Dyrk1A phosphorylates p53 and inhibits proliferation of embryonic neuronal cells

Journal of Biological Chemistry

Volumn 285, Issue 41, 2010, Pages 31895-31906

  Park, Joongkyu ^a   Oh, Yohan ^a   Yoo, Lang ^a   Jung, Min Su ^b   Song, Woo Joo ^b   Lee, Sang Hun ^c   Seo, Hyemyung ^c   Chung, Kwang Chul ^a  

^a Yonsei University   (South Korea)

^b Inje University   (South Korea)

^c Hanyang University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; CELL PROLIFERATION; GENES; HANDICAPPED PERSONS; LAWS AND LEGISLATION; PHASE TRANSITIONS; PHOSPHORYLATION;

CRITICAL REGION; DOWN SYNDROME; ELEVATED LEVEL; GENE GROUPS; GENE PRODUCTS; HUMAN CHROMOSOMES; HUMAN EMBRYONIC STEM CELLS; IN-VITRO; INHIBITORY EFFECT; MENTAL RETARDATION; MOLECULAR MECHANISM; NEURAL DEFECTS; NEURAL PRECURSORS; NEURONAL CELL; POINT MUTATIONS; REGULATED KINASE; TARGET GENES; TRANSGENIC MICE; UP-REGULATION;

STEM CELLS;

DUAL SPECIFICITY TYROSINE PHOSPHORYLATION REGULATED KINASE 1A; PROTEIN P21; PROTEIN P53; PROTEIN TYROSINE KINASE; UNCLASSIFIED DRUG; CDKN1A PROTEIN, HUMAN; CDKN1A PROTEIN, MOUSE; CYCLIN DEPENDENT KINASE INHIBITOR 1A; DYRK KINASE; PROTEIN SERINE THREONINE KINASE; TP53 PROTEIN, HUMAN;

ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL ASSAY; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL CYCLE S PHASE; CELL MUTANT; CELL PROLIFERATION; CHROMOSOME 21; CONTROLLED STUDY; DOWN SYNDROME; EMBRYO; EMBRYO CELL; ENZYME ACTIVITY; ENZYME ASSAY; GENE OVEREXPRESSION; GENE TARGETING; GENETIC TRANSFECTION; HIPPOCAMPUS; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; NERVE CELL; NEUROPATHOLOGY; NONHUMAN; NUCLEOTIDE SEQUENCE; PHASE TRANSITION; POINT MUTATION; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN INDUCTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN SYNTHESIS INHIBITION; STEM CELL; TRANSCRIPTION REGULATION; UPREGULATION; WILD TYPE; ANIMAL; ANIMAL EMBRYO; CELL CYCLE; CELL LINE; GENETICS; METABOLISM; MOUSE; PATHOLOGY; PHOSPHORYLATION; RAT; TRANSGENIC MOUSE;

MUS MUSCULUS; RATTUS;

ANIMALS; CELL CYCLE; CELL LINE; CHROMOSOMES, HUMAN, PAIR 21; CYCLIN-DEPENDENT KINASE INHIBITOR P21; DOWN SYNDROME; EMBRYO, MAMMALIAN; HUMANS; MICE; MICE, TRANSGENIC; NEURONS; PHOSPHORYLATION; POINT MUTATION; PROTEIN-SERINE-THREONINE KINASES; PROTEIN-TYROSINE KINASES; RATS; TUMOR SUPPRESSOR PROTEIN P53;

EID: 77957807271     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.147520     Document Type: Article

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