High frequency of copy number alterations in myeloid leukaemia of Down syndrome

British Journal of Haematology

Volumn 158, Issue 6, 2012, Pages 800-803

  Blink, Marjolein ^a   van den Heuvel Eibrink, Marry M ^a   Aalbers, Anna M ^a,b,c   Balgobind, Brian V ^a   Hollink, Iris H I M ^a   Meijerink, Jules P P ^a   van der Velden, Vincent H J ^c   Beverloo, Berna H ^c   de Haas, Valerie ^d   Hasle, Henrik ^e   Reinhardt, Dirk ^f   Klusmann, Jan Henning ^f   Pieters, Rob ^a   Calado, Rodrigo T ^b   Zwaan, Christian M ^a  

^a SOPHIA CHILDREN S HOSPITAL   (Netherlands)

^b NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

^c ERASMUS MEDICAL CENTER   (Netherlands)

^d DUTCH CHILDHOOD ONCOLOGY GROUP   (Netherlands)

^e AARHUS UNIVERSITY HOSPITAL   (Denmark)

^f HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

Acute leukaemia; Copy number alterations; Down syndrome

Indexed keywords

TELOMERASE;

CHILD; CHROMOSOME 11; CHROMOSOME 1Q; CHROMOSOME ANALYSIS; CLINICAL ARTICLE; COMPARATIVE GENOMIC HYBRIDIZATION; CONTROLLED STUDY; COPY NUMBER VARIATION; DOWN SYNDROME; FEMALE; FLUORESCENCE IN SITU HYBRIDIZATION; GENE MUTATION; GENE REARRANGEMENT; GENOMIC INSTABILITY; HUMAN; INFANT; LETTER; LEUKEMOGENESIS; MALE; MYELOID LEUKEMIA; MYELOID LEUKEMIA OF DOWN SYNDROME; PRESCHOOL CHILD; PRIORITY JOURNAL; TELOMERE HOMEOSTASIS;

ACUTE DISEASE; CHILD, PRESCHOOL; CHROMOSOME ABERRATIONS; DOWN SYNDROME; FEMALE; GENE AMPLIFICATION; GENE DELETION; GENE DOSAGE; GENETIC PREDISPOSITION TO DISEASE; HUMANS; INFANT; KARYOTYPING; LEUKEMIA, MEGAKARYOBLASTIC, ACUTE; LEUKEMIA, MYELOID; MALE; RNA; TELOMERASE; TELOMERE;

EID: 84865537739     PISSN: 00071048     EISSN: 13652141     Source Type: Journal    
DOI: 10.1111/j.1365-2141.2012.09224.x     Document Type: Letter

References (10)

1. Blink, M., van den Heuvel-Eibrink, M.M., de Haas, V., Klusmann, J.H., Hasle, H. & Zwaan, C.M. (2012) Low frequency of type-I and type-II aberrations in myeloid leukemia of Down syndrome, underscoring the unique entity of this disease. Haematologica, 97, 632-634.
2. Calado, R.T., Regal, J.A., Hills, M., Yewdell, W.T., Dalmazzo, L.F., Zago, M.A., Lansdorp, P.M., Hogge, D., Chanock, S.J., Estey, E.H., Falcão, R.P. & Young, N.S. (2009) Constitutional hypomorphic telomerase mutations in patients with acute myeloid leukemia. Proceedings of the National Academy of Sciences of the United States of America, 106, 1187-1192.
3. Creutzig, U., Reinhardt, D., Diekamp, S., Dworzak, M., Stary, J. & Zimmermann, M. (2005) AML patients with Down syndrome have a high cure rate with AML-BFM therapy with reduced dose intensity. Leukemia, 19, 1355-1360.
4. De Lange, T. (2005) Telomere-related genome instability in cancer. Cold Spring Harbor Symposia on Quantitative Biology, 70, 197-204.
5. Forestier, E., Izraeli, S., Beverloo, B., Haas, O., Pession, A., Michalova, K., Stark, B., Harrison, C.J., Teigler-Schlegel, A. & Johansson, B. (2008) Cytogenetic features of acute lymphoblastic and myeloid leukemias in pediatric patients with Down syndrome: an iBFM-SG study. Blood, 111, 1575-1583.
6. Hasle, H. (2001) Pattern of malignant disorders in individuals with Down's syndrome. Lancet Oncology, 2, 429-436.
7. Hitzler, J.K. & Zipursky, A. (2005) Origins of leukaemia in children with Down syndrome. Nature Reviews Cancer, 5, 11-20.
8. Holmes, D.K., Bates, N., Murray, M., Ladusans, E.J., Morabito, A., Bolton-Maggs, P.H., Johnston, T.A., Walkenshaw, S., Wynn, R.F. & Bellantuono, I. (2006) Hematopoietic progenitor cell deficiency in fetuses and children affected by Down's syndrome. Experimental Hematology, 34, 1611-1615.
9. Klusmann, J.H., Creutzig, U., Zimmermann, M., Dworzak, M., Jorch, N., Langebrake, C., Pekrun, A., Macakova-Reinhardt, K. & Reinhardt, D. (2008) Treatment and prognostic impact of transient leukemia in neonates with Down syndrome. Blood, 111, 2991-2998.
10. Lo, K.C., Chalker, J., Strehl, S., Neat, M., Smith, O., Dastugue, N., Kearney, L., Izraeli, S., Kempski, H. & Cowell, J.K. (2008) Array comparative genome hybridization analysis of acute lymphoblastic leukaemia and acute megakaryoblastic leukaemia in patients with Down syndrome. British Journal of Haematology, 142, 934-945.