Age-related autophagy alterations in the brain of senescence accelerated mouse prone 8 (SAMP8) mice

Experimental Gerontology

Volumn 46, Issue 7, 2011, Pages 533-541

  Ma, Qinying ^a,b   Qiang, Jing ^a,b   Gu, Ping ^a,b   Wang, Yanyong ^a,b   Geng, Yuan ^a,b   Wang, Mingwei ^a,b  

^a HEBEI MEDICAL UNIVERSITY   (China)

^b Brain Aging and Cognitive Neuroscience Laboratory of Hebei Province   (China)

Author keywords

Aging; Autophagy; Beclin 1; LC3; SAMP8 mouse

Indexed keywords

BECLIN 1; MICROTUBULE ASSOCIATED PROTEIN; MICROTUBULE ASSOCIATED PROTEIN LIGHT CHAIN 3; UBIQUITIN; UNCLASSIFIED DRUG;

AGING; ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AUTOPHAGY; BRAIN CORTEX; BRAIN REGION; CELL INCLUSION; CELL ULTRASTRUCTURE; CELL VACUOLE; COGNITIVE DEFECT; CONTROLLED STUDY; CYTOPLASM; HIPPOCAMPUS; MALE; MOUSE; NERVE CELL; NERVE DEGENERATION; NERVE FIBER; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; SENESCENCE ACCELERATED MOUSE; TIME; UBIQUITINATION;

AGING; ANIMALS; APOPTOSIS REGULATORY PROTEINS; AUTOPHAGY; CEREBRAL CORTEX; HIPPOCAMPUS; INCLUSION BODIES; MALE; MAZE LEARNING; MEMORY; MICE; MICROTUBULE-ASSOCIATED PROTEINS; NEURONS; UBIQUITIN; UBIQUITINATED PROTEINS;

MUS; RODENTIA;

EID: 79956324801     PISSN: 05315565     EISSN: 18736815     Source Type: Journal    
DOI: 10.1016/j.exger.2011.02.006     Document Type: Article

References (37)

1. Caballero B., Vega-Naredo I., Sierra V., DeGonzalo-Calvo D., Medrano-Campillo P., Guerrero J.M., Tolivia D., Rodríguez-Colunga M.J., Coto-Montes A. Autophagy upregulation and loss of NF-kB in oxidative stress-related immunodeficient SAMP8 mice. Mech. Aging. Dev. 2009, 130:722-730.
2. Canudas A.M., Gutierrez-Cuesta J., Rodríguez M.I., Acuña-Castroviejo D., Sureda F.X., Camins A., Pallàs M. Hyperphosphorylation of microtubule-associated protein tau in senescence-accelerated mouse (SAM). Mech. Aging. Dev. 2005, 126:1300-1304.
3. Ciechanover A. Intracellular protein degradation: from a vague idea thru the lysosome and the ubiquitin-proteasome system and onto human diseases and drug targeting. Cell Death Differ. 2005, 12:1178-1190.
4. Colleen A.McMullen, Amy L.Ferry, Jorge L.Gamboa, Francisco H.Andrade, Esther E.Dupont-Versteegden Age-related changes of cell death pathways in rat extraocular muscle. Exp. Gerontol. 2009, 44:420-425.
5. Del Valle J., Duran-Vilaregut J., Manich G., Casadesús G., Smith M.A., Camins A., Pallàs M., Pelegrí C., Vilaplana J. Early amyloid accumulation in the hippocampus of SAMP8 mice. J. Alzheimers Dis. 2010, 19:1303-1315.
6. Erlich S., Shohami E., Pinkas-Kramarski R. Neurodegeneration induces upregulation of Beclin 1. Autophagy 2006, 2:49-51.
7. Ettore Bergamini Autophagy: a cell repair mechanism that retards ageing and age-associated diseases and can be intensified pharmacologically. Mol. Aspects Med. 2006, 27:403-410.
8. Ghi P., Di Brisco F., Dallorto D., Osella M.C., Orsetti M. Age-related modifications of egr1 expression and ubiquitin-proteasome components in pet dog hippocampus. Mech. Ageing Dev. 2009, 130:320-327.
9. Hara T., Nakamura K., Matsui M., Yamamoto A., Nakahara Y., Suzuki-Migishima R., Yokoyama M., Mishima K., Saito I., Okano H., Mizushima N. Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice. Nature 2006, 441:885-889.
10. Hosokawa M., Kasai R., Higuchi K., Takeshita S., Shimizu K., Hamamoto H., Honma A., Irino M., Toda K., Matsumura A. Grading score system: a method for evaluation of the degree of senescence in senescence accelerated mouse (SAM). Mech. Aging. Dev. 1984, 26:91-102.
11. Juhász G., Erdi B., Sass M., Neufeld T.P. Atg7-dependent autophagy promotes neuronal health, stress tolerance, and longevity but is dispensable for metamorphosis in Drosophila. Genes Dev. 2007, 21:3061-3066.
12. Kawamata T., Akiguchi I., Yagi H., Irino M., Sugiyama H., Akiyama H., Shimada A., Takemura M., Ueno M., Kitabayashi T., Ohnishi K., Seriu N., Higuchi K., Hosokawa M., Takeda T. Neuropathological studies on strains of senescence-accelerated mice (SAM) with age-related deficits in learning and memory. Exp. Gerontol. 1997, 32:161-170.
13. Kim P.K., Hailey D.W., Mullen R.T., Lippincott-Schwartz J. Ubiquitin signals autophagic degradation of cytosolic proteins and peroxisomes. Prog. Nat. Sci. 2008, 105:20567-20574.
14. Komatsu M., Waguri S., Chiba T., Murata S., Iwata J., Tanida I., Ueno T., Koike M., Uchiyama Y., Kominami E., Tanaka K. Loss of autophagy in the central nervous system causes neurodegeneration in mice. Nature 2006, 441:880-884.
15. Kraft C., Peter M., Hofmann K. Selective autophagy: ubiquitin-mediated recognition and beyond. Nat. Cell Biol. 2010, 12:836-841.
16. Levine B., Klionsky D.J. Development by self-digestion: molecular mechanisms and biological functions of autophagy. Dev. Cell 2004, 6:463-477.
17. Levine B., Kroemer G. Autophagy in the pathogenesis of disease. Cell 2008, 132:27-42.
18. Lowe J., Hand N., Mayer R.J. Application of ubiquitin immunohistochemistry to the diagnosis of disease. Methods Enzymol. 2005, 399:86-119.
19. McCray B.A., Taylor J.P. The role of autophagy in age-related neurodegeneration. Neurosignals 2008, 16:75-84.
20. Miyamoto M. Characteristics of age-related behavioural changes in senescence-accelerated mouse SAMP8 and SAMP10. Exp. Gerontol. 1997, 32:139-148.
21. Nixon R.A., Wegiel J., Kumar A., Yu W.H., Peterhoff C., Cataldo A., Cuervo A.M. Extensive involvement of autophagy in Alzheimer disease: an immuno-electron microscopy study. J. Neuropathol. Exp. Neurol. 2005, 64:113-122.
22. Nomura Y., Okuma Y. Age-related defects in lifespan and learning ability in SAMP8 mice. Neurobiol. Aging 1999, 20:111-115.
23. Pickford F., Masliah E., Britschgi M., Lucin K., Narasimhan R., Jaeger P.A., Small S., Spencer B., Rockenstein E., Levine B., Wyss-Coray T. The autophagy-related protein shows reduced expression in early Alzheimer disease and regulates amyloid beta accumulation in mice. J. Clin. Invest. 2008, 118:2190-2199.
24. Rubinsztein D.C., Cuervo A.M., Ravikumar B., Sarkar S., Korolchuk V., Kaushik S., Klionsky D.J. In search of an "autophagomometer". Autophagy 2009, 1:84-91.
25. Shibata M., Lu T., Furuya T., Degterev A., Mizushima N., Yoshimori T., MacDonald M., Yankner B., Yuan J. Regulation of intracellular accumulation of mutant Huntingtin by Beclin 1. J. Biol. Chem. 2006, 281:14474-14485.
26. Shintani T., Klionsky D.J. Autophagy in health and disease: a double-edged sword. Science 2004, 306:990-995.
27. Simonsen A., Cumming R.C., Brech A., Isakson P., Schubert D.R., Finley K.D. Promoting basal levels of autophagy in the nervous system enhances longevity and oxidant resistance in adult Drosophila. Autophagy 2008, 4:176-184.
28. Smith M.A. Alzheimer disease. Int. Rev. Neurobiol. 1998, 42:1-54.
29. Spencer B., Potkar R., Trejo M., Rockenstein E., Patrick C., Gindi R., Adame A., Wyss-Coray T., Masliah E. Beclin 1 gene transfer activates autophagy and ameliorates the neurodegenerative pathology in alpha-synuclein models of Parkinson's and Lewy body diseases. J. Neurosci. 2009, 29:13578-13588.
30. Takeda T., Hosokawa M., Higuchi K., Hosono M., Akiguchi I., Katoh H. A novel murine model of aging, senescence-accelerated mouse (SAM). Arch. Gerontol. Geriatr. 1994, 19:185-192.
31. Takeda T., Matsushita T., Kurozumi M., Takemura K., Higuchi K., Hosokawa M. Pathobiology of the senescence-accelerated mouse (SAM). Exp. Gerontol. 1997, 32:117-127.
32. Tanida I., Minematsu-Ikeguchi N., Ueno T., Kominami E. Lysosomal turnover, but not a cellular level of endogenous LC3 is a marker for autophagy. Autophagy 2005, 1:84-91.
33. Tomobe K., Nomura Y. Neurochemistry, neuropathology, and heredity in SAMP8: a mouse model of senescence. Neurochem. Res. 2009, 34:660-669.
34. Wang F., Chen H., Sun X. Age-related spatial cognitive impairment is correlated with a decrease in ChAT in the cerebral cortex, hippocampus and forebrain of SAMP8 mice. Neurosci. Lett. 2009, 454:212-217.
35. Yue Z., Horton A., Bravin M., DeJager P.L., Selimi F., Heintz N. A novel protein complex linking the 2 glutamate receptor and autophagy: implications for neurodegeneration in lurcher mice. Neuron 2002, 35:921-933.
36. Zhao X.H., Awayam A., Kobayashi H., Ohnuki T., Tokumitsu Y., Nomura Y. Age-related changes in uptake and release on L-[3H] noradrenaline in brain slices of senescence accelerated mouse. Int. J. Dev. Neurosci. 1990, 8:267-272.
37. Zhao X.H., Kitamura Y., Nomura Y. Age-related changes in NMDA-induced [3H]acetylcholine release from brain slices of senescence accelerated mouse. Int. J. Dev. Neurosci. 1992, 10:121-129.