-
1
-
-
84970501665
-
-
Schmidt RF, Thews G Eds, Berlin, Springer-Verlag
-
Grote J. In Schmidt RF, Thews G Eds. Human Physiology. Berlin, Springer-Verlag 1989; 598-613.
-
(1989)
Human Physiology
, pp. 598-613
-
-
Grote, J.1
-
2
-
-
0025105752
-
Myocyte cell loss and myocyte cellular hypeplasia in the hypertrophied aging rat heart
-
Anversa P, Palackal T, Sonnenblick EH, Olivetti G, Meggs LG, Capasso JM. Myocyte cell loss and myocyte cellular hypeplasia in the hypertrophied aging rat heart. Circ Res 1990; 67: 871-85.
-
(1990)
Circ Res
, vol.67
, pp. 871-885
-
-
Anversa, P.1
Palackal, T.2
Sonnenblick, E.H.3
Olivetti, G.4
Meggs, L.G.5
Capasso, J.M.6
-
4
-
-
23644448877
-
Is aging the price for memory?
-
Terman A, Brunk UT. Is aging the price for memory? Biogerontology 2005; 6: 205-10.
-
(2005)
Biogerontology
, vol.6
, pp. 205-210
-
-
Terman, A.1
Brunk, U.T.2
-
5
-
-
33744525885
-
How do cardiomyocytes die? apoptosis and autophagic cell death in cardiac myocytes
-
Kunapuli S, Rosanio S, Schwarz ER. "How do cardiomyocytes die"? apoptosis and autophagic cell death in cardiac myocytes. J Card Fail 2006; 12: 381-91.
-
(2006)
J Card Fail
, vol.12
, pp. 381-391
-
-
Kunapuli, S.1
Rosanio, S.2
Schwarz, E.R.3
-
6
-
-
33846531305
-
The interplay between pro-death and pro-survival signaling pathways in myocardial ischemia/reperfusion injury: Apoptosis meets autophagy
-
Hamacher-Brady A, Brady NR, Gottlieb PA. The interplay between pro-death and pro-survival signaling pathways in myocardial ischemia/reperfusion injury: apoptosis meets autophagy. Cardiovasc Drugs Ther 2006; 20: 445-62.
-
(2006)
Cardiovasc Drugs Ther
, vol.20
, pp. 445-462
-
-
Hamacher-Brady, A.1
Brady, N.R.2
Gottlieb, P.A.3
-
7
-
-
0036628724
-
Role of oxidative stress and protein oxidation in the aging process
-
Sohal RS. Role of oxidative stress and protein oxidation in the aging process. Free Radic Biol Med 2002; 33: 37-44.
-
(2002)
Free Radic Biol Med
, vol.33
, pp. 37-44
-
-
Sohal, R.S.1
-
9
-
-
77049308856
-
Aging: A theory based on free radical and radiation chemistry
-
Harman D. Aging: a theory based on free radical and radiation chemistry. J Gerontol 1956; 211: 298-300.
-
(1956)
J Gerontol
, vol.211
, pp. 298-300
-
-
Harman, D.1
-
10
-
-
0033796250
-
Mitochondrial free radical generation, oxidative stress, and aging
-
Cadenas E, Davies KJ. Mitochondrial free radical generation, oxidative stress, and aging. Free Radic Biol Med 2000; 29: 222-30.
-
(2000)
Free Radic Biol Med
, vol.29
, pp. 222-230
-
-
Cadenas, E.1
Davies, K.J.2
-
11
-
-
0036829433
-
Rate of generation of oxidative stress-related damage and animal longevity
-
Barja G. Rate of generation of oxidative stress-related damage and animal longevity. Free Radic Biol Med 2002; 33: 1167-72.
-
(2002)
Free Radic Biol Med
, vol.33
, pp. 1167-1172
-
-
Barja, G.1
-
12
-
-
30644471961
-
Stem. cells in the etiology and treatment of cancer
-
Zhang M, Rosen JM. Stem. cells in the etiology and treatment of cancer. Curr Opin Genet Dev 2006; 16: 60-4.
-
(2006)
Curr Opin Genet Dev
, vol.16
, pp. 60-64
-
-
Zhang, M.1
Rosen, J.M.2
-
13
-
-
0034537290
-
Autophagy as a regulated pathway of cellular degradation
-
Klionsky DJ, Emr SD. Autophagy as a regulated pathway of cellular degradation. Science 2000; 290: 1717-21.
-
(2000)
Science
, vol.290
, pp. 1717-1721
-
-
Klionsky, D.J.1
Emr, S.D.2
-
14
-
-
4544385218
-
Autophagy: Many paths to the same end
-
Cuervo AM. Autophagy: many paths to the same end. Mol Cell Biochem 2004; 263: 55-72.
-
(2004)
Mol Cell Biochem
, vol.263
, pp. 55-72
-
-
Cuervo, A.M.1
-
15
-
-
33745026738
-
Autophagy and aging: The importance of maintaining "clean" cells
-
Cuervo AM, Bergamini E, Brunk UT, Droge W, Ffrench M, Terman A. Autophagy and aging: the importance of maintaining "clean" cells. Autophagy 2005; 1: 131-40.
-
(2005)
Autophagy
, vol.1
, pp. 131-140
-
-
Cuervo, A.M.1
Bergamini, E.2
Brunk, U.T.3
Droge, W.4
Ffrench, M.5
Terman, A.6
-
16
-
-
27644484061
-
Autophagy: Molecular machinery for self-eating
-
Yorimitsu T, Klionsky DJ. Autophagy: molecular machinery for self-eating. Cell Death Differ 2005; 12 Suppl 2: 1542-52.
-
(2005)
Cell Death Differ
, vol.12
, Issue.SUPPL. 2
, pp. 1542-1552
-
-
Yorimitsu, T.1
Klionsky, D.J.2
-
17
-
-
10744225487
-
A unified nomenclature for yeast autophagy-related genes
-
Klionsky DJ, Cregg JM, Dunn WA, et al. A unified nomenclature for yeast autophagy-related genes. Dev Cell 2003; 5: 539-45.
-
(2003)
Dev Cell
, vol.5
, pp. 539-545
-
-
Klionsky, D.J.1
Cregg, J.M.2
Dunn, W.A.3
-
18
-
-
34547914535
-
The role of autophagy in mediating cell survival and death during ischemia and reperfusion in the heart
-
Takagi H, Matsui Y, Sadoshima J. The role of autophagy in mediating cell survival and death during ischemia and reperfusion in the heart. Antioxid Redox Signal 2007; 9: 1373-81.
-
(2007)
Antioxid Redox Signal
, vol.9
, pp. 1373-1381
-
-
Takagi, H.1
Matsui, Y.2
Sadoshima, J.3
-
19
-
-
34249714158
-
The role of autophagy in cardiomyocytes in the basal state and in response to hemodynamic stress
-
Nakai A, Yamaguchi O, Takeda, T, et al. The role of autophagy in cardiomyocytes in the basal state and in response to hemodynamic stress. Nat Med 2007; 13: 619-24.
-
(2007)
Nat Med
, vol.13
, pp. 619-624
-
-
Nakai, A.1
Yamaguchi, O.2
Takeda, T.3
-
20
-
-
27644467802
-
Autophagy in cardiac myocyte homeostasis, aging, and pathology
-
Terman A, Brunk UT. Autophagy in cardiac myocyte homeostasis, aging, and pathology. Cardiovasc Res 2005; 68: 355-65.
-
(2005)
Cardiovasc Res
, vol.68
, pp. 355-365
-
-
Terman, A.1
Brunk, U.T.2
-
21
-
-
0032730787
-
Ceroid/lipofuscin-loaded human fibroblasts show decreased survival time and diminished autophagocytosis during amino acid starvation
-
Terman A, Dalen H, Brunk UT. Ceroid/lipofuscin-loaded human fibroblasts show decreased survival time and diminished autophagocytosis during amino acid starvation. Exp Gerontol 1999; 34: 943-57.
-
(1999)
Exp Gerontol
, vol.34
, pp. 943-957
-
-
Terman, A.1
Dalen, H.2
Brunk, U.T.3
-
22
-
-
0005677775
-
3-Methyladenine: Specific inhibitor of autophagic/ lysosomal protein degradation in isolated rat hepatocytes
-
Seglen PO, Gordon PB, 3-Methyladenine: specific inhibitor of autophagic/ lysosomal protein degradation in isolated rat hepatocytes. Proc Natl Acad Sci U S A 1982; 79: 1889-92.
-
(1982)
Proc Natl Acad Sci U S A
, vol.79
, pp. 1889-1892
-
-
Seglen, P.O.1
Gordon, P.B.2
-
23
-
-
0022786977
-
Effect of starvation and refeeding on autophagy and heterophagy in rat liver
-
Ohshita T, Kominami E, Ii K, Katunuma N. Effect of starvation and refeeding on autophagy and heterophagy in rat liver. J Biochem (Tokyo) 1986; 100: 623-32.
-
(1986)
J Biochem (Tokyo)
, vol.100
, pp. 623-632
-
-
Ohshita, T.1
Kominami, E.2
Ii, K.3
Katunuma, N.4
-
25
-
-
34548512483
-
Autophagy in the Heart and Liver During Normal Aging and Calorie Restriction
-
Wohlgemuth SE, Julian D, Akin DE, et al. Autophagy in the Heart and Liver During Normal Aging and Calorie Restriction. Rejuvenation Res 2007.
-
(2007)
Rejuvenation Res
-
-
Wohlgemuth, S.E.1
Julian, D.2
Akin, D.E.3
-
26
-
-
0018827202
-
Lysosomal alterations in hypoxic and reoxygenated hearts. I Ultrastructural and cytochemical changes
-
Decker RS, Wildenthal K. Lysosomal alterations in hypoxic and reoxygenated hearts. I Ultrastructural and cytochemical changes. Am J Pathol 1980; 98: 425-44.
-
(1980)
Am J Pathol
, vol.98
, pp. 425-444
-
-
Decker, R.S.1
Wildenthal, K.2
-
27
-
-
25444473426
-
Autophagy in chronically ischemic myocardium
-
Yan L, Vatner DE, Kim SJ, et al. Autophagy in chronically ischemic myocardium. Proc Natl Acad Sci U S A 2005; 102: 13807-12.
-
(2005)
Proc Natl Acad Sci U S A
, vol.102
, pp. 13807-13812
-
-
Yan, L.1
Vatner, D.E.2
Kim, S.J.3
-
28
-
-
33744905803
-
Autophagy: A novel protective mechanism in chronic ischemia
-
Yan L, Sadoshima J, Vatner DE, Vatner SF. Autophagy: a novel protective mechanism in chronic ischemia. Cell Cycle 2006; 5: 1175-7.
-
(2006)
Cell Cycle
, vol.5
, pp. 1175-1177
-
-
Yan, L.1
Sadoshima, J.2
Vatner, D.E.3
Vatner, S.F.4
-
29
-
-
34147168105
-
Distinct roles of autophagy in the heart during ischemia and reperfusion: Roles of AMP-activated protein kinase and Beclin l in mediating autophagy
-
Matsui Y, Takagi H, Qu X, et al. Distinct roles of autophagy in the heart during ischemia and reperfusion: roles of AMP-activated protein kinase and Beclin l in mediating autophagy. Circ Res 2007; 100: 914-22.
-
(2007)
Circ Res
, vol.100
, pp. 914-922
-
-
Matsui, Y.1
Takagi, H.2
Qu, X.3
-
30
-
-
33744536558
-
Urocortin inhibits Beclinl-mediated autophagic cell death in cardiac myocytes exposed to iscbacmia/reperfusion injury
-
Valentim L, Laurence KM, Townsend PA, et al. Urocortin inhibits Beclinl-mediated autophagic cell death in cardiac myocytes exposed to iscbacmia/reperfusion injury. J Mol Cell Cardiol 2006; 40: 846-52.
-
(2006)
J Mol Cell Cardiol
, vol.40
, pp. 846-852
-
-
Valentim, L.1
Laurence, K.M.2
Townsend, P.A.3
-
31
-
-
48249155410
-
-
Klionsky DJ Ed, Georgetown, TX, Landes Bioscience
-
Fengsrud M, Sneve ML, Overbye A, Seglen PO. In: Klionsky DJ Ed, Autophagy. Georgetown, TX, Landes Bioscience 2004; 11-25.
-
(2004)
Autophagy
, pp. 11-25
-
-
Fengsrud, M.1
Sneve, M.L.2
Overbye, A.3
Seglen, P.O.4
-
33
-
-
0036569331
-
Yeast autophagosomes: De novo formation of a membrane structure
-
Noda T, Suzuki K, Ohsumi Y. Yeast autophagosomes: de novo formation of a membrane structure. Trends Cell Biol 2002; 12: 231-5.
-
(2002)
Trends Cell Biol
, vol.12
, pp. 231-235
-
-
Noda, T.1
Suzuki, K.2
Ohsumi, Y.3
-
34
-
-
0025294506
-
Peptide, sequences that target cytosolic proteins for lysosomal proteolysis
-
Dice JF. Peptide, sequences that target cytosolic proteins for lysosomal proteolysis. Trends Biochem Sci 1990; 15: 305-9.
-
(1990)
Trends Biochem Sci
, vol.15
, pp. 305-309
-
-
Dice, J.F.1
-
35
-
-
0029837453
-
A receptor for the selective uptake and degradation of proteins by lysosomes
-
Cuervo AM, Dice JF. A receptor for the selective uptake and degradation of proteins by lysosomes. Science 1996; 273: 501-3.
-
(1996)
Science
, vol.273
, pp. 501-503
-
-
Cuervo, A.M.1
Dice, J.F.2
-
36
-
-
33745023775
-
Chaperone-mediated autophagy in aging and disease
-
Massey AC, Zhang C, Cuervo AM. Chaperone-mediated autophagy in aging and disease. Curr Top Dev Biol 2006; 73: 205-35.
-
(2006)
Curr Top Dev Biol
, vol.73
, pp. 205-235
-
-
Massey, A.C.1
Zhang, C.2
Cuervo, A.M.3
-
37
-
-
0034948738
-
The autophagosomal-lysosomal compartment in programmed cell death
-
Bursch W. The autophagosomal-lysosomal compartment in programmed cell death. Cell Death Differ 2001; 8: 569-81.
-
(2001)
Cell Death Differ
, vol.8
, pp. 569-581
-
-
Bursch, W.1
-
38
-
-
7744235672
-
Death by design: Apoptosis, necrosis and autophagy
-
Edinger AL, Thompson CB. Death by design: apoptosis, necrosis and autophagy. Curr Opin Cell Biol 2004; 16: 663-9.
-
(2004)
Curr Opin Cell Biol
, vol.16
, pp. 663-669
-
-
Edinger, A.L.1
Thompson, C.B.2
-
39
-
-
8344242220
-
Autophagy in health and disease: A double-edged sword
-
Shintani T, Klionsky DJ. Autophagy in health and disease: a double-edged sword. Science 2004; 306: 990-5.
-
(2004)
Science
, vol.306
, pp. 990-995
-
-
Shintani, T.1
Klionsky, D.J.2
-
41
-
-
33845480548
-
Caspase function in programmed cell death
-
Kumar S. Caspase function in programmed cell death. Cell Death Differ 2007; 14: 32-43.
-
(2007)
Cell Death Differ
, vol.14
, pp. 32-43
-
-
Kumar, S.1
-
42
-
-
34247345833
-
The apoptosome: Signalling platform of cell death
-
Riedl SJ, Salvesen GS. The apoptosome: signalling platform of cell death. Nat Rev Mol Cell Biol 2007; 8: 405-13.
-
(2007)
Nat Rev Mol Cell Biol
, vol.8
, pp. 405-413
-
-
Riedl, S.J.1
Salvesen, G.S.2
-
43
-
-
0015383455
-
Apoptosis: A basic biological phenomenon with wide-ranging implications in tissue kinetics
-
Kerr JF, Wyllie AH, Currie AR. Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br J Cancer 1972; 26: 239-57.
-
(1972)
Br J Cancer
, vol.26
, pp. 239-257
-
-
Kerr, J.F.1
Wyllie, A.H.2
Currie, A.R.3
-
46
-
-
0942265544
-
Selective disruption of lysosomes in HeLa cells triggers apoptosis mediated-by cleavage of Bid by multiple papain-like lysosomal cathepsins
-
Cirman T, Oresic K, Mazovec GD, et al. Selective disruption of lysosomes in HeLa cells triggers apoptosis mediated-by cleavage of Bid by multiple papain-like lysosomal cathepsins. J Biol Chem 2004; 279: 3578-87.
-
(2004)
J Biol Chem
, vol.279
, pp. 3578-3587
-
-
Cirman, T.1
Oresic, K.2
Mazovec, G.D.3
-
47
-
-
33646891970
-
Bax inhibition protects against free fatty acid-induced lysosomal permeabilization
-
Feldstein AE, Werneburg NW, Li Z, Bronk SF, Gores GJ. Bax inhibition protects against free fatty acid-induced lysosomal permeabilization. Am J Physiol Gastrointest Liver Physiol 2006; 290: G1339-46.
-
(2006)
Am J Physiol Gastrointest Liver Physiol
, vol.290
-
-
Feldstein, A.E.1
Werneburg, N.W.2
Li, Z.3
Bronk, S.F.4
Gores, G.J.5
-
48
-
-
0034677741
-
Induction of cell death by the lysosomotropic detergent MSDH
-
Li W, Yuan X, Nordgren G, et al. Induction of cell death by the lysosomotropic detergent MSDH. FEBS Lett 2000; 470: 35-9.
-
(2000)
FEBS Lett
, vol.470
, pp. 35-39
-
-
Li, W.1
Yuan, X.2
Nordgren, G.3
-
49
-
-
0035887215
-
Sphingosine-induced apoptosis is dependent on lysosomal proteases
-
Kågedal K, Zhao M, Svensson I, Brunk UT. Sphingosine-induced apoptosis is dependent on lysosomal proteases. Biochem J 2001; 359: 335-43.
-
(2001)
Biochem J
, vol.359
, pp. 335-343
-
-
Kågedal, K.1
Zhao, M.2
Svensson, I.3
Brunk, U.T.4
-
51
-
-
0013473122
-
Histochemistry and Electron Microscopy of Iron-Containing Granules, Lysosomes, and Lipofuscin in Mouse Mammary Glands
-
Miyawaki H. Histochemistry and Electron Microscopy of Iron-Containing Granules, Lysosomes, and Lipofuscin in Mouse Mammary Glands. J Natl Cancer Inst 1965; 34: 601-23.
-
(1965)
J Natl Cancer Inst
, vol.34
, pp. 601-623
-
-
Miyawaki, H.1
-
52
-
-
0014878377
-
Histochemical indications for lysosomal localization of heavy metals in normal rat brain and liver
-
Brun A, Brunk U. Histochemical indications for lysosomal localization of heavy metals in normal rat brain and liver. J Histochem Cytochem 1970; 18: 820-7.
-
(1970)
J Histochem Cytochem
, vol.18
, pp. 820-827
-
-
Brun, A.1
Brunk, U.2
-
54
-
-
0025238656
-
Autophagic degradation of protein generates a pool of ferric iron required for the killing of cultured hepatocytes by an oxidative stress
-
Sakaida I, Kyle ME, Farber JL. Autophagic degradation of protein generates a pool of ferric iron required for the killing of cultured hepatocytes by an oxidative stress. Mol Pharmacol 1990; 37: 435-42.
-
(1990)
Mol Pharmacol
, vol.37
, pp. 435-442
-
-
Sakaida, I.1
Kyle, M.E.2
Farber, J.L.3
-
55
-
-
1842583789
-
Development by self-digestion: Molecular mechanisms and biological functions of autophagy
-
Levine B, Klionsky DJ. Development by self-digestion: molecular mechanisms and biological functions of autophagy. Dev Cell 2004; 6: 463-77.
-
(2004)
Dev Cell
, vol.6
, pp. 463-477
-
-
Levine, B.1
Klionsky, D.J.2
-
56
-
-
32944481457
-
Metallothionein protects against oxidative stress-induced lysosomal destabilization
-
Baird SK, Kurz T, Brunk UT. Metallothionein protects against oxidative stress-induced lysosomal destabilization. Biochem J 2006; 394: 275-83.
-
(2006)
Biochem J
, vol.394
, pp. 275-283
-
-
Baird, S.K.1
Kurz, T.2
Brunk, U.T.3
-
57
-
-
0031422255
-
Lysosomal heterogeneity between and within cells with respect to resistance against oxidative stress
-
Nilsson E, Ghassemifar R, Brunk UT. Lysosomal heterogeneity between and within cells with respect to resistance against oxidative stress. Histochem J 1997; 29: 857-65.
-
(1997)
Histochem J
, vol.29
, pp. 857-865
-
-
Nilsson, E.1
Ghassemifar, R.2
Brunk, U.T.3
-
58
-
-
18844425714
-
Role of compartmentalized redox-active iron in hydrogen peroxide-induced DNA damage and apoptosis
-
Tenopoulou M, Doulias PT, Barbouti A, Brunk U, Galaris D. Role of compartmentalized redox-active iron in hydrogen peroxide-induced DNA damage and apoptosis. Biochem J 2005; 387: 703-10.
-
(2005)
Biochem J
, vol.387
, pp. 703-710
-
-
Tenopoulou, M.1
Doulias, P.T.2
Barbouti, A.3
Brunk, U.4
Galaris, D.5
-
59
-
-
0027180710
-
Visualization of iron in cultured macrophages: A cytochemical light and electron microscopic study using autometallography
-
Zdolsek JM, Roberg K, Brunk UT. Visualization of iron in cultured macrophages: a cytochemical light and electron microscopic study using autometallography. Free Radic Biol Med 1993; 15: 1-11.
-
(1993)
Free Radic Biol Med
, vol.15
, pp. 1-11
-
-
Zdolsek, J.M.1
Roberg, K.2
Brunk, U.T.3
-
60
-
-
0037448105
-
Intralysosomal iron: A major determinant of oxidant-induced cell death
-
Yu Z, Persson HL, Eaton JW, Brunk UT. Intralysosomal iron: a major determinant of oxidant-induced cell death. Free Radic Biol Med 2003; 34: 1243-52.
-
(2003)
Free Radic Biol Med
, vol.34
, pp. 1243-1252
-
-
Yu, Z.1
Persson, H.L.2
Eaton, J.W.3
Brunk, U.T.4
-
61
-
-
4344651318
-
Heat shock protein 70 promotes cell survival by inhibiting lysosomal membrane permeabilization
-
Nylandsted J, Gyrd-Hansen M, Danielewicz A, et al. Heat shock protein 70 promotes cell survival by inhibiting lysosomal membrane permeabilization. J Exp Med 2004; 200: 425-35.
-
(2004)
J Exp Med
, vol.200
, pp. 425-435
-
-
Nylandsted, J.1
Gyrd-Hansen, M.2
Danielewicz, A.3
-
62
-
-
0036284478
-
Prognostic significance of metallothionein in human gastrointestinal cancer
-
Janssen AM, van Duijn W, Kubben FJ, et al. Prognostic significance of metallothionein in human gastrointestinal cancer. Clin Cancer Res 2002; 8: 1889-96.
-
(2002)
Clin Cancer Res
, vol.8
, pp. 1889-1896
-
-
Janssen, A.M.1
van Duijn, W.2
Kubben, F.J.3
-
63
-
-
0035880708
-
Metallothionein expression in patients with small cell carcinoma of the lung: Correlation with other molecular markers and clinical outcome
-
Joseph MG, Banerjee D, Kocha W, Feld R, Stitt LW, Cherian MG. Metallothionein expression in patients with small cell carcinoma of the lung: correlation with other molecular markers and clinical outcome. Cancer 2001; 92: 836-42.
-
(2001)
Cancer
, vol.92
, pp. 836-842
-
-
Joseph, M.G.1
Banerjee, D.2
Kocha, W.3
Feld, R.4
Stitt, L.W.5
Cherian, M.G.6
-
64
-
-
0034797926
-
Thioredoxin expression is associated with lymph node status and prognosis in early operable non-small cell lung cancer
-
Kakolyris S, Giatromanolaki A, Koukourakis M, et al. Thioredoxin expression is associated with lymph node status and prognosis in early operable non-small cell lung cancer., Clin Cancer Res 2001; 7: 3087-91.
-
(2001)
Clin Cancer Res
, vol.7
, pp. 3087-3091
-
-
Kakolyris, S.1
Giatromanolaki, A.2
Koukourakis, M.3
-
65
-
-
34249815482
-
Autophagy, ageing and apoptosis: The role of oxidative stress and lysosomal iron
-
Kurz T, Terman A, Brunk UT. Autophagy, ageing and apoptosis: the role of oxidative stress and lysosomal iron. Arch Biochem Biophys 2007; 462: 220-30.
-
(2007)
Arch Biochem Biophys
, vol.462
, pp. 220-230
-
-
Kurz, T.1
Terman, A.2
Brunk, U.T.3
-
66
-
-
25144457455
-
Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy
-
Pattingre S, Tassa A, Qu X, et al. Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy. Cell 2005; 122: 927-39.
-
(2005)
Cell
, vol.122
, pp. 927-939
-
-
Pattingre, S.1
Tassa, A.2
Qu, X.3
-
67
-
-
33144463000
-
Autophagic cardiomyo- cyte death in cardiomyopathic hamsters and its prevention by granulocyte colony-stimulating factor
-
Miyata S, Takemura G, Kawase Y, et al. Autophagic cardiomyo- cyte death in cardiomyopathic hamsters and its prevention by granulocyte colony-stimulating factor. Am J Pathol 2006; 168: 386-97.
-
(2006)
Am J Pathol
, vol.168
, pp. 386-397
-
-
Miyata, S.1
Takemura, G.2
Kawase, Y.3
-
68
-
-
0034934435
-
Apoptotic versus autophagic cell death in heart failure
-
Knaapen MW, Davies MJ, De Bie M, Haven AJ, Martinet W, Kockx MM. Apoptotic versus autophagic cell death in heart failure. Cardiovasc Res 2001; 51: 304-12.
-
(2001)
Cardiovasc Res
, vol.51
, pp. 304-312
-
-
Knaapen, M.W.1
Davies, M.J.2
De Bie, M.3
Haven, A.J.4
Martinet, W.5
Kockx, M.M.6
-
69
-
-
0037465434
-
Progression from compensated hypertrophy to failure in the pressure-overloaded human heart: Structural deterioration and compensatory mechanisms
-
Hein S, Arnon E, Kostin S, et al. Progression from compensated hypertrophy to failure in the pressure-overloaded human heart: structural deterioration and compensatory mechanisms. Circulation 2003; 107: 984-91.
-
(2003)
Circulation
, vol.107
, pp. 984-991
-
-
Hein, S.1
Arnon, E.2
Kostin, S.3
-
70
-
-
0037453585
-
Myocytes die by multiple mechanisms in failing human hearts
-
Kostin S, Pool L, Elsasser A, et al. Myocytes die by multiple mechanisms in failing human hearts. Circ Res 2003; 92: 715-24.
-
(2003)
Circ Res
, vol.92
, pp. 715-724
-
-
Kostin, S.1
Pool, L.2
Elsasser, A.3
-
72
-
-
0029564967
-
Age-related changes in the lipofuscin accumulation of brain and heart
-
Nakano M, Oenzil F, Mizuno T, Gotoh S. Age-related changes in the lipofuscin accumulation of brain and heart. Gerontology 1995; 41 Suppl 2: 69-79.
-
(1995)
Gerontology
, vol.41
, Issue.SUPPL. 2
, pp. 69-79
-
-
Nakano, M.1
Oenzil, F.2
Mizuno, T.3
Gotoh, S.4
-
73
-
-
0036710928
-
Lipofuscin: Mechanisms of age-related accumulation and influence on cell function
-
Brunk UT, Terman A. Lipofuscin: mechanisms of age-related accumulation and influence on cell function. Free Radic Biol Med 2002; 33: 611-9.
-
(2002)
Free Radic Biol Med
, vol.33
, pp. 611-619
-
-
Brunk, U.T.1
Terman, A.2
-
74
-
-
0018873419
-
Phagocytosis and degradation of rat liver mitochondria by cultivated human glial cells
-
Collins VP, Arborgh B, Brunk U, Schellens JP. Phagocytosis and degradation of rat liver mitochondria by cultivated human glial cells. Lab Invest 1980; 42: 209-16.
-
(1980)
Lab Invest
, vol.42
, pp. 209-216
-
-
Collins, V.P.1
Arborgh, B.2
Brunk, U.3
Schellens, J.P.4
-
75
-
-
33749066763
-
Mitochondrial damage and intralysosomal degradation in cellular aging
-
Terman A, Gustafsson B, Brunk UT. Mitochondrial damage and intralysosomal degradation in cellular aging. Mol Aspects Med 2006; 27: 471-82.
-
(2006)
Mol Aspects Med
, vol.27
, pp. 471-482
-
-
Terman, A.1
Gustafsson, B.2
Brunk, U.T.3
-
76
-
-
0015608201
-
Distribution and shifts of ingested marker particles in residual bodies and other lysosomes. Studies on in vitro cultivated human glia cells in phase II and 3
-
Brunk U. Distribution and shifts of ingested marker particles in residual bodies and other lysosomes. Studies on in vitro cultivated human glia cells in phase II and 3. Exp Cell Res 1973; 79: 15-27.
-
(1973)
Exp Cell Res
, vol.79
, pp. 15-27
-
-
Brunk, U.1
-
77
-
-
0032169551
-
Ceroid/lipofuscin formation in cultured human fibroblasts: The role of oxidative stress and lysosomal proteolysis
-
Terman A, Brunk UT. Ceroid/lipofuscin formation in cultured human fibroblasts: the role of oxidative stress and lysosomal proteolysis. Mech Ageing Dev 1998; 104: 277-91.
-
(1998)
Mech Ageing Dev
, vol.104
, pp. 277-291
-
-
Terman, A.1
Brunk, U.T.2
-
78
-
-
0032579473
-
On the degradability and exocytosis of ceroid/ lipofuscin in cultured rat cardiac myocytes
-
Terman A, Brunk UT. On the degradability and exocytosis of ceroid/ lipofuscin in cultured rat cardiac myocytes. Mech Ageing Dev 1998; 100: 145-56.
-
(1998)
Mech Ageing Dev
, vol.100
, pp. 145-156
-
-
Terman, A.1
Brunk, U.T.2
-
79
-
-
0031081410
-
A proposed refinement of the mitochondrial free radical tbeory of aging
-
de Grey AD. A proposed refinement of the mitochondrial free radical tbeory of aging. Bioessays 1997; 19: 161-6.
-
(1997)
Bioessays
, vol.19
, pp. 161-166
-
-
de Grey, A.D.1
-
80
-
-
0042707790
-
Mitochondrial recycling and aging of cardiac myocres: The role of autophagocytosis
-
Terman A, Dalen H, Eaton JW, Neuzil J, Brunk UT. Mitochondrial recycling and aging of cardiac myocres: the role of autophagocytosis. Exp Gerontol 2003; 38: 863-76.
-
(2003)
Exp Gerontol
, vol.38
, pp. 863-876
-
-
Terman, A.1
Dalen, H.2
Eaton, J.W.3
Neuzil, J.4
Brunk, U.T.5
-
81
-
-
0017751995
-
Ultrastructure of the aging myocardium: A morphometric approach
-
Sachs HG, Colgan JA, Lazarus ML. Ultrastructure of the aging myocardium: a morphometric approach. Am J Anat 1977; 150: 63-71.
-
(1977)
Am J Anat
, vol.150
, pp. 63-71
-
-
Sachs, H.G.1
Colgan, J.A.2
Lazarus, M.L.3
-
82
-
-
0015264490
-
Electron microscopical studies on rat brain neurons. Localization of acid phosphatase and mode of formation of lipofuscin bodies
-
Brunk U, Ericsson JL. Electron microscopical studies on rat brain neurons. Localization of acid phosphatase and mode of formation of lipofuscin bodies. J Ultrastruct Res 1972; 38: 1-15.
-
(1972)
J Ultrastruct Res
, vol.38
, pp. 1-15
-
-
Brunk, U.1
Ericsson, J.L.2
-
83
-
-
0035063178
-
Garbage catastrophe theory of aging: Imperfect removal of oxidative damage?
-
Terman A. Garbage catastrophe theory of aging: imperfect removal of oxidative damage? Redox Rep 2001; 6: 15-26.
-
(2001)
Redox Rep
, vol.6
, pp. 15-26
-
-
Terman, A.1
-
84
-
-
33644641768
-
Oxidative stress, accumulation of biological 'garbage', and aging
-
Terman A, Brunk UT. Oxidative stress, accumulation of biological 'garbage', and aging. Antioxid Redox Signal 2006; 8: 197-204.
-
(2006)
Antioxid Redox Signal
, vol.8
, pp. 197-204
-
-
Terman, A.1
Brunk, U.T.2
-
85
-
-
12344251782
-
Inhibition of autophagy with 3-methyladenine results in impaired turnover of lysosomes and accumulation of lipofuscin-like material
-
Stroikin Y, Dalen H, Loof S, Terman A. Inhibition of autophagy with 3-methyladenine results in impaired turnover of lysosomes and accumulation of lipofuscin-like material. Eur J Cell Biol 2004; 83: 583-90.
-
(2004)
Eur J Cell Biol
, vol.83
, pp. 583-590
-
-
Stroikin, Y.1
Dalen, H.2
Loof, S.3
Terman, A.4
-
86
-
-
3242715838
-
Aging of cardiac myocytes in culture: Oxidative stress, lipofuscin accumulation, and mitochondrial turnover
-
Terman A, Dalen H, Eaton JW, Neuzil J, Brunk UT. Aging of cardiac myocytes in culture: oxidative stress, lipofuscin accumulation, and mitochondrial turnover. Ann N Y Acad Sci 2004; 1019: 70-7.
-
(2004)
Ann N Y Acad Sci
, vol.1019
, pp. 70-77
-
-
Terman, A.1
Dalen, H.2
Eaton, J.W.3
Neuzil, J.4
Brunk, U.T.5
-
87
-
-
33847652900
-
Autophagy and neurodegeneration: When the cleaning crew goes on strike
-
Martinez-Vicente M, Cuervo AM. Autophagy and neurodegeneration: when the cleaning crew goes on strike. Lancet Neurol 2007; 6: 352-61.
-
(2007)
Lancet Neurol
, vol.6
, pp. 352-361
-
-
Martinez-Vicente, M.1
Cuervo, A.M.2
-
88
-
-
4344660368
-
The role of macroautophagy in the ageing process, anti-ageing intervention and age-associated diseases
-
Bergamini E, Cavallini G, Donati A, Gori Z. The role of macroautophagy in the ageing process, anti-ageing intervention and age-associated diseases. Int J Biochem Cell Biol 2004; 36: 2392-404.
-
(2004)
Int J Biochem Cell Biol
, vol.36
, pp. 2392-2404
-
-
Bergamini, E.1
Cavallini, G.2
Donati, A.3
Gori, Z.4
-
89
-
-
0029560552
-
The effect of age on formation and elimination of autophagic vacuoles in mouse hepatocytes
-
Terman A. The effect of age on formation and elimination of autophagic vacuoles in mouse hepatocytes. Gerontology 1995; 41 (Suppl 2): 319-26.
-
(1995)
Gerontology
, vol.41
, Issue.SUPPL. 2
, pp. 319-326
-
-
Terman, A.1
-
90
-
-
0036236006
-
The mitochondrial-lysosomal axis theory of aging: Accumulation of damaged mitochondria as a result of imperfect autophagocytosis
-
Brunk UT, Terman A. The mitochondrial-lysosomal axis theory of aging: accumulation of damaged mitochondria as a result of imperfect autophagocytosis. Eur J Biochem 2002; 269: 1996-2002.
-
(2002)
Eur J Biochem
, vol.269
, pp. 1996-2002
-
-
Brunk, U.T.1
Terman, A.2
-
91
-
-
33749656530
-
The lysosomal-mitochondrial axis theory of postmitotic aging and cell death
-
Terman A, Gustafsson B, Brunk UT. The lysosomal-mitochondrial axis theory of postmitotic aging and cell death. Chem Biol Interact 2006; 163: 29-37.
-
(2006)
Chem Biol Interact
, vol.163
, pp. 29-37
-
-
Terman, A.1
Gustafsson, B.2
Brunk, U.T.3
-
92
-
-
33846120542
-
Increased resistance of lipofuscin-loaded prematurely senescent fibroblasts to starvation-induced programmed cell death
-
Stroikin Y, Johansson U, Asplund S, Ollinger K. Increased resistance of lipofuscin-loaded prematurely senescent fibroblasts to starvation-induced programmed cell death. Biogerontology 2007; 8: 43-53.
-
(2007)
Biogerontology
, vol.8
, pp. 43-53
-
-
Stroikin, Y.1
Johansson, U.2
Asplund, S.3
Ollinger, K.4
-
93
-
-
34548418654
-
Growing cells at 40% ambient oxygen conditions them to subsequent oxidative stress
-
Brunk UT. Growing cells at 40% ambient oxygen conditions them to subsequent oxidative stress. Biogerontology 2007; 8: 619-20.
-
(2007)
Biogerontology
, vol.8
, pp. 619-620
-
-
Brunk, U.T.1
-
94
-
-
0032821609
-
Ceroid/lipofuscin-loaded human fibroblasts show increased susceptibility to oxidative stress
-
Terman A, Abrahamsson N, Brunk UT. Ceroid/lipofuscin-loaded human fibroblasts show increased susceptibility to oxidative stress. Exp Gerontol 1999; 34: 755-70.
-
(1999)
Exp Gerontol
, vol.34
, pp. 755-770
-
-
Terman, A.1
Abrahamsson, N.2
Brunk, U.T.3
-
95
-
-
0024422923
-
-
Codd MB, Sugrue DD, Gersh BJ, Melton LJ, 3rd. Epidemiology of idiopathic dilated and hypertropbic cardiomyopathy, A population-based study in Olmsted County, Minnesota, 1975-1984. Circulation 1989; 80: 564-72.
-
Codd MB, Sugrue DD, Gersh BJ, Melton LJ, 3rd. Epidemiology of idiopathic dilated and hypertropbic cardiomyopathy, A population-based study in Olmsted County, Minnesota, 1975-1984. Circulation 1989; 80: 564-72.
-
-
-
-
96
-
-
0033838655
-
Incidence and epidemiology of heart failure
-
Kannel WB. Incidence and epidemiology of heart failure. Heart Fail Rev 2000; 5: 167-73.
-
(2000)
Heart Fail Rev
, vol.5
, pp. 167-173
-
-
Kannel, W.B.1
-
97
-
-
0029126428
-
A histochemical and electron microscopic study of skeletal and cardiac muscle from a Fabry disease patient and carrier
-
Uchino M, Uyama E, Kawano, H, et al. A histochemical and electron microscopic study of skeletal and cardiac muscle from a Fabry disease patient and carrier. Acta Neuropathol (Berl) 1995; 90: 334-8.
-
(1995)
Acta Neuropathol (Berl)
, vol.90
, pp. 334-338
-
-
Uchino, M.1
Uyama, E.2
Kawano, H.3
-
98
-
-
19244384656
-
Accumulation of autophagic vacuoles and cardiomyopathy in LAMP-2-deficient mice
-
Tanaka Y, Guhde G, Suter A, et al. Accumulation of autophagic vacuoles and cardiomyopathy in LAMP-2-deficient mice. Nature 2000; 406: 902-6.
-
(2000)
Nature
, vol.406
, pp. 902-906
-
-
Tanaka, Y.1
Guhde, G.2
Suter, A.3
-
99
-
-
19944383100
-
Replacing acid alpha-glucosidase in Pompe disease: Recombinant and transgenic enzymes are equipotent, but neither completely clears glycogen from type II muscle fibers
-
Raben N, Fukuda T, Gilbert AL, et al. Replacing acid alpha-glucosidase in Pompe disease: recombinant and transgenic enzymes are equipotent, but neither completely clears glycogen from type II muscle fibers. Mol Ther 2005; 11: 48-56.
-
(2005)
Mol Ther
, vol.11
, pp. 48-56
-
-
Raben, N.1
Fukuda, T.2
Gilbert, A.L.3
-
100
-
-
0026347663
-
Infantile Pompe's disease, lipid storage, and partial carnitine deficiency
-
Verity MA. Infantile Pompe's disease, lipid storage, and partial carnitine deficiency. Muscle Nerve 1991; 14: 435-40.
-
(1991)
Muscle Nerve
, vol.14
, pp. 435-440
-
-
Verity, M.A.1
-
101
-
-
15744378799
-
Altered cholesterol metabolism in Niemann-Pick type C1 mouse brains affects mitochondrial function
-
Yu W, Gong JS, Ko M, Garver WS, Yanagisawa K, Michikawa M. Altered cholesterol metabolism in Niemann-Pick type C1 mouse brains affects mitochondrial function. J Biol Chem 2005; 280: 11731-9.
-
(2005)
J Biol Chem
, vol.280
, pp. 11731-11739
-
-
Yu, W.1
Gong, J.S.2
Ko, M.3
Garver, W.S.4
Yanagisawa, K.5
Michikawa, M.6
-
103
-
-
0037291356
-
Ageing exacerbates the cardiotoxicity of hydrogen peroxide through the Fenton reaction in rats
-
Tanguy S, de Leiris J, Besse S, Boucher F. Ageing exacerbates the cardiotoxicity of hydrogen peroxide through the Fenton reaction in rats. Mech Ageing Dev 2003; 124: 229-35.
-
(2003)
Mech Ageing Dev
, vol.124
, pp. 229-235
-
-
Tanguy, S.1
de Leiris, J.2
Besse, S.3
Boucher, F.4
-
104
-
-
1642463971
-
Relocalized redoxactive lysosomal iron is an important mediator of oxidative-stress-induced DNA damage
-
Kurz T, Leake A, Von Zglinicki T, Brunk UT. Relocalized redoxactive lysosomal iron is an important mediator of oxidative-stress-induced DNA damage. Biochem J 2004; 378: 1039-45.
-
(2004)
Biochem J
, vol.378
, pp. 1039-1045
-
-
Kurz, T.1
Leake, A.2
Von Zglinicki, T.3
Brunk, U.T.4
-
105
-
-
33745205646
-
Intralysosomal iron chelation protects against oxidative stress-induced cellular damage
-
Kurz T, Gustafsson B, Brunk UT. Intralysosomal iron chelation protects against oxidative stress-induced cellular damage. FEBS J 2006; 273: 3106-17.
-
(2006)
FEBS J
, vol.273
, pp. 3106-3117
-
-
Kurz, T.1
Gustafsson, B.2
Brunk, U.T.3
-
106
-
-
0000424901
-
Iron chelators of the pyridoxal isonicotinoyl hydrazone class. Part II. Formation-constants with iron(III) and iron(II)
-
Vitolo LMW, Hefter GT, Clare BW, Webb J. Iron chelators of the pyridoxal isonicotinoyl hydrazone class. Part II. Formation-constants with iron(III) and iron(II). Inorg Chim Acta 1990; 170: 171-6.
-
(1990)
Inorg Chim Acta
, vol.170
, pp. 171-176
-
-
Vitolo, L.M.W.1
Hefter, G.T.2
Clare, B.W.3
Webb, J.4
-
107
-
-
22244446427
-
SIH-a novel lipophilic iron chelator-protects H9c2 cardiomyoblasts from oxidative stress-induced mitochondrial injury and cell death
-
Simunek T, Boer C, Bouwman RA, et al. SIH-a novel lipophilic iron chelator-protects H9c2 cardiomyoblasts from oxidative stress-induced mitochondrial injury and cell death. J Mol Cell Cardiol 2005; 39: 345-54.
-
(2005)
J Mol Cell Cardiol
, vol.39
, pp. 345-354
-
-
Simunek, T.1
Boer, C.2
Bouwman, R.A.3
-
108
-
-
0023214937
-
1,2-Dimethyl-3-hydroxypyrid-4-one, an orally active chelator for treatment of iron overload
-
Kontoghiorghes GJ, Aldouri MA, Sheppard L, Hoffbrand AV. 1,2-Dimethyl-3-hydroxypyrid-4-one, an orally active chelator for treatment of iron overload. Lancet 1987; 1: 1294-5.
-
(1987)
Lancet
, vol.1
, pp. 1294-1295
-
-
Kontoghiorghes, G.J.1
Aldouri, M.A.2
Sheppard, L.3
Hoffbrand, A.V.4
|