DNA damage and repair in children with Down's syndrome

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

Volumn 637, Issue 1-2, 2008, Pages 118-123

  Morawiec, Zbigniew ^a   Janik, Katarzyna ^b   Kowalski, Michal ^c   Stetkiewicz, Tomasz ^d   Szaflik, Jerzy ^c   Morawiec Bajda, Alina ^e   Sobczuk, Anna ^d   Blasiak, Janusz ^b  

^a N Copernicus Hospital   (Poland)

^b UNIVERSITY OF LODZ   (Poland)

^c MEDICAL UNIVERSITY OF WARSAW   (Poland)

^d POLISH MOTHER S MEMORIAL HOSPITAL RESEARCH INSTITUTE   (Poland)

^e MEDICAL UNIVERSITY OF LODZ   (Poland)

Author keywords

Comet assay; DNA damage; DNA repair; Down's syndrome

Indexed keywords

CELL DNA; DNA FORMAMIDOPYRIMIDINE GLYCOSYLASE; ENDONUCLEASE; HYDROGEN PEROXIDE; METHYLNITRONITROSOGUANIDINE;

ADOLESCENT; ADULT; ARTICLE; CANCER SUSCEPTIBILITY; CHILD; CHROMOSOME 21; CLINICAL ARTICLE; COMET ASSAY; DNA DAMAGE; DNA REPAIR; DOWN SYNDROME; FEMALE; GENETIC SUSCEPTIBILITY; GENOMIC INSTABILITY; GENOTOXICITY; HUMAN; HUMAN CELL; LEUKEMIA; LEUKEMOGENESIS; MALE; PERIPHERAL LYMPHOCYTE; PRIORITY JOURNAL;

ADOLESCENT; CHILD; CHILD, PRESCHOOL; COMET ASSAY; DNA DAMAGE; DNA REPAIR; DOWN SYNDROME; FEMALE; HUMANS; HYDROGEN PEROXIDE; MALE; METHYLNITRONITROSOGUANIDINE;

EID: 37148999073     PISSN: 00275107     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mrfmmm.2007.07.010     Document Type: Article

References (21)

1. Lejune J., Gautier M., and Turpin R. Etude des chromosomes somatiques de neuf enfants mongoliens. Compte. Rendu. d'Acad. Sci. 248 (1959) 1721-1722
2. Roizen N.J., and Patterson D. Down's syndrome. Lancet 361 (2003) 1281-1289
3. Jang Q., Rasmussen S.A., and Friedman J.M. Mortality associated with Down's syndrome in the USA from 1983 to 1997: a population-based study. Lancet 359 (2002) 1019-1025
4. Stage D., Sommelet D., Geneis A., Nishi M., Malet P., and Vekemans M. A tumor profile in Down's syndrome. Am. J. Med. Genet. 78 (1998) 207-216
5. Nelson R. GATA1 gene may hold key to AMKL in patients with Down's syndrome. Lancet 360 (2002) 551
6. 2-induced apoptosis: implications for Down's syndrome. Biochem. Biophys. Res. Commun. 287 (2001) 1003-1008
7. Collins A.R., Duthie S.J., and Dobson V.L. Direct enzymatic detection of endogenous base damage in human lymphocyte DNA. Carcinogenesis 14 (1993) 1733-1735
8. David-Cordonnier M.-H., Laval J., and O'Neill P. Clustered DNA damage, influence on damage excision by XRS5 nuclear extracts and Escherichia coli Nth and Fpg proteins. J. Biol. Chem. 275 (2000) 11865-11873
9. Boiteux S., Gajewski E., Laval J., and Dizdaroglu M. Substrate specificity of the Escherichia coli Fpg protein (formamidopyrimidine-DNA glycosylase): excision of purine lesions in DNA produced by ionizing radiation or photosensitization. Biochemistry 31 (1992) 106-110
10. Tchou J., Kasai H., Shibutani S., Chung M.H., Laval J., Grollman A.P., and Nishimura S. 8-Oxoguanine (8-hydroxyguanine) DNA glycosylase and its substrate specificity. Proc. Natl. Acad. Sci. U.S.A. 88 (1991) 4690-4694
11. Maluf S.W., and Erdtmann B. Genomic instability in Down syndrome and Fanconi anemia assessed by micronucleus analysis and single-cell gel electrophoresis. Cancer Genet. Cytogenet. 124 (2001) 71-75
12. Zana M., Szecsenyj A., Czibula A., Bjelik A., Juhasz A., Rimanoczy A., Szabo K., Vetro A., Szucs P., Varkonyi A., Pakasaki M., Boda K., Rasko I., Janka Z., and Kalman J. Age-dependent oxidative stress-induced DNA damage in Down's lymphocytes. Biochim. Biophys. Res. Commun. 345 (2006) 726-733
13. Singh N.P., McCoy T., Tice R.R., and Schneider E.L. A simple technique for of low levels of DNA damage in individual cells. Exp. Cell Res. 175 (1988) 184-192
14. Klaude M., Eriksson S., Nygren J., and Ahnstrom G. The comet assay: mechanisms and technical considerations. Mutat. Res. 12 (1996) 89-96
15. Blasiak J., Gloc E., Woźniak K., Drzewoski J., Zadrozny M., Skorski T., and Pertynski T. Free radicals scavengers can differentially modulate the genotoxicity of amsacrine in normal and cancer cells. Mutat. Res. 535 (2003) 25-34
16. Ashby J., Tinwell H., Lefevre P.A., and Browne M.A. The single cell gel electrophoresis assay for induced DNA damage (comet assay): measurement of tail length and moment. Mutagenesis 10 (1995) 85-90
17. Tice R.R., Agurell E., Anderson D., Burlinson B., Hartmann A., Kobayashi H., Miyamae Y., Rojas E., Ryu J.C., and Sasaki Y.F. Single cell gel/comet assay: guidelines for in vitro and in vivo genetic toxicology testing. Environ. Mol. Mutagen. 35 (2000) 206-221
18. Kolibaba K.S., and Druker B.J. Protein tyrosine kinases and cancer. Biochim. Biophys. Acta 1333 (1997) F217
19. Roat E., Prada N., Ferraresi R., Giovenzana C., Nasi M., Troiano L., Pinti M., Nemes E., Lugli E., Biagioni O., Mariotti M., Ciacci L., Consolo U., Balli F., and Cossarizza A. Mitochondrial alterations and tendency to apoptosis in peripheral blood cells from children with Down syndrome. FEBS Lett. 581 (2007) 521-525
20. Busciglio J., and Yankner B.A. Apoptosis and increased generation of reactive oxygen species in Down's syndrome neurons in vitro. Nature 378 (1995) 776-779
21. Druzhyna N., Nair R.G., LeDoux S.P., and Wilson G.I. Defective repair of oxidative damage in mitochondrial DNA in Down's syndrome. Mutat. Res. 409 (1998) 81-89