The buccal cytome and micronucleus frequency is substantially altered in Down's syndrome and normal ageing compared to young healthy controls

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

Volumn 638, Issue 1-2, 2008, Pages 37-47

  Thomas, Philip ^a,b   Harvey, Sarah ^c   Gruner, Tini ^c   Fenech, Michael ^a  

^a CSIRO   (Australia)

^b UNIVERSITY OF ADELAIDE   (Australia)

^c SOUTHERN CROSS UNIVERSITY   (Australia)

Author keywords

Ageing; Buccal cytome; DNA damage; Down's syndrome; Micronucleus

Indexed keywords

DNA;

ADOLESCENT; ADULT; ARTICLE; CELL DEATH; CELL PROLIFERATION; CHILD; CHROMATIN CONDENSATION; CONTROLLED STUDY; DNA DAMAGE; DOWN SYNDROME; FEMALE; GENE FREQUENCY; GENE MUTATION; HUMAN; HUMAN CELL; MAJOR CLINICAL STUDY; MALE; MICRONUCLEUS; PREMATURE AGING; PRIORITY JOURNAL;

ADOLESCENT; ADULT; AGED; AGING; BIOLOGICAL MARKERS; CELL DEATH; CHILD; CHILD, PRESCHOOL; CHROMOSOMAL INSTABILITY; DNA DAMAGE; DOWN SYNDROME; HUMANS; MICRONUCLEUS TESTS; MIDDLE AGED; MODELS, BIOLOGICAL; MOUTH MUCOSA;

EID: 38049042877     PISSN: 00275107     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mrfmmm.2007.08.012     Document Type: Article

References (34)

1. Bolognesi C., Lando C., Forni A., Landini E., Scarpato R., Migliore L., and Bonassi S. Chromosomal damage and ageing: effect on micronuclei frequency in peripheral blood lymphocytes. Age Ageing 28 (1999) 393-397
2. Miller R.A. The biology of ageing and longevity. In: Hazzard W.R. (Ed). Principles of Geriatric Medicine and Gerontology (1993), McGraw-Hill, New York
3. Fenech M. Chromosomal damage rate, aging, and diet. Ann. NY Acad. Sci. 854 (1998) 23-36
4. Fenech M. The role of folic acid and Vitamin B12 in genomic stability of human cells. Mutat. Res. 475 (2001) 57-67
5. Martin G.M. Genetic and environmental modulations of chromosomal stability. Ann. NY Acad. Sci. 621 (1991) 401-417
6. Fraga C., Shigenaga M., Park J., Degan P., and Ames B. Oxidative damage to DNA during aging: 8-hydroxy-2′-deoxyguanosine in rat organ DNA and urine. PNAS 87 (1990) 4533-4537
7. Goukassian D., Gad F., Yaar M., Eller M.S., Nehal U.S., and Gilchrist B.A. Mechanisms and implications of the age-associated decrease in DNA repair capacity. FASEB J. 14 (2000) 1325-1334
8. Fenech M., and Morley A.A. Cytokinesis-block micronucleus method in human lymphocytes: effect of in vivo ageing and low dose X-irradiation. Mutat. Res. 161 (1986) 193-198
9. Antoccia A., Tanzarella C., Modesti D., and Degrassi F. Cytokinesis-block micronucleus assay with kinetochore detection in colchicine-treated human fibroblasts. Mutat. Res. 287 (1993) 93-99
10. Norppa H., and Falck G.C.-M. What do human micronuclei contain?. Mutagenesis 18 (2003) 221-233
11. 2 and gamma-irradiation with the alkaline comet assay. Mutat. Res. 383 (1997) 71-80
12. Singh N.P., Danner D.B., Tice R.R., Brant L., and Schneider E.L. DNA damage and repair with age in individual human lymphocytes. Mutat. Res. 237 (1990) 123-130
13. Dhillon V.S., Thomas P., and Fenech M. Comparison of DNA damage and repair following radiation challenge in buccal cells and lymphocytes using single-cell gel electrophoresis. Int. J. Radiat. Biol. 80 (2004) 517-528
14. Weirich-Schwaiger H., Weirich H.G., Gruber B., Schweiger M., and Hirsch-Kauffmann M. Correlation between senescence and DNA repair in cells from young and old individuals and in premature aging syndromes. Mutat. Res. 316 (1994) 37-48
15. Belien J.A., Copper M.P., Braakhuis B.J., Snow G.B., and Baak J.P. Standardization of counting micronuclei: definition of a protocol to measure genotoxic damage in human exfoliated cells. Carcinogenesis 16 (1995) 2395-2400
16. Tolbert P.E., Shy C.M., and Allen J.W. Micronuclei and other nuclear anomalies in buccal smears: a field test in snuff users. Am. J. Epidemiol. 134 (1991) 840-850
17. Fenech M., and Crott J.W. Micronuclei, nucleoplasmic bridges and nuclear buds induced in folic acid deficient human lymphocytes-evidence for breakage-fusion-bridge cycles in the cytokinesis-block micronucleus assay. Mutat. Res. 504 (2002) 131-136
18. Shimizu N., Itoh N., Utiyama H., and Wahl G.M. Selective entrapment of extrachromosomally amplified DNA by nuclear budding and micronucleation during S phase. J. Cell Biol. 140 (1998) 1307-1320
19. Shimizu N., Kamezaki F., and Shigematsu S. Tracking of microinjected DNA in live cells reveals the intracellular behavior and elimination of extrachromosomal genetic material. Nucleic Acids Res. 33 (2005) 6296-6307
20. Veiro J.A., and Cummins P.G. Imaging of skin epidermis from various origins using confocal laser scanning microscopy. Dermatology 189 (1994) 16-22
21. Masters B.R., Gonnord G., and Corcuff P. Three-dimensional microscopic biopsy of in vivo human skin: a new technique based on a flexible confocal microscope. J. Microsc. 185 (1997) 329-338 (d01-624.x)
22. Guttenbach M., Schakowski R., and Schmid M. Aneuploidy and ageing: sex chromosome exclusion into micronuclei. Hum. Genet. 94 (1994) 295-298
23. Hando J.C., Nath J., and Tucker J.D. Sex chromosomes, micronuclei and aging in women. Chromosoma 103 (1994) 186-192
24. Gattas G.J., Cardoso Lde A., Medrado-Faria Mde A., and Saldanha P.H. Frequency of oral mucosa micronuclei in gas station operators after introducing methanol. Occup. Med. (Lond) 51 (2001) 107-113
25. Ozkul Y., Donmez H., Erenmemisoglu A., Demirtas H., and Imamoglu N. Induction of micronuclei by smokeless tobacco on buccal mucosa cells of habitual users. Mutagenesis 12 (1997) 285-287
26. Pinto D., Ceballos J.M., Garcia G., Guzman P., Del Razo L.M., Vera E., Gomez H., Garcia A., and Gonsebatt M.E. Increased cytogenetic damage in outdoor painters. Mutat. Res. 467 (2000) 105-111
27. Williams D.M., and Cruchley A.T. The structural aspects of ageing in the oral mucosa. The Effect of Ageing in Oral Mucosa and Skin (1994), CRC Press
28. Burns T., Breathnack S., and Cox N. Rook's Textbook of Dermatology. 7th ed. (2004), Blackwell Publishing, Oxford, UK
29. Thomas D.R. Age-related changes in wound healing. Drugs Aging 18 (2001) 607-620
30. Roizen N.J., and Patterson D. Down's syndrome. Lancet 361 (2003) 1281-1289
31. Korenberg J., Chen X., Schipper R., Sun Z., Gonsky R., Gerwehr S., Carpenter N., Daumer C., Dignan P., Disteche C., et al. Down syndrome phenotypes: the consequences of chromosomal imbalance. PNAS 91 (1994) 4997-5001
32. Maluf S.W., and Erdtmann B. Genomic instability in Down syndrome and Fanconi anemia assessed by micronucleus analysis and single-cell gel electrophoresis. Cancer Genet. Cytogenet. 124 (2001) 71-75
33. Scarfi M.R., Cossarizza A., Monti D., Bersani F., Zannotti M., Lioi M.B., and Franceschi C. Age-related increase of mitomycin C-induced micronuclei in lymphocytes from Down's syndrome subjects. Mutat. Res. 237 (1990) 247-252
34. Shi Q., and King R.W. Chromosome nondisjunction yields tetraploid rather than aneuploid cells in human cell lines. Nature 437 (2005) 1038-1042