Helicobacter pylori infection promotes methylation and silencing of trefoil factor 2, leading to gastric tumor development in mice and humans

Gastroenterology

Volumn 139, Issue 6, 2010, Pages 2005-2017

  Peterson, Anthony J ^a   Menheniott, Trevelyan R ^a   O'Connor, Louise ^a   Walduck, Anna K ^b   Fox, James G ^c   Kawakami, Kazuyuki ^d   Minamoto, Toshinari ^d   Ong, Eng Kok ^a   Wang, Timothy C ^e   Judd, Louise M ^a,b   Giraud, Andrew S ^a,b  

^a ROYAL CHILDREN'S HOSPITAL   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

^c Massachusetts Institute of Technology Cambridge   (United States)

^d KANAZAWA UNIVERSITY   (Japan)

^e Medical School ^*  (United States)

Author keywords

Epigenetics; Stomach Cancer; Trefoil Factor 2; Tumor Suppressor

Indexed keywords

CYTOKINE; GLYCOPROTEIN GP 130; INTESTINAL TREFOIL FACTOR; MESSENGER RNA; TREFOIL FACTOR 2; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER CELL CULTURE; CANCER TISSUE; CELL PROLIFERATION; CONTROLLED STUDY; DEMETHYLATION; DISEASE FREE SURVIVAL; DNA METHYLATION; EPIGENETICS; GENE EXPRESSION; GENE SILENCING; HELICOBACTER INFECTION; HELICOBACTER PYLORI; HUMAN; HUMAN CELL; HUMAN TISSUE; INTESTINE METAPLASIA; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN FUNCTION; STOMACH ANTRUM; STOMACH BIOPSY; STOMACH CANCER; STOMACH CARCINOGENESIS; STOMACH DISEASE; STOMACH GLANDULAR ATROPHY; STOMACH MUCOSA; STOMACH TUMOR; TH1 CELL; TH2 CELL; TUMOR GROWTH; TUMOR SUPPRESSOR GENE; WILD TYPE;

EID: 78649706953     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.gastro.2010.08.043     Document Type: Article

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