of active form of transforming growth factor-beta in cerebrospinal fluid of patients with glioma. Jpn J Cancer Res 1993;84: 544-8.
    • (1993) Jpn J Cancer Res , vol.84 , pp. 544-548
    • Tada, T.1    Yabu, K.2    Kobayashi, S.3
  • 9
    • 0028335982 scopus 로고
    • Analysis of cytokine receptor messenger RNA expression in human glioblastoma cells and normal astrocytes by reverse-transcription polymerase chain reaction
    • Tada M, Diserens AC, Desbaillets I, de Tribolet N. Analysis of cytokine receptor messenger RNA expression in human glioblastoma cells and normal astrocytes by reverse-transcription polymerase chain reaction. J Neurosurg 1994;80:1063-73.
    • (1994) J Neurosurg , vol.80 , pp. 1063-1073
    • Tada, M.1    Diserens, A.C.2    Desbaillets, I.3    De Tribolet, N.4
  • 10
    • 0025741809 scopus 로고
    • Human glioblastoma cell derived transforming growth factor-beta 2: Evidence for secretion of both high and low molecular weight biologically active forms
    • Bodmer S, Huber D, Heid I, Fontana A. Human glioblastoma cell derived transforming growth factor-beta 2: evidence for secretion of both high and low molecular weight biologically active forms. J Neuroimmunol 1991;34:33-42.
    • (1991) J Neuroimmunol , vol.34 , pp. 33-42
    • Bodmer, S.1    Huber, D.2    Heid, I.3    Fontana, A.4
  • 11
    • 0027230932 scopus 로고
    • Factors, including transforming growth factor beta, released in the glioblastoma residual cavity, impair activity of adherent lymphokine-activated killer cells
    • Ruffini PA, Rivoltini L, Silvani A, Boiardi A, Parmiani G. Factors, including transforming growth factor beta, released in the glioblastoma residual cavity, impair activity of adherent lymphokine-activated killer cells. Cancer Immunol Immunother 1993;36:409-16.
    • (1993) Cancer Immunol Immunother , vol.36 , pp. 409-416
    • Ruffini, P.A.1    Rivoltini, L.2    Silvani, A.3    Boiardi, A.4    Parmiani, G.5
  • 12
    • 0024654697 scopus 로고
    • Immunocytochemical study of transforming growth factor expression in benign and malignant gliomas
    • Samuels V, Barrett JM, Bockman S, Pantazis CG, Allen MB Jr. Immunocytochemical study of transforming growth factor expression in benign and malignant gliomas. Am J Pathol 1989;134:894-902.
    • (1989) Am J Pathol , vol.134 , pp. 894-902
    • Samuels, V.1    Barrett, J.M.2    Bockman, S.3    Pantazis, C.G.4    Allen Jr., M.B.5
  • 13
    • 0033934907 scopus 로고    scopus 로고
    • Expression of TGF-beta isoforms, TGF-beta receptors, and SMAD molecules at different stages of human glioma
    • Kjellman C, Olofsson SP, Hansson O, et al. Expression of TGF-beta isoforms, TGF-beta receptors, and SMAD molecules at different stages of human glioma. Int J Cancer 2000;89:251-8.
    • (2000) Int J Cancer , vol.89 , pp. 251-258
    • Kjellman, C.1    Olofsson, S.P.2    Hansson, O.3
  • 14
    • 0036372440 scopus 로고    scopus 로고
    • Transforming growth factor-beta in T-cell biology
    • Gorelik L, Flavell RA. Transforming growth factor-beta in T-cell biology. Nat Rev Immunol 2002;2:46-53.
    • (2002) Nat Rev Immunol , vol.2 , pp. 46-53
    • Gorelik, L.1    Flavell, R.A.2
  • 15
    • 0034785348 scopus 로고    scopus 로고
    • TGF-beta signaling in tumor suppression and cancer progression
    • Derynck R, Akhurst RJ, Balmain A. TGF-beta signaling in tumor suppression and cancer progression. Nat Genet 2001;29:117-29.
    • (2001) Nat Genet , vol.29 , pp. 117-129
    • Derynck, R.1    Akhurst, R.J.2    Balmain, A.3
  • 16
    • 0242499448 scopus 로고    scopus 로고
    • Cytostatic and apoptotic actions of TGF-beta in homeostasis and cancer
    • Siegel PM, Massague J. Cytostatic and apoptotic actions of TGF-beta in homeostasis and cancer. Nat Rev Cancer 2003;3:807-21.
    • (2003) Nat Rev Cancer , vol.3 , pp. 807-821
    • Siegel, P.M.1    Massague, J.2
  • 17
    • 0036512208 scopus 로고    scopus 로고
    • New functions for the matrix metalloproteinases in cancer progression
    • Egeblad M, Werb Z. New functions for the matrix metalloproteinases in cancer progression. Nat Rev Cancer 2002;2:161-74.
    • (2002) Nat Rev Cancer , vol.2 , pp. 161-174
    • Egeblad, M.1    Werb, Z.2
  • 18
    • 0034867240 scopus 로고    scopus 로고
    • Molecular determinants of glioma cell migration and invasion
    • Wild-Bode C, Weller M, Wick W. Molecular determinants of glioma cell migration and invasion. J Neurosurg 2001;94:978-84.
    • (2001) J Neurosurg , vol.94 , pp. 978-984
    • Wild-Bode, C.1    Weller, M.2    Wick, W.3
  • 19
    • 0033618504 scopus 로고    scopus 로고
    • Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICA
    • Wash DC
    • Bauer S, Groh V, Wu J, et al. Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICA. Science (Wash DC) 1999;285:727-9.
    • (1999) Science , vol.285 , pp. 727-729
    • Bauer, S.1    Groh, V.2    Wu, J.3
  • 20
    • 0035949563 scopus 로고    scopus 로고
    • Ectopic expression of retinoic acid early inducible-1 gene (RAE-1) permits natural killer cell-mediated rejection of a MHC class I-bearing tumor in vivo
    • Cerwenka A, Baron JL, Lanier LL. Ectopic expression of retinoic acid early inducible-1 gene (RAE-1) permits natural killer cell-mediated rejection of a MHC class I-bearing tumor in vivo. Proc Natl Acad Sci USA 2001;98:11521-6.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 11521-11526
    • Cerwenka, A.1    Baron, J.L.2    Lanier, L.L.3
  • 21
    • 0035855872 scopus 로고    scopus 로고
    • Rael and H60 ligands of the NKG2D receptor stimulate tumour immunity
    • Diefenbach A, Jensen ER, Jamieson AM, Raulet DH. Rael and H60 ligands of the NKG2D receptor stimulate tumour immunity. Nature (Lond) 2001;413:165-71.
    • (2001) Nature (Lond) , vol.413 , pp. 165-171
    • Diefenbach, A.1    Jensen, E.R.2    Jamieson, A.M.3    Raulet, D.H.4
  • 22
    • 0035914134 scopus 로고    scopus 로고
    • Regulation of cutaneous malignancy by gammadelta T cells
    • Wash DC
    • Girardi M, Oppenheim DE, Steele CR, et al. Regulation of cutaneous malignancy by gammadelta T cells. Science (Wash DC) 2001;294:605-9.
    • (2001) Science , vol.294 , pp. 605-609
    • Girardi, M.1    Oppenheim, D.E.2    Steele, C.R.3
  • 23
    • 9144273780 scopus 로고    scopus 로고
    • MICA/NKG2D-mediated immunogene therapy of experimental gliomas
    • Friese MA, Platten M, Lutz SZ, et al. MICA/NKG2D-mediated immunogene therapy of experimental gliomas. Cancer Res 2003;63:8996-9006.
    • (2003) Cancer Res , vol.63 , pp. 8996-9006
    • Friese, M.A.1    Platten, M.2    Lutz, S.Z.3
  • 24
    • 0028198760 scopus 로고
    • A second lineage of mammalian major histocompatibility complex class I genes
    • Bahram S, Bresnahan M, Geraghty DE, Spies T. A second lineage of mammalian major histocompatibility complex class I genes. Proc Natl Acad Sci USA 1994;91: 6259-63.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 6259-6263
    • Bahram, S.1    Bresnahan, M.2    Geraghty, D.E.3    Spies, T.4
  • 25
    • 0029861713 scopus 로고    scopus 로고
    • Cell stress-regulated human major histocompatibility complex class I gene expressed in gastrointestinal epithelium
    • Groh V, Bahram S, Bauer S, et al. Cell stress-regulated human major histocompatibility complex class I gene expressed in gastrointestinal epithelium. Proc Natl Acad Sci USA 1996;93:12445-50.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 12445-12450
    • Groh, V.1    Bahram, S.2    Bauer, S.3
  • 26
    • 0035347169 scopus 로고    scopus 로고
    • Complex structure of the activating immunoreceptor NKG2D and its MHC class I-like ligand MICA
    • Li P, Morris DL, Willcox BE, et al. Complex structure of the activating immunoreceptor NKG2D and its MHC class I-like ligand MICA. Nat Immunol 2001;2:443-51.
    • (2001) Nat Immunol , vol.2 , pp. 443-451
    • Li, P.1    Morris, D.L.2    Willcox, B.E.3
  • 27
    • 0033536068 scopus 로고    scopus 로고
    • Broad tumor-associated expression and recognition by tumor-derived gamma delta T cells of MICA and MICB
    • Groh V, Rhinehart R, Secrist H, et al. Broad tumor-associated expression and recognition by tumor-derived gamma delta T cells of MICA and MICB. Proc Natl Acad Sci USA 1999;96:6879-84.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 6879-6884
    • Groh, V.1    Rhinehart, R.2    Secrist, H.3
  • 28
    • 0037066502 scopus 로고    scopus 로고
    • Decoding the patterns of self and nonself by the innate immune system
    • Wash DC
    • Medzhitov R, Janeway CA Jr. Decoding the patterns of self and nonself by the innate immune system. Science (Wash DC) 2002;296:298-300.
    • (2002) Science , vol.296 , pp. 298-300
    • Medzhitov, R.1    Janeway Jr., C.A.2
  • 29
    • 0037258399 scopus 로고    scopus 로고
    • Selective intracellular retention of virally induced NKG2D ligands by the human cytomegalovirus UL16 glycoprotein
    • Welte SA, Sinzger C, Lutz SZ et al. Selective intracellular retention of virally induced NKG2D ligands by the human cytomegalovirus UL16 glycoprotein. Eur J Immunol 2003;33:194-203.
    • (2003) Eur J Immunol , vol.33 , pp. 194-203
    • Welte, S.A.1    Sinzger, C.2    Lutz, S.Z.3
  • 30
    • 0038458973 scopus 로고    scopus 로고
    • Human malignant glioma cells express semaphorins and their receptors, neuropilins and plexins
    • Rieger J, Wick W, Weller M. Human malignant glioma cells express semaphorins and their receptors, neuropilins and plexins. Glia 2003;42:379-89
    • (2003) Glia , vol.42 , pp. 379-389
    • Rieger, J.1    Wick, W.2    Weller, M.3
  • 31
    • 0029986943 scopus 로고    scopus 로고
    • Characterization of a cell line, NKL, derived from an aggressive human natural killer cell leukemia
    • Robertson MJ, Cochran KJ, Cameron C, et al. Characterization of a cell line, NKL, derived from an aggressive human natural killer cell leukemia. Exp Hematol 1996; 24:406-15.
    • (1996) Exp Hematol , vol.24 , pp. 406-415
    • Robertson, M.J.1    Cochran, K.J.2    Cameron, C.3
  • 32
    • 0037134020 scopus 로고    scopus 로고
    • A system for stable expression of short interfering RNAs in mammalian cells
    • Wash DC
    • Brummelkamp TR, Bernards R, Agami R. A system for stable expression of short interfering RNAs in mammalian cells. Science (Wash DC) 2002;296:550-3.
    • (2002) Science , vol.296 , pp. 550-553
    • Brummelkamp, T.R.1    Bernards, R.2    Agami, R.3
  • 33
    • 0031717878 scopus 로고    scopus 로고
    • Decorin gene transfer-mediated suppression of TGF-beta synthesis abrogates experimental malignant glioma growth in vivo
    • Ständer M, Naumann U, Dumitrescu L, et al. Decorin gene transfer-mediated suppression of TGF-beta synthesis abrogates experimental malignant glioma growth in vivo. Gene Ther 1998;5:1187-94.
    • (1998) Gene Ther , vol.5 , pp. 1187-1194
    • Ständer, M.1    Naumann, U.2    Dumitrescu, L.3
  • 34
    • 0026496172 scopus 로고
    • TGF beta signals through a heteromeric protein kinase receptor complex
    • Wrana JL, Attisano L, Carcamo J, et al. TGF beta signals through a heteromeric protein kinase receptor complex. Cell 1992;71:1003-14.
    • (1992) Cell , vol.71 , pp. 1003-1014
    • Wrana, J.L.1    Attisano, L.2    Carcamo, J.3
  • 35
    • 0033760187 scopus 로고    scopus 로고
    • AP-1 proteins mediate hyperglycemia-induced activation of the human TGF-beta 1 promoter in mesangial cells
    • Weigert C, Sauer U, Brodbeck K, et al. AP-1 proteins mediate hyperglycemia-induced activation of the human TGF-beta 1 promoter in mesangial cells. J Am Soc Nephrol 2000;11:2007-16.
    • (2000) J Am Soc Nephrol , vol.11 , pp. 2007-2016
    • Weigert, C.1    Sauer, U.2    Brodbeck, K.3
  • 36
    • 33845382806 scopus 로고
    • Non-parametric estimation from incomplete observations
    • Kaplan EL, Meyer P. Non-parametric estimation from incomplete observations. J Am Stat Assoc 1958;53:457-81.
    • (1958) J Am Stat Assoc , vol.53 , pp. 457-481
    • Kaplan, E.L.1    Meyer, P.2
  • 37
    • 0013886333 scopus 로고
    • Evaluation of survival data and two new rank order statistics arising in its consideration
    • Mantel N. Evaluation of survival data and two new rank order statistics arising in its consideration. Cancer Chemother Rep 1966;50:163-70.
    • (1966) Cancer Chemother Rep , vol.50 , pp. 163-170
    • Mantel, N.1
  • 38
    • 0037388134 scopus 로고    scopus 로고
    • Transforming growth factor beta 1 inhibits expression of NKp30 and NKG2D receptors: Consequences for the NK-mediated killing of dendritic cells
    • Castriconi R, Cantoni C, Della Chiesa M, et al. Transforming growth factor beta 1 inhibits expression of NKp30 and NKG2D receptors: consequences for the NK-mediated killing of dendritic cells. Proc Natl Acad Sci USA 2003;100:4120-5.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 4120-4125
    • Castriconi, R.1    Cantoni, C.2    Della Chiesa, M.3
  • 39
    • 2942588777 scopus 로고    scopus 로고
    • Elevated TGF-beta1 secretion and down-modulation of NKG2D underlies impaired NK cytotoxicity in cancer patients
    • Lee JC, Lee KM, Kim DW, Heo DS. Elevated TGF-beta1 secretion and down-modulation of NKG2D underlies impaired NK cytotoxicity in cancer patients. J Immunol 2004;172:7335-40.
    • (2004) J Immunol , vol.172 , pp. 7335-7340
    • Lee, J.C.1    Lee, K.M.2    Kim, D.W.3    Heo, D.S.4
  • 40
    • 0036569659 scopus 로고    scopus 로고
    • A functional role of HLA-G expression in human gliomas: An alternative strategy of immune escape
    • Wiendl H, Mitsdoerffer M, Hofmeister V, et al. A functional role of HLA-G expression in human gliomas: an alternative strategy of immune escape. J Immunol 2002;168:4772-80.
    • (2002) J Immunol , vol.168 , pp. 4772-4780
    • Wiendl, H.1    Mitsdoerffer, M.2    Hofmeister, V.3
  • 41
    • 0036570241 scopus 로고    scopus 로고
    • Identification of CD70-mediated apoptosis of immune effector cells as a novel immune escape pathway of human glioblastoma
    • Wischhusen J, Jung G, Radovanovic I, et al. Identification of CD70-mediated apoptosis of immune effector cells as a novel immune escape pathway of human glioblastoma. Cancer Res 2002;62:2592-9.
    • (2002) Cancer Res , vol.62 , pp. 2592-2599
    • Wischhusen, J.1    Jung, G.2    Radovanovic, I.3
  • 42
    • 0036812626 scopus 로고    scopus 로고
    • The innate immune response to tumors and its role in the induction of T-cell immunity
    • Diefenbach A, Raulet DH. The innate immune response to tumors and its role in the induction of T-cell immunity. Immunol Rev 2002;188:9-21.
    • (2002) Immunol Rev , vol.188 , pp. 9-21
    • Diefenbach, A.1    Raulet, D.H.2
  • 43
    • 0037126310 scopus 로고    scopus 로고
    • Tumour-derived soluble MIC ligands impair expression of NKG2D and T-cell activation
    • Groh V, Wu J, Yee C, Spies T. Tumour-derived soluble MIC ligands impair expression of NKG2D and T-cell activation. Nature (Lond) 2002;419:734-8.
    • (2002) Nature (Lond) , vol.419 , pp. 734-738
    • Groh, V.1    Wu, J.2    Yee, C.3    Spies, T.4
  • 44
    • 0041737535 scopus 로고    scopus 로고
    • Molecular mechanisms of glioma invasiveness: The role of proteases
    • Rao JS. Molecular mechanisms of glioma invasiveness: the role of proteases. Nat Rev Cancer 2003;3:489-501.
    • (2003) Nat Rev Cancer , vol.3 , pp. 489-501
    • Rao, J.S.1
  • 45
    • 0034770605 scopus 로고    scopus 로고
    • Immune-mediated eradication of tumors through the blockade of transforming growth factor-beta signaling in T cells
    • Gorelik L, Flavell RA. Immune-mediated eradication of tumors through the blockade of transforming growth factor-beta signaling in T cells. Nat Med 2001;7:1118-22.
    • (2001) Nat Med , vol.7 , pp. 1118-1122
    • Gorelik, L.1    Flavell, R.A.2
  • 46
    • 0032921601 scopus 로고    scopus 로고
    • Transforming growth factor-beta-induced expression of CD94/NKG2A inhibitory receptors in human T lymphocytes
    • Bertone S, Schiavetti F, Bellomo R, et al. Transforming growth factor-beta-induced expression of CD94/NKG2A inhibitory receptors in human T lymphocytes. Eur J Immunol 1999;29:23-9.
    • (1999) Eur J Immunol , vol.29 , pp. 23-29
    • Bertone, S.1    Schiavetti, F.2    Bellomo, R.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.