Prolonged survival of rats with intracranial C6 gliomas by treatment with TGF-β antisense gene

Neurological Research

Volumn 20, Issue 8, 1998, Pages 742-747

  Liau, Linda M ^a   Fakhrai, Habib ^b   Black, Keith L ^c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b NovaRx/Gene Therapy for Cancer   (United States)

^c CEDARS SINAI MEDICAL CENTER   (United States)

Author keywords

Brain neoplasm; C6 glioma; Cytokines; Gene therapy; Immunotherapy; Rat; Transforming growth factor

Indexed keywords

ANTISENSE OLIGODEOXYNUCLEOTIDE; TRANSFORMING GROWTH FACTOR BETA;

ADOLESCENT; ANIMAL CELL; ANIMAL TISSUE; CANCER IMMUNOTHERAPY; CANCER SURVIVAL; FEMALE; GENE THERAPY; GENETIC TRANSFECTION; GLIOMA; HISTOPATHOLOGY; NONHUMAN; RAT; REVIEW;

EID: 0031698247     PISSN: 01616412     EISSN: None     Source Type: Journal    
DOI: 10.1080/01616412.1998.11740594     Document Type: Review

References (44)

1. Cesano A, Visonneau S, Santoli D. Treatment of experimental glioblastoma with a human major histocompatibility complex nonrestricted cytotoxic T-cell line. Cancer Res 1995; 55: 96-101
2. Rubin JT, Lotze MT. Adoptive cellular immunotherapy of cancer. In: Mitchell MS, ed. Biological Approaches to Cancer Treatment: Biomodulation, New York: McGraw-Hill, Inc., 1993: pp. 379-410
3. Saris S, Spiess P, Lieberman D, Lin S, Walbridge S, Oldfield E. Treatment of murine primary brain tumors with systemic interleukin-2 and tumor-infiltrating lymphocytes. J Neurosurg 1992; 76: 513-519
4. Schneider J, Hofman F, Apuzzo M, Hinton D. Cytokines and immunoregulatory molecules in malignant glial neoplasms. J Neurosurg 1992; 77: 265-273
5. Wen PY. Clinical experience with immunotherapy. In: Black P, Schoene W, Lampson L, eds. Astrocytomas: Diagnosis, Treatment, and Biology, Boston: Blackwell Scientific, 1993: pp. 123-147
6. Rapoport SI. Blood-Brain Barrier in Physiology and Medicine, New York: Raven Press, 1976
7. Kurpad S, Wikstrand C, Bigner D. Immunobiology of malignant astrocytomas. Semin Oncol 1994; 21: 149-161
8. Roszman T, Elliott L, Brooks W. Modulation of T-cell fuction by gliomas. Immunology Today 1991; 12: 370-374
9. Hickey W, Hsu B, Kimura H. T-lymphocyte entry into the central nervous system. J Neurosci Res 1991; 28: 254-260
10. Couraud P. Interactions between lymphocytes, macrophages, and central nervous system cells. J Leukoc Biol 1994; 56: 407-415
11. Akbasak A, Oldfield E, Saris S. Expression and modulation of major histocompatibility antigens on murine primary brain tumor in vitro. J Neurosurg 1991; 75: 922-929
12. Cserr H, Knopf P. Cervical lymphatics, the blood-brain barrier, and the immunoreactivity of the brain: A new view. Immunol Today 1992; 13: 507-512
13. Luheshi G, Hammond E, Van Dam A. Cytokines as messengers of neuroimmune interactions. TINS 1996; 19: 46-47
14. Woodroofe M. Cytokine production in the central nervous system. Neurology 1995; 45(Suppl 6): S6-S10
15. Grimm EA. Biological therapy failures: Sanctuaries for tumors. In: Mitchell MS, ed. Biological Approaches to Cancer Treatment: Biomodulation, New York: McGraw-Hill, Inc., 1993: pp. 172-180
16. Williams N. An immune boost to the war on cancer.Science 1996; 272: 28-30
17. Black K, Chen K, Becker D, Merril J. Inflammatory leukocytes associated with increased immunosuppression by glioblastoma. J Neurosurg 1992; 77: 120-126
18. 1 inhibits growth and tumorgenicity and enhances Fas-mediated apoptosis in a murine high-grade glioma model. Cancer Res 1998; 58: 302-309
19. Sampson J, Ashley D, Archer G, Fuchs H, Dranoff G, Hale L, Bigner D. Characterization of a spontaneous murine astrocytoma and abrogation of its tumorgenicity by cytokine secretion. Neurosurgery 1997; 41: 1365-1372
20. Bethea J, Gillespie G, Chung I. Tumor necrosis factor production and receptor expression by human malignant glioma cell line, D-54MG. J Neuroimmunol 1990; 30: 1-13
21. Bodmer S, Stromer K, Frei K, Siepl C, De Tribolet N, Heid I, Fontana A. Immunosuppression and transforming growth factor-β in glioblastoma. J Immunology 1989; 143: 3222-3229
22. Cowan E, Pierce M, Dhib-Jalbut S. Interleukin-1β decreases HLA class II expression on a glioblastoma multiforme cell line. J Neuroimmunol 1991; 33: 17-28
23. 2 in primary human glioblastomas on immunosuppression and loss of immune surveillance. J Neurosurg 1992; 76: 799-804
24. 1 cDNA escapes immune surveillance. Proc Natl Acad Sci USA 1990; 87: 1486-1490
25. Caux C, Dezutter-Dambuyant D, Schmitt D, Banchereau J. GM-CSF and TNF-α cooperate in the generation of dendritic Langerhans cells. Nature 1992; 360: 258-261
26. Cavallo F, Giovarelli M, Gulino A, Vacca A, Stoppacciaro A, Modesti A, Forni G. Role of neutrophils and CD4+ T-lymphocytes in the primary and memory response to nonimmunogenic murine mammary adenocarcinoma made immunogenic by IL-2 gene. J Immunology 1992; 149: 3627-3635
27. Colombo M, Ferrari G, Stoppacciaro A, Parenza M, Rodolfo M, Mavilio F, Parmiani G. Granulocyte colony-stimulating factor gene transfer suppresses tumorigenicity of a murine adenocarcinoma in vivo. J Exp Med 1991; 173: 889-897
28. Fakhrai H, Shawler D, Gherset R, Naviaux R, Koziol J, Royston I, Sobol R. Cytokine gene therapy with interleukin-2-transduced fibroblasts: Effects of IL-2 dose on anti-tumor immunity. Human Gene Therapy 1995; 6: 631-641
29. Fearon E, Pardoll D, Itaya T, Golumbek P, Levitsky H, Simons J, Karasuyama H, Vogelstein B, Frost P. Interleukin-2 production by tumor cells bypass T-helper function in the generation of an antitumor response. Cell 1990; 60: 397-403
30. Lichtor T, Glick R, Kim T, Hand R, Cohen E. Prolonged survival of mice with glioma injected intracerebrally with double cytokine-secreting cells. J Neurosurg 1995; 83: 1038-1044
31. Hong L, Johannsen L, Krueger J, et al. Modulation of human leukocyte antigen DR expression in glioblastoma cells by interferon-γ and other cytokines. J Neuroimmunol 1991; 35: 139-152
32. Moses H, Sasaki A, Ting J. Identification of an interferon-γ responsive element of class II major histocompatability gene in rat type I astrocytes. J Neuroimmunol 1991; 35: 273-278
33. Shawler D, Dorigo O, Gjerset R, Royston I, Sobol R, Fakhrai H. Comparison of gene therapy with interleukin-2 gene modified fibroblasts and tumor cells in the murine CT-26 model of colorectal carcinoma. J Immunotherapy 1995; 17: 201-208
34. Sobol R, Fakhrai H, Shawler D, Gjerset R, Dorigo O, Carson C, Khaleghi T, Koziol J, Shiftan T, Royston I. Interleukin-2 gene therapy in a patient with glioblastoma. Gene Therapy 1995; 2: 1-4
35. de Martin R, Haendler B, Hofer-Warbinek R, et al. Complementary DNA for human glioblastoma-derived T-cell suppressor factor, a novel member of the transforming growth factor-beta gene family. EMBO J 1987; 6: 673-677
36. 2: Evidence for secretion of both high and low molecular weight biologically active forms. J Neuroimmunol 1991; 34: 33-42
37. Fakhrai H, Dorigo O, Shawler D, Lin H, Mercola D, Black K, Royston I, Sobol R. Eradication of established intracranial rat gliomas by transforming growth factor β antisense gene therapy. Proc Natl Acad Sci USA1996; 93: 2909-2914
38. Mercola D, Cohen J. Antisense approach to cancer gene therapy. Cancer Gene Therapy 1995; 2: 1-13
39. Andreason G, Evans G. Introduction and expression of DNA molecules in eukaryotic cells by electroporation. BioTechniques 1988; 6: 650-660
40. Baum C, Forster P, Hegewisch-Becker S, Harbers K. An optimized electroporation protocol applicable to a wide range of cell lines. BioTechniques 1994; 17: 1058-1062
41. Saleh M, Stacker S, Wilks A. Inhibition of growth of C6 glioma cells in vivo by expression of antisense vascular endothelial growth factor sequence. Cancer Res 1996; 56: 393-401
42. Randal L, Wadhwa M, Thorpe R, Mire-Sluis A. A novel, sensitive bioassay for transforming growth factor β. J Immunol Meth 1993; 164: 61-67
43. Fenstermaker R, Capala J, Barth R, Hujer A, Kung H-J, Kaetzel D. The effect of epidermal growth factor receptor (EGFR) expression on in vivo growth of rat C6 glioma cells. Leukemia 1995; 9(Suppl. 1): S106-S112
44. Trojan J, Johnson T, Rudlin S, Ilan J, Tykocinski M, Ilan J. Treatment and prevention of rat glioblastoma by C6 cells expressing antisense IGF-1 RNA. Science 1993; 259: 94-97