Hematological abnormalities in adult patients with Down's syndrome

Irish Journal of Medical Science

Volumn 178, Issue 1, 2009, Pages 35-38

  McLean, S ^a   McHale, Cathy ^a   Enright, Helen ^a  

^a ADELAIDE AND MEATH HOSPITAL   (Ireland)

Author keywords

Acutemyeloid leukemia; Adult; Down's syndrome; Myelodysplastic syndrome; Trisomy21

Indexed keywords

GRANULOCYTE COLONY STIMULATING FACTOR;

ADULT; ARTICLE; BLOOD CELL COUNT; BLOOD TRANSFUSION; BONE MARROW BIOPSY; BONE MARROW DEPRESSION; CLINICAL ARTICLE; COHORT ANALYSIS; COMORBIDITY; DISEASE COURSE; DOWN SYNDROME; FOLLOW UP; HEMATOLOGIC DISEASE; HUMAN; LEUKOPENIA; LONG TERM CARE; MEGALOCYTOSIS; MYELODYSPLASTIC SYNDROME; OUTCOMES RESEARCH; PATIENT REFERRAL; RETROSPECTIVE STUDY; THROMBOCYTOPENIA; COMPLICATION; FEMALE; IRELAND; MALE; MIDDLE AGED; MYELODYSPLASTIC SYNDROMES; PATHOPHYSIOLOGY;

ADULT; DOWN SYNDROME; FEMALE; HUMANS; IRELAND; MALE; MIDDLE AGED; MYELODYSPLASTIC SYNDROMES; RETROSPECTIVE STUDIES;

EID: 61849176510     PISSN: 00211265     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11845-008-0223-2     Document Type: Article

References (12)

1. Webb D, Roberts I, Vyas P et al (2007) Haematology of Down syndrome. Arch Dis Child Fetal Neonatal Ed 92(6):F503-F507
2. Fong CT, Bordeur GM (1987) Down's syndrome and leukemia: Epidemiology, genetics, cytogenetics and mechanisms of leukemogenesis. Cancer Genet Cytogenet 28(1):55-76
3. de Hingh YC, van der Vossen PW, Gemen EF et al (2005) Intrinsic abnormalities of lymphocyte counts in children with Down's Syndrome. J Pediatr 147(6):744-747
4. Mundschau G, Gurbuxani S, Gamis A et al (2003) Mutagenesis of GATA1 is an initiating event in Down syndrome leukemogenesis. Blood 101(11):4298-4300
5. Ge Y (2005) GATA1, cytidine deaminase, and the high cure rate of Down syndrome children with acute megakaryocytic leukemia. J Natl Cancer Inst 97:226-231
6. Weinstein HJ (1978) Congenital leukaemia and the neonatal myeloproliferative disorders associated with Down's syndrome. Clin Haematol 7(1):147-154
7. Cazzola M, Malcovati L (2005) Myelodysplastic syndromes: Coping with ineffective hematopoiesis. N Engl J Med 352:536
8. Lange BJ, Kobrinsky N, Barnard DR et al (1998) Distinctive demography, biology, and outcome of acute myeloid leukemia and myelodysplastic syndrome in children with Down syndrome: Children's cancer group studies 2861 and 2891. Blood 91(2):608-615
9. David O, Fiorucci GC, Tosi MT et al (1996) Hematological studies in children with Downs syndrome. Pediatr Hematol Oncol 13(3):271-275
10. Wachtel TJ, Pueshel SM (1991) Macrocytosis in Downs syndrome. Am J Ment Retard 95(4):417-420
11. Roizen NJ, Amarose AP (1993) Hematological abnormalities in children with Down syndrome. Am J Med Genet 46(5):510-512
12. Hasle H, Clemmensen HI, Mikkelsen M et al (2000) Risks of leukaemia and solid tumours in individuals with Down's syndrome. Lancet 355(9199):165-169