Amyloid-binding compounds maintain protein homeostasis during ageing and extend lifespan

Nature

Volumn 472, Issue 7342, 2011, Pages 226-230

  Alavez, Silvestre ^a   Vantipalli, Maithili C ^a   Zucker, David J S ^a,b   Klang, Ida M ^a,c   Lithgow, Gordon J ^a  

^a BUCK INSTITUTE FOR RESEARCH ON AGING   (United States)

^b DOMINICAN UNIVERSITY OF CALIFORNIA   (United States)

^c KAROLINSKA INSTITUTE   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID; AMYLOID BETA PROTEIN; CHAPERONE; HEAT SHOCK TRANSCRIPTION FACTOR 1; THIOFLAVINE;

ADULT; AGING POPULATION; BIOACCUMULATION; CELL ORGANELLE; DISEASE PREVALENCE; DRUG; DYE; GENETIC ANALYSIS; HEAT SHOCK; HISTOPATHOLOGY; HOMEOSTASIS; LONGEVITY; METAZOAN; MOLECULAR ANALYSIS; NEMATODE; PEPTIDE; PROTEIN; TOXICITY;

AGING; ARTICLE; AUTOPHAGY; CAENORHABDITIS ELEGANS; CONTROLLED STUDY; HUMAN; IN VIVO STUDY; LIFESPAN; NONHUMAN; PATHOLOGY; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN HOMEOSTASIS; STRESS;

AGING; AMYLOID; AMYLOID BETA-PEPTIDES; ANIMALS; AUTOPHAGY; CAENORHABDITIS ELEGANS; CAENORHABDITIS ELEGANS PROTEINS; CURCUMIN; DNA-BINDING PROTEINS; DOSE-RESPONSE RELATIONSHIP, DRUG; HOMEOSTASIS; HUMANS; LONGEVITY; MOLECULAR CHAPERONES; PARALYSIS; PHENOTYPE; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN BINDING; PROTEINS; SURVIVAL ANALYSIS; THIAZOLES; TRANSCRIPTION FACTORS;

ANIMALIA; CAENORHABDITIS ELEGANS; METAZOA;

EID: 79954571967     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature09873     Document Type: Article

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