메뉴 건너뛰기




Volumn 12, Issue 10, 2012, Pages 721-732

Tumorigenesis in Down's syndrome: Big lessons from a small chromosome

Author keywords

[No Author keywords available]

Indexed keywords

ANTIANGIOGENIC ACTIVITY; CANCER EPIDEMIOLOGY; CANCER PREVENTION; CANCER SUSCEPTIBILITY; CANCER THERAPY; CARCINOGENESIS; CHILDHOOD LEUKEMIA; DOWN SYNDROME; HUMAN; PRIORITY JOURNAL; REVIEW; SOLID TUMOR;

EID: 84866735729     PISSN: 1474175X     EISSN: 14741768     Source Type: Journal    
DOI: 10.1038/nrc3355     Document Type: Review
Times cited : (92)

References (174)
  • 1
    • 0000922691 scopus 로고
    • Observation on an ethnic classification of idiots
    • Down, J. L. H. Observation on an ethnic classification of idiots. Lond. Hosp. Rep. 3, 259-262 (1866).
    • (1866) Lond. Hosp. Rep. , vol.3 , pp. 259-262
    • Down, J.L.H.1
  • 2
    • 56249148900 scopus 로고    scopus 로고
    • Prenatal screening for Down's syndrome: Editorial responsibilities
    • Boys, C. et al. Prenatal screening for Down's syndrome: editorial responsibilities. Lancet 372, 1789-1791 (2008).
    • (2008) Lancet , vol.372 , pp. 1789-1791
    • Boys, C.1
  • 3
    • 79952777513 scopus 로고    scopus 로고
    • Changes in yearly birth prevalence rates of children with Down syndrome in the period 1986-2007 in the Netherlands
    • de Graaf, G. et al. Changes in yearly birth prevalence rates of children with Down syndrome in the period 1986-2007 in The Netherlands. J. Intellect. Disabil. Res. 55, 462-473 (2011).
    • (2011) J. Intellect. Disabil. Res. , vol.55 , pp. 462-473
    • De Graaf, G.1
  • 4
    • 37249045895 scopus 로고    scopus 로고
    • How far can prenatal screening go in preventing birth defects?
    • Savitz, D. A. How far can prenatal screening go in preventing birth defects? J. Pediatr. 152, 3-4 (2008).
    • (2008) J. Pediatr. , vol.152 , pp. 3-4
    • Savitz, D.A.1
  • 5
    • 65549156992 scopus 로고    scopus 로고
    • Persons with Down syndrome in residential care in Israel: Trends for 1998-2006
    • Morad, M., Kandel, I., Merrick-Kenig, E. & Merrick, J. Persons with Down syndrome in residential care in Israel: trends for 1998-2006. Int. J. Adolesc. Med. Health 21, 131-134 (2009).
    • (2009) Int. J. Adolesc. Med. Health , vol.21 , pp. 131-134
    • Morad, M.1    Kandel, I.2    Merrick-Kenig, E.3    Merrick, J.4
  • 6
    • 0342905433 scopus 로고    scopus 로고
    • Risks of leukaemia and solid tumours in individuals with Down's syndrome
    • Hasle, H., Clemmensen, I. H. & Mikkelsen, M. Risks of leukaemia and solid tumours in individuals with Down's syndrome. Lancet 355, 165-169 (2000).
    • (2000) Lancet , vol.355 , pp. 165-169
    • Hasle, H.1    Clemmensen, I.H.2    Mikkelsen, M.3
  • 7
    • 0000638625 scopus 로고
    • Simultaneous occurrence of mongolism and leukemia; Report of a nationwide survey
    • Krivit, W. & Good, R. A. Simultaneous occurrence of mongolism and leukemia; report of a nationwide survey. AMA J. Dis. Child 94, 289-293 (1957).
    • (1957) AMA J. Dis. Child , vol.94 , pp. 289-293
    • Krivit, W.1    Good, R.A.2
  • 9
    • 0037160991 scopus 로고    scopus 로고
    • Mortality associated with Down's syndrome in the USA from 1983 to 1997: A population-based study
    • Yang, Q., Rasmussen, S. A. & Friedman, J. M. Mortality associated with Down's syndrome in the USA from 1983 to 1997: a population-based study. Lancet 359, 1019-1025 (2002).
    • (2002) Lancet , vol.359 , pp. 1019-1025
    • Yang, Q.1    Rasmussen, S.A.2    Friedman, J.M.3
  • 10
    • 0036153957 scopus 로고    scopus 로고
    • Incidence and treatment of potentially lethal diseases in transient leukemia of Down syndrome: Pediatric Oncology Group Study
    • Al-Kasim, F., Doyle, J. J., Massey, G. V., Weinstein, H. J. & Zipursky, A. Incidence and treatment of potentially lethal diseases in transient leukemia of Down syndrome: Pediatric Oncology Group Study. J. Pediatr. Hematol. Oncol. 24, 9-13 (2002).
    • (2002) J. Pediatr. Hematol. Oncol. , vol.24 , pp. 9-13
    • Al-Kasim, F.1    Doyle, J.J.2    Massey, G.V.3    Weinstein, H.J.4    Zipursky, A.5
  • 11
    • 63149148538 scopus 로고    scopus 로고
    • Insights into the manifestations, outcomes, and mechanisms of leukemogenesis in Down syndrome
    • Malinge, S., Izraeli, S. & Crispino, J. D. Insights into the manifestations, outcomes, and mechanisms of leukemogenesis in Down syndrome. Blood 11 3, 2619-2628 (2009).
    • (2009) Blood , vol.113 , pp. 2619-2628
    • Malinge, S.1    Izraeli, S.2    Crispino, J.D.3
  • 12
    • 3042636440 scopus 로고    scopus 로고
    • Microarray transcript profiling distinguishes the transient from the acute type of megakaryoblastic leukaemia (M7) in Down's syndrome, revealing PRAME as a specific discriminating marker
    • McElwaine, S. et al. Microarray transcript profiling distinguishes the transient from the acute type of megakaryoblastic leukaemia (M7) in Down's syndrome, revealing PRAME as a specific discriminating marker. Br. J. Haematol. 125, 729-742 (2004).
    • (2004) Br. J. Haematol. , vol.125 , pp. 729-742
    • McElwaine, S.1
  • 13
    • 77955870488 scopus 로고    scopus 로고
    • Developmental stage-specific interplay of GATA1 and IGF signaling in fetal megakaryopoiesis and leukemogenesis
    • Klusmann, J. H. et al. Developmental stage-specific interplay of GATA1 and IGF signaling in fetal megakaryopoiesis and leukemogenesis. Genes Dev. 24, 1659-1672 (2010).
    • (2010) Genes Dev. , vol.24 , pp. 1659-1672
    • Klusmann, J.H.1
  • 14
    • 0036727413 scopus 로고    scopus 로고
    • Acquired mutations in GATA1 in the megakaryoblastic leukemia of Down syndrome
    • Wechsler, J. et al. Acquired mutations in GATA1 in the megakaryoblastic leukemia of Down syndrome. Nature Genet. 32, 148-152 (2002).
    • (2002) Nature Genet. , vol.32 , pp. 148-152
    • Wechsler, J.1
  • 15
    • 0037906527 scopus 로고    scopus 로고
    • Acquired mutations in GATA1 in neonates with Down's syndrome with transient myeloid disorder
    • Groet, J. et al. Acquired mutations in GATA1 in neonates with Down's syndrome with transient myeloid disorder. Lancet 361, 1617-1620 (2003).
    • (2003) Lancet , vol.361 , pp. 1617-1620
    • Groet, J.1
  • 16
    • 54349086521 scopus 로고    scopus 로고
    • Mutations of JAK2 in acute lymphoblastic leukaemias associated with Down's syndrome
    • Bercovich, D. et al. Mutations of JAK2 in acute lymphoblastic leukaemias associated with Down's syndrome. Lancet 372, 1484-1492 (2008).
    • (2008) Lancet , vol.372 , pp. 1484-1492
    • Bercovich, D.1
  • 17
    • 60249086789 scopus 로고    scopus 로고
    • Specific JAK2 mutation (JAK2R683) and multiple gene deletions in Down syndrome acute lymphoblastic leukemia
    • Kearney, L. et al. Specific JAK2 mutation (JAK2R683) and multiple gene deletions in Down syndrome acute lymphoblastic leukemia. Blood 11 3, 646-648 (2009).
    • (2009) Blood , vol.113 , pp. 646-648
    • Kearney, L.1
  • 18
    • 77649214639 scopus 로고    scopus 로고
    • Down syndrome acute lymphoblastic leukemia, a highly heterogeneous disease in which aberrant expression of CRLF2 is associated with mutated JAK2: A report from the International BFM Study Group
    • Hertzberg, L. et al. Down syndrome acute lymphoblastic leukemia, a highly heterogeneous disease in which aberrant expression of CRLF2 is associated with mutated JAK2: a report from the International BFM Study Group. Blood 11 5, 1006-1017 (2010).
    • (2010) Blood , vol.115 , pp. 1006-1017
    • Hertzberg, L.1
  • 19
    • 70350519430 scopus 로고    scopus 로고
    • Deregulated expression of cytokine receptor gene, CRLF2, is involved in lymphoid transformation in B-cell precursor acute lymphoblastic leukemia
    • Russell, L. J. et al. Deregulated expression of cytokine receptor gene, CRLF2, is involved in lymphoid transformation in B-cell precursor acute lymphoblastic leukemia. Blood 11 4, 2688-2698 (2009).
    • (2009) Blood , vol.114 , pp. 2688-2698
    • Russell, L.J.1
  • 20
    • 33645349057 scopus 로고    scopus 로고
    • An ovarian dysgerminoma in Down syndrome. Hypothesis about the association
    • Satge, D. et al. An ovarian dysgerminoma in Down syndrome. Hypothesis about the association. Int. J. Gynecol. Cancer 16, S375-S379 (2006).
    • (2006) Int. J. Gynecol. Cancer , vol.16
    • Satge, D.1
  • 21
    • 0031023915 scopus 로고    scopus 로고
    • Intracranial germinoma with Down's syndrome: A case report and review of the literature
    • Tanabe, M. et al. Intracranial germinoma with Down's syndrome: a case report and review of the literature. Surg. Neurol. 47, 28-31 (1997).
    • (1997) Surg. Neurol. , vol.47 , pp. 28-31
    • Tanabe, M.1
  • 22
    • 7944222395 scopus 로고    scopus 로고
    • Cancers and immune related diseases associated with Down's syndrome: A record linkage study
    • Goldacre, M. J., Wotton, C. J., Seagroatt, V. & Yeates, D. Cancers and immune related diseases associated with Down's syndrome: a record linkage study. Arch. Dis. Child 89, 1014-1017 (2004).
    • (2004) Arch. Dis. Child , vol.89 , pp. 1014-1017
    • Goldacre, M.J.1    Wotton, C.J.2    Seagroatt, V.3    Yeates, D.4
  • 23
    • 0035412104 scopus 로고    scopus 로고
    • Pattern of malignant disorders in individuals with Down's syndrome
    • Hasle, H. Pattern of malignant disorders in individuals with Down's syndrome. Lancet Oncol. 2, 429-436 (2001).
    • (2001) Lancet Oncol. , vol.2 , pp. 429-436
    • Hasle, H.1
  • 24
    • 0035023396 scopus 로고    scopus 로고
    • Mortality and cancer incidence in persons with Down's syndrome, their parents and siblings
    • Hermon, C., Alberman, E., Beral, V. & Swerdlow, A. J. Mortality and cancer incidence in persons with Down's syndrome, their parents and siblings. Ann. Hum. Genet. 65, 167-176 (2001).
    • (2001) Ann. Hum. Genet. , vol.65 , pp. 167-176
    • Hermon, C.1    Alberman, E.2    Beral, V.3    Swerdlow, A.J.4
  • 25
    • 0037463857 scopus 로고    scopus 로고
    • Mortality and cancer incidence among individuals with Down syndrome
    • Hill, D. A. et al. Mortality and cancer incidence among individuals with Down syndrome. Arch. Intern. Med. 163, 705-711 (2003).
    • (2003) Arch. Intern. Med. , vol.163 , pp. 705-711
    • Hill, D.A.1
  • 26
    • 33644872564 scopus 로고    scopus 로고
    • Cancer incidence of persons with Down syndrome in Finland: A population-based study
    • Patja, K., Pukkala, E., Sund, R., Iivanainen, M. & Kaski, M. Cancer incidence of persons with Down syndrome in Finland: a population-based study. Int. J. Cancer 11 8, 1769-1772 (2006).
    • (2006) Int. J. Cancer , vol.118 , pp. 1769-1772
    • Patja, K.1    Pukkala, E.2    Sund, R.3    Iivanainen, M.4    Kaski, M.5
  • 27
    • 79953034087 scopus 로고    scopus 로고
    • Testicular germ cell tumours: Predisposition genes and the male germ cell niche
    • Gilbert, D., Rapley, E. & Shipley, J. Testicular germ cell tumours: predisposition genes and the male germ cell niche. Nature Rev. Cancer 11, 278-288 (2011).
    • (2011) Nature Rev. Cancer , vol.11 , pp. 278-288
    • Gilbert, D.1    Rapley, E.2    Shipley, J.3
  • 28
    • 0032765295 scopus 로고    scopus 로고
    • Seminoma associated with bilateral cryptorchidism in Down's syndrome: A case report
    • Miki, M., Ohtake, N., Hasumi, M., Ohi, M. & Moriyama, S. Seminoma associated with bilateral cryptorchidism in Down's syndrome: a case report. Int. J. Urol. 6, 377-380 (1999).
    • (1999) Int. J. Urol. , vol.6 , pp. 377-380
    • Miki, M.1    Ohtake, N.2    Hasumi, M.3    Ohi, M.4    Moriyama, S.5
  • 29
    • 29044445171 scopus 로고    scopus 로고
    • Maturation delay of germ cells in fetuses with trisomy 21 results in increased risk for the development of testicular germ cell tumors
    • Cools, M. et al. Maturation delay of germ cells in fetuses with trisomy 21 results in increased risk for the development of testicular germ cell tumors. Hum. Pathol. 37, 101-111 (2006).
    • (2006) Hum. Pathol. , vol.37 , pp. 101-111
    • Cools, M.1
  • 30
    • 0035452428 scopus 로고    scopus 로고
    • Incidence of leukemia and other cancers in Down syndrome subjects in Israel
    • Boker, L. K. et al. Incidence of leukemia and other cancers in Down syndrome subjects in Israel. Int. J. Cancer 93, 741-744 (2001).
    • (2001) Int. J. Cancer , vol.93 , pp. 741-744
    • Boker, L.K.1
  • 32
    • 0020466620 scopus 로고
    • Leukemia and other cancers, anomalies and infections as causes of death in Down's syndrome in the United States during 1976
    • Scholl, T., Stein, Z. & Hansen, H. Leukemia and other cancers, anomalies and infections as causes of death in Down's syndrome in the United States during 1976. Dev. Med. Child Neurol. 24, 817-829 (1982).
    • (1982) Dev. Med. Child Neurol. , vol.24 , pp. 817-829
    • Scholl, T.1    Stein, Z.2    Hansen, H.3
  • 33
    • 14044254171 scopus 로고    scopus 로고
    • Mortality and causes of death in persons with Down syndrome in California
    • Day, S. M., Strauss, D. J., Shavelle, R. M. & Reynolds, R. J. Mortality and causes of death in persons with Down syndrome in California. Dev. Med. Child Neurol. 47, 171-176 (2005).
    • (2005) Dev. Med. Child Neurol. , vol.47 , pp. 171-176
    • Day, S.M.1    Strauss, D.J.2    Shavelle, R.M.3    Reynolds, R.J.4
  • 34
    • 0037817354 scopus 로고    scopus 로고
    • Are solid tumours different in children with Down's syndrome?
    • Satge, D., Sasco, A. J. & Lacour, B. Are solid tumours different in children with Down's syndrome? Int. J. Cancer 106, 297-298 (2003).
    • (2003) Int. J. Cancer , vol.106 , pp. 297-298
    • Satge, D.1    Sasco, A.J.2    Lacour, B.3
  • 35
    • 17144463566 scopus 로고    scopus 로고
    • A lack of neuroblastoma in Down syndrome: A study from 11 European countries
    • Satge, D. et al. A lack of neuroblastoma in Down syndrome: a study from 11 European countries. Cancer Res. 58, 448-452 (1998).
    • (1998) Cancer Res. , vol.58 , pp. 448-452
    • Satge, D.1
  • 36
    • 0033815915 scopus 로고    scopus 로고
    • Aneuploidy the somatic mutation that makes cancer a species of its own
    • Duesberg, P. & Rasnick, D. Aneuploidy, the somatic mutation that makes cancer a species of its own. Cell Motil. Cytoskeleton 47, 81-107 (2000).
    • (2000) Cell Motil. Cytoskeleton , vol.47 , pp. 81-107
    • Duesberg, P.1    Rasnick, D.2
  • 37
    • 75149140916 scopus 로고    scopus 로고
    • Mitotic chromosomal instability and cancer: Mouse modelling of the human disease
    • Schvartzman, J. M., Sotillo, R. & Benezra, R. Mitotic chromosomal instability and cancer: mouse modelling of the human disease. Nature Rev. Cancer 10, 102-115 (2010).
    • (2010) Nature Rev. Cancer , vol.10 , pp. 102-115
    • Schvartzman, J.M.1    Sotillo, R.2    Benezra, R.3
  • 38
    • 84857192718 scopus 로고    scopus 로고
    • Causes and consequences of aneuploidy in cancer
    • Gordon, D. J., Resio, B. & Pellman, D. Causes and consequences of aneuploidy in cancer. Nature Rev. Genet. 13, 189-203 (2012).
    • (2012) Nature Rev. Genet. , vol.13 , pp. 189-203
    • Gordon, D.J.1    Resio, B.2    Pellman, D.3
  • 39
    • 67649522162 scopus 로고    scopus 로고
    • Boveri revisited: Chromosomal instability, aneuploidy and tumorigenesis
    • Holland, A. J. & Cleveland, D. W. Boveri revisited: chromosomal instability, aneuploidy and tumorigenesis. Nature Rev. Mol. Cell Biol. 10, 478-487 (2009).
    • (2009) Nature Rev. Mol. Cell Biol. , vol.10 , pp. 478-487
    • Holland, A.J.1    Cleveland, D.W.2
  • 40
    • 33745450112 scopus 로고    scopus 로고
    • Molecular cytogenetic characteristics of Down syndrome newborns
    • Amiel, A., Goldzak, G., Gaber, E. & Fejgin, M. D. Molecular cytogenetic characteristics of Down syndrome newborns. J. Hum. Genet. 51, 541-547 (2006).
    • (2006) J. Hum. Genet. , vol.51 , pp. 541-547
    • Amiel, A.1    Goldzak, G.2    Gaber, E.3    Fejgin, M.D.4
  • 41
    • 70349886561 scopus 로고    scopus 로고
    • Telomere aggregates in trisomy 21 amniocytes
    • Hadi, E. et al. Telomere aggregates in trisomy 21 amniocytes. Cancer Genet. Cytogenet. 195, 23-26 (2009).
    • (2009) Cancer Genet. Cytogenet. , vol.195 , pp. 23-26
    • Hadi, E.1
  • 42
    • 0031044285 scopus 로고    scopus 로고
    • Increased low-level chromosome 21 mosaicism in older individuals with Down syndrome
    • Jenkins, E. C. et al. Increased low-level chromosome 21 mosaicism in older individuals with Down syndrome. Am. J. Med. Genet. 68, 147-151 (1997).
    • (1997) Am. J. Med. Genet. , vol.68 , pp. 147-151
    • Jenkins, E.C.1
  • 43
    • 0027474055 scopus 로고
    • Age-associated chromosome 21 loss in Down syndrome: Possible relevance to mosaicism and Alzheimer disease
    • Percy, M. E. et al. Age-associated chromosome 21 loss in Down syndrome: possible relevance to mosaicism and Alzheimer disease. Am. J. Med. Genet. 45, 584-588 (1993).
    • (1993) Am. J. Med. Genet. , vol.45 , pp. 584-588
    • Percy, M.E.1
  • 44
    • 4344652781 scopus 로고    scopus 로고
    • Low level chromosome instability in embryonic cells of primary aneuploid mice
    • Lightfoot, D. A. & Hoog, C. Low level chromosome instability in embryonic cells of primary aneuploid mice. Cytogenet. Genome Res. 107, 95-98 (2004).
    • (2004) Cytogenet. Genome Res. , vol.107 , pp. 95-98
    • Lightfoot, D.A.1    Hoog, C.2
  • 45
    • 79954600431 scopus 로고    scopus 로고
    • Sporadic aneuploidy in PHA-stimulated lymphocytes of trisomies 21, 18, and 13
    • Reish, O., Regev, M., Kanesky, A., Girafi, S. & Mashevich, M. Sporadic aneuploidy in PHA-stimulated lymphocytes of trisomies 21, 18, and 13. Cytogenet. Genome Res. 133, 184-189 (2011).
    • (2011) Cytogenet. Genome Res. , vol.133 , pp. 184-189
    • Reish, O.1    Regev, M.2    Kanesky, A.3    Girafi, S.4    Mashevich, M.5
  • 46
    • 63149148209 scopus 로고    scopus 로고
    • Constitutional aneuploidy and cancer predisposition
    • Ganmore, I., Smooha, G. & Izraeli, S. Constitutional aneuploidy and cancer predisposition. Hum. Mol. Genet. 18, R84-R93 (2009).
    • (2009) Hum. Mol. Genet. , vol.18
    • Ganmore, I.1    Smooha, G.2    Izraeli, S.3
  • 47
    • 40749104900 scopus 로고    scopus 로고
    • Cancer incidence in women with Turner syndrome in Great Britain: A national cohort study
    • Schoemaker, M. J., Swerdlow, A. J., Higgins, C. D., Wright, A. F. & Jacobs, P. A. Cancer incidence in women with Turner syndrome in Great Britain: a national cohort study. Lancet Oncol. 9, 239-246 (2008).
    • (2008) Lancet Oncol. , vol.9 , pp. 239-246
    • Schoemaker, M.J.1    Swerdlow, A.J.2    Higgins, C.D.3    Wright, A.F.4    Jacobs, P.A.5
  • 48
    • 0035023397 scopus 로고    scopus 로고
    • Mortality and cancer incidence in persons with numerical sex chromosome abnormalities: A cohort study
    • Swerdlow, A. J. et al. Mortality and cancer incidence in persons with numerical sex chromosome abnormalities: a cohort study. Ann. Hum. Genet. 65, 177-188 (2001).
    • (2001) Ann. Hum. Genet. , vol.65 , pp. 177-188
    • Swerdlow, A.J.1
  • 49
    • 38949098169 scopus 로고    scopus 로고
    • Cytogenetic features of acute lymphoblastic and myeloid leukemias in pediatric patients with Down syndrome: An iBFM-SG study
    • Forestier, E. et al. Cytogenetic features of acute lymphoblastic and myeloid leukemias in pediatric patients with Down syndrome: an iBFM-SG study. Blood 111, 1575-1583 (2008).
    • (2008) Blood , vol.111 , pp. 1575-1583
    • Forestier, E.1
  • 50
    • 84865537739 scopus 로고    scopus 로고
    • High frequency of copy number alterations in myeloid leukaemia of Down syndrome
    • 7 Jul 2012 doi:10.1111/j.1365-2141.2012.09224.x
    • Blink, M. et al. High frequency of copy number alterations in myeloid leukaemia of Down syndrome. Br. J. Haematol. 7 Jul 2012 (doi:10.1111/j.1365- 2141.2012.09224.x).
    • Br. J. Haematol.
    • Blink, M.1
  • 51
    • 70350109641 scopus 로고    scopus 로고
    • ETS gene fusions in prostate cancer
    • Clark, J. P. & Cooper, C. S. ETS gene fusions in prostate cancer. Nature Rev. Urol. 6, 429-439 (2009).
    • (2009) Nature Rev. Urol. , vol.6 , pp. 429-439
    • Clark, J.P.1    Cooper, C.S.2
  • 52
    • 0029417023 scopus 로고
    • Apoptosis and increased generation of reactive oxygen species in Down's syndrome neurons in vitro
    • Busciglio, J. & Yankner, B. A. Apoptosis and increased generation of reactive oxygen species in Down's syndrome neurons in vitro. Nature 378, 776-779 (1995).
    • (1995) Nature , vol.378 , pp. 776-779
    • Busciglio, J.1    Yankner, B.A.2
  • 53
    • 77956197653 scopus 로고    scopus 로고
    • Systemic mitochondrial dysfunction and the etiology of Alzheimer's disease and down syndrome dementia
    • Coskun, P. E. et al. Systemic mitochondrial dysfunction and the etiology of Alzheimer's disease and down syndrome dementia. J. Alzheimers Dis. 20, S293-S310 (2010).
    • (2010) J. Alzheimers Dis. , vol.20
    • Coskun, P.E.1
  • 54
    • 69949164039 scopus 로고    scopus 로고
    • Increased lipid peroxidation in Down's syndrome mouse models
    • Ishihara, K. et al. Increased lipid peroxidation in Down's syndrome mouse models. J. Neurochem. 110, 1965-1976 (2009).
    • (2009) J. Neurochem. , vol.110 , pp. 1965-1976
    • Ishihara, K.1
  • 55
    • 33746331414 scopus 로고    scopus 로고
    • Reactive oxygen species generation in gingival fibroblasts of Down syndrome patients detected by electron spin resonance spectroscopy
    • Komatsu, T. et al. Reactive oxygen species generation in gingival fibroblasts of Down syndrome patients detected by electron spin resonance spectroscopy. Redox Rep. 11, 71-77 (2006).
    • (2006) Redox Rep. , vol.11 , pp. 71-77
    • Komatsu, T.1
  • 56
    • 37148999073 scopus 로고    scopus 로고
    • DNA damage and repair in children with Down's syndrome
    • Morawiec, Z. et al. DNA damage and repair in children with Down's syndrome. Mutat. Res. 637, 118-123 (2008).
    • (2008) Mutat. Res. , vol.637 , pp. 118-123
    • Morawiec, Z.1
  • 57
    • 33646905061 scopus 로고    scopus 로고
    • Age-dependent oxidative stress-induced DNA damage in Down's lymphocytes
    • Zana, M. et al. Age-dependent oxidative stress-induced DNA damage in Down's lymphocytes. Biochem. Biophys. Res. Commun. 345, 726-733 (2006).
    • (2006) Biochem. Biophys. Res. Commun. , vol.345 , pp. 726-733
    • Zana, M.1
  • 58
    • 0035112489 scopus 로고    scopus 로고
    • Down's syndrome fibroblasts anticipate the accumulation of specific ageing-related mtDNA mutations
    • Del Bo, R. et al. Down's syndrome fibroblasts anticipate the accumulation of specific ageing-related mtDNA mutations. Ann. Neurol. 49, 137-138 (2001).
    • (2001) Ann. Neurol. , vol.49 , pp. 137-138
    • Del Bo, R.1
  • 59
    • 0030068056 scopus 로고    scopus 로고
    • Elevation in the ratio of Cu/Zn-superoxide dismutase to glutathione peroxidase activity induces features of cellular senescence and this effect is mediated by hydrogen peroxide
    • de Haan, J. B. et al. Elevation in the ratio of Cu/Zn-superoxide dismutase to glutathione peroxidase activity induces features of cellular senescence and this effect is mediated by hydrogen peroxide. Hum. Mol. Genet. 5, 283-292 (1996).
    • (1996) Hum. Mol. Genet. , vol.5 , pp. 283-292
    • De Haan, J.B.1
  • 60
    • 0035118930 scopus 로고    scopus 로고
    • Effect of overexpression of wild-type and mutant Cu/Zn-superoxide dismutases on oxidative damage and antioxidant defences: Relevance to Down's syndrome and familial amyotrophic lateral sclerosis
    • Lee, M., Hyun, D., Jenner, P. & Halliwell, B. Effect of overexpression of wild-type and mutant Cu/Zn-superoxide dismutases on oxidative damage and antioxidant defences: relevance to Down's syndrome and familial amyotrophic lateral sclerosis. J. Neurochem. 76, 957-965 (2001).
    • (2001) J. Neurochem. , vol.76 , pp. 957-965
    • Lee, M.1    Hyun, D.2    Jenner, P.3    Halliwell, B.4
  • 61
    • 33846483260 scopus 로고    scopus 로고
    • Mitochondrial alterations and tendency to apoptosis in peripheral blood cells from children with Down syndrome
    • Roat, E. et al. Mitochondrial alterations and tendency to apoptosis in peripheral blood cells from children with Down syndrome. FEBS Lett. 581, 521-525 (2007).
    • (2007) FEBS Lett. , vol.581 , pp. 521-525
    • Roat, E.1
  • 62
    • 79954497176 scopus 로고    scopus 로고
    • Deficit of complex i activity in human skin fibroblasts with chromosome 21 trisomy and overproduction of reactive oxygen species by mitochondria: Involvement of the cAMP/PKA signalling pathway
    • Valenti, D., Manente, G. A., Moro, L, Marra, E. & Vacca, R. A. Deficit of complex I activity in human skin fibroblasts with chromosome 21 trisomy and overproduction of reactive oxygen species by mitochondria: involvement of the cAMP/PKA signalling pathway. Biochem. J. 435, 679-688 (2011).
    • (2011) Biochem. J. , vol.435 , pp. 679-688
    • Valenti, D.1    Manente, G.A.2    Moro, L.3    Marra, E.4    Vacca, R.A.5
  • 63
    • 0018879295 scopus 로고
    • Decreased repair of x-ray induced DNA single-strand breaks in lymphocytes in Down's syndrome
    • Athanasiou, K., Sideris, E. G. & Bartsocas, C. Decreased repair of x-ray induced DNA single-strand breaks in lymphocytes in Down's syndrome. Pediatr. Res. 14, 336-338 (1980).
    • (1980) Pediatr. Res. , vol.14 , pp. 336-338
    • Athanasiou, K.1    Sideris, E.G.2    Bartsocas, C.3
  • 64
    • 0031753652 scopus 로고    scopus 로고
    • Defective repair of oxidative damage in mitochondrial DNA in Down's syndrome
    • Druzhyna, N., Nair, R. G., LeDoux, S. P. & Wilson, G. L. Defective repair of oxidative damage in mitochondrial DNA in Down's syndrome. Mutat. Res. 409, 81-89 (1998).
    • (1998) Mutat. Res. , vol.409 , pp. 81-89
    • Druzhyna, N.1    Nair, R.G.2    Ledoux, S.P.3    Wilson, G.L.4
  • 65
    • 0032509749 scopus 로고    scopus 로고
    • Trisomy 21 and accelerated aging: DNA-repair parameters in peripheral lymphocytes of Down's syndrome patients
    • Raji, N. S. & Rao, K. S. Trisomy 21 and accelerated aging: DNA-repair parameters in peripheral lymphocytes of Down's syndrome patients. Mech. Ageing Dev. 100, 85-101 (1998).
    • (1998) Mech. Ageing Dev. , vol.100 , pp. 85-101
    • Raji, N.S.1    Rao, K.S.2
  • 66
    • 70350492497 scopus 로고    scopus 로고
    • Mutational spectrum at GATA1 provides insights into mutagenesis and leukemogenesis in Down syndrome
    • Cabelof, D. C. et al. Mutational spectrum at GATA1 provides insights into mutagenesis and leukemogenesis in Down syndrome. Blood 114, 2753-2763 (2009).
    • (2009) Blood , vol.114 , pp. 2753-2763
    • Cabelof, D.C.1
  • 67
    • 79952495602 scopus 로고    scopus 로고
    • Infections and immunodeficiency in Down syndrome
    • Ram, G. & Chinen, J. Infections and immunodeficiency in Down syndrome. Clin. Exp. Immunol. 164, 9-16 (2011).
    • (2011) Clin. Exp. Immunol. , vol.164 , pp. 9-16
    • Ram, G.1    Chinen, J.2
  • 68
    • 65549115151 scopus 로고    scopus 로고
    • T lymphocyte maturation is impaired in healthy young individuals carrying trisomy 21 (Down syndrome)
    • Guazzarotti, L. et al. T lymphocyte maturation is impaired in healthy young individuals carrying trisomy 21 (Down syndrome). Am. J. Intellect Dev. Disabil. 114, 100-109 (2009).
    • (2009) Am. J. Intellect Dev. Disabil. , vol.114 , pp. 100-109
    • Guazzarotti, L.1
  • 69
    • 80053082182 scopus 로고    scopus 로고
    • Decreased AIRE expression and global thymic hypofunction in Down syndrome
    • Lima, F A. et al. Decreased AIRE expression and global thymic hypofunction in Down syndrome. J. Immunol. 187, 3422-3430 (2011).
    • (2011) J. Immunol. , vol.187 , pp. 3422-3430
    • Lima, F.A.1
  • 70
    • 0026515305 scopus 로고
    • + cells: Evidence for an inefficient release of mature T cells by the DS thymus
    • + cells: evidence for an inefficient release of mature T cells by the DS thymus. Clin. Immunol. Immunopathol. 62, 245-251 (1992).
    • (1992) Clin. Immunol. Immunopathol. , vol.62 , pp. 245-251
    • Murphy, M.1    Epstein, L.B.2
  • 71
    • 68649104004 scopus 로고    scopus 로고
    • YôT cells and the lymphoid stress-surveillance response
    • Hayday, A. C. yôT cells and the lymphoid stress-surveillance response. Immunity 31, 184-196 (2009).
    • (2009) Immunity , vol.31 , pp. 184-196
    • Hayday, A.C.1
  • 72
    • 0036098159 scopus 로고    scopus 로고
    • Different drug sensitivity profiles of acute myeloid and lymphoblastic leukemia and normal peripheral blood mononuclear cells in children with and without Down syndrome
    • Zwaan, C. M. et al. Different drug sensitivity profiles of acute myeloid and lymphoblastic leukemia and normal peripheral blood mononuclear cells in children with and without Down syndrome. Blood 99, 245-251 (2002).
    • (2002) Blood , vol.99 , pp. 245-251
    • Zwaan, C.M.1
  • 73
    • 78649706953 scopus 로고    scopus 로고
    • Helicobacter pylori infection promotes methylation and silencing of trefoil factor 2, leading to gastric tumor development in mice and humans
    • Peterson, A. J. et al. Helicobacter pylori infection promotes methylation and silencing of trefoil factor 2, leading to gastric tumor development in mice and humans. Gastroenterology 139, 2005-2017 (2010).
    • (2010) Gastroenterology , vol.139 , pp. 2005-2017
    • Peterson, A.J.1
  • 74
    • 4043178428 scopus 로고    scopus 로고
    • High seroprevalence of Helicobacter pylori infection in non-institutionalised children with mental retardation
    • Luzza, F. et al. High seroprevalence of Helicobacter pylori infection in non-institutionalised children with mental retardation. Clin. Microbiol. Infect. 10, 670-673 (2004).
    • (2004) Clin. Microbiol. Infect. , vol.10 , pp. 670-673
    • Luzza, F.1
  • 75
    • 33947150465 scopus 로고    scopus 로고
    • Clinical audit of gastrointestinal conditions occurring among adults with Down syndrome attending a specialist clinic
    • Wallace, R. A. Clinical audit of gastrointestinal conditions occurring among adults with Down syndrome attending a specialist clinic. J. Intellect. Dev. Disabil. 32, 45-50 (2007).
    • (2007) J. Intellect. Dev. Disabil. , vol.32 , pp. 45-50
    • Wallace, R.A.1
  • 76
    • 0037110190 scopus 로고    scopus 로고
    • Trisomy 21 as the only recurrent chromosomal anomaly in a clinically aggressive ovarian carcinoma
    • Faruqi, S. A., Noumoff, M. J., Deger, R. B., Jalal, S. M. & Antoniades, K. Trisomy 21 as the only recurrent chromosomal anomaly in a clinically aggressive ovarian carcinoma. Cancer Genet. Cytogenet. 138, 165-168 (2002).
    • (2002) Cancer Genet. Cytogenet. , vol.138 , pp. 165-168
    • Faruqi, S.A.1    Noumoff, M.J.2    Deger, R.B.3    Jalal, S.M.4    Antoniades, K.5
  • 77
    • 0030901159 scopus 로고    scopus 로고
    • Acute lymphoblastic leukemia and chromosome 21
    • Berger, R. Acute lymphoblastic leukemia and chromosome 21. Cancer Genet. Cytogenet. 94, 8-12 (1997).
    • (1997) Cancer Genet. Cytogenet. , vol.94 , pp. 8-12
    • Berger, R.1
  • 78
    • 29444460637 scopus 로고    scopus 로고
    • Further correlations of morphology according to FAB and WHO classification to cytogenetics in de novo acute myeloid leukemia: A study on 2, 235 patients
    • Bacher, U. et al. Further correlations of morphology according to FAB and WHO classification to cytogenetics in de novo acute myeloid leukemia: a study on 2, 235 patients. Ann. Hematol. 84, 785-791 (2005).
    • (2005) Ann. Hematol. , vol.84 , pp. 785-791
    • Bacher, U.1
  • 79
    • 34547811451 scopus 로고    scopus 로고
    • Natural gene-expression variation in Down syndrome modulates the outcome of gene-dosage imbalance
    • Prandini, P. et al. Natural gene-expression variation in Down syndrome modulates the outcome of gene-dosage imbalance. Am. J. Hum. Genet. 81, 252-263 (2007).
    • (2007) Am. J. Hum. Genet. , vol.81 , pp. 252-263
    • Prandini, P.1
  • 80
    • 24744468832 scopus 로고    scopus 로고
    • The proto-oncogene ERG in megakaryoblastic leukemias
    • Rainis, L. et al. The proto-oncogene ERG in megakaryoblastic leukemias. Cancer Res. 65, 7596-7602 (2005).
    • (2005) Cancer Res. , vol.65 , pp. 7596-7602
    • Rainis, L.1
  • 81
    • 77649143631 scopus 로고    scopus 로고
    • MiR-125b-2 is a potential oncomiR on human chromosome 21 in megakaryoblastic leukemia
    • Klusmann, J. H. et al. miR-125b-2 is a potential oncomiR on human chromosome 21 in megakaryoblastic leukemia. Genes Dev. 24, 478-490 (2010).
    • (2010) Genes Dev. , vol.24 , pp. 478-490
    • Klusmann, J.H.1
  • 82
    • 66349125284 scopus 로고    scopus 로고
    • ERG is a megakaryocytic oncogene
    • Salek-Ardakani, S. et al. ERG is a megakaryocytic oncogene. Cancer Res. 69, 4665-4673 (2009).
    • (2009) Cancer Res. , vol.69 , pp. 4665-4673
    • Salek-Ardakani, S.1
  • 83
    • 65349165222 scopus 로고    scopus 로고
    • ETS2 and ERG promote megakaryopoiesis and synergize with alterations in GATA-1 to immortalize hematopoietic progenitor cells
    • Stankiewicz, M. J. & Crispino, J. D. ETS2 and ERG promote megakaryopoiesis and synergize with alterations in GATA-1 to immortalize hematopoietic progenitor cells. Blood 11 3, 3337-3347 (2009).
    • (2009) Blood , vol.113 , pp. 3337-3347
    • Stankiewicz, M.J.1    Crispino, J.D.2
  • 84
    • 77951074754 scopus 로고    scopus 로고
    • Perturbed hematopoiesis in the Tc 1 mouse model of Down syndrome
    • Alford, K. A. et al. Perturbed hematopoiesis in the Tc 1 mouse model of Down syndrome. Blood 11 5, 2928-2937 (2010).
    • (2010) Blood , vol.115 , pp. 2928-2937
    • Alford, K.A.1
  • 85
    • 77952978963 scopus 로고    scopus 로고
    • Trisomy of Erg is required for myeloproliferation in a mouse model of Down syndrome
    • Ng, A. P. et al. Trisomy of Erg is required for myeloproliferation in a mouse model of Down syndrome. Blood 11 5, 3966-3969 (2009).
    • (2009) Blood , vol.115 , pp. 3966-3969
    • Ng, A.P.1
  • 86
    • 84857814609 scopus 로고    scopus 로고
    • Increased dosage of the chromosome 21 ortholog Dyrk1a promotes megakaryoblastic leukemia in a murine model of Down syndrome
    • Malinge, S. et al. Increased dosage of the chromosome 21 ortholog Dyrk1a promotes megakaryoblastic leukemia in a murine model of Down syndrome. J. Clin. Invest. 122, 948-962 (2012).
    • (2012) J. Clin. Invest. , vol.122 , pp. 948-962
    • Malinge, S.1
  • 88
    • 84859211211 scopus 로고    scopus 로고
    • Amplified Segment in the 'Down Syndrome critical region' on HSA21 shared between Down syndrome and euploid AML-M0 excludes RUNX1, ERG and ETS2
    • Canzonetta, C. et al. Amplified segment in the 'Down Syndrome critical region' on HSA21 shared between Down syndrome and euploid AML-M0 excludes RUNX1, ERG and ETS2. Br. J. Haematol. 157, 197-200 (2012).
    • (2012) Br. J. Haematol. , vol.157 , pp. 197-200
    • Canzonetta, C.1
  • 89
    • 70449411506 scopus 로고    scopus 로고
    • Genome wide molecular analysis of minimally differentiated acute myeloid leukemia
    • Silva, F. P. et al. Genome wide molecular analysis of minimally differentiated acute myeloid leukemia. Haematologica 94, 1546-1554 (2009).
    • (2009) Haematologica , vol.94 , pp. 1546-1554
    • Silva, F.P.1
  • 90
    • 70350100470 scopus 로고    scopus 로고
    • Transchromosomic cell model of Down syndrome shows aberrant migration, adhesion and proteome response to extracellular matrix
    • Delom, F. et al. Transchromosomic cell model of Down syndrome shows aberrant migration, adhesion and proteome response to extracellular matrix. Proteome Sci. 7, 31 (2009).
    • (2009) Proteome Sci , vol.7 , pp. 31
    • Delom, F.1
  • 91
    • 21344465482 scopus 로고    scopus 로고
    • Proliferation dynamics in cultured skin fibroblasts from Down syndrome subjects
    • Kimura, M. et al. Proliferation dynamics in cultured skin fibroblasts from Down syndrome subjects. Free Radic. Biol. Med. 39, 374-380 (2005).
    • (2005) Free Radic. Biol. Med. , vol.39 , pp. 374-380
    • Kimura, M.1
  • 92
    • 38049069895 scopus 로고    scopus 로고
    • Trisomy represses Apc(Min)-mediated tumours in mouse models of Down's syndrome
    • Sussan, T. E., Yang, A., Li, F., Ostrowski, M. C. & Reeves, R. H. Trisomy represses Apc(Min)-mediated tumours in mouse models of Down's syndrome. Nature 451, 73-75 (2008).
    • (2008) Nature , vol.451 , pp. 73-75
    • Sussan, T.E.1    Yang, A.2    Li, F.3    Ostrowski, M.C.4    Reeves, R.H.5
  • 93
    • 53049108799 scopus 로고    scopus 로고
    • Ets2 maintains hTERT gene expression and breast cancer cell proliferation by interacting with c-Myc
    • Xu, D., Dwyer, J., Li, H., Duan, W. & Liu, J. P. Ets2 maintains hTERT gene expression and breast cancer cell proliferation by interacting with c-Myc. J. Biol. Chem. 283, 23567-23580 (2008).
    • (2008) J. Biol. Chem. , vol.283 , pp. 23567-23580
    • Xu, D.1    Dwyer, J.2    Li, H.3    Duan, W.4    Liu, J.P.5
  • 94
    • 0037320871 scopus 로고    scopus 로고
    • ETS2 overexpression in transgenic models and in Down syndrome predisposes to apoptosis via the p53 pathway
    • Wolvetang, E. J. et al. ETS2 overexpression in transgenic models and in Down syndrome predisposes to apoptosis via the p53 pathway. Hum. Mol. Genet. 12, 247-255 (2003).
    • (2003) Hum. Mol. Genet. , vol.12 , pp. 247-255
    • Wolvetang, E.J.1
  • 96
    • 57049159874 scopus 로고    scopus 로고
    • The protein kinase DYRK1A regulates caspase-9-mediated apoptosis during retina development
    • Laguna, A. et al. The protein kinase DYRK1A regulates caspase-9-mediated apoptosis during retina development. Dev. Cell 15, 841-853 (2008).
    • (2008) Dev. Cell , vol.15 , pp. 841-853
    • Laguna, A.1
  • 97
    • 77957807271 scopus 로고    scopus 로고
    • Dyrk1A phosphorylates p53 and inhibits proliferation of embryonic neuronal cells
    • Park, J. et al. Dyrk1A phosphorylates p53 and inhibits proliferation of embryonic neuronal cells. J. Biol. Chem. 285, 31895-31906 (2010).
    • (2010) J. Biol. Chem. , vol.285 , pp. 31895-31906
    • Park, J.1
  • 98
    • 79955432610 scopus 로고    scopus 로고
    • DYRK1A protein kinase promotes quiescence and senescence through DREAM complex assembly
    • Litovchick, L., Florens, L. A., Swanson, S. K., Washburn, M. P. & DeCaprio, J. A. DYRK1A protein kinase promotes quiescence and senescence through DREAM complex assembly. Genes Dev. 25, 801-813 (2011).
    • (2011) Genes Dev. , vol.25 , pp. 801-813
    • Litovchick, L.1    Florens, L.A.2    Swanson, S.K.3    Washburn, M.P.4    Decaprio, J.A.5
  • 99
    • 79957648087 scopus 로고    scopus 로고
    • Transient expression of Mnb/Dyrk1a couples cell cycle exit and differentiation of neuronal precursors by inducing p27KIP1 expression and suppressing NOTCH signaling
    • Hammerle, B. et al. Transient expression of Mnb/Dyrk1a couples cell cycle exit and differentiation of neuronal precursors by inducing p27KIP1 expression and suppressing NOTCH signaling. Development 138, 2543-2554 (2011).
    • (2011) Development , vol.138 , pp. 2543-2554
    • Hammerle, B.1
  • 100
    • 51149115754 scopus 로고    scopus 로고
    • DYRK1A-dosage imbalance perturbs NRSF/REST levels, deregulating pluripotency and embryonic stem cell fate in Down syndrome
    • Canzonetta, C. et al. DYRK1A-dosage imbalance perturbs NRSF/REST levels, deregulating pluripotency and embryonic stem cell fate in Down syndrome. Am. J. Hum. Genet. 83, 388-400 (2008).
    • (2008) Am. J. Hum. Genet. , vol.83 , pp. 388-400
    • Canzonetta, C.1
  • 101
    • 20444376939 scopus 로고    scopus 로고
    • A genetic screen for candidate tumor suppressors identifies REST
    • Westbrook, T. F. et al. A genetic screen for candidate tumor suppressors identifies REST. Cell 121, 837-848 (2005).
    • (2005) Cell , vol.121 , pp. 837-848
    • Westbrook, T.F.1
  • 102
    • 78049344289 scopus 로고    scopus 로고
    • Regulation of the NRSF/REST gene by methylation and CREB affects the cellular phenotype of small-cell lung cancer
    • Kreisler, A. et al. Regulation of the NRSF/REST gene by methylation and CREB affects the cellular phenotype of small-cell lung cancer. Oncogene 29, 5828-5838 (2010).
    • (2010) Oncogene , vol.29 , pp. 5828-5838
    • Kreisler, A.1
  • 103
    • 41149130221 scopus 로고    scopus 로고
    • Control of chromosome stability by the β-TrCP-REST-Mad2 axis
    • Guardavaccaro, D. et al. Control of chromosome stability by the β-TrCP-REST-Mad2 axis. Nature 452, 365-369 (2008).
    • (2008) Nature , vol.452 , pp. 365-369
    • Guardavaccaro, D.1
  • 104
    • 64549130400 scopus 로고    scopus 로고
    • DYRK1A interacts with the REST/NRSF-SWI/SNF chromatin remodelling complex to deregulate gene clusters involved in the neuronal phenotypic traits of Down syndrome
    • Lepagnol-Bestel, A. M. et al. DYRK1A interacts with the REST/NRSF-SWI/SNF chromatin remodelling complex to deregulate gene clusters involved in the neuronal phenotypic traits of Down syndrome. Hum. Mol. Genet. 18, 1405-1414 (2009).
    • (2009) Hum. Mol. Genet. , vol.18 , pp. 1405-1414
    • Lepagnol-Bestel, A.M.1
  • 105
    • 79953188323 scopus 로고    scopus 로고
    • REST regulates DYRK1A transcription in a negative feedback loop
    • Lu, M. et al. REST regulates DYRK1A transcription in a negative feedback loop. J. Biol. Chem. 286, 10755-10763 (2011).
    • (2011) J. Biol. Chem. , vol.286 , pp. 10755-10763
    • Lu, M.1
  • 106
    • 79961022039 scopus 로고    scopus 로고
    • P53 Downregulates down syndrome-associated DYRK1A through MiR-1246
    • Zhang, Y., Liao, J. M., Zeng, S. X. & Lu, H. p53 downregulates Down syndrome-associated DYRK1A through miR-1246. EMBO Rep. 12, 811-817 (2011).
    • (2011) EMBO Rep. , vol.12 , pp. 811-817
    • Zhang, Y.1    Liao, J.M.2    Zeng, S.X.3    Lu, H.4
  • 107
    • 84857809799 scopus 로고    scopus 로고
    • DYRK1A in Down syndrome: An oncogene or tumor suppressor?
    • Birger, Y. & Izraeli, S. DYRK1A in Down syndrome: an oncogene or tumor suppressor? J. Clin. Invest. 122, 807-810 (2012).
    • (2012) J. Clin. Invest. , vol.122 , pp. 807-810
    • Birger, Y.1    Izraeli, S.2
  • 108
    • 0035667067 scopus 로고    scopus 로고
    • High serum endostatin levels in Down syndrome: Implications for improved treatment and prevention of solid tumours
    • Zorick, T. S. et al. High serum endostatin levels in Down syndrome: implications for improved treatment and prevention of solid tumours. Eur. J. Hum. Genet. 9, 811-814 (2001).
    • (2001) Eur. J. Hum. Genet. , vol.9 , pp. 811-814
    • Zorick, T.S.1
  • 109
    • 0037106261 scopus 로고    scopus 로고
    • Phase i study of recombinant human endostatin in patients with advanced solid tumors
    • Herbst, R. S. et al. Phase I study of recombinant human endostatin in patients with advanced solid tumors. J. Clin. Oncol. 20, 3792-3803 (2002).
    • (2002) J. Clin. Oncol. , vol.20 , pp. 3792-3803
    • Herbst, R.S.1
  • 110
    • 0041732282 scopus 로고    scopus 로고
    • The threshold pattern of calcineurin-dependent gene expression is altered by loss of the endogenous inhibitor calcipressin
    • Ryeom, S., Greenwald, R. J., Sharpe, A. H. & McKeon, F. The threshold pattern of calcineurin-dependent gene expression is altered by loss of the endogenous inhibitor calcipressin. Nature Immunol. 4, 874-881 (2003).
    • (2003) Nature Immunol. , vol.4 , pp. 874-881
    • Ryeom, S.1    Greenwald, R.J.2    Sharpe, A.H.3    McKeon, F.4
  • 111
    • 67649506317 scopus 로고    scopus 로고
    • Down's syndrome suppression of tumour growth and the role of the calcineurin inhibitor DSCR1
    • Baek, K. H. et al. Down's syndrome suppression of tumour growth and the role of the calcineurin inhibitor DSCR1. Nature 459, 1126-1130 (2009).
    • (2009) Nature , vol.459 , pp. 1126-1130
    • Baek, K.H.1
  • 112
    • 79956087421 scopus 로고    scopus 로고
    • Increased survival following tumorigenesis in Ts65Dn mice that model Down syndrome
    • Yang, A. & Reeves, R. H. Increased survival following tumorigenesis in Ts65Dn mice that model Down syndrome. Cancer Res. 71, 3573-3581 (2011).
    • (2011) Cancer Res. , vol.71 , pp. 3573-3581
    • Yang, A.1    Reeves, R.H.2
  • 113
    • 33646171446 scopus 로고    scopus 로고
    • NFAT dysregulation by increased dosage of DSCR1 and DYRK1A on chromosome 21
    • Arron, J. R. et al. NFAT dysregulation by increased dosage of DSCR1 and DYRK1A on chromosome 21. Nature 441, 595-600 (2006).
    • (2006) Nature , vol.441 , pp. 595-600
    • Arron, J.R.1
  • 114
    • 25444442381 scopus 로고    scopus 로고
    • An aneuploid mouse strain carrying human chromosome 21 with down syndrome phenotypes
    • O'Doherty, A. et al. An aneuploid mouse strain carrying human chromosome 21 with down syndrome phenotypes. Science 309, 2033-2037 (2005).
    • (2005) Science , vol.309 , pp. 2033-2037
    • O'Doherty, A.1
  • 115
    • 77953457835 scopus 로고    scopus 로고
    • Tumour angiogenesis is reduced in the Tc 1 mouse model of Down's syndrome
    • Reynolds, L. E. et al. Tumour angiogenesis is reduced in the Tc 1 mouse model of Down's syndrome. Nature 465, 813-817 (2010).
    • (2010) Nature , vol.465 , pp. 813-817
    • Reynolds, L.E.1
  • 116
    • 0036188832 scopus 로고    scopus 로고
    • Fetal cervico-mediastinal cystic hygroma associated with maternal serum screening positive for Down syndrome
    • Chen, C. P. et al. Fetal cervico-mediastinal cystic hygroma associated with maternal serum screening positive for Down syndrome. Prenat. Diagn. 22, 166 (2002).
    • (2002) Prenat. Diagn. , vol.22 , pp. 166
    • Chen, C.P.1
  • 117
    • 0027958871 scopus 로고
    • Extragonadal choriocarcinoma in a patient with Down syndrome
    • Fountzilas, G. et al. Extragonadal choriocarcinoma in a patient with Down syndrome. Am. J. Clin. Oncol. 17, 452-455 (1994).
    • (1994) Am. J. Clin. Oncol. , vol.17 , pp. 452-455
    • Fountzilas, G.1
  • 118
    • 0033001307 scopus 로고    scopus 로고
    • Tuberous sclerosis with intracardiac rhabdomyoma in a fetus with trisomy 21: Case report and review of literature
    • Krapp, M. et al. Tuberous sclerosis with intracardiac rhabdomyoma in a fetus with trisomy 21: case report and review of literature. Prenat. Diagn. 19, 610-613 (1999).
    • (1999) Prenat. Diagn. , vol.19 , pp. 610-613
    • Krapp, M.1
  • 119
    • 4043062825 scopus 로고    scopus 로고
    • Pineal yolk sac tumour with a solid pattern: A case report in a Chinese adult man with Down's syndrome
    • Tan, H. W. et al. Pineal yolk sac tumour with a solid pattern: a case report in a Chinese adult man with Down's syndrome. J. Clin. Pathol. 57, 882-884 (2004).
    • (2004) J. Clin. Pathol. , vol.57 , pp. 882-884
    • Tan, H.W.1
  • 120
    • 4444347949 scopus 로고    scopus 로고
    • Prenatal origin of GATA1 mutations may be an initiating step in the development of megakaryocytic leukemia in Down syndrome
    • Taub, J. W. et al. Prenatal origin of GATA1 mutations may be an initiating step in the development of megakaryocytic leukemia in Down syndrome. Blood 104, 1588-1589 (2004).
    • (2004) Blood , vol.104 , pp. 1588-1589
    • Taub, J.W.1
  • 121
    • 0033619452 scopus 로고    scopus 로고
    • Prenatal origin of acute lymphoblastic leukaemia in children
    • Wiemels, J. L. et al. Prenatal origin of acute lymphoblastic leukaemia in children. Lancet 354, 1499-1503 (1999).
    • (1999) Lancet , vol.354 , pp. 1499-1503
    • Wiemels, J.L.1
  • 122
    • 0034810253 scopus 로고    scopus 로고
    • What is the true fetal loss rate in pregnancies affected by trisomy 21 and how does this influence whether first trimester detection rates are superior to those in the second trimester?
    • Spencer, K. What is the true fetal loss rate in pregnancies affected by trisomy 21 and how does this influence whether first trimester detection rates are superior to those in the second trimester? Prenat. Diagn. 21, 788-789 (2001).
    • (2001) Prenat. Diagn. , vol.21 , pp. 788-789
    • Spencer, K.1
  • 123
    • 59449099535 scopus 로고    scopus 로고
    • Enhanced apoptosis during early neuronal differentiation in mouse ES cells with autosomal imbalance
    • Kai, Y. et al. Enhanced apoptosis during early neuronal differentiation in mouse ES cells with autosomal imbalance. Cell Res. 19, 247-258 (2009).
    • (2009) Cell Res. , vol.19 , pp. 247-258
    • Kai, Y.1
  • 124
    • 38349120034 scopus 로고    scopus 로고
    • An additional human chromosome 21 causes suppression of neural fate of pluripotent mouse embryonic stem cells in a teratoma model
    • Mensah, A. et al. An additional human chromosome 21 causes suppression of neural fate of pluripotent mouse embryonic stem cells in a teratoma model. BMC Dev. Biol. 7, 131 (2007).
    • (2007) BMC Dev. Biol. , vol.7 , pp. 131
    • Mensah, A.1
  • 125
    • 0037176537 scopus 로고    scopus 로고
    • Neuronal target genes of the neuron-restrictive silencer factor in neurospheres derived from fetuses with Down's syndrome: A gene expression study
    • Bahn, S. et al. Neuronal target genes of the neuron-restrictive silencer factor in neurospheres derived from fetuses with Down's syndrome: a gene expression study. Lancet 359, 310-315 (2002).
    • (2002) Lancet , vol.359 , pp. 310-315
    • Bahn, S.1
  • 126
    • 31944432753 scopus 로고    scopus 로고
    • Defective cerebellar response to mitogenic Hedgehog signaling in Down's syndrome mice
    • Roper, R. J. et al. Defective cerebellar response to mitogenic Hedgehog signaling in Down's syndrome mice. Proc. Natl Acad. Sci. USA 103, 1452-1456 (2006).
    • (2006) Proc. Natl Acad. Sci. USA , vol.103 , pp. 1452-1456
    • Roper, R.J.1
  • 127
    • 77955772813 scopus 로고    scopus 로고
    • Bmi1 directly represses p21Waf1/Cip1 in Shh-induced proliferation of cerebellar granule cell progenitors
    • Subkhankulova, T., Zhang, X., Leung, C. & Marino, S. Bmi1 directly represses p21Waf1/Cip1 in Shh-induced proliferation of cerebellar granule cell progenitors. Mol. Cell. Neurosci. 45, 151-162 (2010).
    • (2010) Mol. Cell. Neurosci. , vol.45 , pp. 151-162
    • Subkhankulova, T.1    Zhang, X.2    Leung, C.3    Marino, S.4
  • 128
    • 78650219403 scopus 로고    scopus 로고
    • Trisomic dose of several chromosome 21 genes perturbs haematopoietic stem and progenitor cell differentiation in Down's syndrome
    • De Vita, S. et al. Trisomic dose of several chromosome 21 genes perturbs haematopoietic stem and progenitor cell differentiation in Down's syndrome. Oncogene 29, 6102-6114 (2010).
    • (2010) Oncogene , vol.29 , pp. 6102-6114
    • De Vita, S.1
  • 129
    • 58149396964 scopus 로고    scopus 로고
    • Trisomy 21 enhances human fetal erythro-megakaryocytic development
    • Chou, S. T. et al. Trisomy 21 enhances human fetal erythro-megakaryocytic development. Blood 11 2, 4503-4506 (2008).
    • (2008) Blood , vol.112 , pp. 4503-4506
    • Chou, S.T.1
  • 130
    • 58149380865 scopus 로고    scopus 로고
    • Abnormalities in the myeloid progenitor compartment in Down syndrome fetal liver precede acquisition of GATA1 mutations
    • Tunstall-Pedoe, O. et al. Abnormalities in the myeloid progenitor compartment in Down syndrome fetal liver precede acquisition of GATA1 mutations. Blood 11 2, 4507-4511 (2008).
    • (2008) Blood , vol.112 , pp. 4507-4511
    • Tunstall-Pedoe, O.1
  • 131
    • 20044381309 scopus 로고    scopus 로고
    • Developmental stage-selective effect of somatically mutated leukemogenic transcription factor GATA1
    • Li, Z. et al. Developmental stage-selective effect of somatically mutated leukemogenic transcription factor GATA1. Nature Genet. 37, 613-619 (2005).
    • (2005) Nature Genet. , vol.37 , pp. 613-619
    • Li, Z.1
  • 132
    • 52649166735 scopus 로고    scopus 로고
    • Megakaryocyte hyperproliferation without GATA1 mutation in foetal liver of a case of Down syndrome with hydrops foetalis
    • De Vita, S. et al. Megakaryocyte hyperproliferation without GATA1 mutation in foetal liver of a case of Down syndrome with hydrops foetalis. Br. J. Haematol. 143, 300-303 (2008).
    • (2008) Br. J. Haematol. , vol.143 , pp. 300-303
    • De Vita, S.1
  • 133
    • 79952200621 scopus 로고    scopus 로고
    • Myeloid proliferation without GATA1 mutations in a fetus with Down syndrome presenting in utero as a pericardial effusion
    • Rougemont, A. L. et al. Myeloid proliferation without GATA1 mutations in a fetus with Down syndrome presenting in utero as a pericardial effusion. Pediatr. Dev. Pathol. 13, 423-426 (2010).
    • (2010) Pediatr. Dev. Pathol. , vol.13 , pp. 423-426
    • Rougemont, A.L.1
  • 134
    • 33845990286 scopus 로고    scopus 로고
    • Hematological abnormalities during the first week of life among neonates with Down syndrome: Data from a multihospital healthcare system
    • Henry, E., Walker, D., Wiedmeier, S. E. & Christensen, R. D. Hematological abnormalities during the first week of life among neonates with Down syndrome: data from a multihospital healthcare system. Am. J. Med. Genet. A 143, 42-50 (2007).
    • (2007) Am. J. Med. Genet. A , vol.143 , pp. 42-50
    • Henry, E.1    Walker, D.2    Wiedmeier, S.E.3    Christensen, R.D.4
  • 135
    • 34247489332 scopus 로고    scopus 로고
    • Loss-of-function JAK3 mutations in TMD and AMKL of Down syndrome
    • De Vita, S. et al. Loss-of-function JAK3 mutations in TMD and AMKL of Down syndrome. Br. J. Haematol. 137, 337-341 (2007).
    • (2007) Br. J. Haematol. , vol.137 , pp. 337-341
    • De Vita, S.1
  • 136
    • 23944431906 scopus 로고    scopus 로고
    • Independent clones at separable stages of differentiation, bearing different GATA1 mutations, in the same TMD patient with Down syndrome
    • Groet, J. et al. Independent clones at separable stages of differentiation, bearing different GATA1 mutations, in the same TMD patient with Down syndrome. Blood 106, 1887-1888 (2005).
    • (2005) Blood , vol.106 , pp. 1887-1888
    • Groet, J.1
  • 137
    • 33745713168 scopus 로고    scopus 로고
    • Activating alleles of JAK3 in acute megakaryoblastic leukemia
    • Walters, D. K. et al. Activating alleles of JAK3 in acute megakaryoblastic leukemia. Cancer Cell 10, 65-75 (2006).
    • (2006) Cancer Cell , vol.10 , pp. 65-75
    • Walters, D.K.1
  • 138
    • 0027486732 scopus 로고
    • Loss of telomeric DNA during aging of normal and trisomy 21 human lymphocytes
    • Vaziri, H. et al. Loss of telomeric DNA during aging of normal and trisomy 21 human lymphocytes. Am. J. Hum. Genet. 52, 661-667 (1993).
    • (1993) Am. J. Hum. Genet. , vol.52 , pp. 661-667
    • Vaziri, H.1
  • 139
    • 33751544732 scopus 로고    scopus 로고
    • Hematopoietic progenitor cell deficiency in fetuses and children affected by Down's syndrome
    • Holmes, D. K. et al. Hematopoietic progenitor cell deficiency in fetuses and children affected by Down's syndrome. Exp. Hematol. 34, 1611-1615 (2006).
    • (2006) Exp. Hematol. , vol.34 , pp. 1611-1615
    • Holmes, D.K.1
  • 140
    • 80052606865 scopus 로고    scopus 로고
    • Defective hematopoietic stem cell and lymphoid progenitor development in the Ts65Dn mouse model of Down syndrome: Potential role of oxidative stress
    • Lorenzo, L. P. et al. Defective hematopoietic stem cell and lymphoid progenitor development in the Ts65Dn mouse model of Down syndrome: potential role of oxidative stress. Antioxid. Redox Signal. 15, 2083-2094 (2011).
    • (2011) Antioxid. Redox Signal. , vol.15 , pp. 2083-2094
    • Lorenzo, L.P.1
  • 141
    • 80055110647 scopus 로고    scopus 로고
    • Aging-associated changes in hematopoiesis and leukemogenesis: What's the connection?
    • Henry, C. J., Marusyk, A. & DeGregori, J. Aging-associated changes in hematopoiesis and leukemogenesis: what's the connection? Aging 3, 643-656 (2011).
    • (2011) Aging , vol.3 , pp. 643-656
    • Henry, C.J.1    Marusyk, A.2    Degregori, J.3
  • 142
    • 77951586942 scopus 로고    scopus 로고
    • Down syndrome fibroblasts and mouse Prep1-overexpressing cells display increased sensitivity to genotoxic stress
    • Micali, N. et al. Down syndrome fibroblasts and mouse Prep1-overexpressing cells display increased sensitivity to genotoxic stress. Nucleic Acids Res. 38, 3595-3604 (2010).
    • (2010) Nucleic Acids Res. , vol.38 , pp. 3595-3604
    • Micali, N.1
  • 143
    • 38049042877 scopus 로고    scopus 로고
    • The buccal cytome and micronucleus frequency is substantially altered in Down's syndrome and normal ageing compared to young healthy controls
    • Thomas, P., Harvey, S., Gruner, T. & Fenech, M. The buccal cytome and micronucleus frequency is substantially altered in Down's syndrome and normal ageing compared to young healthy controls. Mutat. Res. 638, 37-47 (2008).
    • (2008) Mutat. Res. , vol.638 , pp. 37-47
    • Thomas, P.1    Harvey, S.2    Gruner, T.3    Fenech, M.4
  • 144
    • 33746307840 scopus 로고    scopus 로고
    • Transcription factor GATA-1 and Down syndrome leukemogenesis
    • Muntean, A. G., Ge, Y., Taub, J. W. & Crispino, J. D. Transcription factor GATA-1 and Down syndrome leukemogenesis. Leuk. Lymphoma 47, 986-997 (2006).
    • (2006) Leuk. Lymphoma , vol.47 , pp. 986-997
    • Muntean, A.G.1    Ge, Y.2    Taub, J.W.3    Crispino, J.D.4
  • 145
    • 17244367849 scopus 로고    scopus 로고
    • DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis
    • Bartkova, J. et al. DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis. Nature 434, 864-870 (2005).
    • (2005) Nature , vol.434 , pp. 864-870
    • Bartkova, J.1
  • 146
    • 0344441890 scopus 로고    scopus 로고
    • A DNA damage checkpoint response in telomere-initiated senescence
    • d'Adda di Fagagna, F. et al. A DNA damage checkpoint response in telomere-initiated senescence. Nature 426, 194-198 (2003).
    • (2003) Nature , vol.426 , pp. 194-198
    • D'Adda Di Fagagna, F.1
  • 147
    • 17244366865 scopus 로고    scopus 로고
    • Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions
    • Gorgoulis, V. G. et al. Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions. Nature 434, 907-913 (2005).
    • (2005) Nature , vol.434 , pp. 907-913
    • Gorgoulis, V.G.1
  • 148
    • 0042420304 scopus 로고    scopus 로고
    • DNA damage foci at dysfunctional telomeres
    • Takai, H., Smogorzewska, A. & de Lange, T. DNA damage foci at dysfunctional telomeres. Curr. Biol. 13, 1549-1556 (2003).
    • (2003) Curr. Biol. , vol.13 , pp. 1549-1556
    • Takai, H.1    Smogorzewska, A.2    De Lange, T.3
  • 149
    • 35848935069 scopus 로고    scopus 로고
    • DNA damage response mediators MDC1 and 53BP1: Constitutive activation and aberrant loss in breast and lung cancer, but not in testicular germ cell tumours
    • Bartkova, J. et al. DNA damage response mediators MDC1 and 53BP1: constitutive activation and aberrant loss in breast and lung cancer, but not in testicular germ cell tumours. Oncogene 26, 7414-7422 (2007).
    • (2007) Oncogene , vol.26 , pp. 7414-7422
    • Bartkova, J.1
  • 150
    • 0029871363 scopus 로고    scopus 로고
    • Immune dysfunction in Down's syndrome: Primary immune deficiency or early senescence of the immune system?
    • Cuadrado, E. & Barrena, M. J. Immune dysfunction in Down's syndrome: primary immune deficiency or early senescence of the immune system? Clin. Immunol. Immunopathol. 78, 209-214 (1996).
    • (1996) Clin. Immunol. Immunopathol. , vol.78 , pp. 209-214
    • Cuadrado, E.1    Barrena, M.J.2
  • 151
    • 77957151235 scopus 로고    scopus 로고
    • Bone mineral density and respiratory muscle strength in male individuals with mental retardation (with and without Down Syndrome)
    • da Silva, V. Z. et al. Bone mineral density and respiratory muscle strength in male individuals with mental retardation (with and without Down Syndrome). Res. Dev. Disabil. 31, 1585-1589 (2010).
    • (2010) Res. Dev. Disabil. , vol.31 , pp. 1585-1589
    • Da Silva, V.Z.1
  • 152
    • 0037433652 scopus 로고    scopus 로고
    • Down's syndrome
    • Roizen, N. J. & Patterson, D. Down's syndrome. Lancet 361, 1281-1289 (2003).
    • (2003) Lancet , vol.361 , pp. 1281-1289
    • Roizen, N.J.1    Patterson, D.2
  • 153
    • 79959565462 scopus 로고    scopus 로고
    • Leukemogenesis and ageing: 'Fit for transformation'?
    • Greaves, M. Leukemogenesis and ageing: 'fit for transformation'? Aging 3, 79-80 (2011).
    • (2011) Aging , vol.3 , pp. 79-80
    • Greaves, M.1
  • 154
    • 0033166430 scopus 로고    scopus 로고
    • An e mu-BCL-2 transgene facilitates leukaemogenesis by ionizing radiation
    • Gibbons, D. L. et al. An E mu-BCL-2 transgene facilitates leukaemogenesis by ionizing radiation. Oncogene 18, 3870-3877 (1999).
    • (1999) Oncogene , vol.18 , pp. 3870-3877
    • Gibbons, D.L.1
  • 155
    • 0027972308 scopus 로고
    • Cancer incidence in atomic bomb survivors. Part III. Leukemia, lymphoma and multiple myeloma, 1950-1987
    • Preston, D. L. et al. Cancer incidence in atomic bomb survivors. Part III. Leukemia, lymphoma and multiple myeloma, 1950-1987. Radiat. Res. 137, S68-S97 (1994).
    • (1994) Radiat. Res. , vol.137
    • Preston, D.L.1
  • 156
    • 0028358319 scopus 로고
    • Incidence of female breast cancer among atomic bomb survivors, 1950-1985
    • Tokunaga, M. et al. Incidence of female breast cancer among atomic bomb survivors, 1950-1985. Radiat. Res. 138, 209-223 (1994).
    • (1994) Radiat. Res. , vol.138 , pp. 209-223
    • Tokunaga, M.1
  • 157
    • 78751644099 scopus 로고    scopus 로고
    • Genetic variegation of clonal architecture and propagating cells in leukaemia
    • Anderson, K. et al. Genetic variegation of clonal architecture and propagating cells in leukaemia. Nature 469, 356-361 (2011).
    • (2011) Nature , vol.469 , pp. 356-361
    • Anderson, K.1
  • 158
    • 61849176510 scopus 로고    scopus 로고
    • Hematological abnormalities in adult patients with Down's syndrome
    • McLean, S., McHale, C. & Enright, H. Hematological abnormalities in adult patients with Down's syndrome. Ir. J. Med. Sci. 178, 35-38 (2009).
    • (2009) Ir. J. Med. Sci. , vol.178 , pp. 35-38
    • McLean, S.1    McHale, C.2    Enright, H.3
  • 159
    • 36248966518 scopus 로고    scopus 로고
    • Induction of pluripotent stem cells from adult human fibroblasts by defined factors
    • Takahashi, K. et al. Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 131, 861-872 (2007).
    • (2007) Cell , vol.131 , pp. 861-872
    • Takahashi, K.1
  • 160
    • 0033986047 scopus 로고    scopus 로고
    • Narrowing of the region of allelic loss in 21q11-21 in squamous non-small cell lung carcinoma and cloning of a novel ubiquitin-specific protease gene from the deleted segment
    • Groet, J. et al. Narrowing of the region of allelic loss in 21q11-21 in squamous non-small cell lung carcinoma and cloning of a novel ubiquitin-specific protease gene from the deleted segment. Genes Chromosomes Cancer 27, 153-161 (2000).
    • (2000) Genes Chromosomes Cancer , vol.27 , pp. 153-161
    • Groet, J.1
  • 161
    • 48249150023 scopus 로고    scopus 로고
    • Detailed characterization of a homozygously deleted region corresponding to a candidate tumor suppressor locus at 21q11-21 in human lung cancer
    • Yamada, H. et al. Detailed characterization of a homozygously deleted region corresponding to a candidate tumor suppressor locus at 21q11-21 in human lung cancer. Genes Chromosomes Cancer 47, 810-818 (2008).
    • (2008) Genes Chromosomes Cancer , vol.47 , pp. 810-818
    • Yamada, H.1
  • 162
    • 20044395613 scopus 로고    scopus 로고
    • RAS is regulated by the let-7 microRNA family
    • Johnson, S. M. et al. RAS is regulated by the let-7 microRNA family. Cell 120, 635-647 (2005).
    • (2005) Cell , vol.120 , pp. 635-647
    • Johnson, S.M.1
  • 163
    • 84865865798 scopus 로고    scopus 로고
    • MiR-125 in normal and malignant hematopoiesis
    • 24 Apr 2012 doi:10.1038/leu.2012.90
    • Shaham, L., Binder, V., Gefen, N., Borkhardt, A. & Izraeli, S. MiR-125 in normal and malignant hematopoiesis. Leukemia 24 Apr 2012 (doi:10.1038/leu.2012.90).
    • Leukemia
    • Shaham, L.1    Binder, V.2    Gefen, N.3    Borkhardt, A.4    Izraeli, S.5
  • 164
    • 0035937393 scopus 로고    scopus 로고
    • Analysis of the ANA gene as a candidate for the chromosome 21q oral cancer susceptibility locus
    • Yamamoto, N. et al. Analysis of the ANA gene as a candidate for the chromosome 21q oral cancer susceptibility locus. Br. J. Cancer 84, 754-759 (2001).
    • (2001) Br. J. Cancer , vol.84 , pp. 754-759
    • Yamamoto, N.1
  • 165
    • 36048952786 scopus 로고    scopus 로고
    • Tumor protein 53-induced nuclear protein 1 expression is repressed by miR-155, and its restoration inhibits pancreatic tumor development
    • Gironella, M. et al. Tumor protein 53-induced nuclear protein 1 expression is repressed by miR-155, and its restoration inhibits pancreatic tumor development. Proc. Natl Acad. Sci. USA 104, 16170-16175 (2007).
    • (2007) Proc. Natl Acad. Sci. USA , vol.104 , pp. 16170-16175
    • Gironella, M.1
  • 166
    • 0034809324 scopus 로고    scopus 로고
    • Down's syndrome and acute lymphoblastic leukaemia: Clinical features and response to treatment
    • Chessells, J. M. et al. Down's syndrome and acute lymphoblastic leukaemia: clinical features and response to treatment. Arch. Dis. Child. 85, 321-325 (2001).
    • (2001) Arch. Dis. Child. , vol.85 , pp. 321-325
    • Chessells, J.M.1
  • 167
    • 0037062496 scopus 로고    scopus 로고
    • Chromosome translocations and covert leukemic clones are generated during normal fetal development
    • Mori, H. et al. Chromosome translocations and covert leukemic clones are generated during normal fetal development. Proc. Natl Acad. Sci. USA 99, 8242-8247 (2002).
    • (2002) Proc. Natl Acad. Sci. USA , vol.99 , pp. 8242-8247
    • Mori, H.1
  • 168
    • 79959510774 scopus 로고    scopus 로고
    • Genomic characterization implicates iAMP21 as a likely primary genetic event in childhood B-cell precursor acute lymphoblastic leukemia
    • Rand, V. et al. Genomic characterization implicates iAMP21 as a likely primary genetic event in childhood B-cell precursor acute lymphoblastic leukemia. Blood 11 7, 6848-6855 (2011).
    • (2011) Blood , vol.117 , pp. 6848-6855
    • Rand, V.1
  • 169
    • 63449108743 scopus 로고    scopus 로고
    • Ha-Ras transformation of MCF10A cells leads to repression of Singleminded-2s through NOTCH and C/EBPβ
    • Gustafson, T. L. et al. Ha-Ras transformation of MCF10A cells leads to repression of Singleminded-2s through NOTCH and C/EBPβ. Oncogene 28, 1561-1568 (2009).
    • (2009) Oncogene , vol.28 , pp. 1561-1568
    • Gustafson, T.L.1
  • 170
    • 80052468964 scopus 로고    scopus 로고
    • Stem cell gene expression programs influence clinical outcome in human leukemia
    • Eppert, K. et al. Stem cell gene expression programs influence clinical outcome in human leukemia. Nature Med. 17, 1086-1093 (2011).
    • (2011) Nature Med. , vol.17 , pp. 1086-1093
    • Eppert, K.1
  • 171
    • 0033037075 scopus 로고    scopus 로고
    • EWS-FLI1 and EWS-ERG gene fusions are associated with similar clinical phenotypes in Ewing's sarcoma
    • Ginsberg, J. P. et al. EWS-FLI1 and EWS-ERG gene fusions are associated with similar clinical phenotypes in Ewing's sarcoma. J. Clin. Oncol. 17, 1809-1814 (1999).
    • (1999) J. Clin. Oncol. , vol.17 , pp. 1809-1814
    • Ginsberg, J.P.1
  • 172
    • 0035931859 scopus 로고    scopus 로고
    • Opposing effects of Ets and Id proteins on p16INK4a expression during cellular senescence
    • Ohtani, N. et al. Opposing effects of Ets and Id proteins on p16INK4a expression during cellular senescence. Nature 409, 1067-1070 (2001).
    • (2001) Nature , vol.409 , pp. 1067-1070
    • Ohtani, N.1
  • 173
    • 10244252625 scopus 로고    scopus 로고
    • Gastric mucosa abnormalities and tumorigenesis in mice lacking the pS2 trefoil protein
    • Lefebvre, O. et al. Gastric mucosa abnormalities and tumorigenesis in mice lacking the pS2 trefoil protein. Science 274, 259-262 (1996).
    • (1996) Science , vol.274 , pp. 259-262
    • Lefebvre, O.1
  • 174
    • 84872500815 scopus 로고    scopus 로고
    • British Broadcasting Corporation BBC News [online]
    • British Broadcasting Corporation. Many keeping babies with Down's. BBC News [online], http://news. bbc.co.uk/1/hi/health/7741411.stm (2008).
    • (2008) Many Keeping Babies with Down's


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.