Independent clones at separable stages of differentiation, bearing different GATA1 mutations, in the same TMD patient with Down syndrome [3]

Blood

Volumn 106, Issue 5, 2005, Pages 1887-1888

  Groet, Jürgen ^b   Mulligan, Claire ^b   Spinelli, Monica ^b   Serra, Anna ^b   McElwaine, Suzanne ^b   Cotter, Finbarr E ^b   Dagna Bricarelli, Franca ^b   Saglio, Giuseppe ^b   Basso, Giuseppe ^b   Nizetic, Dean ^a  

^a QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CD34 ANTIGEN; TRANSCRIPTION FACTOR GATA 1;

BLOOD SAMPLING; CASE REPORT; CELL CLONING; CELL DIFFERENTIATION; CLINICAL EDUCATION; DOWN SYNDROME; FEMALE; GENE MUTATION; HEMATOPOIESIS; HUMAN; LETTER; MEGAKARYOCYTE; MYELOPROLIFERATIVE DISORDER; NEWBORN; ONTOGENY; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SYMPTOM; TRANSIENT MYELOPROLIFERATIVE DISORDER;

EID: 23944431906     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood-2005-03-1071     Document Type: Letter

References (8)

1. Taub JW, Mundschau G, Ge Y et al. Prenatal origin of GATA1 mutations may be an initiating step in the development of megakaryocytic leukemia in Down syndrome. Blood. 2004;104:1588-1589.
2. Groet J, McElwaine S, Spinelli M et al. Acquired mutations in GATA1 in neonates with Down's syndrome with transient myeloid disorder. Lancet. 2003;361:1617-1620.
3. Shimada A, Xu G, Toki T, Kimura H, Hayashi Y, Ito E. Fetal origin of the GATA1 mutation in identical twins with transient myeloproliferative disorder and acute megakaryoblastic leukemia accompanying Down syndrome. Blood. 2004;103:366.
4. Rainis L, Bercovich D, Strehl S et al. Mutations in exon 2 of GATA1 are early events in megakaryocytic malignancies associated with trisomy 21. Blood. 2003;102:981-986.
5. Ahmed M, Sternberg A, Hall G et al. Natural history of GATA1 mutations in Down syndrome. Blood. 2004;103:2480-2489.
6. Wechsler J, Greene M, McDevitt MA et al. Acquired mutations in GATA1 in the megakaryoblastic leukemia of Down syndrome. Nat Genet. 2002;32:148-152.
7. Hitzler JK and Zipursky A. Origins of leukaemia in children with Down syndrome. Nat Rev Cancer. 2005;5:11-20.
8. Li Z, Godhino F, Klusmann J-H et al. Developmental stage-selective effect of somatically mutated leukemogenic transcription factor GATA1. Nat Genet. 2005;37:613-619.