Temozolomide, quercetin and cell death in the MOGGCCM astrocytoma cell line

Chemico-Biological Interactions

Volumn 188, Issue 1, 2010, Pages 190-203

  Jakubowicz Gil, Joanna ^a   Langner, Ewa ^b   Wertel, Iwona ^c   Piersiak, Tomasz ^a   Rzeski, Wojciech ^a,b  

^a MARIA CURIE SK ODOWSKA UNIVERSITY   (Poland)

^b INSTITUTE OF AGRICULTURAL MEDICINE   (Poland)

^c MEDICAL UNIVERSITY OF LUBLIN   (Poland)

Author keywords

Apoptosis; Astrocytoma; Autophagy; Necrosis; Quercetin; Temozolomide

Indexed keywords

BCL2 RELATED PROTEIN L12; CASPASE 3; CASPASE 8; CELL PROTEIN; CYTOCHROME C; HEAT SHOCK PROTEIN 27; HEAT SHOCK PROTEIN 72; PROTEIN LC3; QUERCETIN; TEMOZOLOMIDE; UNCLASSIFIED DRUG; DACARBAZINE;

APOPTOSIS; ARTICLE; ASTROCYTOMA; ASTROCYTOMA CELL; AUTOPHAGY; CELL DEATH; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG EFFICACY; DRUG POTENTIATION; ENZYME ACTIVATION; ENZYME RELEASE; FLOW CYTOMETRY; GLIOMA CELL; HUMAN; HUMAN CELL; MIGRATION INHIBITION; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRIAL RESPIRATION; NUCLEAR SHAPE; PROTEIN EXPRESSION; PROTEIN SYNTHESIS INHIBITION; SIGNAL TRANSDUCTION; ANALOGS AND DERIVATIVES; BRAIN TUMOR; DRUG EFFECTS; FLUORESCENT ANTIBODY TECHNIQUE; PATHOLOGY; TUMOR CELL LINE; WESTERN BLOTTING;

APOPTOSIS; ASTROCYTOMA; BLOTTING, WESTERN; BRAIN NEOPLASMS; CELL DEATH; CELL LINE, TUMOR; DACARBAZINE; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; HUMANS; QUERCETIN;

EID: 77956177148     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cbi.2010.07.015     Document Type: Article

References (51)

1. Kleihues P., Louis D.N., Scheithauer B.W., Rorke L.B., Reifenberger G., Burger P.C., Cavenee W.K. The WHO classification of tumors of the nervous system. J. Neuropathol. Exp. Neurol. 2002, 61:215-225.
2. Omuro A.M., Faivre S., Raymond E. Lessons learned in the development of targeted therapy for malignant gliomas. Mol. Cancer Ther. 2007, 6:1909-1919.
3. Yakovlev A.G., Faden A.I. Mechanisms of neural cell death: implications for development of neuroprotective treatment strategies. J. Am. Soc. Exp. Neurother. 2004, 1:5-16.
4. Ohgaki H., Kleihues P. Population-based studies on incidence, survival rates and genetic alterations in astrocytic and oligodendroglial gliomas. J. Neuropathol. Exp. Neurol. 2005, 64:479-489.
5. Ghobrial I.M., Witzig T.E., Adjei A. Targeting apoptosis pathways in cancer therapy. CA Cancer J. Clin. 2005, 55:178-194.
6. Lefranc F., Facchini V., Kiss R. Proautophagic drugs: a novel means to combat apoptosis-resistant cancers, with a special emphasis on gliomas. Oncologist 2007, 12:1395-1403.
7. Friedman H.S, Kerby T., Calvert H. Temozolomide and treatment of malignant glioma. Clin. Cancer Res. 2000, 6:2585-2597.
8. Uzzman M., Keller G., Germano I.M. Enhanced proapoptotic effects of tumor necrosis factor-related apoptosis-inducing ligand on Temozolomide-resistant glioma cells. J. Neurosurg. 2007, 106:646-651.
9. Brada M., Hoang-Xuuan K., Rampling R. Multicenter phase II trial of Temozolomide in patients with glioblastoma multiforme at first relapse. Ann. Oncol. 2001, 12:259-266.
10. Kanzawa T., Germano I.M., Komata T., Kondo Y., Kondo S. Role of autophagy in Temozolomide-induced cytotoxicity for malignant glioma cells. Cell Death Differ. 2004, 11:448-457.
11. Tentori L., Graziani G. Recent approaches to improve the antitumor efficacy of Temozolomide. Curr. Med. Chem. 2009, 16:254-257.
12. Ramos S. Effects of dietary flavonoids on apoptotic pathways related to cancer chemoprevention. J. Nutr. Biochem. 2007, 18:427-442.
13. Russo G.L. Ins and outs of dietary phytochemicals in cancer chemoprevention. Biochem. Pharmacol. 2007, 22:317-320.
14. Birt D.F., Hendrich S., Wang W. Dietary agents in cancer prevention: flavonoids and isoflavonoids. Pharmacol. Ther. 2001, 90:157-177.
15. Braganhol E., Zamin L.L., Canedo A.D., Horn F., Tamajusuku A.S., Wink M.R., Salbego C., Battastini A.M. Antiproliferative effect of quercetin in the human U138MG glioma cell line. Anticancer Drugs 2006, 17:663-671.
16. Marchand L.L. Cancer preventive effects of flavonoids - a review. Biomed. Pharmacother. 2002, 56:296-301.
17. Schültke E., Kamencic H., Zhao M., Tian G.F., Baker A.J., Griebel R.W., Juurlink B.H. Neuroprotection following fluid percussion brain trauma: a pilot study using quercetin. J. Neurotrauma 2005, 22:1475-1484.
18. Chowdhury S.A., Kishino K., Satoh R., Hashimoto K., Kikuchi H., Nishikawa H., Shirataki Y., Sakagami H. Tumor-specificity and apoptosis-inducing activity of stilbenes and flavonoids. Anticancer Res. 2005, 25:2055-2063.
19. Clark J.I. Therapeutic applications of heat shock proteins and molecular chaperones. Expert Opin. Ther. Pat. 2001, 11:1153-1160.
20. Voellmy R., Boellmann F. Chaperone regulation of the heat shock protein response. Adv. Exp. Med. Biol. 2007, 594:89-99.
21. Jolly C., Morimoto R.I. Role of heat shock response and molecular chaperones in oncogenesis and cell death. J. Nat. Cancer Inst. 2000, 92:1564-1572.
22. Sarto C., Binz P.-A., Mocarelli P. Heat shock proteins in human cancer. Electrophoresis 2000, 21:1218-1226.
23. Sreedhar A.S., Csermley P. Heat shock proteins in the regulation of apoptosis: new strategies in tumor therapy. A comprehensive review. Pharm. Ther. 2004, 101:227-257.
24. Graner M.W., Cumming R.I., Binger D.D. The heat shock response and chaperone/heat shock proteins in brain tumors: surface expression, release and possible immune consequences. J. Neurosci. 2007, 27:11214-11227.
25. Stegh A.H., Kesari S., Mahoney J.E., Jenq H.T., Forloney K.L., Protopopov A., Louis D.N., Chin L., DePinho R.A. Bcl2L12-mediated inhibition of effector caspase-3 and caspase-7 via distinct mechanisms in glioblastoma. PNAS 2008, 105:10703-10708.
26. Stegh A.H., Kim H., Bachoo R.M., Forloney K.L., Zhang J., Schulze H., Park K., Hannon G.J., Yuan J., Louis D.N., DePinho R.A., Chin L. Bcl2L12 inhibits post-mitochondrial apoptosis signaling in glioblastoma. Genes Dev. 2006, 21:98-111.
27. Bradford M.M. A rapid and sensitive method for quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 1976, 72:248-254.
28. Laemmli U.K. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 1970, 227:680-685.
29. Jankowska A., Skonieczna D., Rommerts F.F.C., Warchoł J.B. Investigations on apoptosis in Leydig cells cultured in vitro. Folia Histochem. Cytobiol. 1997, 33:99-110.
30. Takeuchi H., Kondo Y., Fujiwara K., Kanzawa T., Aoki H., Mills G.B., Kondo S. Synergistic augmentation of rapamycin-induced autophagy in malignant glioma cells by phosphatidylinositol 3-kinase/protein kinase B inhibitors. Cancer Res. 2005, 65:3336-3346.
31. Kim E.J., Choi C.H., Park J.Y., Kang S.K., Kim Y.K. Underlying mechanism of quercetin-induced cell death in human glioma cells. Neurochem. Res. 2008, 33:971-979.
32. Rzeski W., Matysiak J., Kandefer-Szerszeń M. Anticancer, neuroprotective activities and computational studies of 2-amino-1,3,4-thiadiazole based compound. Bioorg. Med. Chem. 2007, 15:3201-3207.
33. Nafe R., Franz K., Schlote W., Schneider B. Morphology of tumor cell nuclei is significantly related with survival time of patients with glioblastomas. Clin. Cancer Res. 2005, 11:2141-2148.
34. Nafe R., Franz K., Schlote W., Schneider B. The morphology of perinecrotic tumor cell nuclei in glioblastomas shows a significant relationship with survival time. Oncol. Rep. 2006, 16:555-562.
35. Russo M., Palumbo R., Tedesco I., Mazzarella G., Russo P., Iacomino G., Russo G.L. Quercetin and antiCD95(Fas/Apo1) enhance apoptosis in HPB-ALL cell line. FEBS Lett. 1999, 462:322-328.
36. Min K., Ebeler S.E. Flavonoid effects on DNA oxidation at low concentrations relevant to physiological levels. Food Chem. Toxicol. 2008, 46:96-104.
37. Ellis S., Killender M., Andreson R.L. Heat induced alterations in the localization of Hsp72 and Hsp73 as measured by indirect immunohistochemistry and immunogold electron microscopy. J. Histochem. Cytochem. 2000, 48:321-331.
38. Hosokawa N., Hirayoshi K., Kudo H., Takechi H., Aoike A., Kawai K., Nagata K. Inhibition of the activation of heat shock factor in vivo and in vitro by flavonoids. Mol. Cell. Biol. 1992, 12:3490-3498.
39. Sõti C., Sreedhar A.S., Csermely P. Apoptosis, necrosis and cellular senescence: chaperone occupancy as a potential switch. Aging Cell 2003, 2:39-45.
40. Kanno S, Tomizawa A., Ohtake T., Koiwai K., Iijbe M., Ishikawa M. Naringenin-induced apoptosis via activation of NF-kappa B and necrosis involving the loss of ATP in human promyeloleukemia HL-60 cells. Toxicol. Lett. 2006, 166:131-139.
41. Paglin S., Lee N.Y., Nakar C., Fitzgeralg M., Plotkin J., Deuel B., Hackett N., McMahill M., Sphicas E., Lampen N., Yahalom J. Rapamycin-sensitive pathway regulates mitochondrial membrane potential, autophagy and survival in irradiated MCF-7 cells. Cancer Res. 2005, 65:11061-11070.
42. Lefranc F., Kiss R. Autophagy, the Trojan horse to combat glioblastomas. Neurosurg. Focus 2006, 20:E7.
43. Roos W.P., Batista L.F., Naumann S.C., Wick W., Weller M., Menck C.F., Kaina B. Apoptosis in malignant gliomas cells triggered by Temozolomide-induced DNA lesion O6-methyguanine. Oncogene 2007, 26:186-197.
44. Balasubramanian K., Schroit A.J. Aminophospholipid asymmetry: a matter of life and death. Annu. Rev. Physiol. 2003, 65:701-734.
45. Melino G., Knight R.A., Nicotera P. How many ways to die? How many different models of cell death?. Cell Death Differ. 2005, 12:S1457-S1462.
46. Kabeya Y., Mizushima N., Ueno T., Yamamoto A., Kirisako T., Noda T., Kominami E., Ohsumi Y., Yoshimori T. LC3 a mammalian homologue of yeast Apg8p is localized in autophagosome membranes after processing. EMBO J. 2000, 19:5720-5728.
47. Jakubowicz-Gil J., Rzymowska J., Gawron A. Quercetin, apoptosis, heat shock. Biochem. Pharmacol. 2002, 64:1591-1595.
48. Jakubowicz-Gil J, Pawlikowska-Pawle{ogonek}ga B., Piersiak T., Pawelec J., Gawron A. Quercetin suppresses heat shock-induced nuclear translocation of Hsp72. Folia Histochem. Cytobiol. 2005, 43:123-128.
49. Jakubowicz-Gil J., Rzeski W., Zdzisińska B., Piersiak T., Weiksza K., Głowniak K., Gawron A. Different sensitivity of neurons and neuroblastoma cells to quercetin treatment. Acta Neurobiol. Exp. (Wars.) 2008, 68:463-476.
50. Thangasamy T., Sittadjody S., Mitchell G.C., Mendoza E.E., Radhakrishnan V.M., Limesand K.H., Burd R. Quercetin abrogates chemoresistance in melanoma cells by modulating deltaNp73. BMC Cancer 2010, 10:282.
51. Joy A.M., Beaudry C.E., Tran N.L., Ponce F.A., Holz D.R., Demuth T., Berens M.E. Migrating glioma cells activate the PI3-K pathway and display decreased susceptibility to apoptosis. J. Cell Sci. 2003, 116:4409-4417.