Hematopoietic progenitor cell deficiency in fetuses and children affected by Down's syndrome

Experimental Hematology

Volumn 34, Issue 12, 2006, Pages 1611-1615

  Holmes, Denise K ^a   Bates, Nicola ^a   Murray, Mary ^b   Ladusans, E J ^b   Morabito, Antonino ^a   Bolton Maggs, Paula H B ^b   Johnston, Tracey A ^c   Walkenshaw, Steve ^d   Wynn, Robert F ^a   Bellantuono, Ilaria ^e  

^a ROYAL MANCHESTER CHILDREN S HOSPITAL   (United Kingdom)

^b ALDER HEY CHILDREN S HOSPITAL   (United Kingdom)

^c ST MARY S HOSPITAL   (United Kingdom)

^d LIVERPOOL WOMEN S HOSPITAL   (United Kingdom)

^e UNIVERSITY OF SHEFFIELD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

TRANSCRIPTION FACTOR GATA 1;

ARTICLE; BLOOD DISEASE; CELL COUNT; CHILD; CHROMOSOME SIZE; CLONAL VARIATION; CONTROLLED STUDY; DOWN SYNDROME; EXON; FETUS; GENE MUTATION; GENETIC PREDISPOSITION; GESTATIONAL AGE; HEMATOPOIETIC STEM CELL; HEMATOPOIETIC STEM CELL DEFICIENCY; HUMAN; HUMAN CELL; LEUKEMOGENESIS; PRIORITY JOURNAL; TELOMERE;

ADOLESCENT; CHILD; CHILD, PRESCHOOL; DOWN SYNDROME; EXONS; FETUS; GATA1 TRANSCRIPTION FACTOR; HEMATOPOIETIC STEM CELLS; HUMANS; INFANT; MUTATION; TELOMERE;

EID: 33751544732     PISSN: 0301472X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.exphem.2006.10.013     Document Type: Article

References (19)

1. Korenberg J.R., Chen X.N., Schipper R., et al. Down syndrome phenotypes: the consequences of chromosomal imbalance. Proc Natl Acad Sci U S A 91 (1994) 4997-5001
2. Lange B. The management of neoplastic disorders of haematopoiesis in children with Down's syndrome. Br J Haematol 110 (2000) 512-524
3. Vaziri H., Schachter F., Uchida I., et al. Loss of telomeric DNA during aging of normal and trisomy 21 human lymphocytes. Am J Hum Genet 52 (1993) 661-667
4. Wynn R.F., Cross M.A., Hatton C., et al. Accelerated telomere shortening in young recipients of allogeneic bone-marrow transplants. Lancet 351 (1998) 178-181
5. Li X., Leteurtre F., Rocha V., et al. Abnormal telomere metabolism in Fanconi's anaemia correlates with genomic instability and the probability of developing severe aplastic anaemia. Br J Haematol 120 (2003) 836-845
6. Mason P.J. Stem cells, telomerase and dyskeratosis congenita. Bioessays 25 (2003) 126-133
7. Zipursky A. Transient leukaemia-a benign form of leukaemia in newborn infants with trisomy 21. Br J Haematol 120 (2003) 930-938
8. Epstein C.J., Hofmeister B.G., Yee D., et al. Stem cell deficiencies and thymic abnormalities in fetal mouse trisomy 16. J Exp Med 162 (1985) 695-712
9. Mundschau G., Gurbuxani S., Gamis A.S., Greene M.E., Arceci R.J., and Crispino J.D. Mutagenesis of GATA1 is an initiating event in Down syndrome leukemogenesis. Blood 101 (2003) 4298-4300
10. Taub J.W., Mundschau G., Ge Y., et al. Prenatal origin of GATA1 mutations may be an initiating step in the development of megakaryocytic leukemia in Down syndrome. Blood 104 (2004) 1588-1589
11. Bellantuono I., Gao L., Parry S., et al. Two distinct HLA-A0201-presented epitopes of the Wilms tumor antigen 1 can function as targets for leukemia-reactive CTL. Blood 100 (2002) 3835-3837
12. Dexter T.M., Allen T.D., and Lajtha L.G. Conditions controlling the proliferation of haemopoietic stem cells in vitro. J Cell Physiol 91 (1977) 335-344
13. Sutherland H.J., Lansdorp P.M., Henkelman D.H., Eaves A.C., and Eaves C.J. Functional characterization of individual human hematopoietic stem cells cultured at limiting dilution on supportive marrow stromal layers. Proc Natl Acad Sci U S A 87 (1990) 3584-3588
14. Hitzler J.K., Cheung J., Li Y., Scherer S.W., and Zipursky A. GATA1 mutations in transient leukemia and acute megakaryoblastic leukemia of Down syndrome. Blood 101 (2003) 4301-4304
15. Rainis L., Bercovich D., Strehl S., et al. Mutations in exon 2 of GATA1 are early events in megakaryocytic malignancies associated with trisomy 21. Blood 102 (2003) 981-986
16. Edvardsson L., Dykes J., Olsson M.L., and Olofsson T. Clonogenicity, gene expression and phenotype during neutrophil versus erythroid differentiation of cytokine-stimulated CD34+ human marrow cells in vitro. Br J Haematol 127 (2004) 451-463
17. Takano H., Ema H., Sudo K., and Nakauchi H. Asymmetric division and lineage commitment at the level of hematopoietic stem cells: inference from differentiation in daughter cell and granddaughter cell pairs. J Exp Med 199 (2004) 295-302
18. Singh H. Gene targeting reveals a hierarchy of transcription factors regulating specification of lymphoid cell fates. Curr Opin Immunol 8 (1996) 160-165
19. Adolfsson J., Mansson R., Buza-Vidas N., et al. Identification of Flt3+ lympho-myeloid stem cells lacking erythro-megakaryocytic potential a revised road map for adult blood lineage commitment. Cell 121 (2005) 295-306